Neutrophils to the ROScue: Mechanisms of NADPH Oxidase Activation and Bacterial Resistance
Tóm tắt
Từ khóa
Tài liệu tham khảo
Abram, 2009, The ins and outs of leukocyte integrin signaling, Annu. Rev. Immunol., 27, 339, 10.1146/annurev.immunol.021908.132554
Ago, 1999, Mechanism for phosphorylation-induced activation of the phagocyte NADPH oxidase protein p47(phox). Triple replacement of serines 303, 304, and 328 with aspartates disrupts the SH3 domain-mediated intramolecular interaction in p47(phox), thereby activating the oxidase, J. Biol. Chem., 274, 33644, 10.1074/jbc.274.47.33644
Alenghat, 2012, Macrophages require Skap2 and Sirpalpha for integrin-stimulated cytoskeletal rearrangement, J. Cell. Sci., 125, 5535, 10.1242/jcs.111260
Ali, 1998, Differential regulation of formyl peptide and platelet-activating factor receptors. Role of phospholipase Cbeta3 phosphorylation by protein kinase A, J. Biol. Chem., 273, 11012, 10.1074/jbc.273.18.11012
Allen, 2005, Helicobacter pylori disrupts NADPH oxidase targeting in human neutrophils to induce extracellular superoxide release, J. Immunol., 174, 3658, 10.4049/jimmunol.174.6.3658
Allen, 1999, Transient association of the nicotinamide adenine dinucleotide phosphate oxidase subunits p47phox and p67phox with phagosomes in neutrophils from patients with X-linked chronic granulomatous disease, Blood, 93, 3521, 10.1182/blood.V93.10.3521.410k21_3521_3530
Altuvia, 1997, A small, stable RNA induced by oxidative stress: role as a pleiotropic regulator and antimutator, Cell, 90, 43, 10.1016/S0092-8674(00)80312-8
Ambruso, 1999, Human neutrophil immunodeficiency syndrome is associated with an inhibitory Rac2 mutation, Proc. Natl. Acad. Sci. U.S.A., 97, 4654, 10.1073/pnas.080074897
Anderson, 2010, PtdIns3P and Rac direct the assembly of the NADPH oxidase on a novel, pre-phagosomal compartment during FcR-mediated phagocytosis in primary mouse neutrophils, Blood, 116, 4978, 10.1182/blood-2010-03-275602
Aslund, 1999, Regulation of the OxyR transcription factor by hydrogen peroxide and the cellular thiol-disulfide status, Proc. Natl. Acad. Sci. U.S.A., 96, 6161, 10.1073/pnas.96.11.6161
Aussel, 2011, Salmonella detoxifying enzymes are sufficient to cope with the host oxidative burst, Mol. Microbiol., 80, 628, 10.1111/j.1365-2958.2011.07611.x
Bae, 2011, Regulation of reactive oxygen species generation in cell signaling, Mol. Cells, 32, 491, 10.1007/s10059-011-0276-3
Baehner, 1967, Leukocyte oxidase: defective activity in chronic granulomatous disease, Science, 155, 835, 10.1126/science.155.3764.835
Bagaitkar, 2017, PI(3)P-p40phox binding regulates NADPH oxidase activation in mouse macrophages and magnitude of inflammatory responses in vivo, J. Leukoc. Biol., 101, 449, 10.1189/jlb.3AB0316-139R
Bagaitkar, 2012, Activation of neutrophil respiratory burst by fungal particles requires phosphatidylinositol 3-phosphate binding to p40(phox) in humans but not in mice, Blood, 120, 3385, 10.1182/blood-2012-07-445619
Bagg, 1987, Ferric uptake regulation protein acts as a repressor, employing iron (II) as a cofactor to bind the operator of an iron transport operon in Escherichia coli, Biochemistry, 26, 5471, 10.1021/bi00391a039
Bedard, 2007, The NOX family of ROS-generating NADPH oxidases: physiology and pathophysiology, Physiol. Rev., 87, 245, 10.1152/physrev.00044.2005
Berton, 1992, Generation of signals activating neutrophil functions by leukocyte integrins: LFA-1 and gp150/95, but not CR3, are able to stimulate the respiratory burst of human neutrophils, J. Cell Biol., 116, 1007, 10.1083/jcb.116.4.1007
Bliska, 1995, Inhibition of the Fc receptor-mediated oxidative burst in macrophages by the Yersinia pseudotuberculosis tyrosine phosphatase, Infect. Immun., 63, 681, 10.1128/IAI.63.2.681-685.1995
Bloes, 2015, Enemy attraction: bacterial agonists for leukocyte chemotaxis receptors, Nat. Rev. Microbiol., 13, 95, 10.1038/nrmicro3390
Bokoch, 2006, Regulation of the phagocyte NADPH oxidase by Rac GTPase, Antioxid. Redox Signal., 8, 1533, 10.1089/ars.2006.8.1533
Bokoch, 2009, Emerging evidence for the importance of phosphorylation in the regulation of NADPH oxidases, Antioxid. Redox Signal., 11, 2429, 10.1089/ARS.2009.2590
Boras, 2017, Skap2 is required for β2 integrin–mediated neutrophil recruitment and functions, J. Exp. Med, 214, 851, 10.1084/jem.20160647
Borregaard, 1983, Subcellular localization of the b-cytochrome component of the human neutrophil microbicidal oxidase: translocation during activation, J. Cell Biol., 97, 52, 10.1083/jcb.97.1.52
Boussetta, 2010, The prolyl isomerase Pin1 acts as a novel molecular switch for TNF-alpha-induced priming of the NADPH oxidase in human neutrophils, Blood, 116, 5795, 10.1182/blood-2010-03-273094
Brenot, 2004, Contribution of glutathione peroxidase to the virulence of Streptococcus pyogenes, Infect. Immun., 72, 408, 10.1128/IAI.72.1.408-413.2004
Brinkmann, 2010, Neutrophil extracellular traps: how to generate and visualize them, J. Vis. Exp., e1724, 10.3791/1724
Brown, 2004, Distinct ligand-dependent roles for p38 MAPK in priming and activation of the neutrophil NADPH oxidase, J. Biol. Chem., 279, 27059, 10.1074/jbc.M314258200
Bruhns, 2012, Properties of mouse and human IgG receptors and their contribution to disease models, Blood, 119, 5640, 10.1182/blood-2012-01-380121
Brunelli, 1995, The comparative toxicity of nitric oxide and peroxynitrite to Escherichia coli, Arch. Biochem. Biophys., 316, 327, 10.1006/abbi.1995.1044
Buchmeier, 1995, DNA repair is more important than catalase for Salmonella virulence in mice, J. Clin. Invest., 95, 1047, 10.1172/JCI117750
Burton, 2014, Disparate impact of oxidative host defenses determines the fate of Salmonella during systemic infection in mice, Cell Host Microbe, 15, 72, 10.1016/j.chom.2013.12.006
