Neutrophils, Dendritic Cells, Toll-Like Receptors, and Interferon-α in Lupus Nephritis
Tài liệu tham khảo
Lech, 2013, The pathogenesis of lupus nephritis, J Am Soc Nephrol, 24, 1357, 10.1681/ASN.2013010026
Munoz, 2010, The role of defective clearance of apoptotic cells in systemic autoimmunity, Nat Rev Rheumatol, 6, 280, 10.1038/nrrheum.2010.46
Hakkim, 2010, Impairment of neutrophil extracellular trap degradation is associated with lupus nephritis, Proc Natl Acad Sci U S A, 107, 9813, 10.1073/pnas.0909927107
Marshak-Rothstein, 2007, Immunologically active autoantigens: the role of toll-like receptors in the development of chronic inflammatory disease, Annu Rev Immunol, 25, 419, 10.1146/annurev.immunol.22.012703.104514
Migliorini, 2012, A novel pathogenetic concept-antiviral immunity in lupus nephritis, Nat Rev Nephrol, 8, 183, 10.1038/nrneph.2011.197
Hiepe, 2011, Long-lived autoreactive plasma cells drive persistent autoimmune inflammation, Nat Rev Rheumatol, 7, 170, 10.1038/nrrheum.2011.1
Chung, 2014, Lupus nephritis susceptibility loci in women with systemic lupus erythematosus, J Am Soc Nephrol, 25, 2859, 10.1681/ASN.2013050446
Lennon, 2015, Coinheritance of COL4A5 and MYO1E mutations accentuate the severity of kidney disease, Pediatr Nephrol, 30, 1459, 10.1007/s00467-015-3067-9
Papazachariou, 2014, Frequency of COL4A3/COL4A4 mutations amongst families segregating glomerular microscopic hematuria and evidence for activation of the unfolded protein response. Focal and segmental glomerulosclerosis is a frequent development during ageing, PLoS One, 9, e115015, 10.1371/journal.pone.0115015
Lech, 2011, IRF4 deficiency abrogates lupus nephritis despite enhancing systemic cytokine production, J Am Soc Nephrol, 22, 1443, 10.1681/ASN.2010121260
Anders, 2014, Immunopathology of lupus nephritis, Semin Immunopathol, 36, 443, 10.1007/s00281-013-0413-5
Linkermann, 2014, Regulated cell death and inflammation: an auto-amplification loop causes organ failure, Nat Rev Immunol, 14, 759, 10.1038/nri3743
Yu, 2013, Neutrophil extracellular traps and systemic lupus erythematosus, J Clin Cell Immunol, 4
Han, 2014, Expression of an anti-RNA autoantibody in a mouse model of SLE increases neutrophil and monocyte numbers as well as IFN-I expression, Eur J Immunol, 44, 215, 10.1002/eji.201343714
Brinkmann, 2004, Neutrophil extracellular traps kill bacteria, Science, 303, 1532, 10.1126/science.1092385
Cheng, 2015, Human neutrophil peptide 1-3, a component of the neutrophil extracellular trap, as a potential biomarker of lupus nephritis, Int J Rheum Dis, 18, 533, 10.1111/1756-185X.12433
Zhang, 2014, Elevated plasma cfDNA may be associated with active lupus nephritis and partially attributed to abnormal regulation of neutrophil extracellular traps (NETs) in patients with systemic lupus erythematosus, Intern Med, 53, 2763, 10.2169/internalmedicine.53.2570
Smith, 2014, Neutrophil extracellular trap-derived enzymes oxidize high-density lipoprotein: an additional proatherogenic mechanism in systemic lupus erythematosus, Arthritis Rheum, 66, 2532, 10.1002/art.38703
Knight, 2013, Peptidylarginine deiminase inhibition is immunomodulatory and vasculoprotective in murine lupus, J Clin Invest, 123, 2981, 10.1172/JCI67390
Knight, 2014, Peptidylarginine deiminase inhibition disrupts NET formation and protects against kidney, skin and vascular disease in lupus-prone MRL/lpr mice, Ann Rheum Dis
Campbell, 2012, NADPH oxidase inhibits the pathogenesis of systemic lupus erythematosus, Sci Transl Med, 4, 157ra41, 10.1126/scitranslmed.3004801
Kessenbrock, 2009, Netting neutrophils in autoimmune small-vessel vasculitis, Nat Med, 15, 623, 10.1038/nm.1959
