Neuroprotective effects of curcumin-loaded nanophytosome on ketamine-induced schizophrenia-like behaviors and oxidative damage in male mice

Albayrak, 2013, Reduced total antioxidant level and increased oxidative stress in patients with deficit schizophrenia: a preliminary study, Prog. Neuro-Psychopharmacol. Biol. Psychiatry, 45, 144, 10.1016/j.pnpbp.2013.04.020 Ben-Azu, 2016, Neuroprotective effects of the ethanol stem bark extracts of Terminalia ivorensis in ketamine-induced schizophrenia-like behaviors and oxidative damage in mice, Pharm. Biol., 54, 2871, 10.1080/13880209.2016.1190382 Hauser, 2017, Disturbances of novel object exploration and recognition in a chronic ketamine mouse model of schizophrenia, Behav. Brain Res., 332, 316, 10.1016/j.bbr.2017.06.013 Ahmed, 2018, Vinpocetine halts ketamine-induced schizophrenia-like deficits in rats: impact on BDNF and GSK-3β/β-catenin pathway, Naunyn-Schmiedeberg's Arch. Pharmacol., 391, 1327, 10.1007/s00210-018-1552-y Unal, 2021, α7 nicotinic receptor agonist and positive allosteric modulators differently improved schizophrenia-like cognitive deficits in male rats, Behav. Brain Res., 397, 112946, 10.1016/j.bbr.2020.112946 Coughlin, 2020, A multimodal approach to studying the relationship between peripheral glutathione, brain glutamate, and cognition in health and in schizophrenia, Mol. Psychiatry Solberg, 2019, A five-year follow-up study of antioxidants, oxidative stress and polyunsaturated fatty acids in schizophrenia, Acta Neuropsychiatrica, 31, 202, 10.1017/neu.2019.14 Zhou, 2020, Reduced levels and disrupted biosynthesis pathways of plasma free fatty acids in first-episode antipsychotic-naïve schizophrenia patients, Front. Neurosci., 14, 10.3389/fnins.2020.00784 Madireddy, 2020, Regulation of reactive oxygen species-mediated damage in the pathogenesis of schizophrenia, Brain Sci., 10, 742, 10.3390/brainsci10100742 Fan, 2016, Profiling the psychotic, depressive and anxiety symptoms in chronic ketamine users, Psychiatry Res., 237, 311, 10.1016/j.psychres.2016.01.023 Zhou, 2014, Ketamine-induced antidepressant effects are associated with AMPA receptors-mediated upregulation of mTOR and BDNF in rat hippocampus and prefrontal cortex, Eur. Psychiatry, 29, 419, 10.1016/j.eurpsy.2013.10.005 Monte, 2013, Prevention and reversal of ketamine-induced schizophrenia related behavior by minocycline in mice: possible involvement of antioxidant and nitrergic pathways, J. Psychopharm., 27, 1032, 10.1177/0269881113503506 Yadav, 2018, Protective effects of Spinacia oleracea seeds extract in an experimental model of schizophrenia: possible behavior, biochemical, neurochemical and cellular alterations, Biomed. Pharmacother., 105, 1015, 10.1016/j.biopha.2018.06.043 F.C.C. da Silva, M. do Carmo de Oliveira Cito, M.I.G. da Silva, B.A. Moura, M.R. de Aquino Neto, M.L. Feitosa, R. de Castro Chaves, D.S. Macedo, S.M.M. de Vasconcelos, M.M. de França Fonteles, F.C.F. de Sousa, Behavioral alterations and pro-oxidant effect of a single ketamine administration to mice, Brain Res. Bull. 83 (2010) 9–15. https://doi.org/10.1016/j.brainresbull.2010.05.011. Ben-Azu, 2018, Doxycycline prevents and reverses schizophrenic-like behaviors induced by ketamine in mice via modulation of oxidative, nitrergic and cholinergic pathways, Brain Res. Bull., 139, 114, 10.1016/j.brainresbull.2018.02.007 Wang, 2014, The effects of curcumin on depressive-like behavior in mice after lipopolysaccharide administration, Behav. Brain Res., 274, 282, 10.1016/j.bbr.2014.08.018 Bassani, 2017, Effects of curcumin on