Neuroplasticity and cellular resilience in mood disorders
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Goldberg JF, Harrow M . Bipolar Disorders: Clinical Course and Outcome American Psychiatric Press: Washington, DC 1999
Goodwin FK, Jamison KR . Manic-depressive Illness Oxford University Press: New York 1990
Musselman DL, Evans DL, Nemeroff CB . The relationship of depression to cardiovascular disease: epidemiology, biology, and treatment Arch Gen Psychiatry 1998; 55: 580–592
Licinio J, Wong ML . The role of inflammatory mediators in the biology of major depression: central nervous system cytokines modulate the biological substrate of depressive symptoms, regulate stress-responsive systems, and contribute to neurotoxicity and neuroprotection Mol Psychiatry 1999; 4: 317–327
Schulz R, Beach SR, Ives DG, Martire LM, Ariyo AA, Kop WJ . Association between depression and mortality in older adults: the Cardiovascular Health Study Arch Intern Med 2000; 160: 1761–1768
Murray CJ, Lopez AD . Global mortality, disability, and the contribution of risk factors: Global Burden of Disease Study Lancet 1997; 349: 1436–1442
Murray CJ, Lopez AD . Alternative projections of mortality and disability by cause 1990–2020: Global Burden of Disease Study Lancet 1997; 349: 1498–1504
Mesulam MM . Neuroplasticity failure in Alzheimer's disease: bridging the gap between plaques and tangles Neuron 1999; 24: 521–529
Kandel ER . From metapsychology to molecular biology: explorations into the nature of anxiety Am J Psychiatry 1983; 140: 1277–1293
Duman RS, Heninger GR, Nestler EJ . A molecular and cellular theory of depression Arch Gen Psychiatry 1997; 54: 597–606
Manji HK, Moore GJ, Chen G . Clinical and preclinical evidence for the neurotrophic and effects of mood-stabilizing agents: implications for the pathophysiology and treatment of manic-depressive illness Biol Psychiatry 2000; (in press
Elkis H, Friedman L, Wise A, Meltzer HY . Meta-analyses of studies of ventricular enlargement and cortical sulcal prominence in mood disorders. Comparisons with controls or patients with schizophrenia Arch Gen Psychiatry 1995; 52: 735–746
Soares JC, Mann JJ . The anatomy of mood disorders: review of structural neuroimaging studies Biol Psychiatry 1997; 41: 86–106
Drevets WC, Price JL, Simpson JR et al. Subgenual prefrontal cortex abnormalities in mood disorders Nature 1997; 386: 824–827
Drevets WC, Gadde KM, Krishnan KRR . Neuroimaging studies of mood disorders, In: DS Charney, EJ Nestler, BS Bunney (eds) Neurobiology of Mental Illness Oxford University Press: New York 1999; pp 394–418
Sheline YI, Wany P, Gado MH, Csernansky JG, Vannier MW . Hippocampal atrophy in recurrent major depression Proc Natl Acad Sci USA 1996; 93: 3908–3913
Sheline Y, Sang M, Mintum M, Gado M . Depression duration but not age predicts hippocampal volume loss in medical healthy women with recurrent major depression J Neurosci 1999; 19: 5034
Steffens DC, Krishnan KR . Structural neuroimaging and mood disorders: recent findings, implications for classification, and future directions Biol Psychiatry 1998; 43: 705–712
Hirayasu Y, Shenton ME, Salisbury DF, Kwon JS, Wible CG, Fischer IA et al. Subgenual cingulate cortex volume in first-episode psychosis Am J Psychiatry 1999; 156: 1091–1093
