Neuropathology of patients with COVID-19 in Germany: a post-mortem case series

The Lancet Neurology - Tập 19 Số 11 - Trang 919-929 - 2020
Jakob Matschke1, Marc Lütgehetmann2,3, Christian Hagel1, Jan Sperhake4, Ann Sophie Schröder4, Carolin Edler4, Herbert Mushumba4, Antonia Fitzek4, Lena Allweiss5, Maura Dandri2,5, Matthias Dottermusch1, Axel Heinemann4, Susanne Pfefferle3, Marius Schwabenland6, Daniel Sumner Magruder7, Stefan Bonn8,7, Marco Prinz9,6,10, Christian Gerloff11, Klaus Püschel4, Susanne Krasemann1, Martin Aepfelbacher3, Markus Glatzel1
1Institute of Neuropathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
2Center for Infection Research, Partner Site Hamburg-Borstel-Lübeck-Riems, Germany
3Institute of Medical Microbiology, Virology and Hygiene, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
4Institute of Legal Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
5I. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
6Institute of Neuropathology, University of Freiburg, Freiburg, Germany
7Institute of Medical Systems Biology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
8German Center for Neurodegenerative Diseases, Tübingen, Germany
9Center for Basics in NeuroModulation, Faculty of Medicine, University of Freiburg, Freiburg, Germany
10Signaling Research Centers BIOSS and CIBSS, University of Freiburg, Freiburg, Germany
11Department of Neurology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany

Tóm tắt

Từ khóa


Tài liệu tham khảo

Zou, 2020, SARS-CoV-2 viral load in upper respiratory specimens of infected patients, N Engl J Med, 382, 1177, 10.1056/NEJMc2001737

Wichmann, 2020, Autopsy findings and venous thromboembolism in patients with COVID-19: a prospective cohort study, Ann Intern Med, 173, 268, 10.7326/M20-2003

Varga, 2020, Endothelial cell infection and endotheliitis in COVID-19, Lancet, 395, 1417, 10.1016/S0140-6736(20)30937-5

Poyiadji, 2020, COVID-19-associated acute hemorrhagic necrotizing encephalopathy: CT and MRI features, Radiology, 296, 10.1148/radiol.2020201187

Mao, 2020, Neurologic manifestations of hospitalized patients with coronavirus disease 2019 in Wuhan, China, JAMA Neurol, 77, 683, 10.1001/jamaneurol.2020.1127

Helms, 2020, Neurologic features in severe SARS-CoV-2 infection, N Engl J Med, 382, 2268, 10.1056/NEJMc2008597

Oxley, 2020, Large-vessel stroke as a presenting feature of COVID-19 in the young, N Engl J Med, 382, e60, 10.1056/NEJMc2009787

Huang, 2020, SARS-CoV-2 detected in cerebrospinal fluid by PCR in a case of COVID-19 encephalitis, Brain Behav Immun, 87, 149, 10.1016/j.bbi.2020.05.012

Bernard-Valnet, 2020, Two patients with acute meningo-encephalitis concomitant to SARS-CoV-2 infection, Eur J Neurol, 27, e43, 10.1111/ene.14298

Moriguchi, 2020, A first case of meningitis/encephalitis associated with SARS-coronavirus-2, Int J Infect Dis, 94, 55, 10.1016/j.ijid.2020.03.062

Gutierrez-Ortiz, 2020, Miller Fisher syndrome and polyneuritis cranialis in COVID-19, Neurology, 95, e601, 10.1212/WNL.0000000000009619

Zhao, 2020, Guillain-Barré syndrome associated with SARS-CoV-2 infection: causality or coincidence?, Lancet Neurol, 19, 383, 10.1016/S1474-4422(20)30109-5

Toscano, 2020, Guillain-Barré syndrome associated with SARS-CoV-2, N Engl J Med, 382, 2574, 10.1056/NEJMc2009191