Nakazawa, 2012, Abnormal conformation and impaired degradation of propylthiouracil-induced neutrophil extracellular traps: implications of disordered neutrophil extracellular traps in a rat model of myeloperoxidase antineutrophil cytoplasmic antibody-associated vasculitis, Arthritis Rheum, 64, 3779, 10.1002/art.34619
Kumar, 2015, Neutrophil extracellular trap-related extracellular histones cause vascular necrosis in severe GN, J Am Soc Nephrol, 10.1681/ASN.2014070673
Carmona-Rivera, 2015, Neutrophil extracellular traps induce endothelial dysfunction in systemic lupus erythematosus through the activation of matrix metalloproteinase-2, Ann Rheum Dis, 74, 1417, 10.1136/annrheumdis-2013-204837
MacDonald, 2002, Characterization of human blood dendritic cell subsets, Blood, 100, 4512, 10.1182/blood-2001-11-0097
Mackern-Oberti, 2015, Role of dendritic cells in the initiation, progress and modulation of systemic autoimmune diseases, Autoimmun Rev, 14, 127, 10.1016/j.autrev.2014.10.010
Palombo, 2013, Therapeutic implications of immunogenic cell death in human cancer, Front Immunol, 4, 503
Villadangos, 2008, Antigen-presentation properties of plasmacytoid dendritic cells, Immunity, 29, 352, 10.1016/j.immuni.2008.09.002
Wang, 2014, Bruton’s tyrosine kinase regulates TLR9 but not TLR7 signaling in human plasmacytoid dendritic cells, Eur J Immunol, 44, 1130, 10.1002/eji.201344030
Anders, 2010, Interferon-alpha and -beta in kidney inflammation, Kidney Int, 77, 848, 10.1038/ki.2010.71
Rowland, 2014, Early, transient depletion of plasmacytoid dendritic cells ameliorates autoimmunity in a lupus model, J Exp Med, 211, 1977, 10.1084/jem.20132620
Davison, 2015, Sialic acid-binding immunoglobulin-type lectin H-positive plasmacytoid dendritic cells drive spontaneous lupus-like disease development in B6.Nba2 mice, Arthritis Rheum, 67, 1012, 10.1002/art.38989
Zhan, 2015, Bcl-2 antagonists kill plasmacytoid dendritic cells from lupus-prone mice and dampen interferon-alpha production, Arthritis Rheum, 67, 797, 10.1002/art.38966
Sisirak, 2014, Genetic evidence for the role of plasmacytoid dendritic cells in systemic lupus erythematosus, J Exp Med, 211, 1969, 10.1084/jem.20132522
Teichmann, 2010, Dendritic cells in lupus are not required for activation of T and B cells but promote their expansion, resulting in tissue damage, Immunity, 33, 967, 10.1016/j.immuni.2010.11.025
Teichmann, 2013, Signals via the adaptor MyD88 in B cells and DCs make distinct and synergistic contributions to immune activation and tissue damage in lupus, Immunity, 38, 528, 10.1016/j.immuni.2012.11.017
Lamagna, 2013, Hyperactivated MyD88 signaling in dendritic cells, through specific deletion of Lyn kinase, causes severe autoimmunity and inflammation, Proc Natl Acad Sci U S A, 110, E3311, 10.1073/pnas.1300617110
Gleisner, 2013, Dendritic and stromal cells from the spleen of lupic mice present phenotypic and functional abnormalities, Mol Immunol, 54, 423, 10.1016/j.molimm.2013.01.011
Carreno, 2009, Disease activity in systemic lupus erythematosus is associated with an altered expression of low-affinity Fc gamma receptors and costimulatory molecules on dendritic cells, Immunology, 128, 334, 10.1111/j.1365-2567.2009.03138.x
Clatworthy, 2014, FcgammaRIIb inhibits immune complex-induced VEGF-A production and intranodal lymphangiogenesis, Proc Natl Acad Sci U S A, 111, 17971, 10.1073/pnas.1413915111
Rupanagudi, 2015, Cathepsin S inhibition suppresses systemic lupus erythematosus and lupus nephritis because cathepsin S is essential for MHC class II-mediated CD4 T cell and B cell priming, Ann Rheum Dis, 74, 452, 10.1136/annrheumdis-2013-203717
Yang, 2007, Interaction between antigen presenting cells and autoreactive T cells derived from BXSB mice with murine lupus, Cell Res, 17, 556, 10.1038/sj.cr.7310146