short-term spatial and recognition memory, adult neurogenesis and neuroinflammation in a streptozotocin-induced rat model of dementia of Alzheimer’s type, Behav. Brain Res., 335, 41, 10.1016/j.bbr.2017.08.014 Fan, 2018, Curcumin protects against chronic stress-induced dysregulation of neuroplasticity and depression-like behaviors via suppressing IL-1β pathway in rats, Neuroscience, 392, 92, 10.1016/j.neuroscience.2018.09.028 Choudhary, 2013, Ameliorative effect of Curcumin on seizure severity, depression like behavior, learning and memory deficit in post-pentylenetetrazole-kindled mice, Eur. J. Pharmacol., 704, 33, 10.1016/j.ejphar.2013.02.012 Černý, 2011, Hepatoprotective effect of curcumin in lipopolysaccharide/-galactosamine model of liver injury in rats: Relationship to HO-1/CO antioxidant system, Fitoterapia, 82, 786, 10.1016/j.fitote.2011.04.003 Nazari-Vanani, 2017, In vivo evaluation of a self-nanoemulsifying drug delivery system for curcumin, Biomed. Pharmacother., 88, 715, 10.1016/j.biopha.2017.01.102 Hashemian, 2017, Curcumin-loaded chitosan-alginate-STPP nanoparticles ameliorate memory deficits and reduce glial activation in pentylenetetrazol-induced kindling model of epilepsy, Prog. Neuro-Psychopharmacol. Biol. Psychiatry, 79, 462, 10.1016/j.pnpbp.2017.07.025 Naeimi, 2018, Curcumin-loaded nanoparticles ameliorate glial activation and improve myelin repair in lyolecithin-induced focal demyelination model of rat corpus callosum, Neurosci. Lett., 674, 1, 10.1016/j.neulet.2018.03.018 Maiti, 2007, Curcumin–phospholipid complex: preparation, therapeutic evaluation and pharmacokinetic study in rats, Int. J. Pharm., 330, 155, 10.1016/j.ijpharm.2006.09.025 Köllner, 2017, Self-emulsifying drug delivery systems: design of a novel vaginal delivery system for curcumin, Eur. J. Pharm. Biopharm., 115, 268, 10.1016/j.ejpb.2017.03.012 El-Naggar, 2019, Curcumin-loaded PLA-PEG copolymer nanoparticles for treatment of liver inflammation in streptozotocin-induced diabetic rats, Colloids Surf. B. Biointerfaces, 177, 389, 10.1016/j.colsurfb.2019.02.024 Semalty, 2010, Supramolecular phospholipids–polyphenolics interactions: the PHYTOSOME® strategy to improve the bioavailability of phytochemicals, Fitoterapia, 81, 306, 10.1016/j.fitote.2009.11.001 El-Menshawe, 2018, Nanosized soy phytosome-based thermogel as topical anti-obesity formulation: an approach for acceptable level of evidence of an effective novel herbal weight loss product, Int. J. Nanomed., 13, 307, 10.2147/IJN.S153429 Baradaran, 2020, Protective effects of curcumin and its nano-phytosome on carrageenan-induced inflammation in mice model: behavioral and biochemical responses, J. Inflamm. Res., 13, 45, 10.2147/JIR.S232462 Jaques, 2013, Free and nanoencapsulated curcumin prevents cigarette smoke-induced cognitive impairment and redox imbalance, Neurobiol. Learn. Mem., 100, 98, 10.1016/j.nlm.2012.12.007 Gazal, 2014, Neuroprotective and antioxidant effects of curcumin in a ketamine-induced model of mania in rats, Eur. J. Pharmacol., 724, 132, 10.1016/j.ejphar.2013.12.028 Moghaddam, 2020, Preventive effect of silymarin-loaded chitosan nanoparticles against global cerebral ischemia/reperfusion injury in rats, Eur. J. Pharmacol., 877, 173066, 10.1016/j.ejphar.2020.173066 Mokhtari Sangdehi, 2020, Anti-apoptotic effect of silymarin-loaded chitosan nanoparticles on hippocampal Caspase-3 and Bcl-2 expression following cerebral ischemia/reperfusion injury, Int. J. Neurosci., 1 Bradford, 1976, A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding, Anal. Biochem., 72, 248, 10.1016/0003-2697(76)90527-3 Fukuzawa, 1976, Glutathione peroxidase activity in tissues of vitamin e-deficient mice, J. Nutr. Sci. Vitaminol., 22, 405, 10.3177/jnsv.22.405 H. Esterbauer, K. Cheeseman, Determination of Aldehydic Lipid Peroxidation Products Malonaldehyde and 4 Hydroxynonenal. 