Neurosteroids and neuropathic pain management: Basic evidence and therapeutic perspectives
Tài liệu tham khảo
Afrazi, 2014, Allopregnanolone suppresses diabetes-induced neuropathic pain and motor deficit through inhibition of GABAA receptor down-regulation in the spinal cord of diabetic rats, Iran. J. Basic Med. Sci., 17, 312
Akwa, 1999, The amygdala mediates the anxiolytic-like effect of the neurosteroid allopregnanolone in rat, Behav. Brain Res., 106, 119, 10.1016/S0166-4328(99)00101-1
Aloisi, 2003, Gonadal hormones and sex differences in pain reactivity, Clin. J. Pain, 19, 168, 10.1097/00002508-200305000-00004
Aloisi, 2006, Sex hormones, central nervous system and pain, Horm. Behav., 50, 1, 10.1016/j.yhbeh.2005.12.002
Aloisi, 2003, Gonadectomy affects hormonal and behavioral responses to repetitive nociceptive stimulation in male rats, Ann. N. Y. Acad. Sci., 1007, 232, 10.1196/annals.1286.022
Aloisi, 2004, Testosterone affects formalin-induced responses differently in male and female rats, Neurosci. Lett., 361, 262, 10.1016/j.neulet.2003.12.023
Antoine, 2007, Peripheral nervous system involvement in patients with cancer, Lancet Neurol., 6, 75, 10.1016/S1474-4422(06)70679-2
Arendt-Nielsen, 2004, Visceral pain: gender differences in response to experimental and clinical pain, Eur. J. Pain, 8, 465, 10.1016/j.ejpain.2004.03.001
Arevalo, 2015, The neuroprotective actions of oestradiol and oestrogen receptors, Nat. Rev. Neurosci., 16, 17, 10.1038/nrn3856
Authier, 2009, Animal models of chemotherapy-evoked painful peripheral neuropathies, Neurotherapeutics, 6, 620, 10.1016/j.nurt.2009.07.003
Ayoola, 2014, Inhibition of CaV3.2 T-type calcium channels in peripheral sensory neurons contributes to analgesic properties of epipregnanolone, Psychopharmacology (Berlin), 231, 3503, 10.1007/s00213-014-3588-0
Baez-Jurado, 2019, Molecular mechanisms involved in the protective actions of Selective Estrogen Receptor Modulators in brain cells, Front. Neuroendocrinol., 52, 44, 10.1016/j.yfrne.2018.09.001
Baker, 2003, Oxaliplatin: a new drug for the treatment of metastatic carcinoma of the colon or rectum, Rev. Gastroenteron. Disord., 3, 31
Balthazart, 2018, Steroids and the brain: 50years of research, conceptual shifts and the ascent of non-classical and membrane-initiated actions, Horm. Behav., 99, 1, 10.1016/j.yhbeh.2018.01.002
Bansal, 2017, Exploring the potential of natural and synthetic neuroprotective steroids against neurodegenerative disorders: a literature review, Med. Res. Rev.
Barnes, 1998, Anti-inflammatory actions of glucocorticoids: molecular mechanisms, Clin. Sci. (Lond.), 94, 557, 10.1042/cs0940557
Barnes, 1993, Anti-inflammatory actions of steroids: molecular mechanisms, Trends Pharmacol. Sci., 14, 436, 10.1016/0165-6147(93)90184-L
Baulieu, 1999
Belanger, 1989, Comparison of residual C-19 steroids in plasma and prostatic tissue of human, rat and guinea pig after castration: unique importance of extratesticular androgens in men, J. Steroid Biochem., 32, 695, 10.1016/0022-4731(89)90514-1
Belelli, 2005, Neurosteroids: endogenous regulators of the GABA(A) receptor, Nat. Rev. Neurosci., 6, 565, 10.1038/nrn1703
Belvisi, 2003, Soft steroids: a new approach to the treatment of inflammatory airways diseases, Pulm. Pharmacol. Ther., 16, 321, 10.1016/S1094-5539(03)00105-6
Bennett, 1988, A peripheral mononeuropathy in rat that produces disorders of pain sensation like those seen in man, Pain, 33, 87, 10.1016/0304-3959(88)90209-6
Bitran, 1996, Chronic anabolic-androgenic steroid treatment affects brain GABA(A) receptor-gated chloride ion transport, Life Sci., 58, 573, 10.1016/0024-3205(95)02326-7
Bitran, 1991, Anxiolytic effects of 3 alpha-hydroxy-5 alpha[beta]-pregnan-20-one: endogenous metabolites of progesterone that are active at the GABAA receptor, Brain Res., 561, 157, 10.1016/0006-8993(91)90761-J
Brann, 1990, Dose-related effects of progesterone and 5 alpha-dihydroprogesterone upon estrogen-induced prolactin release, J. Neuroendocrinol., 2, 341, 10.1111/j.1365-2826.1990.tb00415.x
Brewer, 2016, Chemotherapy-induced peripheral neuropathy: current status and progress, Gynecol. Oncol., 140, 176, 10.1016/j.ygyno.2015.11.011
Burke, 2017, Psychological stress in early life as a predisposing factor for the development of chronic pain: Clinical and preclinical evidence and neurobiological mechanisms, J. Neurosci. Res., 95, 1257, 10.1002/jnr.23802