Bremner JD, Narayan M, Anderson ER, Staib LH, Miller HL, Charney DS . Hippocampal volume reduction in major depression Am J Psychiatry 2000; 157: 115–118
Krishnan KR, Doraiswamy PM, Figiel GS, Husain MM, Shah SA, Na C et al. Hippocampal abnormalities in depression J Neuropsychiatry Clin Neurosci 1991; 3: 387–391
Shah PJ, Ebmeier KP, Glabus MF, Goodwin GM . Cortical grey matter reductions associated with treatment-resistant chronic unipolar depression Br J Psychiatry 1998; 172: 527–532
Brown ES, Rush AJ, McEwen BS . Hippocampal remodeling and damage by corticosteroids: implications for mood disorders Neuropsychopharmacology 1999; 21: 474–484
Sapolsky RM . The possibility of neurotoxicity in the hippocampus in major depression: a primer on neuron death Biol Psychiatry 2000; (in press
Baslow MH . Functions of N-acetyl-L-aspartate and N-acetyl-L-aspartylglutamate in the vertebrate brain: role in glial cell-specific signaling J Neurochem 2000; 75: 453–459
Bates TE, Strangward M, Keelan J, Davey GP, Munro PM, Clark JB . Inhibition of N-acetylaspartate production: implications for 1H MRS studies in vivo Neuroreport 1996; 7: 1397–1400
Bertolino A, Frye M, Callicott JH, Repella JD, Rakow RL, Post RM et al. Neuronal pathology in the hippocampal area of patients with bipolar disorder: A H-1-MRSI study Biol Psychiatry 1999; 45: 135S
Frye MA, Bertolino A, Callicott JH, Repella JD, Rakow RL, Post RM, Weiberger DR . A 1H-MRSI hippocampal study in bipolar patients with a history of alcohol abuse Biol Psychiatry 2000; 47: 260S
Winsberg ME, Sachs N, Tate DL, Adalsteinsson E, Spielman D, Ketter TA . Decreased dorsolateral prefrontal N-acetyl aspartate in bipolar disorders Biol Psychiatry 2000; 47: 475–481
Kato T, Takahashi S, Shioiri T, Murashita J, Hamakawa H, Inubushi T . Reduction of brain phosphocreatine in bipolar II disorder detected by phosphorus-31 magnetic resonance spectroscopy J Affect Disord 1994; 31: 125–133
Kato T, Shioiri T, Murashita J, Hamakawa H, Inubushi T, Takahashi S . Phosphorous-31 magnetic resonance spectroscopy and ventricular enlargement in bipolar disorder Psychiatry Res: Neuroimaging 1994; 55: 41–50
Kato T, Takahashi S, Shioiri T, Inubushi T . Brain phosphorous metabolism in depressive disorders detected by phosphorus-31 magnetic resonance spectroscopy J Affect Disord 1992; 26: 223–230
Kato T, Shioiri T, Murashita J, Hamakawa H, Takashashi Y, Inubushi T et al. Lateralized abnormality of high energy phosphate metabolism in the frontal lobes of patients with bipolar disorder detected by phase-encoded 31P-MRS Psychol Med 1995; 25: 557–566
Deicken RF, Fein G, Weiner MW . Abnormal frontal lobe phosphorus metabolism in bipolar disorder Am J Psychiatry 1995; 152: 915–918
Deicken RF, Weiner MW, Fein G . Decreased temporal lobe phosphomonoesters in bipolar disorder J Affect Disord 1995; 33: 195–199
Volz HP, Rzanny R, Riehemann S, May S, Hegewald H, Preussler B et al. 31P magnetic resonance spectroscopy in the frontal lobe of major depressed patients Eur Arch Psychiatry Clin Neurosci 1998; 248: 289–295
Kato T, Shioiri T, Takashashi S, Inubushi T . Measurement of phosphoinositide metabolism in bipolar patients using in vivo 31P-MRS J Affect Disord 1991; 22: 185–190