Buvelot, 2017, Staphylococcus aureus, phagocyte NADPH oxidase and chronic granulomatous disease, FEMS Microbiol. Rev., 41, 139, 10.1093/femsre/fuw042
Buxhofer-Ausch, 2014, Decanucleotide insertion polymorphism of F7 significantly influences the risk of thrombosis in patients with essential thrombocythemia, Eur. J. Haematol., 93, 103, 10.1111/ejh.12307
Campbell, 2011, Integrin structure, activation, and interactions, Cold Spring Harb. Perspect. Biol., 3, a004994, 10.1101/cshperspect.a004994
Camps, 1992, Isozyme-selective stimulation of phospholipase C-B2 by G protein Bγ-subunits, Nature, 360, 684, 10.1038/360684a0
Carstanjen, 2005, Rac2 regulates neutrophil chemotaxis, superoxide production, and myeloid colony formation through multiple distinct effector pathways, J. Immunol., 174, 4613, 10.4049/jimmunol.174.8.4613
Cerny, 2017, cAMP signaling of adenylate cyclase toxin blocks the oxidative burst of neutrophils through Epac-mediated inhibition of phospholipase C activity, J. Immunol., 198, 1285, 10.4049/jimmunol.1601309
Chen, 2003, Akt phosphorylates p47phox and mediates respiratory burst activity in human neutrophils, J. Immunol., 170, 5302, 10.4049/jimmunol.170.10.5302
Chessa, 2010, Phosphorylation of threonine 154 in p40phox is an important physiological signal for activation of the neutrophil NADPH oxidase, Blood, 116, 6027, 10.1182/blood-2010-08-300889
Choi, 2014, The iron-sensing fur regulator controls expression timing and levels of salmonella pathogenicity island 2 genes in the course of environmental acidification, Infect. Immun., 82, 2203, 10.1128/IAI.01625-13
Clemens, 2004, PRAM-1 is required for optimal integrin-dependent neutrophil function, Mol. Cell. Biol., 24, 10923, 10.1128/MCB.24.24.10923-10932.2004
Condliffe, 2006, RhoG regulates the neutrophil NADPH oxidase, J. Immunol., 176, 5314, 10.4049/jimmunol.176.9.5314
Conway, 2012, p40phox expression regulates neutrophil recruitment and function during the resolution phase of intestinal inflammation, J. Immunol., 189, 3631, 10.4049/jimmunol.1103746
Crawford, 2006, Bacillus anthracis toxins inhibit human neutrophil NADPH oxidase activity, J. Immunol., 176, 7557, 10.4049/jimmunol.176.12.7557
Creed, 2017, Endocytosis is required for exocytosis and priming of respiratory burst activity in human neutrophils, Inflamm. Res., 10.1007/s00011-017-1070-2
Cremasco, 2008, Vav/Phospholipase Cg2-mediated control of a neutrophil-dependent murine model of rheumatoid arthritis, Arthrit. Rheumotol., 58, 272, 10.1002/art.23757
Criss, 2008, Neisseria gonorrhoeae suppresses the oxidative burst of human polymorphonuclear leukocytes, Cell. Microbiol., 10, 2257, 10.1111/j.1462-5822.2008.01205.x
Cross, 2004, The NADPH oxidase of professional phagocytes–prototype of the NOX electron transport chain systems, Biochim. Biophys. Acta, 1657, 1, 10.1016/j.bbabio.2004.03.008
Damoulakis, 2014, P-Rex1 directly activates RhoG to regulate GPCR-driven Rac signalling and actin polarity in neutrophils, J. Cell. Sci., 127, 2589, 10.1242/jcs.153049
Dang, 2001, Protein kinase C ζ phosphorylates a subset of selective sites of the NADPH oxidase component p47phox and participates in formyl peptide-mediated neutrophil respiratory burst, J. Immunol., 166, 1206, 10.4049/jimmunol.166.2.1206
Dang, 2003, Phosphorylation of the NADPH oxidase component p67(PHOX) by ERK2 and P38MAPK: selectivity of phosphorylated sites and existence of an intramolecular regulatory domain in the tetratricopeptide-rich region, Biochemistry, 42, 4520, 10.1021/bi0205754
Dang, 2011, The NADPH oxidase cytosolic component p67phox is constitutively phosphorylated in human neutrophils: Regulation by a protein tyrosine kinase, MEK1/2 and phosphatases 1/2A, Biochem. Pharmacol., 82, 1145, 10.1016/j.bcp.2011.07.070
Dang, 2006, A specific p47phox-serine phosphorylated by convergent MAPKs mediates neutrophil NADPH oxidase priming at inflammatory sites, J. Clin. Invest., 116, 2033, 10.1172/JCI27544
Daniels, 1992, Recombinant human monocyte IL-8 primes NADPH-oxidase and phospholipase A2 activation in human neutrophils, Immunology, 75, 157
Davis, 2015, Community behavior and spatial regulation within a bacterial microcolony in deep tissue sites serves to protect against host attack, Cell Host Microbe, 17, 21, 10.1016/j.chom.2014.11.008
De Groote, 1997, Periplasmic superoxide dismutase protects Salmonella from products of phagocyte NADPH-oxidase and nitric oxide synthase, Proc. Natl. Acad. Sci. U.S.A., 94, 13997, 10.1073/pnas.94.25.13997
de Souza Santos, 2017, T3SS effector VopL inhibits the host ROS response, promoting the intracellular survival of Vibrio parahaemolyticus, PLoS Pathog., 13, e1006438, 10.1371/journal.ppat.1006438
Decoursey, 2005, Regulation and termination of NADPH oxidase activity, Cell. Mol. Life Sci., 62, 2173, 10.1007/s00018-005-5177-1
Dekker, 2000, Protein kinase C-β contributes to NADPH oxidase activation in neutrophils, Biochem. J., 347, 285, 10.1042/bj3470285
DeLeo, 1999, NADPH oxidase activation and assembly during phagocytosis, J. Immunol., 163, 6732, 10.4049/jimmunol.163.12.6732
DeLeo, 1998, Neutrophils exposed to bacterial lipopolysaccharide upregulate NADPH oxidase assembly, J. Clin. Invest., 101, 455, 10.1172/JCI949
Demple, 1983, Escherichia coli xth mutants are hypersensitive to hydrogen peroxide, J. Bacteriol., 153, 1079, 10.1128/JB.153.2.1079-1082.1983
Dewas, 2000, The mitogen-activated protein kinase extracellular signal-regulated kinase 1/2 pathway is involved in formyl-Methionyl-Leucyl-Phenylalanine-induced p47phox phosphorylation in human neutrophils, J. Immunol., 165, 5238, 10.4049/jimmunol.165.9.5238
Diebold, 2001, Molecular basis for Rac2 regulation of phagocyte NADPH oxidase, Nat. Immunol., 2, 211, 10.1038/85259