Calabrese, 2014, Diabetic neuropathic pain: a role for testosterone metabolites, J. Endocrinol., 221, 1, 10.1530/JOE-13-0541
Cashin, 1927, The physiological action of cholesterol, Am. J. Physiol., 82, 294, 10.1152/ajplegacy.1927.82.2.294
Catley, 2000, A naturalistic evaluation of cortisol secretion in persons with fibromyalgia and rheumatoid arthritis, Arthritis Care Res., 13, 51, 10.1002/1529-0131(200002)13:1<51::AID-ART8>3.0.CO;2-Q
Catterall, 2000, From ionic currents to molecular mechanisms: the structure and function of voltage-gated sodium channels, Neuron, 26, 13, 10.1016/S0896-6273(00)81133-2
Cavaletti, 2015, Chemotherapy-induced peripheral neurotoxicity, Curr. Opin. Neurol., 28, 500, 10.1097/WCO.0000000000000234
Ceccarelli, 2003, Long-term ovariectomy changes formalin-induced licking in female rats: the role of estrogens, Reprod. Biol. Endocrinol., 1, 24, 10.1186/1477-7827-1-24
Chakrabarti, 2010, Formation of mu-/kappa-opioid receptor heterodimer is sex-dependent and mediates female-specific opioid analgesia, Proc. Natl. Acad. Sci. U S A, 107, 20115, 10.1073/pnas.1009923107
Choi, 2007, Attenuated pain responses in mice lacking Ca(V)3.2 T-type channels, Genes Brain Behav., 6, 425, 10.1111/j.1601-183X.2006.00268.x
Ciriza, 2004, Reduced progesterone metabolites protect rat hippocampal neurones from kainic acid excitotoxicity in vivo, J. Neuroendocrinol., 16, 58, 10.1111/j.1365-2826.2004.01121.x
Ciriza, 2006, Reduced metabolites mediate neuroprotective effects of progesterone in the adult rat hippocampus. The synthetic progestin medroxyprogesterone acetate (Provera) is not neuroprotective, J. Neurobiol., 66, 916, 10.1002/neu.20293
Clatworthy, 1995, Role of peri-axonal inflammation in the development of thermal hyperalgesia and guarding behavior in a rat model of neuropathic pain, Neurosci. Lett., 184, 5, 10.1016/0304-3940(94)11154-B
Colloca, 2017, Neuropathic pain, Nat. Rev. Dis. Primers, 3, 17002, 10.1038/nrdp.2017.2
Compagnone, 2000, Neurosteroids: biosynthesis and function of these novel neuromodulators, Front. Neuroendocrinol., 21, 1, 10.1006/frne.1999.0188
Coronel, 2011, Progesterone prevents nerve injury-induced allodynia and spinal NMDA receptor upregulation in rats, Pain Med., 12, 1249, 10.1111/j.1526-4637.2011.01178.x
Coronel, 2016, Temporal changes in the expression of the translocator protein TSPO and the steroidogenic enzyme 5alpha-reductase in the dorsal spinal cord of animals with neuropathic pain: Effects of progesterone administration, Neurosci. Lett., 624, 23, 10.1016/j.neulet.2016.04.067
Craft, 2004, Sex differences in pain and analgesia: the role of gonadal hormones, Eur. J. Pain, 8, 397, 10.1016/j.ejpain.2004.01.003
Critchlow, 1963, Sex difference in resting pituitary-adrenal function in the rat, Am. J. Physiol., 205, 807, 10.1152/ajplegacy.1963.205.5.807
Cruccu, 2017, A review of neuropathic pain: from guidelines to clinical practice, Pain Ther., 6, 35, 10.1007/s40122-017-0087-0
Dableh, 2011, Progesterone prevents development of neuropathic pain in a rat model: timing and duration of treatment are critical, J. Pain Res., 4, 91
Dalla-Valle, 1992, Extraglandular hormonal steroidogenesis in aged rats, J. Steroid Biochem. Mol. Biol., 43, 1095, 10.1016/0960-0760(92)90337-I
De Nicola, 2018, Neurosteroidogenesis and progesterone anti-inflammatory/neuroprotective effects, J. Neuroendocrinol., 30, 10.1111/jne.12502
Devor, 1985, Corticosteroids suppress ectopic neural discharge originating in experimental neuromas, Pain, 22, 127, 10.1016/0304-3959(85)90173-3
Ding, 1998, Sex hormone-binding globulin mediates prostate androgen receptor action via a novel signaling pathway, Endocrinology, 139, 213, 10.1210/endo.139.1.5681
Dougherty, 2007, Dysfunction in multiple primary afferent fiber subtypes revealed by quantitative sensory testing in patients with chronic vincristine-induced pain, J. Pain Symptom Manage., 33, 166, 10.1016/j.jpainsymman.2006.08.006
Durand, 2005, Clinical activity of venlafaxine and topiramate against oxaliplatin-induced disabling permanent neuropathy, Anticancer Drugs, 16, 587, 10.1097/00001813-200506000-00015
Edinger, 2004, Testosterone's analgesic, anxiolytic, and cognitive-enhancing effects may be due in part to actions of its 5alpha-reduced metabolites in the hippocampus, Behav. Neurosci., 118, 1352, 10.1037/0735-7044.118.6.1352
