Neuroprotective effects of quercetin in a mouse model of brain ischemic/reperfusion injury via anti-apoptotic mechanisms based on the Akt pathway

Molecular Medicine Reports - Tập 12 Số 3 - Trang 3688-3696 - 2015
Xiaoming Lei1, Chao Hai-lian1, Zhenni Zhang1, Jianrui Lv1, Li Siyuan1, Wei Wang1, Rongliang Xue1, Fang Li1, Songhua Xu2
1Department of Anesthesiology, Second Affiliated Hospital, Xi'an Jiaotong University, Xi'an, Shaanxi 710004, P.R. China
2Department of General Surgery, Second Affiliated Hospital, Xi'an Jiaotong University, Xi'an, Shaanxi 710004, P.R. China

Tóm tắt

Từ khóa


Tài liệu tham khảo

Cherubini, 2008, Dietary antioxidants as potential pharmacological agents for ischemic stroke, Curr Med Chem, 15, 1236, 10.2174/092986708784310431

Harwood, 2007, A critical review of the data related to the safety of quercetin and lack of evidence of in vivo toxicity, including lack of genotoxic/carcinogenic properties, Food Chem Toxicol, 45, 2179, 10.1016/j.fct.2007.05.015

Lee, 2003, The antioxidant, rather than prooxidant, activities of quercetin on normal cells: Quercetin protects mouse thymocytes from glucose oxidase-mediated apoptosis, Exp Cell Res, 291, 386, 10.1016/S0014-4827(03)00410-5

Lapi, 2012, Protective effects of Quercetin on Rat Pial micro-vascular changes during transient bilateral common carotid artery occlusion and reperfusion, Front Physiol, 3, 32

Ghosh, 2013, Neuroprotective role of nanoencapsulated quercetin in combating ischemia-reperfusion induced neuronal damage in young and aged rats, PLoS One, 8, e57735, 10.1371/journal.pone.0057735

Mattson, 2001, Neurodegenerative disorders and ischemic brain diseases, Apoptosis, 6, 69, 10.1023/A:1009676112184

Kowaltowski, 2001, Mitochondrial permeability transition and oxidative stress, FEBS Lett, 495, 12, 10.1016/S0014-5793(01)02316-X

Kuwana, 2002, Bid, Bax and lipids cooperate to form supramolecular openings in the outer mitochondrial membrane, Cell, 111, 331, 10.1016/S0092-8674(02)01036-X

Lei, 2011, Reactive oxygen species scavenger inhibits STAT3 activation after transient focal cerebral ischemia-reperfusion injury in rats, Anesth Analg, 113, 153, 10.1213/ANE.0b013e31821a9fbe

Priyadarsini, 2012, Quercetin suppresses cytochrome P450 mediated ROS generation and NF kappaB activation to inhibit the development of 7,12-dimethylbenz a anthracene (DMBA) induced hamster buccal pouch carcinomas, Free Radic Res, 46, 41, 10.3109/10715762.2011.637204

Yao, 2012, Quercetin attenuates cell apoptosis in focal cerebral ischemia rat brain via activation of BDNF-TrkB-PI3K/Akt signaling pathway, Neurochem Res, 37, 2777, 10.1007/s11064-012-0871-5

Mayo, 2001, A phosphatidylinositol 3-kinase/Akt pathway promotes translocation of Mdm2 from the cytoplasm to the nucleus, Proc Natl Acad Sci USA, 98, 11598, 10.1073/pnas.181181198

Janelidze, 2001, Alterations of Akt1 (PKBalpha) and p70 (S6K) in transient focal ischemia, Neurobiol Dis, 8, 147, 10.1006/nbdi.2000.0325

Shibata, 2002, Upregulation of Akt phosphorylation at the early stage of middle cerebral artery occlusion in mice, Brain Res, 942, 1, 10.1016/S0006-8993(02)02474-5

Noshita, 2001, Evidence of phosphorylation of Akt and neuronal survival after transient focal cerebral ischemia in mice, J Cereb Blood Flow Metab, 21, 1442, 10.1097/00004647-200112000-00009

Xue, 2009, Relationship between transmembrane signal transduction pathway and DNA repair and the mechanism after global cerebral ischemia-reperfusion in rats, Neurosci Bull, 25, 115, 10.1007/s12264-009-8818-9

Hadley, 2014, A method of inducing global cerebral ischemia, Methods Mol Biol, 1135, 111, 10.1007/978-1-4939-0320-7_10

Geocadin, 2000, A novel quantitative EEG injury measure of global cerebral ischemia, Clin Neurophysiol, 111, 1779, 10.1016/S1388-2457(00)00379-5