407–421. G, 1990. Aebi, 1974, Catalase, 673 Genet, 2002, Alterations in antioxidant enzymes and oxidative damage in experimental diabetic rat tissues: effect of vanadate and fenugreek (Trigonella foenum graecum), Mol. Cell. Biochem., 236, 7, 10.1023/A:1016103131408 Pinto, 1969, The effect of age and sex on glutathione reductase and glutathione peroxidase activities and on aerobic glutathione oxidation in rat liver homogenates, Biochem. J., 112, 109, 10.1042/bj1120109 J.T. Rotruck, A.L. Pope, H.E. Ganther, A.B. Swanson, D.G. Hafeman, W.G. Hoekstra, Selenium: biochemical role as a component of glutathione peroxidase, Science 179 (1973) 588–590. https://doi.org/10.1126/science.179.4073.588. Becker, 2003, Ketamine-induced changes in rat behaviour: a possible animal model of schizophrenia, Prog. Neuro-Psychopharmacol. Biol. Psychiatry, 27, 687, 10.1016/S0278-5846(03)00080-0 Coronel-Oliveros, 2018, Prenatal exposure to ketamine in rats: implications on animal models of schizophrenia, Dev. Psychobiol., 60, 30, 10.1002/dev.21586 Kandratavicius, 2015, Effects of nitric oxide-related compounds in the acute ketamine animal model of schizophrenia, BMC Neurosci., 16, 9, 10.1186/s12868-015-0149-3 Serafini, 2013, Pharmacological properties of glutamatergic drugs targeting NMDA receptors and their application in major depression, Curr. Pharm. Des., 19, 1898, 10.2174/13816128113199990293 Solati, 2011, 5HT1A and 5HT1B receptors of medial prefrontal cortex modulate anxiogenic-like behaviors in rats, Neurosci. Lett., 504, 325, 10.1016/j.neulet.2011.09.058 du Bois, 2009, Excitatory and inhibitory neurotransmission is chronically altered following perinatal NMDA receptor blockade, Eur. Neuropsychopharmacol., 19, 256, 10.1016/j.euroneuro.2008.12.002 Gilhotra, 2010, GABAergic and nitriergic modulation by curcumin for its antianxiety-like activity in mice, Brain Res., 1352, 167, 10.1016/j.brainres.2010.07.007 Lee, 2018, Systemic administration of curcumin affect anxiety-related behaviors in a rat model of posttraumatic stress disorder via activation of serotonergic systems, Evid. Based Complement. Alternat. Med., 2018, 1, 10.1155/2018/7635197 Newcomer, 1999, Ketamine-induced NMDA receptor hypofunction as a model of memory impairment and psychosis, Neuropsychopharmacology, 20, 106, 10.1016/S0893-133X(98)00067-0 Kegeles, 2000, Modulation of amphetamine-induced striatal dopamine release by ketamine in humans: implications for schizophrenia, Biol. Psychiatry, 48, 627, 10.1016/S0006-3223(00)00976-8 Flatow, 2013, Meta-analysis of oxidative stress in schizophrenia, Biol. Psychiatry, 74, 400, 10.1016/j.biopsych.2013.03.018 Dolatabadi, 2019, Curcumin effects on memory impairment and restoration of irregular neuronal distribution in the hippocampal CA1 region after global cerebral ischemia in male rats, Basic Clin. Neurosci., 10, 527, 10.32598/bcn.9.10.365 Chindo, 2012, Ketamine-enhanced immobility in forced swim test: a possible animal model for the negative symptoms of schizophrenia, Prog. Neuro-Psychopharmacol. Biol. Psychiatry, 38, 310, 10.1016/j.pnpbp.2012.04.018 Hou, 2013, Neuronal injury, but not microglia activation, is associated with ketamine-induced experimental schizophrenic model in mice, Prog. Neuro-Psychopharmacol. Biol. Psychiatry, 