Edinger, 2007, Androgens' effects to enhance learning may be mediated in part through actions at estrogen receptor-beta in the hippocampus, Neurobiol. Learn. Mem., 87, 78, 10.1016/j.nlm.2006.07.001
Fakih, 2002, Glucocorticoids and treatment of prostate cancer: a preclinical and clinical review, Urology, 60, 553, 10.1016/S0090-4295(02)01741-7
Fehrenbacher, 2015, Chemotherapy-induced peripheral neuropathy, Prog. Mol. Biol. Transl. Sci., 131, 471, 10.1016/bs.pmbts.2014.12.002
Ferdousi, 2018, Stress-induced modulation of pain: Role of the endogenous opioid system, Prog. Brain Res., 239, 121, 10.1016/bs.pbr.2018.07.002
Fillingim, 2004, Sex differences in opioid analgesia: clinical and experimental findings, Eur. J. Pain, 8, 413, 10.1016/j.ejpain.2004.01.007
Finn, 2006, A new look at the 5alpha-reductase inhibitor Finasteride, CNS Drug Rev., 12, 53, 10.1111/j.1527-3458.2006.00053.x
Finnerup, 2015, Pharmacotherapy for neuropathic pain in adults: a systematic review and meta-analysis, Lancet Neurol., 14, 162, 10.1016/S1474-4422(14)70251-0
Finnerup, 2016, Neuropathic pain: an updated grading system for research and clinical practice, Pain, 157, 1599, 10.1097/j.pain.0000000000000492
Firestein, 1991, Gene expression (collagenase, tissue inhibitor of metalloproteinases, complement, and HLA-DR) in rheumatoid arthritis and osteoarthritis synovium. Quantitative analysis and effect of intraarticular corticosteroids, Arthritis Rheum., 34, 1094, 10.1002/art.1780340905
Flatters, 2015, The contribution of mitochondria to sensory processing and pain, Prog. Mol. Biol. Transl. Sci., 131, 119, 10.1016/bs.pmbts.2014.12.004
Frederic, 1993, IL-1 and LPS induce a sexually dimorphic response of the hypothalamo-pituitary-adrenal axis in several mouse strains, Eur. Cytokine Netw., 4, 321
Frye, 2007, Self-administration of 3alpha-androstanediol increases locomotion and analgesia and decreases aggressive behavior of male hamsters, Pharmacol. Biochem. Behav., 86, 415, 10.1016/j.pbb.2006.05.025
Frye, 1996, Behavioral effects of 3 alpha-androstanediol. II: Hypothalamic and preoptic area actions via a GABAergic mechanism, Behav. Brain Res., 79, 119, 10.1016/0166-4328(96)00005-8
Frye, 2001, Testosterone increases analgesia, anxiolysis, and cognitive performance of male rats, Cogn. Affect Behav. Neurosci., 1, 371, 10.3758/CABN.1.4.371
Gambhir, 2002, Evaluation of the analgesic effect of neurosteroids and their possible mechanism of action, Indian J. Physiol. Pharmacol., 46, 202
Gamelin, 2004, Prevention of oxaliplatin-related neurotoxicity by calcium and magnesium infusions: a retrospective study of 161 patients receiving oxaliplatin combined with 5-Fluorouracil and leucovorin for advanced colorectal cancer, Clin. Cancer Res., 10, 4055, 10.1158/1078-0432.CCR-03-0666
Giatti, 2019, Sex differences in the brain expression of steroidogenic molecules under basal conditions and after gonadectomy, J. Neuroendocrinol., 31, e12736, 10.1111/jne.12736
Goel, 2008, Organizational and activational effects of testosterone on masculinization of female physiological and behavioral stress responses, Endocrinology, 149, 6399, 10.1210/en.2008-0433
Gonzalez, 2019, Allopregnanolone and progesterone in experimental neuropathic pain: former and new insights with a translational perspective, Cell. Mol. Neurobiol., 39, 523, 10.1007/s10571-018-0618-1
Goodchild, 2000, Antinociceptive properties of neurosteroids I. Spinally-mediated antinociceptive effects of water-soluble aminosteroids, Pain, 88, 23, 10.1016/S0304-3959(00)00301-8
Goodchild, 2001, Antinociceptive properties of neurosteroids IV: pilot study demonstrating the analgesic effects of alphadolone administered orally to humans, Br. J. Anaesth., 86, 528, 10.1093/bja/86.4.528
Grace, 2016, Morphine paradoxically prolongs neuropathic pain in rats by amplifying spinal NLRP3 inflammasome activation, Proc. Natl. Acad. Sci. U S A, 113, E3441, 10.1073/pnas.1602070113
Green, 1997, 17 alpha-estradiol exerts neuroprotective effects on SK-N-SH cells, J. Neurosci., 17, 511, 10.1523/JNEUROSCI.17-02-00511.1997
Griffin, 2004, Niemann-Pick type C disease involves disrupted neurosteroidogenesis and responds to allopregnanolone, Nat. Med., 10, 704, 10.1038/nm1073