Dinauer, 2016, Primary immune deficiencies with defects in neutrophil function, Hematol. Am. Soc. Hematol. Educ. Program, 2016, 43, 10.1182/asheducation-2016.1.43
Ding, 1995, Antagonists of phosphatidylinositol 3-kinase block activation of several novel protein-kinases in neutrophils, J. Biol. Chem., 270, 11684, 10.1074/jbc.270.19.11684
Dong, 2005, P-Rex1 is a primary Rac2 guanine nucleotide exchange factor in mouse neutrophils, Curr. Biol., 15, 1874, 10.1016/j.cub.2005.09.014
Dupre-Crochet, 2013, ROS production in phagocytes: why, when, and where?, J. Leukoc. Biol., 94, 657, 10.1189/jlb.1012544
Eiamphungporn, 2006, Agrobacterium tumefaciens soxR is involved in superoxide stress protection and also directly regulates superoxide-inducible expression of itself and a target gene, J. Bacteriol., 188, 8669, 10.1128/JB.00856-06
El Benna, 1996, Phosphorylation of the respiratory burst oxidase subunit p47phox as determined by two-dimensional phosphopeptide mapping, J. Biol. Chem., 271, 6374, 10.1074/jbc.271.11.6374
El-Benna, 2008, Priming of the neutrophil NADPH oxidase activation: role of p47phox phosphorylation and NOX2 mobilization to the plasma membrane, Semin. Immunopathol., 30, 279, 10.1007/s00281-008-0118-3
El-Benna, 2009, p47phox, the phagocyte NADPH oxidase/NOX2 organizer: structure, phosphorylation and implication in diseases, Exp. Mol. Med., 41, 217, 10.3858/emm.2009.41.4.058
El-Benna, 2016, Priming of the neutrophil respiratory burst: role in host defense and inflammation, Immunol. Rev., 273, 180, 10.1111/imr.12447
Ellson, 2006, Neutrophils from p40phox-/- mice exhibit severe defects in NADPH oxidase regulation and oxidant-dependent bacterial killing, J. Exp. Med., 203, 1927, 10.1084/jem.20052069
Fernandes, 2005, Signaling through CD16b in human neutrophils involves the Tec family of tyrosine kinases, J. Leukoc. Biol., 78, 524, 10.1189/jlb.0804479
Filippi, 2004, Localization of Rac2 via the C terminus and aspartic acid 150 specifies superoxide generation, actin polarity and chemotaxis in neutrophils, Nat. Immunol., 5, 744, 10.1038/ni1081
Fischer, 1988, Gonococci possessing only certain P.II outer membrane proteins interact with human neutrophils, Infect. Immun., 56, 1574, 10.1128/IAI.56.6.1574-1579.1988
Fischer, 2016, How did life survive Earth's great oxygenation?, Curr. Opin. Chem. Biol., 31, 166, 10.1016/j.cbpa.2016.03.013
Fontayne, 2002, Phosphorylation of p47phox sites by PKC α, β II, δ, and ζ: effect on binding to p22phox and on NADPH oxidase activation, Biochemistry, 41, 7743, 10.1021/bi011953s
Forsberg, 2003, Activation of Rac2 and Cdc42 on Fc and complement receptor ligation in human neutrophils, J. Leukoc. Biol., 74, 611, 10.1189/jlb.1102525
Fredriksson, 2003, The G-protein-coupled receptors in the human genome form five main families. Phylogenetic analysis, paralogon groups, and fingerprints, Mol. Pharmacol., 63, 1256, 10.1124/mol.63.6.1256
Fuchs, 2007, Novel cell death program leads to neutrophil extracellular traps, J. Cell Biol., 176, 231, 10.1083/jcb.200606027
Fumagalli, 2013, Class I phosphoinositide-3-kinases and SRC kinases play a nonredundant role in regulation of adhesion-independent and -dependent neutrophil reactive oxygen species generation, J. Immunol., 190, 3648, 10.4049/jimmunol.1201951
Fumagalli, 2007, The Src family kinases Hck and Fgr regulate neutrophil responses to N-formyl-methionyl-leucyl-phenylalanine, J. Immunol., 178, 3874, 10.4049/jimmunol.178.6.3874
Futosi, 2013, Neutrophil cell surface receptors and their intracellular signal transduction pathways, Int. Immunopharmacol., 17, 638, 10.1016/j.intimp.2013.06.034
Gakidis, 2004, Vav GEFs are required for β2 integrin-dependent functions of neutrophils, J. Cell Biol., 166, 273, 10.1083/jcb.200404166
Gallois, 2001, Salmonella pathogenicity island 2-encoded type III secretion system mediates exclusion of NADPH oxidase assembly from the phagosomal membrane, J. Immunol., 166, 5741, 10.4049/jimmunol.166.9.5741
Gambardella, 2013, Phosphoinositide 3-OH kinase regulates integrin-dependent processes in neutrophils by signaling through its effector ARAP3, J. Immunol., 190, 381, 10.4049/jimmunol.1201330
Garcia-Garcia, 2002, Signal transduction during Fc receptor-mediated phagocytosis, J. Leukoc. Biol., 72, 1092, 10.1189/jlb.72.6.1092
Ghosh, 2015, Methodological advances: the unsung heroes of the GPCR structural revolution, Nat. Rev. Mol. Cell Biol., 16, 69, 10.1038/nrm3933
Giagulli, 2006, The Src family kinases Hck and Fgr are dispensable for inside-out chemoattractant-induced signaling regulating β2 integrin affinity and valency in neutrophils, but are required for β2 integrin-mediated outside-in signaling involved in sustained adhesion, J. Immunol., 177, 604, 10.4049/jimmunol.177.1.604
Gorlach, 2015, Calcium and ROS: a mutual interplay, Redox Biol., 6, 260, 10.1016/j.redox.2015.08.010
Graham, 2007, Neutrophil-mediated oxidative burst and host defense are controlled by a Vav-PLCγ2 signaling axis in mice, J. Clin. Invest., 117, 3445, 10.1172/JCI32729
Green, 2016, Fis is essential for Yersinia pseudotuberculosis virulence and protects against reactive oxygen species produced by phagocytic cells during infection, PLoS Pathog., 12, e1005898, 10.1371/journal.ppat.1005898
Grizot, 2001, Crystal structure of the Rac1-RhoGDI complex involved in NADPH oxidase activation, Biochemistry, 40, 10007, 10.1021/bi010288k
Groemping, 2005, Activation and assembly of the NADPH oxidase: a structural perspective, Biochem. J., 386, 401, 10.1042/BJ20041835
Gu, 2003, Hematopoietic cell regulation by Rac1 and Rac2 guanosine triphosphatases, Science, 302, 445, 10.1126/science.1088485
Guichard, 2005, Interleukin-8-induced priming of neutrophil oxidative burst requires sequential recruitment of NADPH oxidase components into lipid rafts, J. Biol. Chem., 280, 37021, 10.1074/jbc.M506594200
