New Insights and Modern Treatment of AL Amyloidosis
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•• Comenzo RL. How I treat amyloidosis. Blood. 2009;114(15):3147–57. This is an excellent review for readers who want to grasp the fundamental basics of AL amyloidosis. Written in a case based format supported by in-depth and critical analysis of the literature in the field makes it a must read article by all who are interested in this disease.
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•• Merlini G, Wechalekar AD, Palladini G. Systemic light chain amyloidosis: an update for treating physicians. Blood. 2013 May 13. This is another must-read up-to-date review article likely to have wide spread reading and citations in the field of AL amyloidosis. The authors have done a commendable job in presenting the review concise yet complete for clinicians who diagnose and treat patients with AL amyloidosis.
•• Comenzo RL, Reece D, Palladini G, Seldin D, Sanchorawala V, Landau H, et al. Consensus guidelines for the conduct and reporting of clinical trials in systemic light-chain amyloidosis. Leukemia. 2012;26(11):2317–25. This article will have far reaching influences because it provides the basis for design and conduct of future clinical trial and pharma-academia collaboration for innovative strategies to our fight against AL amyloidosis.
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• Zhou P, Hoffman J, Landau H, Hassoun H, Iyer L, Comenzo RL. Clonal plasma cell pathophysiology and clinical features of disease are linked to clonal plasma cell expression of cyclin D1 in systemic light-chain amyloidosis. Clin Lymphoma Myeloma Leuk. 2012;12(1):49–58. Both references 21 and 22 are about the information in the genetics of clonal plasma cells in the outcome of patients with AL amyloidosis. The emphasis in the genetic information should be the part of work up in clinics and in the translational researches in AL.
• Bryce AH, Ketterling RP, Gertz MA, Lacy M, Knudson RA, Zeldenrust S, et al. Translocation t(11;14) and survival of patients with light chain (AL) amyloidosis. Haematologica. 2009;94(3):380–6. Both references 21 and 22 are about the information in the genetics of clonal plasma cells in the outcome of patients with AL amyloidosis. The emphasis in the genetic information should be the part of work up in clinics and in the translational researches in AL.
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Study of Dexamethasone Plus MLN9708 or Physician's Choice of Treatment in Relapsed or Refractory Systemic Light Chain (AL) Amyloidosis. ClinicalTrials.gov Identifier:NCT01659658
Phase II Study of the Combination of Bendamustine and Dexamethasone in Patients with Relapsed AL Amyloidosis. ClinicalTrials.gov Identifier:NCT01222260
A Phase I/II Trial of Pomalidomide and Dexamethasone in Subjects with Previously-Treated AL Amyloidosis. ClinicalTrials.gov Identifier:NCT01570387
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