Keshavan MS, Pettegrew JW, Panchalingan K, Kaplan D, Brar J, Campbell K . In vivo 31P-MRS of the frontal lobe in neuroleptic-näive first-episode psychosis: preliminary observations Schizophrenia Res 1989; 2: 123
Kato T, Takahashi S, Shioiri T, Inubushi T . Alterations in brain phosphorous metabolism in bipolar disorder detected by in vivo 31P and 7Li magnetic resonance spectroscopy J Affect Disord 1993; 27: 53–60
Murashita J, Kato T, Shioiri T, Inubushi T, Kato N . Altered brain energy metabolism in lithium-resistant bipolar disorder detected by photic stimulated 31P-MR spectroscopy Psychol Med 2000; 30: 107–115
Baumann B, Danos P, Krell D et al. Reduced volume of limbic system-affiliated basalganglia in mood disorders: preliminary data from a postmortem study J Neuropsych Clin Neurosci 1999; 11: 71–78
Baumann B, Bogerts B . Post-mortem studies on bipolar disorder Br J Psychiatry 2000; (in press
Rajkowska G, Miguel-Hidalgo JJ, Wei J, Dilley G, Pittman SD, Meltzer HY et al. Morphometric evidence for neuronal and glial prefrontal cell pathology in major depression Biol Psychiatry 1999; 45: 1085–1098
Rajkowska G, Selemon LD, Halaris A . Reductions in neuronal and glial density characterize the dorsolateral prefrontal cortex in bipolar disorder Am J Psychiatry 2000; (under revision
Diekmann S, Baumann B, Schmidt U, Bogerts B . Significant reduction of calretinin-IR neurons in layer II in the anterior cingulate cortex in subjects with affective disorders Soc Neurosci Abs 1998; 24: 386.5
Vincent SL, Todtenkopf MS, Benes FM . A comparison of the density of pyramidal and nonpyramidal neurons in the anterior cingulate cortex of schizophrenics and manic depressives Soc Neurosci 1997; 23: 2199
Benes FM, Kwok EW, Vincent SL, Todtenkopf MS . A reduction of nonpyramidal cells in sector CA2 of schizophrenics and manic depressives Biol Psychiatry 1998; 15: 4: 88–97
Rajkowska G . Histopathology of the prefrontal cortex in depression: what does it tell us about dysfunctional monoaminergic circuits Prog Brain Res 2000; 126: 397–412
Manji HK, Potter WZ, Lenox RH . Signal transduction pathways: molecular targets for lithium's action Arch Gen Psychiatry 1995; 52: 531–543
Manji HK, Lenox RH . Signaling: cellular insights into the pathophysiology of bipolar disorder Biol Psychiatry 2000; 48: 518–530
Rajkowska G, Selemon LD, Goldman-Rakic PS . Marked glial neuropathology in prefrontal cortex distinguishes bipolar disorder from schizophrenia Schizophr Res 1997; 24: 41
Rajkowska G . Postmortem studies in blood disorders indicate altered numbers of neurons and glial cells Biol Psychiatry 2000; (in press
Miguel-Hidalgo JJ, Bauco CH, Dilley G, Overholser J, Meltzer H, Stockmeier C et al, GFAP immunoreactivity in the dorsolateral prefrontal cortex separates young from old adults with major depressive disorder Biol Psychiatry 2000; (in press
Ongur D, Drevets WC, Price JL . Glial reduction in the subgenual prefrontal cortex in mood disorders Proc Natl Acad Sci USA 1998; 95: 13290–13295
Coyle JT, Schwarcz R . Mind glue: implications of glial cell biology for psychiatry Arch Gen Psychiatry 2000; 57: 90–93
LoTurco JJ . Neural circuits in the 21st century: synaptic networks of neurons and glia Proc Natl Acad Sci USA 2000; 97: 8196–8197
Sapolsky RM . Stress, glucocorticoids, and damage to the nervous system: the current state of confusion Stress 1996; 1: 1–19