Hallett, 1995, Neutrophil priming: the cellular signals that say ‘amber’ but not ‘green’, Immunol. Today, 16, 264, 10.1016/0167-5699(95)80178-2
Halsey, 2004, The ferritin-like Dps protein is required for Salmonella enterica serovar Typhimurium oxidative stress resistance and virulence, Infect. Immun., 72, 1155, 10.1128/IAI.72.2.1155-1158.2004
Harris, 2003, Catalase (KatA) and KatA-associated protein (KapA) are essential to persistent colonization in the Helicobacter pylori SS1 mouse model, Microbiology, 149, 665, 10.1099/mic.0.26012-0
Hassan, 1977, Regulation of the synthesis of superoxide dismutase in Escherichia coli. Induction by methyl viologen, J. Biol. Chem., 252, 7667, 10.1016/S0021-9258(17)41019-2
Hawkins, 2010, PI3K signaling in neutrophils, Curr. Top. Microbiol. Immunol., 346, 183, 10.1007/82_2010_40
Hebrard, 2009, Redundant hydrogen peroxide scavengers contribute to Salmonella virulence and oxidative stress resistance, J. Bacteriol., 191, 4605, 10.1128/JB.00144-09
Heyworth, 1994, Rac translocates independently of the neutrophil NADPH oxidase components p47phox and p67phox. Evidence for its interaction with flavocytochrome b558, J. Biol. Chem., 269, 30749, 10.1016/S0021-9258(18)47341-3
Heyworth, 1991, Neutrophil nicotinamide adenine dinucleotide phosphate oxidase assembly. Translocation of p47-phox and p67-phox requires interaction between p47-phox and cytochrome b558, J. Clin. Invest., 87, 352, 10.1172/JCI114993
Hidalgo, 1997, Redox signal transduction: mutations shifting [2Fe-2S] centers of the SoxR sensor-regulator to the oxidized form, Cell, 88, 121, 10.1016/S0092-8674(00)81864-4
Hill, 2011, Coxiella burnetii acid phosphatase inhibits the release of reactive oxygen intermediates in polymorphonuclear leukocytes, Infect. Immun., 79, 414, 10.1128/IAI.01011-10
Hillar, 2000, Modulation of the activities of catalase-peroxidase HPI of Escherichia coli by site-directed mutagenesis, Biochemistry, 39, 5868, 10.1021/bi0000059
Hirsch, 2000, Central role for G protein-coupled phosphoinositide 3-Kinase γ in infammation, Science, 287, 1049, 10.1126/science.287.5455.1049
Hodge, 2016, Regulating Rho GTPases and their regulators, Nat. Rev. Mol. Cell Biol., 17, 496, 10.1038/nrm.2016.67
Holland, 2013, Chronic granulomatous disease, Hematol. Oncol. Clin. North Am., 27, 89, 10.1016/j.hoc.2012.11.002
Holmes, 1967, Studies of the metabolic activity of leukocytes from patients with a genetic abnormality of phagocytic function, J. Clin. Invest., 46, 1422, 10.1172/JCI105634
Honn, 2017, Lack of OxyR and KatG results in extreme susceptibility of Francisella tularensis LVS to oxidative stress and marked attenuation in vivo, Front. Cell. Infect. Microbiol., 7, 14, 10.3389/fcimb.2017.00014
Houslay, 2016, Coincident signals from GPCRs and receptor tyrosine kinases are uniquely transduced by PI3Kβ in myeloid cells, Sci. Signal., 9, ra82, 10.1126/scisignal.aae0453
Huang, 1999, Activation of the phagocyte NADPH oxidase protein p47(phox). Phosphorylation controls SH3 domain-dependent binding to p22(phox), J. Biol. Chem., 274, 19731, 10.1074/jbc.274.28.19731
Huizinga, , Biallelic neutrophil Na-antigen system is associated with a polymorphism on the phospho-inositol-linked Fc gamma receptor III (CD16), Blood, 75, 213, 10.1182/blood.V75.1.213.213
Huizinga, , Maternal genomic neutrophil FcRIII deficiency leading to neonatal isoimmune neutropenia, Blood, 76, 1927, 10.1182/blood.V76.10.1927.1927
Hynes, 1987, Integrins: a family of cell surface receptors, Cell, 48, 549, 10.1016/0092-8674(87)90233-9
Imlay, 2006, Iron-sulphur clusters and the problem with oxygen, Mol. Microbiol., 59, 1073, 10.1111/j.1365-2958.2006.05028.x
Imlay, 2008, Cellular defenses against superoxide and hydrogen peroxide, Annu. Rev. Biochem., 77, 755, 10.1146/annurev.biochem.77.061606.161055
Imlay, 1991, Assay of metabolic superoxide production in Escherichia coli, J. Biol. Chem., 266, 6957, 10.1016/S0021-9258(20)89596-9
Imlay, 1987, Mutagenesis and stress responses induced in Escherichia coli by hydrogen peroxide, J. Bacteriol., 169, 2967, 10.1128/jb.169.7.2967-2976.1987
Ivashkiv, 2009, Cross-regulation of signaling by ITAM-associated receptors, Nat. Immunol., 10, 340, 10.1038/ni.1706
IJdo, 2004, Neutrophil NADPH oxidase is reduced at the Anaplasma phagocytophilum phagosome, Infect. Immun., 72, 5392, 10.1128/IAI.72.9.5392-5401.2004
Jakus, 2007, Immunoreceptor-like signaling by β2 and β3 integrins, Trends Cell Biol., 17, 493, 10.1016/j.tcb.2007.09.001
Jakus, 2008, Critical but overlapping role of FcγRIII and FcγRIV in activation of murine neutrophils by immobilized immune complexes, J. Immunol., 180, 618, 10.4049/jimmunol.180.1.618
Jakus, 2009, Critical role of phospholipase Cg2 in integrin and Fc receptor-mediated neutrophil functions and the effector phase of autoimmune arthritis, J. Exp. Med., 206, 577, 10.1084/jem.20081859
Jang, 2010, Hydrogen peroxide inactivates the Escherichia coli Isc iron-sulphur assembly system, and OxyR induces the Suf system to compensate, Mol. Microbiol., 78, 1448, 10.1111/j.1365-2958.2010.07418.x
Jesaitis, 1990, Ultrastructural localization of cytochrome b in the membranes of resting and phagocytosing human granulocytes, J. Clin. Invest., 85, 821, 10.1172/JCI114509
Johnson, 2010, Rab27a and Rab27b regulate neutrophil azurophilic granule exocytosis and NADPH oxidase activity by independent mechanisms, Traffic, 11, 533, 10.1111/j.1600-0854.2009.01029.x
Kahn, 2006, Integrins and ITAMs: more than just good neighbors, Nat. Immunol., 7, 1286, 10.1038/ni1206-1286
Kanai, 2001, The PX domains of p47phox and p40phox bind to lipid products of PI(3)K, Nat. Cell Biol., 3, 675, 10.1038/35083070
