Neuroprotective Effect of Simvastatin in Stroke: A Comparison Between Adult and Neonatal Rat Models of Cerebral Ischemia

Amin-Hanjan, 2001, Mevastatin, an HMG-CoA reductase inhibitor, reduces stroke damage and upregulates endothelial nitric oxide synthase in mice, Stroke, 32, 980, 10.1161/01.STR.32.4.980

Balduini, 2004, New therapeutic strategies in perinatal stroke, Curr Drug Targets CNS Neurol Disord, 3, 315, 10.2174/1568007043337247

Balduini, 2000, Long-lasting behavioral alterations following a hypoxic/ischemic brain injury in neonatal rats, Brain Res, 859, 318, 10.1016/S0006-8993(00)01997-1

Balduini, 2001, Simvastatin protects against long-lasting behavioral and morphological consequences of neonatal hypoxic/ischemic brain injury, Stroke, 32, 2185, 10.1161/hs0901.094287

Balduini, 2003, Prophylactic but not delayed administration of simvastatin protects against long-lasting cognitive and morphological consequences of neonatal hypoxic-ischemic brain injury, reduces interleukin-1beta and tumor necrosis factor-alpha mRNA induction, and does not affect endothelial nitric oxide synthase expression, Stroke, 34, 2007, 10.1161/01.STR.0000080677.24419.88

Byington, 2001, Reduction of stroke events with pravastatin: the Prospective Pravastatin Pooling (PPP) Project, Circulation, 103, 387, 10.1161/01.CIR.103.3.387

Dalkara, 1994, Dual role of nitric oxide in focal cerebral ischemia, Neuropharmacology, 33, 1447, 10.1016/0028-3908(94)90048-5

Dirnagl, 1999, Pathobiology of ischaemic stroke: an integrated view, Trends Neurosci, 22, 391, 10.1016/S0166-2236(99)01401-0

Endres, 2003, Mechanisms of stroke protection by physical activity, Ann Neurol, 54, 582, 10.1002/ana.10722

Endres, 1998, Stroke protection by 3-hydroxy-3-methylglutaryl (HMG)-CoA reductase inhibitors mediated by endothelial nitric oxide synthase, Proc Natl Acad Sci USA, 95, 8880, 10.1073/pnas.95.15.8880

Endres, 2004, Targeting eNOS for stroke protection, Trends Neurosci, 27, 283, 10.1016/j.tins.2004.03.009

Gil-Nunez, 2001, Advantages of lipid-lowering therapy in cerebral ischemia: role of HMG-CoA reductase inhibitors, Cerebrovasc Dis, 11, 85, 10.1159/000049130

Ginsberg, 1989, Rodent models of cerebral ischemia, Stroke, 20, 1627, 10.1161/01.STR.20.12.1627

Rice, 1981, The influence of immaturity on hypoxic-ischemic brain damage in the rat, Ann Neurol, 9, 131, 10.1002/ana.410090206

Sironi, 2003, Treatment with statins after induction of focal ischemia in rats reduces the extent of brain damage, Arterioscler Thromb Vasc Biol, 23, 322, 10.1161/01.ATV.0000044458.23905.3B

Takemoto, 2001, Pleiotropic effects of 3-hydroxy-3-methylglutaryl coenzyme a reductase inhibitors, Arterioscler Thromb Vasc Biol, 21, 1712, 10.1161/hq1101.098486

Vannucci, 1999, Rat model of perinatal hypoxic-ischemic brain damage, J Neurosci Res, 55, 158, 10.1002/(SICI)1097-4547(19990115)55:2<158::AID-JNR3>3.0.CO;2-1

Vannucci, 2004, Hypoxia-ischemia in the immature brain, J Exp Biol, 207, 3149, 10.1242/jeb.01064

Vaughan, 1999, Neuroprotective properties of statins in cerebral ischemia and stroke, Stroke, 30, 1969, 10.1161/01.STR.30.9.1969

Vaughan, 2001, Statin therapy and stroke prevention, Curr Opin Cardiol, 16, 219, 10.1097/00001573-200107000-00001

Volpe, 2001, Perinatal brain injury: from pathogenesis to neuroprotection, Ment Retard Dev Disabil Res Rev, 7, 56, 10.1002/1098-2779(200102)7:1<56::AID-MRDD1008>3.0.CO;2-A