Gaspal, 2011, Abrogation of CD30 and OX40 signals prevents autoimmune disease in FoxP3-deficient mice, J Exp Med, 208, 1579, 10.1084/jem.20101484
Chiba, 2012, Tumor-infiltrating DCs suppress nucleic acid-mediated innate immune responses through interactions between the receptor TIM-3 and the alarmin HMGB1, Nat Immunol, 13, 832, 10.1038/ni.2376
Maurya, 2014, Immunoregulation of dendritic cells by the receptor T cell Ig and mucin protein-3 via Bruton’s tyrosine kinase and c-Src, J Immunol, 193, 3417, 10.4049/jimmunol.1400395
Wu, 2015, Alternatively activated dendritic cells derived from systemic lupus erythematosus patients have tolerogenic phenotype and function, Clin Immunol, 156, 43, 10.1016/j.clim.2014.10.011
Liu, 2014, Lupus nephritis: from pathogenesis to targets for biologic treatment, Nephron Clin Pract, 128, 224, 10.1159/000368581
Andreoli, 2015, A 24-month prospective study on the efficacy and safety of two different monthly regimens of vitamin D supplementation in pre-menopausal women with systemic lupus erythematosus, Lupus, 24, 499, 10.1177/0961203314559089
Sahu, 2014, Structure and function of renal macrophages and dendritic cells from lupus-prone mice, Arthritis Rheumatol, 66, 1596, 10.1002/art.38410
Fiore, 2008, Immature myeloid and plasmacytoid dendritic cells infiltrate renal tubulointerstitium in patients with lupus nephritis, Mol Immunol, 45, 259, 10.1016/j.molimm.2007.04.029
Patole, 2005, G-rich DNA suppresses systemic lupus, J Am Soc Nephrol, 16, 3273, 10.1681/ASN.2005060658
Pawar, 2006, Toll-like receptor-7 modulates immune complex glomerulonephritis, J Am Soc Nephrol, 17, 141, 10.1681/ASN.2005070714
Pawar, 2007, Inhibition of Toll-like receptor-7 (TLR-7) or TLR-7 plus TLR-9 attenuates glomerulonephritis and lung injury in experimental lupus, J Am Soc Nephrol, 18, 1721, 10.1681/ASN.2006101162
Anders, 2004, Activation of toll-like receptor-9 induces progression of renal disease in MRL-Fas(lpr) mice, FASEB J, 18, 534, 10.1096/fj.03-0646fje
Lech, 2007, Different roles of TiR8/Sigirr on toll-like receptor signaling in intrarenal antigen-presenting cells and tubular epithelial cells, Kidney Int, 72, 182, 10.1038/sj.ki.5002293
Allam, 2008, The role of innate immunity in autoimmune tissue injury, Curr Opin Rheumatol, 20, 538, 10.1097/BOR.0b013e3283025ed4
Christensen, 2006, Toll-like receptor 7 and TLR9 dictate autoantibody specificity and have opposing inflammatory and regulatory roles in a murine model of lupus, Immunity, 25, 417, 10.1016/j.immuni.2006.07.013
Savarese, 2008, Requirement of Toll-like receptor 7 for pristane-induced production of autoantibodies and development of murine lupus nephritis, Arthritis Rheum, 58, 1107, 10.1002/art.23407
Anders, 2008, Molecular mimicry in innate immunity? The viral RNA recognition receptor TLR7 accelerates murine lupus, Eur J Immunol, 38, 1795, 10.1002/eji.200838478
Subramanian, 2006, A Tlr7 translocation accelerates systemic autoimmunity in murine lupus, Proc Natl Acad Sci U S A, 103, 9970, 10.1073/pnas.0603912103
Deane, 2007, Control of Toll-like receptor 7 expression is essential to restrict autoimmunity and dendritic cell proliferation, Immunity, 27, 801, 10.1016/j.immuni.2007.09.009
Zhuang, 2014, Toll-like receptor 7-stimulated tumor necrosis factor alpha causes bone marrow damage in systemic lupus erythematosus, Arthritis Rheumatol, 66, 140, 10.1002/art.38189
Kanno, 2015, Targeting cell surface TLR7 for therapeutic intervention in autoimmune diseases, Nat Commun, 6, 6119, 10.1038/ncomms7119
Ramirez-Ortiz, 2015, The receptor TREML4 amplifies TLR7-mediated signaling during antiviral responses and autoimmunity, Nat Immunol, 16, 495, 10.1038/ni.3143