Karathanassis, 2002, Binding of the PX domain of p47phox to phosphatidylinositol 3,4-bisphosphate and phosphatidic acid is masked by an intramolecular interaction, EMBO J., 21, 5057, 10.1093/emboj/cdf519
Karimi, 2014, Assembly of phagocyte NADPH oxidase: a concerted binding process?, Biochim. Biophys. Acta, 1840, 3277, 10.1016/j.bbagen.2014.07.022
Kato, 2006, Regulation of neutrophil functions by proinflammatory cytokines, Int. J. Hematol., 84, 205, 10.1532/IJH97.06141
Katritch, 2013, Structure-function of the G protein-coupled receptor superfamily, Annu. Rev. Pharmacol. Toxicol., 53, 531, 10.1146/annurev-pharmtox-032112-135923
Kawasaki, 2014, Toll-like receptor signaling pathways, Front. Immunol., 5, 461, 10.3389/fimmu.2014.00461
Keyer, 1996, Superoxide accelerates DNA damage by elevating free-iron levels, Proc. Natl. Acad. Sci. U.S.A., 93, 13635, 10.1073/pnas.93.24.13635
Kim, 2001, Rac2 is an essential regulator of neutrophil nicotinamide adenine dinucleotide phosphate oxidase activation in response to specific signaling pathways, J. Immunol., 166, 1223, 10.4049/jimmunol.166.2.1223
Kim, 2006, Impaired NADPH oxidase activity in Rac2-deficient murine neutrophils does not result from defective translocation of p47phox and p67phox and can be rescued by exogenous arachidonic acid, J. Leukoc. Biol., 79, 223, 10.1189/jlb.0705371
Kim, 2003, The hemopoietic Rho/Rac guanine nucleotide exchange factor Vav1 regulates N-formyl-methionyl-leucyl-phenylalanine-activated neutrophil functions, J. Immunol, 171, 4425, 10.4049/jimmunol.171.8.4425
Klebanoff, 1970, Myeloperoxidase: contribution to the microbicidal activity of intact leukocytes, Science, 169, 1095, 10.1126/science.169.3950.1095
Klebanoff, 2013, Myeloperoxidase: a front-line defender against phagocytosed microorganisms, J. Leukoc. Biol., 93, 185, 10.1189/jlb.0712349
Kobayashi, 2004, Activation of SoxR-dependent transcription in Pseudomonas aeruginosa, J. Biochem., 136, 607, 10.1093/jb/mvh168
Kobayashi, 2003, Bacterial pathogens modulate an apoptosis differentiation program in human neutrophils, Proc. Natl. Acad. Sci. U.S.A., 100, 10948, 10.1073/pnas.1833375100
Koga, 1999, Tetratricopeptide Repeat (TPR) motifs of p67phox participate in interaction with the small GTPase Rac and activation of the phagocyte NADPH Oxidase*, J. Biol. Chem., 274, 25051, 10.1074/jbc.274.35.25051
Kolaczkowska, 2013, Neutrophil recruitment and function in health and inflammation, Nat. Rev. Immunol., 13, 159, 10.1038/nri3399
Konigsberger, 2010, HPK1 associates with SKAP-HOM to negatively regulate Rap1-mediated B-lymphocyte adhesion, PLoS ONE, 5, e12468, 10.1371/journal.pone.0012468
Korshunov, 2002, A potential role for periplasmic superoxide dismutase in blocking the penetration of external superoxide into the cytosol of Gram-negative bacteria, Mol. Microbiol., 43, 95, 10.1046/j.1365-2958.2002.02719.x
Kovacs, 2014, The Src family kinases Hck, Fgr, and Lyn are critical for the generation of the in vivo inflammatory environment without a direct role in leukocyte recruitment, J. Exp. Med., 211, 1993, 10.1084/jem.20132496
Kruger, 2015, Neutrophils: between host defence, immune modulation, and tissue injury, PLoS Pathog., 11, e1004651, 10.1371/journal.ppat.1004651
Kulkani, 2011, PI3KB plays a critical role in neutrophil activation by immune complexes, Sci. Signal., 4, ra23, 10.1126/scisignal.2001617
Kulkarni, 2016, Clinical, immunological, and molecular findings of patients with p47phox defect Chronic Granulomatous Disease (CGD) in Indian families, J. Clin. Immunol., 36, 774, 10.1007/s10875-016-0333-y
Lam, 2011, Listeriolysin O suppresses phospholipase C-mediated activation of the microbicidal NADPH oxidase to promote Listeria monocytogenes infection, Cell Host Microbe, 10, 627, 10.1016/j.chom.2011.11.005
Lambeth, 2004, NOX enzymes and the biology of reactive oxygen, Nat. Rev. Immunol., 4, 181, 10.1038/nri1312
Lapouge, 2000, Structure of the TPR domain of p67phox in complex with RacGTP, Mol. Cell, 6, 899, 10.1016/S1097-2765(05)00091-2
Lawson, 2011, P-Rex1 and Vav1 cooperate in the regulation of formyl-methionyl-leucyl-phenylalanine-dependent neutrophil responses, J. Immunol., 186, 1467, 10.4049/jimmunol.1002738
Leusen, , 156Pro–>Gln substitution in the light chain of cytochrome b558 of the human NADPH oxidase (p22-phox) leads to defective translocation of the cytosolic proteins p47-phox and p67-phox, J. Exp. Med., 180, 2329, 10.1084/jem.180.6.2329
Leusen, , A point mutation in gp91-phox of cytochrome b558 of the human NADPH oxidase leading to defective translocation of the cytosolic proteins p47-phox and p67-phox, J. Clin. Invest., 93, 2120, 10.1172/JCI117207
Levine, 2016, The NADPH oxidase and microbial killing by neutrophils, with a particular emphasis on the proposed antimicrobial role of myeloperoxidase within the phagocytic vacuole, Microbiol. Spectr., 4, 1, 10.1128/microbiolspec.MCHD-0018-2015
Lewis, 2010, Phosphorylation of p22phox on threonine 147 enhances NADPH oxidase activity by promoting p47phox binding, J. Biol. Chem., 285, 2959, 10.1074/jbc.M109.030643
Li, 2010, p47phox Phox homology domain regulates plasma membrane but not phagosome neutrophil NADPH oxidase activation, J. Biol. Chem., 285, 35169, 10.1074/jbc.M110.164475
Li, 2000, Roles of PLC-β2 and -β3 and PI3Kγ in chemoattractant-mediated signal transduction, Science, 287, 1046, 10.1126/science.287.5455.1046
Liochev, 1994, The role of O2.- in the production of HO.: in vitro and in vivo, Free Radic. Biol. Med., 16, 29, 10.1016/0891-5849(94)90239-9
Liochev, 1999, Induction of the soxRS regulon of Escherichia coli by superoxide, J. Biol. Chem., 274, 9479, 10.1074/jbc.274.14.9479
