Neurological mortality among U.S. veterans of the Persian Gulf War: 13‐year follow‐up

American Journal of Industrial Medicine - Tập 52 Số 9 - Trang 663-670 - 2009
Shannon K. Barth1, Han K. Kang1, Tim A. Bullman1, Mitchell T. Wallin2
1Department of Veterans Affairs, Environmental Epidemiology Service, Washington, District of Columbia
2Department of Veterans Affairs Medical Center, Neurology Service, Washington, District of Columbia

Tóm tắt

AbstractBackgroundThis study focuses on long‐term mortality, specifically brain cancer, amyotrophic lateral sclerosis (ALS), Parkinson's disease, and multiple sclerosis (MS) of 621,902 veterans who served in the 1990–1991 Persian Gulf War (GW), and 746,248 non‐GW veterans.MethodsFollow‐up began with the date the veteran left the GW theater or May 1, 1991 and ended with the date of death or December 31, 2004. Cox proportional hazard models were used for analyses.ResultsAdjusted mortality rate ratios (aRR) of GW veterans compared to non‐GW veterans were not statistically significant for brain cancer (aRR = 0.90, 95% confidence interval (CI): 0.73, 1.11), MS (aRR = 0.61, 95% CI: 0.23, 1.63), Parkinson's disease (aRR = 0.71, 95% CI: 0.17, 2.99), or ALS (aRR = 0.96, 95% CI: 0.56, 1.62). GW veterans potentially exposed to nerve agents for 2 or more days and GW veterans exposed to oil well fire smoke were at increased risk for brain cancer mortality (aRR = 2.71, 95% CI: 1.25, 5.87; aRR = 1.81, 95% CI: 1.00, 3.27; respectively).ConclusionsThe risk of death due to ALS, MS, Parkinson's disease, and brain cancer was not associated with 1991 GW service in general. However, GW veterans potentially exposed to nerve agents at Khamisiyah, Iraq, and to oil well fire smoke had an increased risk of mortality due to brain cancer. Am. J. Ind. Med. 52:663–670, 2009. © 2009 Wiley‐Liss, Inc.

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American Journal of Industrial Medicine

Tập 52 Số 9

663-670

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