Starkman MN, Giordani B, Gebarski SS, Berent S, Schork MA, Schteingart DE . Decrease in cortisol reverses human hippocampal atrophy following treatment of Cushing's disease Biol Psychiatry 1999; 46: 1595–1602
Simmons NE, Do HM, Lipper MH, Laws ER Jr . Cerebral atrophy in Cushing's disease Surg Neurol 2000; 53: 72–76
DeBellis MD, Keshavan MS, Clark DB, Casey BJ, Giedd JN, Boring AM et al. Developmental traumatology. Part II: Brain development Biol Psychiatry 1999; 45: 1271–1284
Roettger V, Lipton P . Mechanism of glutamate release from rat hippocampal slices during in vitro ischemia Neuroscience 1996; 75: 677–685
Hokin LE, Dixon JF, Los, GV . Acute inhibition but chronic upregulation and stabilization of glutamate uptake in synaptosomes by lithium. In: Manji HK, Bowden CL, Balmaker RH (eds) Bipolar Medications: Mechanisms of Action American Psychiatric Press: Washington, DC 2000; pp 65–85
Mattson MP, LaFerla FM, Chan SL, Leissring MA, Shepel PN, Geiger JD . Calcium signaling in the ER: its role in neuronal plasticity and neurodegenerative disorders Trends Neurosci 2000; 23: 222–229
Dubovsky S, Murphy J, Christiano J et al. The calcium second messenger system in bipolar disorders: data supporting new research directions J Neuropsychiatry Clin Neurosci 1992; 4: 3–14
Emamghoreishi M, Schlichter L, Li PP, Pariksh S, Sen J, Kamble A et al. High intracellular calcium concentrations in transformed lymphoblasts from subjects with bipolar I disorder Am J Psychiatry 1997; 154: 976–982
Wang JF, Young LT, Li PP, Warsh JJ . Signal transduction abnormalities in bipolar disorder In: Joffe RT, Young LT (eds) Bipolar Disorder: Biological Models and their Clinical Application Marcel Dekker: New York 1997; 41–79
Jacobsen NJ, Lyons I, Hoogendoorn B, Burge S, Kwok PY, O'Donovan MC et al. ATP2A2 mutations in Darier's disease and their relationship to neuropsychiatric phenotypes Hum Mol Genet 1999; 8: 1631–1636
Hough C, Lu SJ, Davis CL, Chuang DM, Post RM . Elevated basal and thapsigargin stimulated intracellular calcium of platelets and lymphocytes from bipolar affective disorder patients measured by a fluorometric microassay Biol Psychiatry 1999; 46: 247–255
Chen G, Zeng WZ, Jiang L, Yuan PX, Zhao J, Manji HK . The mood stabilizing agents lithium and valproate robustly increase the expression of the neuroprotective protein bcl-2 in the CNS J Neurochemistry 1999; 72: 879–882
Chen RW, Chuang DM . Long term lithium treatment suppresses p53 and Bax expression but increases bcl-2 expression J Biol Chem 1999; 274: 6039–6042
Manji HK, Moore GJ, Chen G . Lithium at 50: have the neuroprotective effects of this unique cation been overlooked? Biol Psychiatry 1999; 46: 929–940
Manji HK, Chen G, Hsiao JK, Masana MI, Moore GJ, Potter WZ . Regulation of signal transduction pathways by mood stabilizing agents: implications for the pathophysiology and treatment of bipolar affective disorder. In: Manji HK, Bowden CL, Balnater RH (eds) Bipolar Medications: Mechanisms of Action American Psychiatric Press: Washington, DC 2000; pp 129–177
Manji HK, Moore GJ, Chen G . Lithium uprgulates the cytoprotective protein bcl-2 in vitro and in the CNS in vivo: a role for neurotrophic and neuroprotective effects in manic-depressive illness J Clin Psychiatry 2000; 61: 82–96