Kelley, 2007, Variation in the relative copy number of the TLR7 gene in patients with systemic lupus erythematosus and healthy control subjects, Arthritis Rheum, 56, 3375, 10.1002/art.22916
Garcia-Ortiz, 2010, Association of TLR7 copy number variation with susceptibility to childhood-onset systemic lupus erythematosus in Mexican population, Ann Rheum Dis, 69, 1861, 10.1136/ard.2009.124313
Shen, 2010, Sex-specific association of X-linked Toll-like receptor 7 (TLR7) with male systemic lupus erythematosus, Proc Natl Acad Sci U S A, 107, 15838, 10.1073/pnas.1001337107
Lyn-Cook, 2014, Increased expression of Toll-like receptors (TLRs) 7 and 9 and other cytokines in systemic lupus erythematosus (SLE) patients: ethnic differences and potential new targets for therapeutic drugs, Mol Immunol, 61, 38, 10.1016/j.molimm.2014.05.001
Kawasaki, 2011, TLR7 single-nucleotide polymorphisms in the 3′ untranslated region and intron 2 independently contribute to systemic lupus erythematosus in Japanese women: a case-control association study, Arthritis Res Ther, 13, R41, 10.1186/ar3277
Wang, 2014, Genetic variations in Toll-like receptors (TLRs 3/7/8) are associated with systemic lupus erythematosus in a Taiwanese population, Sci Rep, 4, 3792, 10.1038/srep03792
Jackson, 2014, Opposing impact of B cell-intrinsic TLR7 and TLR9 signals on autoantibody repertoire and systemic inflammation, J Immunol, 192, 4525, 10.4049/jimmunol.1400098
Summers, 2010, TLR9 and TLR4 are required for the development of autoimmunity and lupus nephritis in pristane nephropathy, J Autoimmun, 35, 291, 10.1016/j.jaut.2010.05.004
Nickerson, 2010, TLR9 regulates TLR7- and MyD88-dependent autoantibody production and disease in a murine model of lupus, J Immunol, 184, 1840, 10.4049/jimmunol.0902592
Desnues, 2014, TLR8 on dendritic cells and TLR9 on B cells restrain TLR7-mediated spontaneous autoimmunity in C57BL/6 mice, Proc Natl Acad Sci U S A, 111, 1497, 10.1073/pnas.1314121111
Fukui, 2011, Unc93B1 restricts systemic lethal inflammation by orchestrating Toll-like receptor 7 and 9 trafficking, Immunity, 35, 69, 10.1016/j.immuni.2011.05.010
Fukui, 2009, Unc93B1 biases Toll-like receptor responses to nucleic acid in dendritic cells toward DNA- but against RNA-sensing, J Exp Med, 206, 1339, 10.1084/jem.20082316
Klonowska-Szymczyk, 2014, Expression of toll-like receptors 3, 7, and 9 in peripheral blood mononuclear cells from patients with systemic lupus erythematosus, Mediators Inflamm, 2014, 381418, 10.1155/2014/381418
Chauhan, 2013, Distinct autoantibody profiles in systemic lupus erythematosus patients are selectively associated with TLR7 and TLR9 upregulation, J Clin Immunol, 33, 954, 10.1007/s10875-013-9887-0
Tsao, 2012, Altered IL-10 and TNF-alpha production in peripheral blood mononuclear cells of systemic lupus erythematosus patients after Toll-like receptor 2, 4, or 9 activation, Clin Exp Med, 12, 153, 10.1007/s10238-011-0161-6
Capolunghi, 2010, Pharmacological inhibition of TLR9 activation blocks autoantibody production in human B cells from SLE patients, Rheumatology (Oxford), 49, 2281, 10.1093/rheumatology/keq226
Patole, 2005, Viral double-stranded RNA aggravates lupus nephritis through Toll-like receptor 3 on glomerular mesangial cells and antigen-presenting cells, J Am Soc Nephrol, 16, 1326, 10.1681/ASN.2004100820
Sadanaga, 2007, Protection against autoimmune nephritis in MyD88-deficient MRL/lpr mice, Arthritis Rheum, 56, 1618, 10.1002/art.22571
Annable, 2015, Using Poly I:C as an adjuvant does not induce or exacerbate models of systemic lupus erythematosus, Autoimmunity, 48, 29, 10.3109/08916934.2014.959166
Cervantes, 2013, Human TLR8 is activated upon recognition of Borrelia burgdorferi RNA in the phagosome of human monocytes, J Leukoc Biol, 94, 1231, 10.1189/jlb.0413206
