New, highly efficient formulation of diclofenac for the topical, transdermal administration in ultradeformable drug carriers, Transfersomes

J.I.F. Reynolds (Ed.), The Extra Pharmacopoeia (Martindale), Pharmaceutical Press, London, 1993.

Todd, 1988, Diclofenac sodium. A reappraisal of its pharmacodynamic and pharmacokinetic properties and therapeutic efficacy, Drugs, 35, 244, 10.2165/00003495-198835030-00004

Riess, 1986, Die perkutane Resorption von Diclofenac, Arzeim. Forsch. Drug Res., 36, 1092

Singh, 1994, Skin permeability and local tissue concentrations of non-steroidal anti-inflammatory drugs after topical application, J. Pharmacol. Exp. Ther., 268, 144

Radermacher, 1991, Diclofenac concentration in synovial fluid and plasma after cutaneous application in inflammatory and degenerative joint disease, Br. J. Clin. Pharmacol., 31, 537, 10.1111/j.1365-2125.1991.tb05576.x

Voltaren Emulgel, company brochure, Ciba, Basel, 1993.

Assandri, 1993, Local tolerability and pharmacokinetic profile of a new transdermal delivery system, diclofenac hydroxyethylpyrrolidine plaster, Drugs Exp. Clin. Res., 19, 89

Schreier, 1994, Liposomes and niosomes as topical drug carriers: dermal and transdermal drug delivery, J. Controlled Release, 30, 1, 10.1016/0168-3659(94)90039-6

Zellmer, 1995, Interaction of phosphatidylcholine liposomes with the human stratum corneum, Biochim. Biophys. Acta, 1237, 176, 10.1016/0005-2736(95)00100-H

Lauer, 1995, Transfollicular drug delivery, Pharm. Res., 12, 179, 10.1023/A:1016250422596

Nishihata, 1987, Rat percutaneous transport of diclofenac and influence of hydrogenated soya phospholipids, Chem. Pharm. Bull., 35, 3807, 10.1248/cpb.35.3807

Maffei-Facino, 1993, Antioxidant profile of nimesulide, indomethacin and diclofenac in phosphatidylcholine liposomes (PCL) as membrane model, Int. J. Tissue React., 15, 225

Cevc, 1992, Lipid vesicles penetrate into intact skin owing to the transdermal osmotic gradients and hydration force, Biochim. Biophys. Acta, 1104, 226, 10.1016/0005-2736(92)90154-E

G. Cevc, Dermal insulin, in: M. Berger, F.A. Gries (Eds.), Frontiers in Insulin Pharmacology, Georg Thieme, Stuttgart, 1993, pp. 161 ff.

Cevc, 1995, Transdermal drug carriers: basic properties, optimization and transfer-efficiency in the case of epicutaneously applied peptides, J. Controlled Release, 36, 3, 10.1016/0168-3659(95)00056-E

Cevc, 1996, The skin: a pathway for the systemic treatment with patches and lipid-based agent carriers, Adv. Drug Deliv. Rev., 18, 349, 10.1016/0169-409X(95)00091-K

Cevc, 1996, Transfersomes mediated transepidermal delivery improves the regio-specificity and biological activity of corticosteroids in vivo, J. Controlled Release, 45, 211, 10.1016/S0168-3659(96)01566-0

Cevc, 1996, Lipid suspensions on the skin. Permeation enhancement, vesicle penetration and transdermal drug delivery, Crit. Rev. Ther. Drug Deliv. Systems, 13, 257, 10.1615/CritRevTherDrugCarrierSyst.v13.i3-4.30

G. Cevc, Material transport across permeability barriers by means of lipid vesicles, in: R. Lipowsky, E. Sackmann (Eds.), Handbook of Physics of Biological Systems, Vol. 1, Elsevier, Amsterdam, 1995, pp. 441–464.

G. Cevc, European patent 91 114 163.8-2114, 1991.

Schätzlein, 1998, Non-uniform cellular packing of the stratum corneum and permeability barrier function of intact skin: a high-resolution confocal laser scanning microscopy study using highly deformable vesicles (Transfersomes), Br. J. Dermatol., 138, 583, 10.1046/j.1365-2133.1998.02166.x

K.A. Walters, J. Hadgraft (Eds.), Pharmaceutical Skin Penetration Enhancement, Marcel Dekker, New York, 1993, pp. 383–408.

Friedman, 1995, Submicron emulsion vehicle for enhanced transdermal delivery of steroidal and nonsteroidal antiinflammatory drugs, J. Pharm. Sci., 84, 324, 10.1002/jps.2600840312

Hiramatsu, 1990, Assessment of topical non-steroidal anti-inflammatory drugs in animal models, Arzneimittelforschung, 40, 1117

Gallacchi, 1993, Pharmacokinetics of diclofenac hydroxyethylpyrrolidine (DHEP) plasters in patients with monolateral knee joint effusion, Drugs Exp. Clin. Res., 19, 95

el Hadidi, 1991, Double-blind study comparing the use of Voltaren Emulgel versus regular gel during ultrasonic sessions in the treatment of localized traumatic and rheumatic painful conditions, J. Int. Med. Res., 19, 219, 10.1177/030006059101900307

M.A. Yorek, in: G. Cevc (Ed.). Phospholipids Handbook, Marcel Dekker, New York, 1993, p. 759.

Figueras, 1994, Spontaneous reporting of adverse drug reactions to non-steroidal anti-inflammatory drugs. A report from the Spanish System of Pharmacovigilance, including an early analysis of topical and enteric-coated formulations, Eur. J. Clin. Pharmacol., 47, 297, 10.1007/BF00191158

M.J. Parnham, A. Wendel, Phospholipids and Liposomes, Scientific Publication No. 2, Natterman Phospholipid GmbH, Cologne, 1992.

Gebhardt, 1994, Allergic contact dermatitis from topical diclofenac, Contact Dermatitis, 30, 183, 10.1111/j.1600-0536.1994.tb00711.x

Gonzalez, 1992, Noninvasive, percutaneous induction of topical analgesia by a new type of drug carriers and prolongation of the local pain-insensitivity by analgesic liposomes, Anesth. Analg., 95, 615

Zimmerman, 1995, Upper gastrointestinal hemorrhage associated with cutaneous application of diclofenac gel, Am. J. Gastroenterol., 90, 2032

Martin, 1981, Membrane damage by bile salts: the protective function of phospholipids, J. Pharm. Pharmacol., 31, 754, 10.1111/j.2042-7158.1981.tb13926.x

Vyas, 1995, Liposomally encapsulated diclofenac for sonophoresis induced systemic delivery, J. Microencapsul., 12, 149, 10.3109/02652049509015285

Rosenthal, 1993, A controlled clinical study on the new topical dosage form of DHEP plasters in patients suffering from localized inflammatory diseases, Drugs Exp. Clin. Res., 19, 99

Cevc, 1998, Ultraflexible vesicles, Transfersomes, have an extremely low permeation resistance and transport therapeutic amounts of insulin across the intact mammalian skin, Biochim. Biophys. Acta, 1368, 201, 10.1016/S0005-2736(97)00177-6