Wang JF, Bown C, Young LT . Differential display PCR reveals novel targets for the mood-stabilizing drug valproate including the molecular chaperone GRP78 Mol Pharmacol 1999; 55: 521–527
Smith MA, Makino S, Kvetnansky R, Post RM . Stress alters the expression of brain-derived neurotrophic factor and neurotrophin-3 mRNAs in the hippocampus J Neurosci 1995; 15: 1768–1777
Nibuya M, Takahashi M, Russell DS, Duman RS . Repeated stress increases catalytic TrkB mRNA in rat hippocampus Neurosci Lett 1999; 267: 81–84
Mamounas LA, Blue ME, Siuciak JA, Anthony AC . BDNF promotes the survival and sprouting of serotonergic axons in the rat brain J Neurosci 1995; 15: 7929–7939
Murray CA, Lynch MA . Evidence that increased hippocampal expression of the cytokine interleukin-1β is a common trigger for age- and stress-induced impairments in long-term potentiation J Neurosci 1998; 18: 2974–2981
Nijhawan D, Honarpour N, Wang X . Apoptosis in neural development and disease Annu Rev Neurosci 2000; 23: 73–87
Bruckheimer EM, Cho SH, Sarkiss M, Hermann J, McDonnell TJ . The Bcl-2 gene family and apoptosis Adv Biochem Eng Biotechnol 1998; 62: 75–105
Pinton P, Ferrari D, Magalhaes P, Schulze-Osthoff K, Di Virgilio F, Poaazn T et al. Reduced loading of intracellular Ca(2+) stores and downregulation of capacitative Ca(2+) influx in Bcl-2-overexpressing cells J Cell Biol 2000; 148: 857–862
Hacki J, Egger L, Monney L, Conus S, Rosse T, Fellay I et al. Apoptotic crosstalk between the endoplasmic reticulum and mitochondria controlled by Bcl-2 Oncogene 2000; 19: 2286–2295
Kuo TH, Kim HR, Zhu L, Yu Y, Lin HM, Tsang W . Modulation of endoplasmic reticulum calcium pump by Bcl-2 Oncogene 1998; 17: 1903–1910
He H, Lam M, McCormick TS, Distelhorst CW . Maintenance of calcium homeostasis in the endoplasmic reticulum by Bcl-2 J Cell Biol 1997; 138: 1219–1228
Chen DF, Schneider GE, Martinou JC, Tonegawa S . Bcl-2 promotes regeneration of severed axons in mammalian CNS Nature 1997; 385: 434–439
Hilton M, Middleton G, Davies AM . Bcl-2 influences axonal growth rate in embryonic sensory neurons Curr Biol 1997; 7: 798–800
Zhang KZ, Westberg JA, Holtta E, Andersson LC . BCL2 regulates neural differentiation Proc Natl Acad Sci USA 1996; 93: 4504–4508
Suzuki A, Tsutomi Y . Bcl-2 accelerates the neuronal differentiation: new evidence approaching to the biofunction of bcl-2 in the neuronal system Brain Res 1998; 801: 59–66
Segal RA, Greenberg ME . Intracellular signaling pathways activated by neurotrophic factors Annu Rev Neurosci 1996; 19: 463–489
Tao X, Finkbeiner S, Arnold DB, Shaywitz AJ, Greenberg ME . Ca2+ influx regulates BDNF transcription by a CREB family transcription factor-dependent mechanism Neuron 1998; 20: 709–726
Riccio A, Ahn S, Davenport CM, Blendy JA, Ginty DD . Mediation by a CREB family transcription factor of NGF-dependent survival of sympathetic neurons Science 1999; 286: 2358–2361
Bonni A, Brunet A, West AE, Datta SR, Takasu MA, Greenberg ME . Cell survival promoted by the Ras-MAPK signaling pathway by transcription-dependent and -independent mechanisms Science 1999; 286: 1358–1362
Eriksson PS, Perfilieva E, Bjork-Eriksson T, Alborn AM, Nordborg C, Peterson DA et al. Neurogenesis in the adult human hippocampus Nature Med 1998; 4: 1313–1317