Grimm, 2016, Alzheimer, mitochondria and gender, Neurosci. Biobehav. Rev., 67, 89, 10.1016/j.neubiorev.2016.04.012
Grimm, 2014, Improvement of neuronal bioenergetics by neurosteroids: implications for age-related neurodegenerative disorders, BBA, 1842, 2427
Gunn, 2015, GABAA receptor-acting neurosteroids: a role in the development and regulation of the stress response, Front. Neuroendocrinol., 36, 28, 10.1016/j.yfrne.2014.06.001
Guo, 2013, Significant changes in mitochondrial distribution in different pain models of mice, Mitochondrion, 13, 292, 10.1016/j.mito.2013.03.007
Gwak, 2013, Reactive oxygen species contribute to neuropathic pain and locomotor dysfunction via activation of CamKII in remote segments following spinal cord contusion injury in rats, Pain, 154, 1699, 10.1016/j.pain.2013.05.018
Haines, 1997, The spinal cord, 129
Hau, 2004, Testosterone reduces responsiveness to nociceptive stimuli in a wild bird, Horm. Behav., 46, 165, 10.1016/j.yhbeh.2004.02.007
Hayashi, 2008, Systemic glucocorticoid therapy reduces pain and the number of endoneurial tumor necrosis factor-alpha (TNFalpha)-positive mast cells in rats with a painful peripheral neuropathy, J. Pharmacol. Sci., 106, 559, 10.1254/jphs.FP0072181
Heim, 2008, The link between childhood trauma and depression: insights from HPA axis studies in humans, Psychoneuroendocrinology, 33, 693, 10.1016/j.psyneuen.2008.03.008
Hershman, 2014, Prevention and management of chemotherapy-induced peripheral neuropathy in survivors of adult cancers: American Society of Clinical Oncology clinical practice guideline, J. Clin. Oncol., 32, 1941, 10.1200/JCO.2013.54.0914
Higashi, 2007, Studies on Neurosteroids XXI: an improved liquid chromatography-tandem mass spectrometric method for determination of 5alpha-androstane-3alpha,17beta-diol in rat brains, Anal. Sci., 23, 1015, 10.2116/analsci.23.1015
Holmberg, 2013, Allopregnanolone induces a diurnally dependent hyperphagic effect and alters feeding latency and duration in male Wistar rats, Acta Physiol. (Oxf.), 208, 400, 10.1111/apha.12100
Holzbauer, 1976, Proceedings: physiological aspects of the hypnotic properties of steroid hormones, Br. J. Pharmacol., 56
Hosie, 2006, Endogenous neurosteroids regulate GABAA receptors through two discrete transmembrane sites, Nature, 444, 486, 10.1038/nature05324
Hou, 2018, Treatment of chemotherapy-induced peripheral neuropathy: systematic review and recommendations, Pain Physician, 21, 571
Huang, 2016, Neurosteroid allopregnanolone suppresses median nerve injury-induced mechanical hypersensitivity and glial extracellular signal-regulated kinase activation through gamma-aminobutyric acid type A receptor modulation in the rat cuneate nucleus, Anesthesiology, 125, 1202, 10.1097/ALN.0000000000001360
Iwasaki-Sekino, 2009, Psychoneuroendocrinology, 34, 226, 10.1016/j.psyneuen.2008.09.003
Jamieson, 2009, Oxaliplatin-induced loss of phosphorylated heavy neurofilament subunit neuronal immunoreactivity in rat DRG tissue, Mol. Pain, 5, 66, 10.1186/1744-8069-5-66
Jensen, 2011, Psychosocial factors and adjustment to chronic pain in persons with physical disabilities: a systematic review, Arch. Phys. Med. Rehabil., 92, 146, 10.1016/j.apmr.2010.09.021
Johansson, 1997, Effect of local methylprednisolone on pain in a nerve injury model. A pilot study, Reg. Anesth., 22, 59, 10.1016/S1098-7339(06)80057-X
Joksimovic, 2018, Neurosteroids in pain management: a new perspective on an old player, Front. Pharmacol., 9, 1127, 10.3389/fphar.2018.01127
Joksimovic, 2019, Inhibition of multiple voltage-gated calcium channels may contribute to spinally mediated analgesia by epipregnanolone in a rat model of surgical paw incision, Channels (Austin), 13, 48, 10.1080/19336950.2018.1564420
Joksimovic, 2018, Selective inhibition of CaV3.2 channels reverses hyperexcitability of peripheral nociceptors and alleviates postsurgical pain, Sci. Signal, 11, 10.1126/scisignal.aao4425
Jones, 1993, Gonadal steroids and neuronal regeneration. A therapeutic role, Adv. Neurol., 59, 227
Karout, 2016, Novel analogs of allopregnanolone show improved efficiency and specificity in neuroprotection and stimulation of proliferation, J. Neurochem., 139, 782, 10.1111/jnc.13693
Kibaly, 2008, Biochemical and functional evidence for the control of pain mechanisms by dehydroepiandrosterone endogenously synthesized in the spinal cord, FASEB J., 22, 93, 10.1096/fj.07-8930com