Diebold, 2008, Recognition of viral single-stranded RNA by Toll-like receptors, Adv Drug Deliv Rev, 60, 813, 10.1016/j.addr.2007.11.004
Heil, 2004, Species-specific recognition of single-stranded RNA via toll-like receptor 7 and 8, Science, 303, 1526, 10.1126/science.1093620
Alexopoulou, 2012, [Toll-like receptor 8: the awkward TLR], Med Sci (Paris), 28, 96, 10.1051/medsci/2012281023
Demaria, 2010, TLR8 deficiency leads to autoimmunity in mice, J Clin Invest, 120, 3651
Umiker, 2014, Dosage of X-linked Toll-like receptor 8 determines gender differences in the development of systemic lupus erythematosus, Eur J Immunol, 44, 1503, 10.1002/eji.201344283
Anders, 2010, Toll-like receptors and danger signaling in kidney injury, J Am Soc Nephrol, 21, 1270, 10.1681/ASN.2010030233
Anders, 2014, Beyond tissue injury-damage-associated molecular patterns, toll-like receptors, and inflammasomes also drive regeneration and fibrosis, J Am Soc Nephrol, 25, 1387, 10.1681/ASN.2014010117
Lee, 2014, Interactions of surface-expressed TLR-4 and endosomal TLR-9 accelerate lupus progression in anti-dsDNA antibody transgenic mice, Exp Biol Med (Maywood), 239, 715, 10.1177/1535370214525299
Liu, 2006, TLR4 up-regulation at protein or gene level is pathogenic for lupus-like autoimmune disease, J Immunol, 177, 6880, 10.4049/jimmunol.177.10.6880
Lartigue, 2009, Critical role of TLR2 and TLR4 in autoantibody production and glomerulonephritis in lpr mutation-induced mouse lupus, J Immunol, 183, 6207, 10.4049/jimmunol.0803219
Kirchner, 2013, Surface expression and genotypes of Toll-like receptors 2 and 4 in patients with juvenile idiopathic arthritis and systemic lupus erythematosus, Pediatr Rheumatol Online J, 11, 9, 10.1186/1546-0096-11-9
Kaiser, 2014, A polymorphism in TLR2 is associated with arterial thrombosis in a multiethnic population of patients with systemic lupus erythematosus, Arthritis Rheumatol, 66, 1882, 10.1002/art.38520
Dominguez-Villar, 2015, TLR7 induces anergy in human CD4(+) T cells, Nat Immunol, 16, 118, 10.1038/ni.3036
Celhar, 2014, Toll-like receptors in systemic lupus erythematosus: potential for personalized treatment, Front Pharmacol, 5, 265, 10.3389/fphar.2014.00265
Applequist, 2002, Variable expression of Toll-like receptor in murine innate and adaptive immune cell lines, Int Immunol, 14, 1065, 10.1093/intimm/dxf069
Lau, 2005, RNA-associated autoantigens activate B cells by combined B cell antigen receptor/Toll-like receptor 7 engagement, J Exp Med, 202, 1171, 10.1084/jem.20050630
Leadbetter, 2002, Chromatin-IgG complexes activate B cells by dual engagement of IgM and Toll-like receptors, Nature, 416, 603, 10.1038/416603a
Boule, 2004, Toll-like receptor 9-dependent and -independent dendritic cell activation by chromatin-immunoglobulin G complexes, J Exp Med, 199, 1631, 10.1084/jem.20031942
Hwang, 2012, B cell TLR7 expression drives anti-RNA autoantibody production and exacerbates disease in systemic lupus erythematosus-prone mice, J Immunol, 189, 5786, 10.4049/jimmunol.1202195
Fairhurst, 2008, Yaa autoimmune phenotypes are conferred by overexpression of TLR7, Eur J Immunol, 38, 1971, 10.1002/eji.200838138
Soni, 2014, B cell-intrinsic TLR7 signaling is essential for the development of spontaneous germinal centers, J Immunol, 193, 4400, 10.4049/jimmunol.1401720
Zhu, 2012, The largely normal response to Toll-like receptor 7 and 9 stimulation and the enhanced expression of SIGIRR by B cells in systemic lupus erythematosus, PLoS One, 7, e44131, 10.1371/journal.pone.0044131
Hua, 2014, Requirement for MyD88 signaling in B cells and dendritic cells for germinal center anti-nuclear antibody production in Lyn-deficient mice, J Immunol, 192, 875, 10.4049/jimmunol.1300683
