Neuropeptide Y‐immunoreactive Neurons in the Cerebral Cortex of Humans and Other Haplorrhine Primates

American Journal of Primatology - Tập 75 Số 5 - Trang 415-424 - 2013
Mary Ann Raghanti1, TIFFINI CONLEY1, Jessica Sudduth1, Joseph Erwin2, Cheryl D. Stimpson2, Patrick R. Hof3,4, Chet C. Sherwood2
1Department of Anthropology and School of Biomedical Sciences Kent State University Kent, Ohio
2Department of Anthropology The George Washington University Washington, District of Colombia
3Fishberg Department of Neuroscience and Friedman Brain Institute, Mount Sinai School of Medicine, New York, New York
4New York Consortium in Evolutionary Primatology, New York, New York

Tóm tắt

We examined the distribution of neurons immunoreactive for neuropeptide Y (NPY) in the posterior part of the superior temporal cortex (Brodmann's area 22 or area Tpt) of humans and nonhuman haplorrhine primates. NPY has been implicated in learning and memory and the density of NPY‐expressing cortical neurons and axons is reduced in depression, bipolar disorder, schizophrenia, and Alzheimer's disease. Due to the role that NPY plays in both cognition and neurodegenerative diseases, we tested the hypothesis that the density of cortical and interstitial neurons expressing NPY was increased in humans relative to other primate species. The study sample included great apes (chimpanzee and gorilla), Old World monkeys (pigtailed macaque, moor macaque, and baboon) and New World monkeys (squirrel monkey and capuchin). Stereologic methods were used to estimate the density of NPY‐immunoreactive (‐ir) neurons in layers I‐VI of area Tpt and the subjacent white matter. Adjacent Nissl‐stained sections were used to calculate local densities of all neurons. The ratio of NPY‐ir neurons to total neurons within area Tpt and the total density of NPY‐ir neurons within the white matter were compared among species. Overall, NPY‐ir neurons represented only an average of 0.006% of the total neuron population. While there were significant differences among species, phylogenetic trends in NPY‐ir neuron distributions were not observed and humans did not differ from other primates. However, variation among species warrants further investigation into the distribution of this neuromodulator system. Am. J. Primatol. 75:415‐424, 2013. © 2012 Wiley Periodicals, Inc.

Từ khóa


Tài liệu tham khảo

10.1371/journal.pone.0003378

10.1073/pnas.012481899

Bailey P, 1950, The isocortex of the chimpanzee, 440

10.1038/35016580

10.1002/ana.410200303

10.1007/BF00308809

10.1111/j.1749-6632.2011.05980.x

10.1097/00001756-199906030-00022

10.1523/JNEUROSCI.3065-04.2004

10.1016/0166-2236(94)90046-9

10.1023/A:1024130211265

10.1002/(SICI)1096-9861(19970324)379:4<515::AID-CNE4>3.0.CO;2-5

10.1002/(SICI)1096-9861(19981221)402:3<372::AID-CNE6>3.0.CO;2-2

10.1093/cercor/8.3.193

10.1093/cercor/bhp009

10.1016/0028-3932(94)90104-X

10.1002/cne.21432

10.1126/science.341314

10.1007/978-1-4684-4148-2_13

10.1126/science.279.5348.220

10.1016/j.brainres.2007.12.041

10.1016/S0010-9452(67)80007-8

10.1093/cercor/3.3.249

10.1016/S0891-0618(98)00022-2

10.1016/S0531-5131(02)00193-0

10.1006/anbe.2000.1518

10.1016/j.cub.2007.02.040

Hendry SH, 1984, Morphology, distribution, and synaptic relations of somatostatin‐ and neuropeptide Y‐immunoreactive neurons in rat and monkey neocortex, J Neurosci, 4, 2497, 10.1523/JNEUROSCI.04-10-02497.1984

HendrySH JonesEG DeFelipeJ SchmechelD BrandonC EmsonPC.1984b.Neuropeptide‐containing neurons of the cerebral cortex are alsoGABAergic.Proc Nat Acad Sci U S A81:6526–6530.

10.1371/journal.pone.0012438

10.1093/cercor/2.6.456

10.1002/(SICI)1096-9861(19961202)376:1<112::AID-CNE7>3.0.CO;2-6

10.1525/aa.1966.68.1.02a00090

10.1016/j.bbr.2009.12.012

10.1002/ana.410230202

10.1016/0006-8993(94)91060-X

10.1002/cne.902800305

10.1002/cne.902800306

10.1016/S1567-133X(01)00003-5

10.1038/nrn1648

10.1002/1096-9861(20001204)428:1<79::AID-CNE7>3.0.CO;2-Q

Michel MC, 1998, XVI. International Union of Pharmacology recommendations for the nomenclature of neuropeptide Y, Peptide YY, and pancreatic polypeptide receptors, Pharmacol Rev, 50, 143

10.1212/WNL.41.4.479

10.1016/j.brainres.2009.09.077

10.2535/ofaj1936.73.5_219

10.1016/j.schres.2009.09.014

Naidich TP, 2001, Anatomic substrates of language emphasizing speech, Neuroimaging Clin N Am, 11, 305

10.1038/nature02268

10.1002/cne.903100403

10.1006/brcg.1999.1129

10.1016/j.neuroscience.2008.10.058

10.1093/cercor/bhm089

10.1016/j.neuroscience.2008.05.008

10.1002/cne.21546

Rakic P., 1987, Encyclopedia of neuroscience, 594

10.1007/BF01939380

Savage‐Rumbaugh ES, 1980, Do apes use language, Am Sci, 68, 49

10.1159/000075673

10.1159/000096986

10.1098/rspb.2009.1831

10.1007/s00429-008-0198-9

10.1098/rspb.2010.0011

10.3389/neuro.05.007.2009

10.1093/cercor/bhn157

10.1038/296659a0

10.1523/JNEUROSCI.5589-03.2004

von Bohlen und Halbach O, 2006, Handbook of receptors and biological effects, 386

10.1093/cercor/bhn198

Thông tin
Thông tin xuất bản

American Journal of Primatology

Tập 75 Số 5

415-424

Thông tin tác giả