Kibaly, 2005, Molecular and neurochemical evidence for the biosynthesis of dehydroepiandrosterone in the adult rat spinal cord, J. Neurochem., 93, 1220, 10.1111/j.1471-4159.2005.03113.x
Kim, 2003, Thalamic control of visceral nociception mediated by T-type Ca2+ channels, Science, 302, 117, 10.1126/science.1088886
Kimonides, 1998, Dehydroepiandrosterone (DHEA) and DHEA-sulfate (DHEAS) protect hippocampal neurons against excitatory amino acid-induced neurotoxicity, Proc. Natl. Acad. Sci. U S A, 95, 1852, 10.1073/pnas.95.4.1852
Kingery, 1997, A critical review of controlled clinical trials for peripheral neuropathic pain and complex regional pain syndromes, Pain, 73, 123, 10.1016/S0304-3959(97)00049-3
Kingery, 1999, Methylprednisolone prevents the development of autotomy and neuropathic edema in rats, but has no effect on nociceptive thresholds, Pain, 80, 555, 10.1016/S0304-3959(98)00251-6
Kraulis, 1975, Distribution, metabolism and biological activity of deoxycorticosterone in the central nervous system, Brain Res., 88, 1, 10.1016/0006-8993(75)90942-7
Labombarda, 2006, Injury elicited increase in spinal cord neurosteroid content analyzed by gas chromatography mass spectrometry, Endocrinology, 147, 1847, 10.1210/en.2005-0955
Lang, 1996, Venlafaxine hydrochloride (Effexor) relieves thermal hyperalgesia in rats with an experimental mononeuropathy, Pain, 68, 151, 10.1016/S0304-3959(96)03223-X
Lauria, 2005, EFNS guidelines on the use of skin biopsy in the diagnosis of peripheral neuropathy, Eur. J. Neurol., 12, 747, 10.1111/j.1468-1331.2005.01260.x
Le Goascogne, 1987, Neurosteroids: cytochrome P-450scc in rat brain, Science, 237, 1212, 10.1126/science.3306919
Lee, 2007, Ameliorative effects of proanthocyanidin on oxidative stress and inflammation in streptozotocin-induced diabetic rats, J. Agric. Food Chem., 55, 9395, 10.1021/jf071523u
Lejri, 2017, Allopregnanolone and its analog BR 297 rescue neuronal cells from oxidative stress-induced death through bioenergetic improvement, BBA, 1863, 631
Leonelli, 2007, Progesterone and its derivatives are neuroprotective agents in experimental diabetic neuropathy: a multimodal analysis, Neuroscience, 144, 1293, 10.1016/j.neuroscience.2006.11.014
Ling, 2007, Behavioral and pharmacological description of oxaliplatin-induced painful neuropathy in rat, Pain, 128, 225, 10.1016/j.pain.2006.09.016
Ling, 2007, Behavioral and immunohistological assessment of painful neuropathy induced by a single oxaliplatin injection in the rat, Toxicology, 234, 176, 10.1016/j.tox.2007.02.013
Loyd, 2006, Sex differences in the anatomical and functional organization of the periaqueductal gray-rostral ventromedial medullary pathway in the rat: a potential circuit mediating the sexually dimorphic actions of morphine, J. Comp. Neurol., 496, 723, 10.1002/cne.20962
Loyd, 2008, Androgen and estrogen (alpha) receptor localization on periaqueductal gray neurons projecting to the rostral ventromedial medulla in the male and female rat, J. Chem. Neuroanat., 36, 216, 10.1016/j.jchemneu.2008.08.001
Lussier, 2004, Adjuvant analgesics in cancer pain management, Oncologist, 9, 571, 10.1634/theoncologist.9-5-571
Maccari, 2014, The consequences of early-life adversity: neurobiological, behavioural and epigenetic adaptations, J. Neuroendocrinol., 26, 707, 10.1111/jne.12175
Majewska, 1992, Neurosteroids: endogenous bimodal modulators of the GABAA receptor. Mechanism of action and physiological significance, Prog. Neurobiol., 38, 379, 10.1016/0301-0082(92)90025-A
Marchand, 2003, Evidence for a monoamine mediated, opioid-independent, antihyperalgesic effect of venlafaxine, a non-tricyclic antidepressant, in a neurogenic pain model in rats, Pain, 103, 229, 10.1016/S0304-3959(03)00168-4
Martel, 1994, Widespread tissue distribution of steroid sulfatase, 3 beta-hydroxysteroid dehydrogenase/delta 5-delta 4 isomerase (3 beta-HSD), 17 beta-HSD 5 alpha-reductase and aromatase activities in the rhesus monkey, Mol. Cell. Endocrinol., 104, 103, 10.1016/0303-7207(94)90056-6
Maurice, 2006, Neuro(active)steroids actions at the neuromodulatory sigma1 (sigma1) receptor: biochemical and physiological evidences, consequences in neuroprotection, Pharmacol. Biochem. Behav., 84, 581, 10.1016/j.pbb.2006.07.009
McEwen, 1994, Endocrine effects on the brain and their relationship to behavior, 1003