Lofgren, 1999, CR3, FcgammaRIIA and FcgammaRIIIB induce activation of the respiratory burst in human neutrophils: the role of intracellular Ca2+, phospholipase D and tyrosine phosphorylation, Biochim. Biophys. Acta, 1452, 46, 10.1016/S0167-4889(99)00112-3
Love, 2010, ITAM-mediated signaling by the T-cell antigen receptor, Cold Spring Harb. Perspect. Biol., 2, a002485, 10.1101/cshperspect.a002485
Lowell, 2011, Src-family and Syk kinases in activating and inhibitory pathways in innate immune cells: signaling cross talk, Cold Spring Harb. Perspect. Biol., 3, a002352, 10.1101/cshperspect.a002352
Lowell, 1996, Deficiency of Src family kinases p59/61hck and p58c-fgr results in defective adhesion-dependent neutrophil functions, J. Cell Biol., 133, 895, 10.1083/jcb.133.4.895
Maehara, 2010, A conserved region between the TPR and activation domains of p67(phox) participates in activation of the phagocyte NADPH oxidase, J. Biol. Chem., 285, 31435, 10.1074/jbc.M110.161166
Makni-Maalej, 2012, The TLR7/8 agonist CL097 primes N-formyl-methionyl-leucyl-phenylalanine-stimulated NADPH oxidase activation in human neutrophils: critical role of p47phox phosphorylation and the proline isomerase Pin1, J. Immunol., 189, 4657, 10.4049/jimmunol.1201007
Makni-Maalej, 2015, TLR8, but not TLR7, induces the priming of the NADPH oxidase activation in human neutrophils, J. Leukoc. Biol., 97, 1081, 10.1189/jlb.2A1214-623R
Marcoux, 2010, p47phox molecular activation for assembly of the neutrophil NADPH oxidase complex, J. Biol. Chem., 285, 28980, 10.1074/jbc.M110.139824
Matute, 2009, A new genetic subgroup of chronic granulomatous disease with autosomal recessive mutations in p40 phox and selective defects in neutrophil NADPH oxidase activity, Blood, 114, 3309, 10.1182/blood-2009-07-231498
Mazaki, 2006, Neutrophil direction sensing and superoxide production linked by the GTPase-activating protein GIT2, Nat. Immunol., 7, 724, 10.1038/ni1349
McCaffrey, 2006, Francisella tularensis LVS evades killing by human neutrophils via inhibition of the respiratory burst and phagosome escape, J. Leukoc. Biol., 80, 1224, 10.1189/jlb.0406287
McCaffrey, 2010, Multiple mechanisms of NADPH oxidase inhibition by type A and type B Francisella tularensis, J. Leukoc. Biol., 88, 791, 10.1189/jlb.1209811
McLeish, 1998, Activation of mitogen-activated protein kinase cascades during priming of human neutrophils by TNF-alpha and GM-CSF, J. Leukoc. Biol., 64, 537, 10.1002/jlb.64.4.537
McLeish, 2017, Frontline science: tumor necrosis factor-alpha stimulation and priming of human neutrophil granule exocytosis, J. Leukoc. Biol., 102, 19, 10.1189/jlb.3HI0716-293RR
Meijles, 2014, Molecular insights of p47phox phosphorylation dynamics in the regulation of NADPH oxidase activation and superoxide production, J. Biol. Chem., 289, 22759, 10.1074/jbc.M114.561159
Migeotte, 2006, Formyl peptide receptors: a promiscuous subfamily of G protein-coupled receptors controlling immune responses, Cytokine Growth Factor Rev., 17, 501, 10.1016/j.cytogfr.2006.09.009
Minchinton, 1995, Abnormal neutrophil phenotype and neutrophil FcRIII deficiency corrected by bone marrow transplantation, Transfusion, 35, 874, 10.1046/j.1537-2995.1995.351096026372.x
Miralda, 2017, Multiple phenotypic changes define neutrophil priming, Front. Cell. Infect. Microbiol., 7, 217, 10.3389/fcimb.2017.00217
Miyano, 2012, Assessment of the role for Rho family GTPases in NADPH oxidase activation, Methods Mol. Biol., 827, 195, 10.1007/978-1-61779-442-1_14
Miyano, 2003, Remarkable stabilization of neutrophil NADPH oxidase using RacQ61L and a p67phox-p47phox fusion protein, Biochemistry, 42, 184, 10.1021/bi0269052
Mocsai, 2013, Diverse novel functions of neutrophils in immunity, inflammation, and beyond, J. Exp. Med., 210, 1283, 10.1084/jem.20122220
Mocsai, 2006, Integrin signaling in neutrophils and macrophages uses adaptors containing immunoreceptor tyrosine-based activation motifts, Nat. Immunol., 7, 1326, 10.1038/ni1407
Mocsai, 2011, The SYK tyrosine kinase: a crucial player in diverse biological functions, Nat. Rev. Immunol., 10, 387, 10.1038/nri2765
Mocsai, 2002, Syk is required for integrin signaling in neutrophils, Immunity, 16, 547, 10.1016/S1074-7613(02)00303-5
Monfregola, 2012, MUNC13-4 protein regulates the oxidative response and is essential for phagosomal maturation and bacterial killing in neutrophils, J. Biol. Chem., 287, 44603, 10.1074/jbc.M112.414029
Murphy, 2012, Janeway's Immunobiology
Myung, 2001, Differential requirement for SLP-76 domains in T cell development and function, Immunity, 15, 1011, 10.1016/S1074-7613(01)00253-9
Naik, 2011, Mitochondrial reactive oxygen species drive proinflammatory cytokine production, J. Exp. Med., 208, 417, 10.1084/jem.20110367
Nathan, 2013, Beyond oxidative stress: an immunologist's guide to reactive oxygen species, Nat. Rev. Immunol., 13, 349, 10.1038/nri3423
Navarro-Yepes, 2014, Oxidative stress, redox signaling, and autophagy: cell death versus survival, Antioxid. Redox Signal., 21, 66, 10.1089/ars.2014.5837
Newbrough, 2003, SLP-76 regulates Fcg receptor and integrin signaling in neutrophils, Immunity, 19, 759, 10.1016/S1074-7613(03)00305-4
Nunes, 2013, Regulation of the NADPH oxidase and associated ion fluxes during phagocytosis, Traffic, 14, 1118, 10.1111/tra.12115
O'Neill, 2015, Genetic disorders coupled to ROS deficiency, Redox Biol., 6, 135, 10.1016/j.redox.2015.07.009
Paclet, 2000, P67-phox-mediated NADPH oxidase assembly: imaging of cytochrome b558 liposomes by atomic force microscopy, Biochemistry, 39, 9302, 10.1021/bi000483j
Paiva, 2014, Are reactive oxygen species always detrimental to pathogens?, Antioxid. Redox Signal., 20, 1000, 10.1089/ars.2013.5447
Panday, 2015, NADPH oxidases: an overview from structure to innate immunity-associated pathologies, Cell. Mol. Immunol., 12, 5, 10.1038/cmi.2014.89
