Depsidone và dichromone mới từ thân cây Garcinia paucinervis với hoạt tính chống phát triển tế bào

Journal of Natural Medicines - Tập 73 - Trang 278-282 - 2018
CuiCui Jia1,2, JingJing Xue1,2, XinYu Li1,2, DaHong Li1,2, ZhanLin Li1,2, HuiMing Hua1,2
1Key Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang, China
2School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, People’s Republic of China

Tóm tắt

Một depsidone mới, paucinervin Q (1), một dichromone mới, paucinervin R (2), và một hợp chất đã biết, paucinervin B (3), đã được phân lập từ thân cây Garcinia paucinervis bằng các phương pháp sắc ký khác nhau. Cấu trúc của các hợp chất được xác định thông qua phân tích dữ liệu quang phổ. Các hợp chất phân lập được đánh giá về hoạt tính chống phát triển tế bào đối với ba dòng tế bào ung thư HL-60, PC-3 và CaCo-2. Hợp chất 1 cho thấy hoạt tính ức chế đáng kể.

Từ khóa

#depsidone #dichromone #Garcinia paucinervis #hoạt tính chống phát triển tế bào #HL-60 #PC-3 #CaCo-2

Tài liệu tham khảo

Semwal RB, Semwal DK, Vermaak I, Viljoen A (2015) A comprehensive scientific overview of Garcina cambogia. Fitoterapia 102:134–148 Li DH, Li CX, Jia CC, Sun YT, Xue CM, Bai J, Hua HM, Liu XQ, Li ZL (2016) Xanthones from Garcinia paucinervis with in vitro anti-proliferative activity against HL-60 cells. Arch Pharm Res 39:172–177 Liu B, Zhang XB, Bussmann RW, Hart RH, Li P, Bai YJ, Long CL (2017) Garcinia in southern China: ethnobotany, management, and niche modeling. Econ Bot 70:417–430 Jouda JB, Tamokou JD, Mbazoa CD, Clovis DM, Sarkar P, Bag PK, Wandji J (2016) Antibacterial and cytotoxic cytochalasins from the endophytic fungus Phomopsis sp. harbored in Garcinia kola (Heckel) nut. BMC Complement Altern Med 16:462–470 Fan YM, Yi P, Li Y, Yan C, Huang T, Gu W, Ma Y, Huang LJ, Zhang JX, Yang CL, Li Y, Yuan CM, Hao XJ (2015) Two unusual polycyclic polyprenylated acylphloroglucinols, including a pair of enantiomers from Garcinia multiflora. Org Lett 17:2066–2069 Li P, Yue GGL, Kwok HF, Long CL, Lau CBS, Kennelly EJ (2017) Using ultra-performance liquid chromatography quadrupole time of flight mass spectrometry-based chemometrics for the identification of anti-angiogenic biflavonoids from edible Garcinia species. J Agric Food Chem 65:8348–8355 Richard JA, Pouwer RH, Chen DYK (2012) The chemistry of the polycyclic polyprenylated acylphloroglucinols. Angew Chem Int Ed 51:4536–4561 Genovese S, Fiorito S, Taddeo VA, Epifano F (2016) Recent developments in the pharmacology of prenylated xanthones. Drug Discov Today 21:1814–1819 Yang H, Figueroa M, To S, Baggett S, Jiang B, Basile MJ, Weinstein B, Kennelly EJ (2010) Benzophenones and biflavonoids from Garcinia livingstonei fruits. J Agric Food Chem 58:4749–4755 Johnson OO, Zhao M, Gunn J, Santarsiero BD, Yin ZQ, Ayoola GA, Coker HAB, Che CT (2016) α-Glucosidase inhibitory prenylated anthranols from Harungana madagascariensis. J Nat Prod 79:224–229 Mbwambo ZH, Kapingu MC, Moshi MJ, Machumi F, Apers S, Cos P, Ferreira D, Marais JPJ, Berghe DV, Maes L, Vlietinck A, Pieters L (2006) Antiparasitic activity of some xanthones and biflavonoids from the root bark of Garcinia livingstonei. J Nat Prod 69:369–372 Lin YM, Anderson H, Flavin MT, Pai YHS (1997) In vitro anti-HIV activity of biflavonoids isolated from Rhus succedanea and Garcinia multiflora. J Nat Prod 60:884–888 Xu WJ, Li RJ, Quasie O, Yang MH, Kong LY, Luo J (2016) Polyprenylated tetraoxygenated xanthones from the roots of Hypericum monogynum and their neuroprotective activities. J Nat Prod 79:1971–1981 Stark TD, Salger M, Frank O, Balemba OB, Wakamatsu J, Hofmann T (2015) Antioxidative compounds from Garcinia buchananii stem bark. J Nat Prod 78:234–240 Gao XM, Yu T, Lai FSF, Zhou Y, Liu X, Qiao CF, Song JZ, Chen SL, Luo KQ, Xu HX (2010) Identification and evaluation of apoptotic compounds from Garcinia paucinervis. Bioorg Med Chem 18:4957–4964 Hu QF, Meng YL, Yao JH, Qin YH, Yang ZY, Zhao GL, Yang ZX, Gao XM, Li TF (2014) Flavonoids from Garcinia paucinervis and their biological activities. Chem Nat Compd 50:994–997 Li P, Senthilkumar HA, Figueroa M, Wu SB, Fata JE, Kennelly EJ, Long C (2016) UPLC-QTOFMSE-guided dereplication of the endangered Chinese species Garcinia paucinervis to identify additional benzophenone derivatives. J Nat Prod 79:1619–1627 Wu YP, Zhao W, Xia ZY, Kong GH, Lu XP, Hu QF, Gao XM (2013) Three novel xanthones from Garcinia paucinervis and their anti-TMV activity. Molecules 18:9663–9669 Gao XM, Yu T, Lai FSF, Pu JX, Qiao CF, Zhou Y, Liu X, Song JZ, Luo KQ, Xu HX (2010) Novel polyisoprenylated benzophenone derivatives from Garcinia paucinervis. Tetrahedron Lett 51:2442–2446 Li DH, Li CX, Jia CC, Sun YT, Xue CM, Bai J, Hua HM, Liu XQ, Li ZL (2016) Xanthones from Garcinia paucinervis with in vitro anti-proliferative activity against HL-60 cells. Arch Pharm Res 39:172–177 Jia CC, Han T, Xu J, Li SG, Sun YT, Li DH, Li ZL, Hua HM (2017) A new biflavonoid and a new triterpene from the leaves of Garcinia paucinervis and their biological activities. J Nat Med 71:642–649 Jia CC, Xue JJ, Gong C, Li XY, Li ZL, Hua HM (2018) Chiral resolution and anticancer effect of xanthones from Garcinia paucinervis. Fitoterapia 127:220–225 Fan QF, Na Z, Hu HB, Xu YK, Tang T (2012) Chemical constituents from stem barks of Garcinia paucinervis. Chin Tradit Herb Drugs 43:436–439 Xu ST, Yao H, Hu M, Li DH, Zhu ZY, Xie WJ, Yao HQ, Wu L, Chen ZS, Xu JY (2017) 6,7-Seco-ent-kauranoids derived from oridonin as potential anticancer agents. J Nat Prod 80:2391–2398