Melcangi, 2008, Neuroactive steroids: state of the art and new perspectives, Cell. Mol. Life Sci., 65, 777, 10.1007/s00018-007-7403-5
Melcangi, 2006, Neuroprotective effects of neuroactive steroids in the spinal cord and peripheral nerves, J. Mol. Neurosci., 28, 1, 10.1385/JMN:28:1:1
Mellon, 2002, Neurosteroids: biochemistry and clinical significance, Trends Endocrinol. Metab., 13, 35, 10.1016/S1043-2760(01)00503-3
Mensah-Nyagan, 1999, Neurosteroids: expression of steroidogenic enzymes and regulation of steroid biosynthesis in the central nervous system, Pharmacol. Rev., 51, 63
Mensah-Nyagan, 1996, In vivo and in vitro evidence for the biosynthesis of testosterone in the telencephalon of the female frog, J. Neurochem., 67, 413, 10.1046/j.1471-4159.1996.67010413.x
Mensah-Nyagan, 1996, Localization of 17beta-hydroxysteroid dehydrogenase and characterization of testosterone in the brain of the male frog, Proc. Natl. Acad. Sci. U S A, 93, 1423, 10.1073/pnas.93.4.1423
Mensah-Nyagan, 2008, Endogenous steroid production in the spinal cord and potential involvement in neuropathic pain modulation, J. Steroid Biochem. Mol. Biol., 109, 286, 10.1016/j.jsbmb.2008.03.002
Mensah-Nyagan, 2008, Assessment of neuroactive steroid formation in diabetic rat spinal cord using high-performance liquid chromatography and continuous flow scintillation detection, Neurochem. Int., 52, 554, 10.1016/j.neuint.2007.06.010
Meyer, 2010, Cellular and functional evidence for a protective action of neurosteroids against vincristine chemotherapy-induced painful neuropathy, Cell. Mol. Life Sci., 10.1007/s00018-010-0372-0
Meyer, 2011, Allopregnanolone prevents and suppresses oxaliplatin-evoked painful neuropathy: multi-parametric assessment and direct evidence, Pain, 152, 170, 10.1016/j.pain.2010.10.015
Meyer, 2013, Neurosteroid 3alpha-androstanediol efficiently counteracts paclitaxel-induced peripheral neuropathy and painful symptoms, PLoS ONE, 8, e80915, 10.1371/journal.pone.0080915
Meyer, 2008, The biological activity of 3alpha-hydroxysteroid oxido-reductase in the spinal cord regulates thermal and mechanical pain thresholds after sciatic nerve injury, Neurobiol. Dis., 30, 30, 10.1016/j.nbd.2007.12.001
Millan, 1999, The induction of pain: an integrative review, Prog. Neurobiol., 57, 1, 10.1016/S0301-0082(98)00048-3
Millan, 2002, Descending control of pain, Prog. Neurobiol., 66, 355, 10.1016/S0301-0082(02)00009-6
Mitsushima, 2003, Sex differences in the stress-induced release of acetylcholine in the hippocampus and corticosterone from the adrenal cortex in rats, Neuroendocrinology, 78, 234, 10.1159/000073707
Nadeson, 2000, Antinociceptive properties of neurosteroids II. Experiments with Saffan and its components alphaxalone and alphadolone to reveal separation of anaesthetic and antinociceptive effects and the involvement of spinal cord GABA(A) receptors, Pain, 88, 31, 10.1016/S0304-3959(00)00300-6
Nadeson, 2001, Antinociceptive properties of neurosteroids III: experiments with alphadolone given intravenously, intraperitoneally, and intragastrically, Br. J. Anaesth., 86, 704, 10.1093/bja/86.5.704
Ocvirk, 2008, Antinociceptive profile of ring A-reduced progesterone metabolites in the formalin test, Pain, 138, 402, 10.1016/j.pain.2008.01.019
Olsen, 2018, GABAA receptor: positive and negative allosteric modulators, Neuropharmacology, 136, 10, 10.1016/j.neuropharm.2018.01.036
Park, 2006, Levels of mitochondrial reactive oxygen species increase in rat neuropathic spinal dorsal horn neurons, Neurosci. Lett., 391, 108, 10.1016/j.neulet.2005.08.055
Pathirathna, 2005, New evidence that both T-type calcium channels and GABAA channels are responsible for the potent peripheral analgesic effects of 5alpha-reduced neuroactive steroids, Pain, 114, 429, 10.1016/j.pain.2005.01.009
Patte-Mensah, 2003, Cellular distribution and bioactivity of the key steroidogenic enzyme, cytochrome P450side chain cleavage, in sensory neural pathways, J. Neurochem., 86, 1233, 10.1046/j.1471-4159.2003.01935.x
Patte-Mensah, 2006, Neurogenic pain and steroid synthesis in the spinal cord, J. Mol. Neurosci., 28, 17, 10.1385/JMN:28:1:17
Patte-Mensah, 2005, Substance P inhibits progesterone conversion to neuroactive metabolites in spinal sensory circuit: a potential component of nociception, Proc. Natl. Acad. Sci. U S A, 102, 9044, 10.1073/pnas.0502968102