Gould E, Reeves AJ, Graziano MS, Gross CG . Neurogenesis in the neocortex of adult primates Science 1999; 286: 548–552
Cameron HA, McKay RD . Restoring production of hippocampal neurons in old age Nat Neurosci 1999; 2: 894–897
Duman RS, Malberg K, Nakagawa S, D'Sa C . Neuronal plasticity and survival in mood disorders Biol Psychiatry 2000; (in press)
Thome J, Impey S, Storm D, Duman RS . Induction of CRE gene expression by antidepressant treatment J Neurosci 2000; (in press
Shieh PB, Hu SC, Bobb K, Timmusk T, Ghosh A . Identification of a signaling pathway involved in calcium regulation of BDNF expression Neuron 1998; 20: 727–740
Nibuya M, Morinobu S, Duman RS . Regulation of BDNF and trkB mRNA in rat brain by chronic electroconvulsive seizure and antidepressant drug treatments J Neurosci 1995; 15: 7539–7547
Nibuya M, Nestler EJ, Duman RS . Chronic antidepressant administration increases the expression of cAMP response element binding protein (CREB) in rat hippocampus J Neurosci 1996; 16: 2365–2372
Malberg JE, AJ Eisch, EJ Nestler, RS Duman . Antidepressant treatment increases the birth and survival of hippocampal neurons 2000; (submitted
Nakamura S . Antidepressants induce regeneration of catecholaminergic axon terminals in the rate cerebral cortex Neurosci Lett 1990; 111: 64–68
Watanabe Y, Gould E, Daniels DC, Cameron H, McEwen BS . Tianeptine attenuates stress-induced morphological changes in the hippocampus Eur J Pharmacol 1992; 222: 157–162
Stewart CA, IC Reid . Repeated ECS and fluoxetine administration have equivalent effects on hippocampal synaptic plasticity Psychopharmacology 2000; 148: 217–223
Chen G, Rajkowska G, Du F, Seraji-Bozorgzad N, Manji HK . Enhancement of hippocampal neurogenesis by lithium J Neurochem 2000; 75: 1729–1734
Lu R, Song L, Jope RS . Lithium attenuates p53 levels in human neuroblastoma SH-SH-SY5Y cells Neuroreport 1999; 10: 1123–1125
Klein PS, Melton DA . A molecular mechanism for the effect of lithium on development Proc Natl Acad Sci USA 1996; 93: 8455–8459
Willert K, Nusse R . Beta-catenin: a key mediator of Wnt signaling Curr Opin Genet Dev 1998; 8: 95–102
Zhang Z, Hartmann H, Do VM, Abramowski D, Struchler-Pierrat C, Staufenbiel M et al. Destabilization of beta catenin by mutations in presenilin-1 potentiates neuronal apoptosis Nature 1998; 395: 698–702
Nishimura M, Yu G, Levesque G, Zhang DM et al. Presenilin mutations associated with Alzheimer disease cause defective intracellular trafficking of beta-catenin, a component of the presenilin protein complex Nature Med 1999; 5: 164–169
Pap M, Cooper GM . Role of glycogen synthase kinase-3 in the phosphatidylinositol 3 Kinase/Akt cell survival pathway J Biol Chem 1998; 273: 19929–19932
Bijur GM, De Sarno P, Jope RS . Glycogen synthase kinase-3 facilitates staurosporine- and heat shock-induced apoptosis: protection by lithium J Biol Chem 2000; 275: 7583–7590
Munoz-Montano JR, Moreno FJ, Avila J, Diaz-Nido J . Lithium inhibits Alzheimer's disease-like tau protein phosphorylation in neurons FEBS Lett 1997; 411: 183–188
Hong M, Chen DC, Klein PS, Lee VM . Lithium reduces tau phosphorylation by inhibition of glycogen synthase kinase-3 J Biol Chem 1997; 272: 25326–25332
