New antimalarial targets: The example of glucose transport

Newton, 1998, Severe falciparum malaria in children: current understanding of pathophysiology and supportive treatment, Pharmacol Ther, 79, 1, 10.1016/S0163-7258(98)00008-4

White, 1996, The treatment of malaria, N Engl J Med, 335, 800, 10.1056/NEJM199609123351107

Planche, 2006, Severe malaria: metabolic complications, Curr Mol Med, 6, 141, 10.2174/156652406776055177

Agbenyega, 2000, Glucose and lactate kinetics in children with severe malaria, J Clin Endocrinol Metab, 85, 1569, 10.1210/jc.85.4.1569

Krishna, 1999, Expression of parasite transporters in Xenopus oocytes, Novartis Found Symp, 226, 126

Ruebush, 2003, Chloroquine-resistant Plasmodium vivax malaria in Peru, Am J Trop Med Hyg, 69, 548, 10.4269/ajtmh.2003.69.548

Plowe, 1997, Mutations in Plasmodium falciparum dihydrofolate reductase and dihydropteroate synthase and epidemiologic patterns of pyrimethamine–sulfadoxine use and resistance, J Infect Dis, 176, 1590, 10.1086/514159

Yuvaniyama, 2003, Insights into antifolate resistance from malarial DHFR-TS structures, Nat Struct Biol, 10, 357, 10.1038/nsb921

Price, 2004, Mefloquine resistance in Plasmodium falciparum and increased pfmdr1 gene copy number, Lancet, 364, 438, 10.1016/S0140-6736(04)16767-6

Roth, 1987, Malarial parasite hexokinase and hexokinase-dependent glutathione reduction in the Plasmodium falciparum-infected human erythrocyte, J Biol Chem, 262, 15678, 10.1016/S0021-9258(18)47780-0

Sherman, 1979, Biochemistry of Plasmodium (malarial parasites), Microbiol Rev, 43, 453, 10.1128/MMBR.43.4.453-495.1979

Makler, 1993, Parasite lactate dehydrogenase as an assay for Plasmodium falciparum drug sensitivity, Am J Trop Med Hyg, 48, 739, 10.4269/ajtmh.1993.48.739

Gomez, 1997, Substrate and cofactor specificity and selective inhibition of lactate dehydrogenase from the malarial parasite P. falciparum, Mol Biochem Parasitol, 90, 235, 10.1016/S0166-6851(97)00140-0

Royer, 1986, Biologically active derivatives of gossypol: synthesis and antimalarial activities of peri-acylated gossylic nitriles, J Med Chem, 29, 1799, 10.1021/jm00159a043

Razakantoanina, 2000, Antimalarial activity of new gossypol derivatives, Parasitol Res, 86, 665, 10.1007/PL00008549

Dunn, 1996, The structure of lactate dehydrogenase from Plasmodium falciparum reveals a new target for anti-malarial design, Nat Struct Biol, 3, 912, 10.1038/nsb1196-912

Joet, 2003, Validation of the hexose transporter of Plasmodium falciparum as a novel drug target, Proc Natl Acad Sci USA, 100, 7476, 10.1073/pnas.1330865100

Kirk, 1996, Glucose uptake in Plasmodium falciparum-infected erythrocytes is an equilibrative not an active process, Mol Biochem Parasitol, 82, 195, 10.1016/0166-6851(96)02734-X

Goodyer, 1997, Efflux of 6-deoxy-d-glucose from Plasmodium falciparum-infected erythrocytes via two saturable carriers, Mol Biochem Parasitol, 84, 229, 10.1016/S0166-6851(96)02802-2

Penny, 1998, Expression of substrate-specific transporters encoded by Plasmodium falciparum in Xenopus laevis oocytes, Mol Biochem Parasitol, 93, 81, 10.1016/S0166-6851(98)00024-3

Woodrow, 1999, Intraerythrocytic Plasmodium falciparum expresses a high affinity facilitative hexose transporter, J Biol Chem, 274, 7272, 10.1074/jbc.274.11.7272

Joet, 2002, Comparative characterization of hexose transporters of Plasmodium knowlesi, Plasmodium yoelii and Toxoplasma gondii highlights functional differences within the apicomplexan family, Biochem J, 368, 923, 10.1042/bj20021189

Mueckler, 1985, Sequence and structure of a human glucose transporter, Science, 229, 941, 10.1126/science.3839598

Zolg, 1984, The accumulation of lactic acid and its influence on the growth of Plasmodium falciparum in synchronized cultures, In Vitro, 20, 205, 10.1007/BF02618189

Rager, 2001, Localization of the Plasmodium falciparum PfNT1 nucleoside transporter to the parasite plasma membrane, J Biol Chem, 276, 41095, 10.1074/jbc.M107037200

Krishna, 2000, Hexose transport in asexual stages of Plasmodium falciparum and kinetoplastidae, Parasitol Today, 16, 516, 10.1016/S0169-4758(00)01762-2

Abramson, 2003, The lactose permease of Escherichia coli: overall structure, the sugar-binding site and the alternating access model for transport, FEBS Lett, 555, 96, 10.1016/S0014-5793(03)01087-1

Huang, 2003, Structure and mechanism of the glycerol-3-phosphate transporter from Escherichia coli, Science, 301, 616, 10.1126/science.1087619

Mueckler, 1994, Glutamine 161 of Glut1 glucose transporter is critical for transport activity and exofacial ligand binding, J Biol Chem, 269, 20533, 10.1016/S0021-9258(17)32026-4

Woodrow, 2000, Hexose permeation pathways in Plasmodium falciparum-infected erythrocytes, Proc Natl Acad Sci USA, 97, 9931, 10.1073/pnas.170153097

Fayolle, 2006, Probing structure/affinity relationships for the Plasmodium falciparum hexose transporter with glucose derivatives, Bioorg Med Chem Lett, 16, 1267, 10.1016/j.bmcl.2005.11.068

Ionita, 2007, Interaction of O-(undec-10-en)-yl-d-glucose derivatives with the Plasmodium falciparum hexose transporter (PfHT), Bioorg Med Chem Lett, 10.1016/j.bmcl.2007.06.021

Saliba, 2004, Inhibition of hexose transport and abrogation of pH homeostasis in the intraerythrocytic malaria parasite by an O-3-hexose derivative, FEBS Lett, 570, 93, 10.1016/j.febslet.2004.06.032

Broach, 1996, High-throughput screening for drug discovery, Nature, 384, 14

Horrocks, 2003, Human cell systems for drug discovery, Curr Opin Drug Discov Dev, 6, 570

Baniecki, 2007, High-throughput Plasmodium falciparum growth assay for malaria drug discovery, Antimicrob Agents Chemother, 51, 716, 10.1128/AAC.01144-06

Weisman, 2006, Searching for new antimalarial therapeutics amongst known drugs, Chem Biol Drug Des, 67, 409, 10.1111/j.1747-0285.2006.00391.x

Woodrow, 2005, Molecular approaches to malaria: glycolysis in asexual stage parasites