Patte-Mensah, 2004, Impact of neuropathic pain on the gene expression and activity of cytochrome P450side-chain-cleavage in sensory neural networks, Cell. Mol. Life Sci., 61, 2274, 10.1007/s00018-004-4235-4
Patte-Mensah, 2008, Peripheral neuropathy and neurosteroid formation in the central nervous system, Brain Res. Rev., 57, 454, 10.1016/j.brainresrev.2007.05.007
Patte-Mensah, 2010, Regulatory effect of dehydroepiandrosterone on spinal cord nociceptive function, Front Biosci. (Elite Ed.), 2, 1528, 10.2741/e212
Patte-Mensah, 2014, Potential role of allopregnanolone for a safe and effective therapy of neuropathic pain, Prog. Neurobiol., 113, 70, 10.1016/j.pneurobio.2013.07.004
Patte-Mensah, 2004, Anatomical and cellular localization of neuroactive 5 alpha/3 alpha-reduced steroid-synthesizing enzymes in the spinal cord, J. Comp. Neurol., 477, 286, 10.1002/cne.20251
Pettersson, 2009, CYP7B1-mediated metabolism of 5alpha-androstane-3alpha,17beta-diol (3alpha-Adiol): a novel pathway for potential regulation of the cellular levels of androgens and neurosteroids, BBA, 1791, 1206
Polomano, 2001, Chemotherapy-evoked painful peripheral neuropathy, Pain Med., 2, 8, 10.1046/j.1526-4637.2001.002001008.x
Purdy, 1991, Stress-induced elevations of gamma-aminobutyric acid type A receptor-active steroids in the rat brain, Proc. Natl. Acad. Sci. U S A, 88, 4553, 10.1073/pnas.88.10.4553
Ravula, 2007, Spatiotemporal localization of injury potentials in DRG neurons during vincristine-induced axonal degeneration, Neurosci. Lett., 415, 34, 10.1016/j.neulet.2007.01.009
Reddy, 2008, Mass spectrometric assay and physiological-pharmacological activity of androgenic neurosteroids, Neurochem. Int., 52, 541, 10.1016/j.neuint.2007.05.019
Rhodes, 2004, Androgens in the hippocampus can alter, and be altered by, ictal activity, Pharmacol. Biochem. Behav., 78, 483, 10.1016/j.pbb.2004.04.020
Riva, 2010, Fibromyalgia syndrome is associated with hypocortisolism, Int. J. Behav. Med., 17, 223, 10.1007/s12529-010-9097-6
Roglio, 2009, Docetaxel-induced peripheral neuropathy: protective effects of dihydroprogesterone and progesterone in an experimental model, J. Peripher. Nerv. Syst., 14, 36, 10.1111/j.1529-8027.2009.00204.x
Roglio, 2008, Neuroprotective effects of dihydroprogesterone and progesterone in an experimental model of nerve crush injury, Neuroscience, 155, 673, 10.1016/j.neuroscience.2008.06.034
Rudolph, 2016, Actions of steroids: new neurotransmitters, J. Neurosci., 36, 11449, 10.1523/JNEUROSCI.2473-16.2016
Sapolsky, 1996, Stress, glucocorticoids, and damage to the nervous system: the current state of confusion, Stress, 1, 1, 10.3109/10253899609001092
Saredi, 2005, Effect of streptozotocin-induced diabetes on the gene expression and biological activity of 3beta-hydroxysteroid dehydrogenase in the rat spinal cord, Neuroscience, 135, 869, 10.1016/j.neuroscience.2005.06.033
Sayeed, 2006, Allopregnanolone, a progesterone metabolite, is more effective than progesterone in reducing cortical infarct volume after transient middle cerebral artery occlusion, Ann. Emerg. Med., 47, 381, 10.1016/j.annemergmed.2005.12.011
Schaeffer, 2010, Sciatic nerve injury induces apoptosis of dorsal root ganglion satellite glial cells and selectively modifies neurosteroidogenesis in sensory neurons, Glia, 58, 169, 10.1002/glia.20910
Schaeffer, 2010, Progress in dorsal root ganglion neurosteroidogenic activity: basic evidence and pathophysiological correlation, Prog. Neurobiol., 92, 33, 10.1016/j.pneurobio.2010.04.009
Schwartz, 2008, Oxidative stress in the spinal cord is an important contributor in capsaicin-induced mechanical secondary hyperalgesia in mice, Pain, 138, 514, 10.1016/j.pain.2008.01.029
Seale, 2004, Gonadectomy reverses the sexually diergic patterns of circadian and stress-induced hypothalamic-pituitary-adrenal axis activity in male and female rats, J. Neuroendocrinol., 16, 516, 10.1111/j.1365-2826.2004.01195.x
Seckl, 1997, 11beta-Hydroxysteroid dehydrogenase in the brain: a novel regulator of glucocorticoid action?, Front. Neuroendocrinol., 18, 49, 10.1006/frne.1996.0143
Selye, 1942, Additional steroids with luteoid activity, Science, 96, 358, 10.1126/science.96.2494.358.a
Seretny, 2014, Incidence, prevalence, and predictors of chemotherapy-induced peripheral neuropathy: a systematic review and meta-analysis, Pain, 155, 2461, 10.1016/j.pain.2014.09.020