Vorhees, 2006, Morris water maze: procedures for assessing spatial and related forms of learning and memory, Nat Protoc, 1, 848, 10.1038/nprot.2006.116

Stackman, 2012, Directional responding of C57BL/6J mice in the Morris water maze is influenced by visual and vestibular cues and is dependent on the anterior thalamic nuclei, J Neurosci, 32, 10211, 10.1523/JNEUROSCI.4868-11.2012

Simao, 2011, Resveratrol prevents oxidative stress and inhibition of Na(+)K(+)-ATPase activity induced by transient global cerebral ischemia in rats, J Nutr Biochem, 22, 921, 10.1016/j.jnutbio.2010.07.013

Johansson, 2014, Early MEK1/2 inhibition after global cerebral ischemia in rats reduces brain damage and improves outcome by preventing delayed vasoconstrictor receptor upregulation, PLoS One, 9, e92417, 10.1371/journal.pone.0092417

Ahmad, 2011, Quercetin protects against oxidative stress associated damages in a rat model of transient focal cerebral ischemia and reperfusion, Neurochem Res, 36, 1360, 10.1007/s11064-011-0458-6

Pandey, 2011, The role of ASIC1a in neuroprotection elicited by quercetin in focal cerebral ischemia, Brain Res, 1383, 289, 10.1016/j.brainres.2011.01.085

Rizk, 2006, Cerebral ischemia-induced apoptosis and necrosis in normal and diabetic rats: effects of insulin and C-peptide, Brain Res, 1096, 204, 10.1016/j.brainres.2006.04.060

Solaroglu, 2006, Anti-apoptotic effect of granulocyte-colony stimulating factor after focal cerebral ischemia in the rat, Neuroscience, 143, 965, 10.1016/j.neuroscience.2006.09.014

Yousuf, 2009, Resveratrol exerts its neuroprotective effect by modulating mitochondrial dysfunctions and associated cell death during cerebral ischemia, Brain Res, 1250, 242, 10.1016/j.brainres.2008.10.068

Wang, 2008, Effect of compound preparation Tongqiao Jiannao capsules on neural cell apoptosis and Bcl-2 and Bax protein levels in a rat model of brain ischemia/reperfusion injury, Neural Regener Res, 3, 871

Babu, 2000, Immunohistochemical expression of Bcl-2, Bax and cytochrome c following focal cerebral ischemia and effect of hypothermia in rat, Neurosci Lett, 291, 196, 10.1016/S0304-3940(00)01404-X

Wang, 2009, Protection by tetrahydroxystilbene glucoside against cerebral ischemia: involvement of JNK, SIRT1 and NF-kappaB pathways and inhibition of intracellular ROS/RNS generation, Free Radic Biol Med, 47, 229, 10.1016/j.freeradbiomed.2009.02.027

Wu, 2008, Reactive oxygen species mediate ERK activation through different Raf-1-dependent signaling pathways following cerebral ischemia, Neurosci Lett, 432, 83, 10.1016/j.neulet.2007.11.073

Wang, 2007, Ethanol preconditioning protects against ischemia/reperfusion-induced brain damage: Role of NADPH oxidase-derived ROS, Free Radic Biol Med, 43, 1048, 10.1016/j.freeradbiomed.2007.06.018

Liang, 2013, Role of mitochondrial function in the protective effects of ischaemic postconditioning on ischaemia/reperfusion cerebral damage, J Int Med Res, 41, 618, 10.1177/0300060513476587

Zhang, 2007, The PI3K/Akt pathway mediates the neuroprotective effect of atorvastatin in extending thrombolytic therapy after embolic stroke in the rat, Arterioscler Thromb Vasc Biol, 27, 2470, 10.1161/ATVBAHA.107.150748

Endo, 2006, Activation of the Akt/GSK3beta signaling pathway mediates survival of vulnerable hippocampal neurons after transient global cerebral ischemia in rats, J Cereb Blood Flow Metab, 26, 1479, 10.1038/sj.jcbfm.9600303

Fang, 2013, Neuroprotection of interleukin-6 against NMDA-induced neurotoxicity is mediated by JAK/STAT3, MAPK/ERK and PI3K/AKT signaling pathways, Cell Mol Neurobiol, 33, 241, 10.1007/s10571-012-9891-6

Gu, 2009, Angiopoietin-1 mRNA and Bcl-2 expression following estradiol treatment in ovariectomized rats with focal cerebral ischemia/reperfusion injury, Neural Regener Res, 4, 780

Kitagawa, 2007, CREB and cAMP response element-mediated gene expression in the ischemic brain, FEBS J, 274, 3210, 10.1111/j.1742-4658.2007.05890.x