Papp-Szabo, 1994, Comparison of the sensitivities of Salmonella typhimurium oxyR and katG mutants to killing by human neutrophils, Infect. Immun., 62, 2662, 10.1128/IAI.62.7.2662-2668.1994
Paul, 2008, Myeloid Src kinases regulate phagocytosis and oxidative burst in pneumococcal meningitis by activating NADPH oxidase, J. Leukoc. Biol., 84, 1141, 10.1189/jlb.0208118
Pereira, 2003, The Lyn tyrosine kinase negatively regulates neutrophil integrin signaling, J. Immunol., 171, 1319, 10.4049/jimmunol.171.3.1319
Quie, 1967, In vitro bactericidal capacity of human polymorphonuclear leukocytes: diminished activity in chronic granulomatous disease of childhood, J. Clin. Invest., 46, 668, 10.1172/JCI105568
Raad, 2009, Regulation of the phagocyte NADPH oxidase activity: phosphorylation of gp91phox/NOX2 by protein kinase C enhances its diaphorase activity and binding to Rac2, p67phox, and p47phox, FASEB J., 23, 1011, 10.1096/fj.08-114553
Rabiet, 2007, The N-formyl peptide receptors and the anaphylatoxin C5a receptors: an overview, Biochimie, 89, 1089, 10.1016/j.biochi.2007.02.015
Rada, 2004, Dual role of phagocytic NADPH oxidase in bacterial killing, Blood, 104, 2947, 10.1182/blood-2004-03-1005
Rae, 1998, X-Linked chronic granulomatous disease: mutations in the CYBB gene encoding the gp91-phox component of respiratory-burst oxidase, Am. J. Hum. Genet., 62, 1320, 10.1086/301874
Ray, 2012, Reactive oxygen species (ROS) homeostasis and redox regulation in cellular signaling, Cell. Signal., 24, 981, 10.1016/j.cellsig.2012.01.008
Reczek, 2014, ROS-dependent signal transduction, Curr. Opin. Cell Biol., 33, 8, 10.1016/j.ceb.2014.09.010
Reeves, 2002, Killing activity of neutrophils is mediated through activation of proteases by K+ flux, Nature, 416, 291, 10.1038/416291a
Regier, 2000, Phosphorylation of p22phox is mediated by phospholipase D-dependent and -independent mechanisms. Correlation of NADPH oxidase activity and p22phox phosphorylation, J. Biol. Chem., 275, 28406, 10.1074/jbc.M004703200
Roberts, 1999, Deficiency of the hematopoietic cell-specific Rho family GTPase Rac2 is characterized by abnormalities in neutrophil function and host defense, Immunity, 10, 183, 10.1016/S1074-7613(00)80019-9
Robinson, 2008, Reactive oxygen species in phagocytic leukocytes, Histochem. Cell Biol., 130, 281, 10.1007/s00418-008-0461-4
Roggenkamp, 1997, Contribution of the Mn-cofactored superoxide dismutase (SodA) to the virulence of Yersinia enterocolitica serotype O8, Infect. Immun., 65, 4705, 10.1128/IAI.65.11.4705-4710.1997
Rolan, 2013, Identifying Yersinia YopH-targeted signal transduction pathways that impair neutrophil responses during in vivo murine infection, Cell Host Microbe, 14, 306, 10.1016/j.chom.2013.08.013
Rosen, 1979, Bactericidal activity of a superoxide anion-generating system. A model for the polymorphonuclear leukocyte, J. Exp. Med., 149, 27, 10.1084/jem.149.1.27
Royer-Pokora, 1986, Cloning the gene for an inherited human disorder - chronic granulomatous disease - on the basis of its chromosomal location, Nature, 322, 32, 10.1038/322032a0
Ruoslahti, 1996, RGD and other recognition sequences for integrins, Annu. Rev. Cell Dev. Biol., 12, 697, 10.1146/annurev.cellbio.12.1.697
Sarfstein, 2004, Dual role of Rac in the assembly of NADPH oxidase, tethering to the membrane and activation of p67phox: a study based on mutagenesis of p67phox-Rac1 chimeras, J. Biol. Chem., 279, 16007, 10.1074/jbc.M312394200
Schieber, 2014, ROS function in redox signaling and oxidative stress, Curr. Biol., 24, R453, 10.1016/j.cub.2014.03.034
Seaver, 2001, Alkyl hydroperoxide reductase is the primary scavenger of endogenous hydrogen peroxide in Escherichia coli, J. Bacteriol., 183, 7173, 10.1128/JB.183.24.7173-7181.2001
Segal, 1978, Novel cytochrome b system in phagocytic vacuoles of human granulocytes, Nature, 276, 515, 10.1038/276515a0
Selvatici, 2006, Signal transduction pathways triggered by selective formylpeptide analogues in human neutrophils, Eur. J. Pharmacol., 534, 1, 10.1016/j.ejphar.2006.01.034
Sheppard, 2005, Structural organization of the neutrophil NADPH oxidase: phosphorylation and translocation during priming and activation, J. Leukoc. Biol., 78, 1025, 10.1189/jlb.0804442
Sheshachalam, 2014, Granule protein processing and regulated secretion in neutrophils, Front. Immunol., 5, 448, 10.3389/fimmu.2014.00448
Shiose, 2000, Arachidonic acid and phosphorylation synergistically induce a conformational change of p47phox to activate the phagocyte NADPH oxidase, J. Biol. Chem., 275, 13793, 10.1074/jbc.275.18.13793
Siemsen, 2009, Inhibition of the human neutrophil NADPH oxidase by Coxiella burnetii, Microbes Infect., 11, 671, 10.1016/j.micinf.2009.04.005
Simons, 2005, Interactions of Neisseria gonorrhoeae with adherent polymorphonuclear leukocytes, Infect. Immun., 73, 1971, 10.1128/IAI.73.4.1971-1977.2005
Smirnov, 2014, Assembly of NADPH oxidase in human neutrophils is modulated by the opacity-associated protein expression State of Neisseria gonorrhoeae, Infect. Immun., 82, 1036, 10.1128/IAI.00881-13
Songsungthong, 2010, ROS-inhibitory activity of YopE is required for full virulence of Yersinia in mice, Cell. Microbiol., 12, 988, 10.1111/j.1462-5822.2010.01448.x
Spinner, 2008, Yersinia pestis type III secretion system-dependent inhibition of human polymorphonuclear leukocyte function, Infect. Immun., 76, 3754, 10.1128/IAI.00385-08
Standish, 2009, Human neutrophils kill Streptococcus pneumoniae via serine proteases, J. Immunol., 183, 2602, 10.4049/jimmunol.0900688
Stephens, 1994, A novel phosphoinositide 3 kinase activity in myeloid-derived cells is activated by G protein Bg subunits, Cell, 77, 83, 10.1016/0092-8674(94)90237-2