Lovestone S, Davis DR, Webster MT, Kaech S, Brion JP, Matus A et al. Lithium reduces tau phosphorylation: effects in living cells and in neurons at therapeutic concentrations Biol Psychiatry 1999; 45: 995–1003
Hetman M, Cavanaugh JE, Kimelman D, Xia Z . Role of glycogen synthase kinase-3beta in neuronal apoptosis induced by trophic withdrawal J Neurosci 2000; 20: 2567–2574
Chen G, Huang LD, Jiang YM, Manji HK . The mood stabilizing agent valproate inhibits the activity of glycogen synthase kinase 3 J Neurochem 1999; 72: 1327–1330
Volonte C, Rukenstein A . Lithium promotes short-term survival of PC12 cells after serum and NGF deprivation Lithium 1993; 4: 211–219
D'Mello SR, Anelli R, Calissano P . Lithium induces apoptosis in immature cerebellar granule cells but promotes survival of mature neurons Exp Cell Res 1994; 211: 332–338
Li R, Shen Y, El-Mallakh RS . Lithium protects against ouabain-induced cell death Lithium 1994; 5: 211–216
Alvarez G, Munoz-Montano JR, Satrustegui J, Avila J, Bogonez E, Diaz-Nido J . Lithium protects cultured neurons against beta-amyloid-induced neurodegeneration FEBS Lett 1999; 453: 260–264
Inouye M, Yamamura H, Nakano A . Lithium delays the radiation-induced apoptotic process in external granule cells of mouse cerebellum J Radiat Res (Tokyo) 1995; 36: 203–208
Pascual T, Gonzalez JL . A protective effect of lithium on rat behaviour altered by ibotenic acid lesions of the basal forebrain cholinergic system Brain Res 1995; 695: 289–292
Grignon S, Levy N, Couraud F, Bruguerolle B . Tyrosine kinase inhibitors and cycloheximide inhibit Li+ protection of cerebellar granule neurons switched to non depolarizing medium Eur J Pharmacol 1996; 315: 111–114
Nonaka S, Hough CJ, Chuang DM . Chronic lithium treatment robustly protects neurons in the central nervous system against excitotoxicity by inhibiting N-methyl-D-aspartate receptor-mediated calcium influx Proc Natl Acad Sci USA 1998; 95: 2642–2647
Nonaka S, Katsube N, Chuang DM . Lithium protects rat cerebellar granule cells against apoptosis induced by anticonvulsants, phenytoin and carbamazepine J Pharmacol Exp Ther 1998; 286: 539–547
Arendt T, Lehmann K, Seeger G, Gartner U . Synergistic effects of tetrahydroaminoacridine and lithium on cholinergic function after excitotoxic basal forebrain lesions in rat Pharmacopsychiatry 1999; 32: 242–247
Sparapani M, Virgili M, Ortali F, Contestabile A . Effects of chronic lithium treatment on ornithine decarboxylase induction and excitotoxic neuropathology in the rat Brain Res 1997; 765: 164–168
Nonaka S, Chuang DM . Neuroprotective effects of chronic lithium on focal cerebral ischemia in rats Neuroreport 1998; 9: 2081–2084
Chuang DM, Wei H, Qin Z, Wei W, Wang Y, Qian Y . Lithium inhibits striatal damage in an animal model of Huntington disease Soc Neurosci Abs 1999; 241.7
Chalecka-Franaszek E, Chuang DM . Lithium activates the serine/threonine kinase Akt-1 and suppresses glutamate-induced inhibition of Akt-1 activity in neurons Proc Natl Acad Sci USA 1999; 96: 8745–8750
Kempermann G, Gage FH . Experience-dependent regulation of adult hippocampal neurogenesis: effects of long-term stimulation and stimulus withdrawal Hippocampus 1999; 9: 321–332
Bruno V, Sortino MA, Scapagnini U, Nicoletti F, Canonico P . Antidegenerative effects of Mg(2+) valproate in cultured cerebellar neurons Funct Neurol 1995; 10: 121–130