Pawar, 2006, Microbial nucleic acids pay a Toll in kidney disease, Am J Physiol Renal Physiol, 291, F509, 10.1152/ajprenal.00453.2005
Anders, 2005, Molecular mechanisms of autoimmunity triggered by microbial infection, Arthritis Res Ther, 7, 215, 10.1186/ar1818
Allam, 2009, Viral RNA and DNA trigger common antiviral responses in mesangial cells, J Am Soc Nephrol, 20, 1986, 10.1681/ASN.2008101067
Patole, 2006, Expression and regulation of Toll-like receptors in lupus-like immune complex glomerulonephritis of MRL-Fas(lpr) mice, Nephrol Dial Transplant, 21, 3062, 10.1093/ndt/gfl336
Timmerman, 1997, Antigen-antibody complexes enhance the production of complement component C3 by human mesangial cells, J Am Soc Nephrol, 8, 1257, 10.1681/ASN.V881257
Imaizumi, 2014, Toll-like receptor 3 signaling contributes to the expression of a neutrophil chemoattractant, CXCL1 in human mesangial cells, Clin Exp Nephrol
Lichtnekert, 2009, Trif is not required for immune complex glomerulonephritis: dying cells activate mesangial cells via Tlr2/Myd88 rather than Tlr3/Trif, Am J Physiol Renal Physiol, 296, F867, 10.1152/ajprenal.90213.2008
Ka, 2007, Mesangial cells of lupus-prone mice are sensitive to chemokine production, Arthritis Res Ther, 9, R67, 10.1186/ar2226
Svenson, 2014, Estrogen receptor alpha modulates mesangial cell responses to toll-like receptor ligands, Am J Med Sci, 348, 492, 10.1097/MAJ.0000000000000339
Kimura, 2014, Overexpression of Toll-like receptor 8 correlates with the progression of podocyte injury in murine autoimmune glomerulonephritis, Sci Rep, 4, 7290, 10.1038/srep07290
Benigni, 2007, Involvement of renal tubular Toll-like receptor 9 in the development of tubulointerstitial injury in systemic lupus, Arthritis Rheum, 56, 1569, 10.1002/art.22524
Papadimitraki, 2009, Glomerular expression of toll-like receptor-9 in lupus nephritis but not in normal kidneys: implications for the amplification of the inflammatory response, Lupus, 18, 831, 10.1177/0961203309103054
Frieri, 2012, Toll-like receptor 9 and vascular endothelial growth factor levels in human kidneys from lupus nephritis patients, J Nephrol, 25, 1041, 10.5301/jn.5000091
Machida, 2010, Expression of Toll-like receptor 9 in renal podocytes in childhood-onset active and inactive lupus nephritis, Nephrol Dial Transplant, 25, 2530, 10.1093/ndt/gfq058
Pawar, 2009, Bacterial lipopeptide triggers massive albuminuria in murine lupus nephritis by activating Toll-like receptor 2 at the glomerular filtration barrier, Immunology, 128, e206, 10.1111/j.1365-2567.2008.02948.x
Bezalel, 2014, Type I interferon signature in systemic lupus erythematosus, Isr Med Assoc J, 16, 246
Flur, 2009, Viral RNA induces type I interferon-dependent cytokine release and cell death in mesangial cells via melanoma-differentiation-associated gene-5: implications for viral infection-associated glomerulonephritis, Am J Pathol, 175, 2014, 10.2353/ajpath.2009.080585
Hagele, 2009, Double-stranded RNA activates type I interferon secretion in glomerular endothelial cells via retinoic acid-inducible gene (RIG)-1, Nephrol Dial Transplant, 24, 3312, 10.1093/ndt/gfp339
Anders, 2009, Pseudoviral immunity—a novel concept for lupus, Trends Mol Med, 15, 553, 10.1016/j.molmed.2009.10.004
Funabiki, 2014, Autoimmune disorders associated with gain of function of the intracellular sensor MDA5, Immunity, 40, 199, 10.1016/j.immuni.2013.12.014
Oliveira, 2014, Dysregulation of antiviral helicase pathways in systemic lupus erythematosus, Front Genet, 5, 418, 10.3389/fgene.2014.00418
Maringer, 2014, Message in a bottle: lessons learned from antagonism of STING signalling during RNA virus infection, Cytokine Growth Factor Rev, 25, 669, 10.1016/j.cytogfr.2014.08.004