Siau, 2006, Paclitaxel- and vincristine-evoked painful peripheral neuropathies: loss of epidermal innervation and activation of Langerhans cells, Exp. Neurol., 201, 507, 10.1016/j.expneurol.2006.05.007
Sibilia, 2003, Corticosteroids and inflammation, Rev. Prat., 53, 495
Sommer, 2004, Recent findings on how proinflammatory cytokines cause pain: peripheral mechanisms in inflammatory and neuropathic hyperalgesia, Neurosci. Lett., 361, 184, 10.1016/j.neulet.2003.12.007
Stoner, 1990, The clinical development of a 5alpha-reductase inhibitor, finasteride, J. Steroid Biochem. Molec. Biol., 37, 375, 10.1016/0960-0760(90)90487-6
Sui, 2013, Understanding the role of mitochondria in the pathogenesis of chronic pain, Postgrad. Med. J., 89, 709, 10.1136/postgradmedj-2012-131068
Sze, 2018, Sex-dependent changes in neuroactive steroid concentrations in the rat brain following acute swim stress, J. Neuroendocrinol., 30, e12644, 10.1111/jne.12644
Takeda, 2004, Effect of methylprednisolone on neuropathic pain and spinal glial activation in rats, Anesthesiology, 100, 1249, 10.1097/00000542-200405000-00029
Taleb, 2017, Behavioral and electromyographic assessment of oxaliplatin-induced motor dysfunctions: evidence for a therapeutic effect of allopregnanolone, Behav. Brain Res., 320, 440, 10.1016/j.bbr.2016.10.040
Taleb, 2018, Evidence for effective structure-based neuromodulatory effects of new analogues of neurosteroid allopregnanolone, J. Neuroendocrinol., 30, 10.1111/jne.12568
Timby, 2006, Pharmacokinetic and behavioral effects of allopregnanolone in healthy women, Psychopharmacology (Berlin), 186, 414, 10.1007/s00213-005-0148-7
Todorovic, 2001, Redox modulation of T-type calcium channels in rat peripheral nociceptors, Neuron, 31, 75, 10.1016/S0896-6273(01)00338-5
Todorovic, 2002, Mechanical and thermal antinociception in rats following systemic administration of mibefradil, a T-type calcium channel blocker, Brain Res., 951, 336, 10.1016/S0006-8993(02)03350-4
Todorovic, 2004, 5beta-reduced neuroactive steroids are novel voltage-dependent blockers of T-type Ca2+ channels in rat sensory neurons in vitro and potent peripheral analgesics in vivo, Mol. Pharmacol., 66, 1223, 10.1124/mol.104.002402
Todorovic, 1998, Enantioselective blockade of T-type Ca2+ current in adult rat sensory neurons by a steroid that lacks gamma-aminobutyric acid-modulatory activity, Mol. Pharmacol., 54, 918, 10.1124/mol.54.5.918
Todorovic, 2003, Potent analgesic effects of anticonvulsants on peripheral thermal nociception in rats, Br. J. Pharmacol., 140, 255, 10.1038/sj.bjp.0705434
Treede, 2008, Neuropathic pain: redefinition and a grading system for clinical and research purposes, Neurology, 70, 1630, 10.1212/01.wnl.0000282763.29778.59
Tuem, 2017, Neuroactive steroids: receptor interactions and responses, Front. Neurol., 8, 442, 10.3389/fneur.2017.00442
Uno, 1989, Hippocampal damage associated with prolonged and fatal stress in primates, J. Neurosci., 9, 1705, 10.1523/JNEUROSCI.09-05-01705.1989
Uzunova, 1998, Increase in the cerebrospinal fluid content of neurosteroids in patients with unipolar major depression who are receiving fluoxetine or fluvoxamine, Proc. Natl. Acad. Sci. U S A, 95, 3239, 10.1073/pnas.95.6.3239
Vachon-Presseau, 2013, The stress model of chronic pain: evidence from basal cortisol and hippocampal structure and function in humans, Brain, 136, 815, 10.1093/brain/aws371
Wang, 2010, Allopregnanolone reverses neurogenic and cognitive deficits in mouse model of Alzheimer's disease, Proc. Natl. Acad. Sci. U S A, 107, 6498, 10.1073/pnas.1001422107
Wang, 2011, Neurosteroids and GABA-A receptor function, Front Endocrinol. (Lausanne), 2, 44, 10.3389/fendo.2011.00044
Wareham, 2004, Postherpetic neuralgia, Clin. Evid., 1182
Xiao, 2012, Effects of mitochondrial poisons on the neuropathic pain produced by the chemotherapeutic agents, paclitaxel and oxaliplatin, Pain, 153, 704, 10.1016/j.pain.2011.12.011
Yu, 1989, Survival of motoneurons following axotomy is enhanced by lactation or by progesterone treatment, Brain Res., 491, 379, 10.1016/0006-8993(89)90075-9
Zamora-Sanchez, 2017, Allopregnanolone promotes proliferation and differential gene expression in human glioblastoma cells, Steroids, 119, 36, 10.1016/j.steroids.2017.01.004