45, 107, 10.1016/j.pnpbp.2013.04.006 Chatterjee, 2011, Effect of ‘chronic’ versus ‘acute’ ketamine administration and its ‘withdrawal’ effect on behavioural alterations in mice: Implications for experimental psychosis, Behav. Brain Res., 216, 247, 10.1016/j.bbr.2010.08.001 Noda, 1995, Enhancement of immobility in a forced swimming test by subacute or repeated treatment with phencyclidine: a new model of schizophrenia, Br. J. Pharmacol., 116, 2531, 10.1111/j.1476-5381.1995.tb15106.x Zugno, 2016, Effect of folic acid on oxidative stress and behavioral changes in the animal model of schizophrenia induced by ketamine, J. Psychiatr. Res., 81, 23, 10.1016/j.jpsychires.2016.06.013 Onaolapo, 2017, Ketamine-induced behavioural and brain oxidative changes in mice: an assessment of possible beneficial effects of zinc as mono- or adjunct therapy, Psychopharmacology, 234, 2707, 10.1007/s00213-017-4666-x Onaolapo, 2019, Subchronic ketamine alters behaviour, metabolic indices and brain morphology in adolescent rats: Involvement of oxidative stress, glutamate toxicity and caspase-3-mediated apoptosis, J. Chem. Neuroanat., 96, 22, 10.1016/j.jchemneu.2018.12.002 de Oliveira, 2009, Different sub-anesthetic doses of ketamine increase oxidative stress in the brain of rats, Prog. Neuro-Psychopharmacol. Biol. Psychiatry, 33, 1003, 10.1016/j.pnpbp.2009.05.010 Banday, 2007, Oxidative stress reduces renal dopamine D1 receptor-Gq/11α G protein-phospholipase C signaling involving G protein-coupled receptor kinase 2, Am. J. Physiol.-Renal Physiol., 293, F306, 10.1152/ajprenal.00108.2007 Wood, 2009, Neurobiology of schizophrenia spectrum disorders: the role of oxidative stress, Ann. Acad. Med. Singapore, 38, 396, 10.47102/annals-acadmedsg.V38N5p396 Al-Kahtani, 2020, Curcumin phytosome modulates aluminum-induced hepatotoxicity via regulation of antioxidant, Bcl-2, and caspase-3 in rats, Environ. Sci. Pollut., 27, 21977, 10.1007/s11356-020-08636-0 Reeta, 2009, Curcumin is protective against phenytoin-induced cognitive impairment and oxidative stress in rats, Brain Res., 1301, 52, 10.1016/j.brainres.2009.09.027 Ghasemi, 2019, Protective effects of curcumin on diabetic nephropathy via attenuation of kidney injury molecule 1 (KIM-1) and neutrophil gelatinase-associated lipocalin (NGAL) expression and alleviation of oxidative stress in rats with type 1 diabetes, Iran J. Basic Med. Sci., 22, 376 Mehla, 2010, Protective effect of curcumin against seizures and cognitive impairment in a pentylenetetrazole-kindled epileptic rat model, Life Sci., 87, 596, 10.1016/j.lfs.2010.09.006 Briskey, 2019, Increased bioavailability of curcumin using a novel dispersion technology system (LipiSperse®), Eur. J. Nutr., 58, 2087, 10.1007/s00394-018-1766-2 Chen, 2016, Nanostructured lipid carriers enhance the bioavailability and brain cancer inhibitory efficacy of curcumin both in vitro and in vivo, Drug Deliv., 23, 1383, 10.3109/10717544.2015.1049719 Cuomo, 2011, Comparative absorption of a standardized curcuminoid mixture and its lecithin formulation, J. Nat. Prod., 74, 664, 10.1021/np1007262 Marczylo, 2007, Comparison of systemic availability of curcumin with that of curcumin formulated with phosphatidylcholine, Cancer Chemother. Pharmacol., 60, 171, 10.1007/s00280-006-0355-x Pawar, 2015, Phytosome as a novel biomedicine: a microencapsulated drug delivery system, J. Bioanal. Biomed., 7, 6 M. Rana, A. Kumar, A.J. Rana, Drug Delivery through Targeted Approach with Special References to Phytosomes, Role of Novel Drug Delivery Vehicles in Nanobiomedicine (2020) 125.