Neuroprotective Effects of Quercetin and Rutin on Spatial Memory Impairment in an 8-Arm Radial Maze Task and Neuronal Death Induced by Repeated Cerebral Ischemia in Rats

10.1002/jcb.10667

10.1254/jphs.92.291

3 Novakovic A, Gojkovic-Bukarica L, Peric M, Nezic D, Djukanovic B, Markovic-Lipkovski J, et al. The mechanism of endothelium-independent relaxation induced by the wine polyphenol resveratrol in human internal mammary artery. J Pharmacol Sci. 2006;101:85–90.

10.1016/S0304-3940(00)01159-9

10.1254/jphs.CRJ04003X

6 Borbulevych OY, Jankun J, Selman SH, Skrzypczak-Jankun E. Lipoxygenase interactions with natural flavonoid, quercetin, reveal a complex with protocatechuic acid in its X-ray structure at 2.1 A resolution. Proteins. 2004;54:13–19.

7 Potapovich AI, Kostyuk VA. Comparative study of antioxidant properties and cytoprotective activity of flavonoids. Biochem (Mosc). 2003;68:514–519.

8 Yokozawa T, Rhyu DY, Cho EJ. (−)-Epicatechin 3-O-gallate ameliorates the damages related to peroxynitrite production by mechanisms distinct from those of other free radical inhibitors. J Pharm Pharmacol. 2004;56:231–239.

10.1016/S0014-827X(01)01111-9

10 Pulsinelli WA, Brierley JB. A new model of bilateral hemispheric ischemia in the unanesthetized rat. Stroke. 1979;10:267–272.

10.1016/S0024-3205(02)02269-5

10.1016/j.brainres.2003.09.064

10.1016/S0024-3205(02)02270-1

10.1254/jphs.FP0061229

10.1254/jphs.94.393

1995, 274, 602

17 Rahmana RMA, Nair SM, Helps SC, Shawa OM, Sims NR, Rosengren RJ, et al. (−)-Epigallocatechin gallate as an intervention for the acute treatment of cerebral ischemia. Neurosci Lett. 2005;382:227–230.

18 Furukawa A, Oikawa S, Murata M, Hiraku Y, Kawanishi S. (−)-Epigallocatechin gallate causes oxidative damage to isolated and cellular DNA. Biochem Pharma. 2003;66:1769–1778.

19 Goodin MG, Rosengren RJ. Epigallocatechin gallate modulates CYP450 isoforms in the female Swiss-Webster mouse. Toxicol Sci. 2003;76:262–270.

INANAMI O, 1998, 29, 359, 10.1080/10715769800300401

10.1016/j.phytochem.2007.02.013

22 Khlebnikov AI, Schepetkin IA, Domina NG, Kirpotina LN, Quinn MT. Improved quantitative structure-activity relationship models to predict antioxidant activity of flavonoids in chemical, enzymatic, and cellular systems. Bioorg Med Chem. 2007;15:1749–1770.

10.1073/pnas.0607822103

24 Prouillet C, Maziere JC, Maziere C, Wattel A, Brazier M, Kamel S. Stimulatory effect of naturally occurring flavonols quercetin and kaempferol on alkaline phosphatase activity in MG-63 human osteoblasts through ERK and estrogen receptor pathway. Biochem Pharmacol. 2004;67:1307–1313.

10.1016/j.freeradbiomed.2003.09.022