Ahn, 2014, Self-DNA, STING-dependent signaling and the origins of autoinflammatory disease, Curr Opin Immunol, 31, 121, 10.1016/j.coi.2014.10.009
Ahn, 2012, STING manifests self DNA-dependent inflammatory disease, Proc Natl Acad Sci U S A, 109, 19386, 10.1073/pnas.1215006109
Reboulet, 2010, Prolonged antigen storage endows merocytic DC with enhanced capacity to prime anti-tumor responses in tumor-bearing mice, J Immunol, 185, 3337, 10.4049/jimmunol.1001619
Klarquist, 2014, STING-mediated DNA sensing promotes antitumor and autoimmune responses to dying cells, J Immunol, 193, 6124, 10.4049/jimmunol.1401869
Kawane, 2006, Chronic polyarthritis caused by mammalian DNA that escapes from degradation in macrophages, Nature, 443, 998, 10.1038/nature05245
Sharma, 2015, Suppression of systemic autoimmunity by the innate immune adaptor STING, Proc Natl Acad Sci U S A, 112, E710, 10.1073/pnas.1420217112
Jeremiah, 2014, Inherited STING-activating mutation underlies a familial inflammatory syndrome with lupus-like manifestations, J Clin Invest, 124, 5516, 10.1172/JCI79100
Kumagai, 2009, Cutting edge: TLR-dependent viral recognition along with type I IFN positive feedback signaling masks the requirement of viral replication for IFN-{alpha} production in plasmacytoid dendritic cells, J Immunol, 182, 3960, 10.4049/jimmunol.0804315
Decembre, 2014, Sensing of immature particles produced by dengue virus infected cells induces an antiviral response by plasmacytoid dendritic cells, PLoS Pathog, 10, e1004434, 10.1371/journal.ppat.1004434
Lovgren, 2004, Induction of interferon-alpha production in plasmacytoid dendritic cells by immune complexes containing nucleic acid released by necrotic or late apoptotic cells and lupus IgG, Arthritis Rheum, 50, 1861, 10.1002/art.20254
Kassim, 2013, Systematic identification of novel SLE related autoantibodies responsible for type I IFN production in human plasmacytoid dendritic cells, Cell Immunol, 284, 119, 10.1016/j.cellimm.2013.07.017
Ko, 2013, Activation of the interferon pathway is dependent upon autoantibodies in African-American SLE patients, but not in European-American SLE patients, Front Immunol, 4, 309, 10.3389/fimmu.2013.00309
Ronnblom, 2008, The innate immune system in SLE: type I interferons and dendritic cells, Lupus, 17, 394, 10.1177/0961203308090020
Cai, 2014, PIKfyve, a class III lipid kinase, is required for TLR-induced type I IFN production via modulation of ATF3, J Immunol, 192, 3383, 10.4049/jimmunol.1302411
Lindau, 2014, TLR9 independent interferon alpha production by neutrophils on NETosis in response to circulating chromatin, a key lupus autoantigen, Ann Rheum Dis, 73, 2199, 10.1136/annrheumdis-2012-203041
Lopez, 2014, Interferon-alpha-induced B-lymphocyte stimulator expression and mobilization in healthy and systemic lupus erthymatosus monocytes, Rheumatology (Oxford), 53, 2249, 10.1093/rheumatology/keu249
Chang, 2015, Interferon-alpha induces altered transitional B cell signaling and function in systemic lupus erythematosus, J Autoimmun, 58, 100, 10.1016/j.jaut.2015.01.009
Rodriguez-Pla, 2014, IFN priming is necessary but not sufficient to turn on a migratory dendritic cell program in lupus monocytes, J Immunol, 192, 5586, 10.4049/jimmunol.1301319
Thibault, 2009, Type I interferon receptor controls B-cell expression of nucleic acid-sensing Toll-like receptors and autoantibody production in a murine model of lupus, Arthritis Res Ther, 11, R112, 10.1186/ar2771
Theofilopoulos, 2012, TLRs and IFNs: critical pieces of the autoimmunity puzzle, J Clin Invest, 122, 3464, 10.1172/JCI63835
Hron, 2004, Type I IFN protects against murine lupus, J Immunol, 173, 2134, 10.4049/jimmunol.173.3.2134