De Felice, 2020, Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and the central nervous system, Trends Neurosci, 43, 355, 10.1016/j.tins.2020.04.004

Barton, 2020, COVID-19 autopsies, Oklahoma, USA, Am J Clin Pathol, 153, 725, 10.1093/ajcp/aqaa062

Solomon, 2020, Neuropathological features of COVID-19, N Engl J Med, 10.1056/NEJMc2019373

Schaller, 2020, Postmortem examination of patients with COVID-19, JAMA, 323, 10.1001/jama.2020.8907

Reichard, 2020, Neuropathology of COVID-19: a spectrum of vascular and acute disseminated encephalomyelitis (ADEM)-like pathology, Acta Neuropathol, 140, 1, 10.1007/s00401-020-02166-2

von Weyhern, 2020, Early evidence of pronounced brain involvement in fatal COVID-19 outcomes, Lancet, 395, e109, 10.1016/S0140-6736(20)31282-4

Puelles, 2020, Multiorgan and renal tropism of SARS-CoV-2, N Engl J Med, 383, 590, 10.1056/NEJMc2011400

Darmanis, 2015, A survey of human brain transcriptome diversity at the single cell level, Proc Natl Acad Sci USA, 112, 7285, 10.1073/pnas.1507125112

Marouf, 2020, Realistic in silico generation and augmentation of single-cell RNA-seq data using generative adversarial networks, Nat Commun, 11, 166, 10.1038/s41467-019-14018-z

Pfefferle, 2020, Evaluation of a quantitative RT-PCR assay for the detection of the emerging coronavirus SARS-CoV-2 using a high throughput system, Euro Surveill, 25, 10.2807/1560-7917.ES.2020.25.9.2000152

Tichopad, 2003, Standardized determination of real-time PCR efficiency from a single reaction set-up, Nucleic Acids Res, 31, e122, 10.1093/nar/gng122

Rockx, 2020, Comparative pathogenesis of COVID-19, MERS, and SARS in a nonhuman primate model, Science, 368, 1012, 10.1126/science.abb7314

Edler, 2020, Dying with SARS-CoV-2 infection—an autopsy study of the first consecutive 80 cases in Hamburg, Germany, Int J Legal Med, 134, 1275, 10.1007/s00414-020-02317-w

Hoffmann, 2020, SARS-CoV-2 cell entry depends on ACE2 and TMPRSS2 and is blocked by a clinically proven protease inhibitor, Cell, 181, 271, 10.1016/j.cell.2020.02.052

Verkhratsky, 2017, Stratification of astrocytes in healthy and diseased brain, Brain Pathol, 27, 629, 10.1111/bpa.12537

Ludlow, 2016, Neurotropic virus infections as the cause of immediate and delayed neuropathology, Acta Neuropathol, 131, 159, 10.1007/s00401-015-1511-3

Tröscher, 2019, Microglial nodules provide the environment for pathogenic T cells in human encephalitis, Acta Neuropathol, 137, 619, 10.1007/s00401-019-01958-5

Gu, 2005, Multiple organ infection and the pathogenesis of SARS, J Exp Med, 202, 415, 10.1084/jem.20050828

Desforges, 2014, Human coronaviruses: viral and cellular factors involved in neuroinvasiveness and neuropathogenesis, Virus Res, 194, 145, 10.1016/j.virusres.2014.09.011

Le Guennec, 2018, Ischemic and hemorrhagic brain injury during venoarterial-extracorporeal membrane oxygenation, Ann Intensive Care, 8, 129, 10.1186/s13613-018-0475-6

Li, 2020, The neuroinvasive potential of SARS-CoV2 may play a role in the respiratory failure of COVID-19 patients, J Med Virol, 92, 552, 10.1002/jmv.25728

Glatzel, 2020, Neuropathology of COVID-19: where are the neuropathologists?, Brain Pathol, 30, 729, 10.1111/bpa.12871