Mark RJ, Ashford JW, Goodman Y, Mattson MP . Anticonvulsants attenuate amyloid beta peptide neurotoxicity, Ca2+ deregulation, and cytoskeletal pathology Neurobiol Aging 1995; 16: 187–198
Mora A, Gonzalez-Polo RA, Fuentes JM, Soler G, Centeno F . Different mechanisms of protection against apoptosis by valproate and Li+ Eur J Biochem 1999; 266: 886–891
Chen G, Yuan PX, Jiang Y, Huang LD, Manji HK . Valproate robustly enhances AP-1 mediated gene expression Mol Brain Res 1999; 64: 52–58
Gutkind JS . The pathways connecting G protein-coupled receptors to the nucleus through divergent mitogen-activated protein kinase cascades J Biol Chem 1998; 273: 1839–1842
Chen G, Yuan PX, Huong LD, Gutkind JS, Manji HK . Valproic acid activates mitogen activated protein kinases and promotes neurite growth J Biol Chem 2000; (under revision
Moore GJ, Bebchuk JM, Hasanat K, Chen G, Seraji-Bozorgzad N, Wilds IB et al. Lithium increases N-acetyl-aspartate in the human brain: in vivo evidence in support of bcl-2's neurotrophic effects? Biol Psychiatry 2000; 48: 1–8
Moore GJ, Wilds IB, Bebchuk JM, Mitchell S, Chen G, Glitz DA et al. Pharmacologic in human grey matter The Lancet 2000; (in press
Birken DL, Oldendorf WH . N-acetyl-L-aspartic acid: a literature review of a compound prominent in 1H-NMR spectroscopic studies of brain Neurosci Biobehav Rev 1989; 13: 23–31
MacQueen GM, Young LT, Robb JC, Marriott M, Cooke RG, Joffe RT . Effect of number of episodes on wellbeing and functioning of patients with bipolar disorder Acta Psychiatr Scand 2000; 101: 374–381
Strakowski SM, Keck PE Jr, McElroy SL, West SA, Sax KW, Hawkins JM et al. Twelve-month outcome after a first hospitalization for affective psychosis Arch Gen Psychiatry 1998; 55: 49–55
Keck PE Jr, McElroy SL, Strakowski SM, West SA, Sax KW, Hawkins JM et al. 12-month outcome of patients with bipolar disorder following hospitalization for a manic or mixed episode Am J Psychiatry 1998; 155: 646–652
Strakowski SM, Wilson DR, Tohen M et al. Structural brain abnormalities in first-episode mania Biol Psychiatry 1993; 33: 602–609
Doraiswamy PM, MacFall J, Krishnan KR, O'Connor C, Wan X, Benaur M et al. Magnetic resonance assessment of cerebral perfusion in depressed cardiac patients: preliminary findings Am J Psychiatry 1999; 156: 1641–1643
Steffens DC, Helms MJ, Krishnan KR, Burke G . Cerebrovascular disease and depression symptoms in the cardiovascular health study Stroke 1999; 30: 2159–2166
Pillay SS, Renshaw PF, Bonello CM, Lafer B, Fava M, Yurgelun-Todd D . A quantitative magnetic resonance imaging study of caudate and lenticular nucleus gray matter volume in primary unipolar major depression: relationship to treatment response and clinical severity Psychiatry Res 1998; 84: 61–74
Vakili K, Pillay SS, Lafer B, Fava M, Renshaw PF, Bonello-Cintron BF et al. Hippocampal volume in primary unipolar major depression: a magnetic resonance imaging study Biol Psychiatry 2000; 47: 1087–1090
Zamzami N, Brenner C, Marzo I, Susin SA, Kroemer G . Subcellular and submitochondrial mode of action of Bcl-2-like oncoproteins Oncogene 1998; 16: 2265–2282
Guo Z, Zhou D, Schultz PG . Designing small-molecule switches for protein—protein interactions Science 2000; 288: 2042–2045