Baccala, 2012, Anti-IFN-alpha/beta receptor antibody treatment ameliorates disease in lupus-predisposed mice, J Immunol, 189, 5976, 10.4049/jimmunol.1201477
Liu, 2011, IFN-alpha confers resistance of systemic lupus erythematosus nephritis to therapy in NZB/W F1 mice, J Immunol, 187, 1506, 10.4049/jimmunol.1004142
Ytterberg, 1982, Serum interferon levels in patients with systemic lupus erythematosus, Arthritis Rheum, 25, 401, 10.1002/art.1780250407
Gota, 2003, Induction of clinical autoimmune disease by therapeutic interferon-alpha, Autoimmunity, 36, 511, 10.1080/08916930310001605873
Baechler, 2003, Interferon-inducible gene expression signature in peripheral blood cells of patients with severe lupus, Proc Natl Acad Sci U S A, 100, 2610, 10.1073/pnas.0337679100
Pollard, 2013, Interferon-gamma and systemic autoimmunity, Discov Med, 16, 123
Petri, 2009, Longitudinal expression of type I interferon responsive genes in systemic lupus erythematosus, Lupus, 18, 980, 10.1177/0961203309105529
Petri, 2013, Sifalimumab, a human anti-interferon-alpha monoclonal antibody, in systemic lupus erythematosus: a phase I randomized, controlled, dose-escalation study, Arthritis Rheum, 65, 1011, 10.1002/art.37824
Hagele, 2009, Double-stranded DNA activates glomerular endothelial cells and enhances albumin permeability via a toll-like receptor-independent cytosolic DNA recognition pathway, Am J Pathol, 175, 1896, 10.2353/ajpath.2009.090182
Migliorini, 2013, The antiviral cytokines IFN-alpha and IFN-beta modulate parietal epithelial cells and promote podocyte loss: implications for IFN toxicity, viral glomerulonephritis, and glomerular regeneration, Am J Pathol, 183, 431, 10.1016/j.ajpath.2013.04.017
Fairhurst, 2008, Systemic IFN-alpha drives kidney nephritis in B6.Sle123 mice, Eur J Immunol, 38, 1948, 10.1002/eji.200837925
Fairhurst, 2009, Type I interferons produced by resident renal cells may promote end-organ disease in autoantibody-mediated glomerulonephritis, J Immunol, 183, 6831, 10.4049/jimmunol.0900742
Zagury, 2009, IFNalpha kinoid vaccine-induced neutralizing antibodies prevent clinical manifestations in a lupus flare murine model, Proc Natl Acad Sci U S A, 106, 5294, 10.1073/pnas.0900615106
Jorgensen, 2007, Type I interferon signaling is involved in the spontaneous development of lupus-like disease in B6.Nba2 and (B6.Nba2 x NZW)F(1) mice, Genes Immun, 8, 653, 10.1038/sj.gene.6364430
Santiago-Raber, 2003, Type-I interferon receptor deficiency reduces lupus-like disease in NZB mice, J Exp Med, 197, 777, 10.1084/jem.20021996
Agrawal, 2009, Deficiency of type I IFN receptor in lupus-prone New Zealand mixed 2328 mice decreases dendritic cell numbers and activation and protects from disease, J Immunol, 183, 6021, 10.4049/jimmunol.0803872
Dai, 2014, Interferon alpha on NZM2328.Lc1R27: enhancing autoimmunity and immune complex-mediated glomerulonephritis without end stage renal failure, Clin Immunol, 154, 66, 10.1016/j.clim.2014.06.008
Nacionales, 2007, Deficiency of the type I interferon receptor protects mice from experimental lupus, Arthritis Rheum, 56, 3770, 10.1002/art.23023
Nickerson, 2013, Exacerbated autoimmunity in the absence of TLR9 in MRL.Fas(lpr) mice depends on Ifnar1, J Immunol, 190, 3889, 10.4049/jimmunol.1203525
Braun, 2003, Type I interferon controls the onset and severity of autoimmune manifestations in lpr mice, J Autoimmun, 20, 15, 10.1016/S0896-8411(02)00109-9
Kono, 2013, TLRs and interferons: a central paradigm in autoimmunity, Curr Opin Immunol, 25, 720, 10.1016/j.coi.2013.10.006
Abeler-Dorner, 2013, Interferon-alpha abrogates the suppressive effect of apoptotic cells on dendritic cells in an in vitro model of systemic lupus erythematosus pathogenesis, J Rheumatol, 40, 1683, 10.3899/jrheum.121299