New approach for preparation of 2,3,7-trisubstituted 3,4-dihydroisoquinolinone libraries on solid phase
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To reduce the list of potential building blocks to a manageable size, large number of building blocks are sieved through several layers of filters, such as availability, compatibility and molecular weight. Building blocks that fit these criteria are computationally evaluated using our two-step diversity analysis process to ensure the library produced is maximally diverse. For further details, see: R. S. Pearlman and K. M. Smith, Drugs Future, 23 (1998), 885.