Takahashi, 2013, Protein kinase A-dependent phosphorylation of Rap1 regulates its membrane localization and cell migration, J. Biol. Chem., 288, 27712, 10.1074/jbc.M113.466904
Tao, 2002, The TRQQKRP motif located near the C-terminus of Rac2 is essential for Rac2 biologic functions and intracellular localization, Blood, 100, 1679, 10.1182/blood.V100.5.1679.h81702001679_1679_1688
Togni, 2005, Regulation of in vitro and in vivo immune functions by the cytosolic adaptor protein SKAP-HOM, Mol. Cell. Biol., 25, 8052, 10.1128/MCB.25.18.8052-8063.2005
Trachootham, 2008, Redox regulation of cell survival, Antioxid. Redox Signal., 10, 1343, 10.1089/ars.2007.1957
Troxell, 2013, Transcriptional regulation by Ferric Uptake Regulator (Fur) in pathogenic bacteria, Front. Cell. Infect. Microbiol., 3, 59, 10.3389/fcimb.2013.00059
Uchiyama, 2015, Streptolysin O rapidly impairs neutrophil oxidative burst and antibacterial responses to group A Streptococcus, Front. Immunol., 6, 581, 10.3389/fimmu.2015.00581
Uriarte, 2011, Granule exocytosis contributes to priming and activation of the human neutrophil respiratory burst, J. Immunol., 187, 391, 10.4049/jimmunol.1003112
Utomo, 2006, Vav proteins in neutrophils are required for FcγR-mediated signaling to Rac GTPases and nicotinamide adenine dinucleotide phosphate oxidase component p40(phox), J. Immunol., 177, 6388, 10.4049/jimmunol.177.9.6388
Van Acker, 2017, The role of reactive oxygen species in antibiotic-mediated killing of bacteria, Trends Microbiol, 25, 456, 10.1016/j.tim.2016.12.008
van den Berg, 2009, Chronic granulomatous disease: the European experience, PLoS ONE, 4, e5234, 10.1371/journal.pone.0005234
van der Heijden, 2015, Direct measurement of oxidative and nitrosative stress dynamics in Salmonella inside macrophages, Proc. Natl. Acad. Sci. U.S.A., 112, 560, 10.1073/pnas.1414569112
van der Heijden, 2014, Haplotypes of FcgammaRIIa and FcgammaRIIIb polymorphic variants influence IgG-mediated responses in neutrophils, J. Immunol., 192, 2715, 10.4049/jimmunol.1203570
Van Sluys, 1986, Escherichia coli xthA mutant is not hypersensitive to ascorbic acid/copper treatment–an H2O2 generating reaction, Mutat. Res., 174, 265, 10.1016/0165-7992(86)90045-X
Vareechon, 2017, Pseudomonas aeruginosa effector ExoS inhibits ROS production in human neutrophils, Cell Host Microbe, 611 e615, 10.1016/j.chom.2017.04.001
Vazquez-Torres, 2001, Salmonella evasion of the NADPH phagocyte oxidase, Microbes Infect., 3, 1313, 10.1016/S1286-4579(01)01492-7
Vazquez-Torres, 2001, Defective localization of the NADPH phagocyte oxidase to Salmonella-containing phagosomes in tumor necrosis factor p55 receptor-deficient macrophages, Proc. Natl. Acad. Sci. U.S.A., 98, 2561, 10.1073/pnas.041618998
Vazquez-Torres, 2000, Salmonella pathogenicity island 2-dependent evasion of the phagocyte NADPH oxidase, Science, 287, 1655, 10.1126/science.287.5458.1655
Velayudhan, 2007, The role of ferritins in the physiology of Salmonella enterica sv. Typhimurium: a unique role for ferritin B in iron-sulphur cluster repair and virulence, Mol. Microbiol, 63, 1495, 10.1111/j.1365-2958.2007.05600.x
Volmering, 2016, The Neutrophil Btk signalosome regulates integrin activation during sterile inflammation, Immunity, 44, 73, 10.1016/j.immuni.2015.11.011
Ward, 2000, Priming of the neutrophil respiratory burst involves p38 mitogen-activated protein kinase-dependent exocytosis of flavocytochrome b558-containing granules, J. Biol. Chem., 275, 36713, 10.1074/jbc.M003017200
Watanabe, 2014, DOCK2 and DOCK5 act additively in neutrophils to regulate chemotaxis, superoxide production, and extracellular trap formation, J. Immunol., 193, 5660, 10.4049/jimmunol.1400885
Williams, 1999, Integrin-mediated signaling in human neutrophil functioning, J. Leukoc. Biol., 65, 725, 10.1002/jlb.65.6.725
Winograd-Katz, 2014, The integrin adhesome: from genes and proteins to human disease, Nat. Rev. Mol. Cell Biol., 15, 273, 10.1038/nrm3769
Winterbourn, 2006, Modeling the reactions of superoxide and myeloperoxidase in the neutrophil phagosome: implications for microbial killing, J. Biol. Chem., 281, 39860, 10.1074/jbc.M605898200
Winterbourn, 2016, Reactive oxygen species and neutrophil function, Annu. Rev. Biochem., 85, 765, 10.1146/annurev-biochem-060815-014442
Wolach, 2017, Chronic granulomatous disease: clinical, functional, molecular, and genetic studies. The Israeli experience with 84 patients, Am. J. Hematol., 92, 28, 10.1002/ajh.24573
Woolery, 2014, AMPylation of Rho GTPases subverts multiple host signaling processes, J. Biol. Chem., 289, 32977, 10.1074/jbc.M114.601310
Wozniak, 1993, Interleukin-8 primes human neutrophils for enhanced superoxide anion production, Immunology, 79, 608
Yan, 2002, Lipopolysaccharide-binding protein- and CD14-dependent activation of mitogen-activated protein kinase p38 by lipopolysaccharide in human neutrophils is associated with priming of respiratory burst, Infect. Immun., 70, 4068, 10.1128/IAI.70.8.4068-4074.2002
Yuo, 1989, Tumor necrosis factor as an activator of human-granulocytes - potentiation of the metabolisms triggered by the Ca2+-mobilizing agonists, J. Immunol., 142, 1678, 10.4049/jimmunol.142.5.1678
Zhan, 2002, The p40phox and p47phox PX domains of NADPH oxidase target cell membranes via direct and indirect recruitment by phosphoinositides, J. Biol. Chem., 277, 4512, 10.1074/jbc.M109520200
Zheng, 1998, Activation of the OxyR transcription factor by reversible disulfide bond formation, Science, 279, 1718, 10.1126/science.279.5357.1718
Zheng, 1999, OxyR and SoxRS regulation of fur, J. Bacteriol., 181, 4639, 10.1128/JB.181.15.4639-4643.1999
Zheng, 2001, DNA microarray-mediated transcriptional profiling of the Escherichia coli response to hydrogen peroxide, J. Bacteriol., 183, 4562, 10.1128/JB.183.15.4562-4570.2001