Dấu hiệu thần kinh tinh tế và hành vi rối loạn ở trẻ em của cha mẹ lệ thuộc opioids

Jeffrey J. Wilson1, Daniel S. Pine2, Abba Cargan3, Rise B. Goldstein3, Edward V. Nunes3, Myrna M. Weissman3
1College of Physicians and Surgeons, Columbia University, New York
2National Institute of Mental Health, USA
3College of Physicians & Surgeons, Columbia University, USA

Tóm tắt

Nghiên cứu hiện tại điều tra mối quan hệ giữa các dấu hiệu thần kinh tinh tế và các triệu chứng tâm thần ở trẻ em có cha mẹ lệ thuộc opioids. Một chuỗi liên tiếp 102 trẻ em có cha mẹ lệ thuộc opioids đã được thực hiện các đánh giá tâm lý và thần kinh theo chuẩn. Các triệu chứng của rối loạn hành vi bên ngoài nhưng không phải rối loạn nội tâm có liên quan đến hiệu suất kém trong bài kiểm tra dấu hiệu tinh tế, kiểm soát cho độ tuổi, trí thông minh và tình trạng kinh tế xã hội. Với tầm quan trọng của các rối loạn hành vi bên ngoài trong sự phát triển của các rối loạn sử dụng chất gây nghiện, các nghiên cứu về trẻ em có nguy cơ cao mắc rối loạn sử dụng chất gây nghiện cũng nên xem xét việc sàng lọc và đánh giá trẻ em về các dấu hiệu thần kinh tinh tế.

Từ khóa

#dấu hiệu thần kinh tinh tế #cha mẹ lệ thuộc opioids #rối loạn hành vi bên ngoài #trẻ em #triệu chứng tâm thần

Tài liệu tham khảo

Steiner H, Wilson JJ:Conduct disorder. In: Disruptive Behavior Disorders in Children and Adolescents, ed. Hendren RL:Washington, D.C.: American Psychiatric Press, pp. 47-98, 1999.

Wilens TE, Biederman J, Spencer TJ: Attention deficit/hyperactivity disorder in Child Psychiatry and Human Development 32 youth. In: Disruptive Behavior Disorders in Children and Adolescents, ed. Hendren RL:Washington, D.C.: American Psychiatric Press, pp. 1-46, 1999.

Riggs PD. & Whitmore EA.: Substance use disorders and disruptive behavior disorders. In: Disruptive Behavior Disorders in Children and Adolescents, ed. Hendren RL:Washington, D.C.: American Psychiatric Press, pp. 133-174, 1999.

Rutter M., Giller H. & Hagell A: Antisocial behavior by young people. New York, Cambridge University Press, 1998.

Pine DS., Wasserman GA, Fried JE, Parides M & Shaffer D: Neurological soft signs: one year stability and relationship to psychiatric symptoms in boys. J Am Acad Child Adol Psychiatry 36:1579-86, 1997.

Gupta S, Andreasen NC, Arndt S, Flaum M, Schultz SK, Hubbard WC, Smith M: Neurological soft signs in neuroleptic-naive and neuroleptic-treated schizophrenic patients and in normal comparison subjects, Am J Psychiatry 152: 191-196, 1995.

Neeper R. & Greenwood RS: On the psychiatric importance of neurological soft signs. In: Advances in Clinical Child Psychology, volume 10, eds. B Lahey and AE Kazdin: New York, Plenum Press, pp. 217-58, 1987.

Shaffer D, Schonfeld IS, O'Connor P, et al.: Neurological soft signs and their relationship to psychiatric disorder and intelligence in childhood and adolescence. Arch Gen Psychiatry 42: 342-351, 1985.

Tupper D: Soft Neurological Signs: New York: Grune and Stratton, 1987.

Carte ET, Nigg JT & Hinshaw SP: Neuropsychological functioning, motor speed, and language processing in boys with and without ADHD. J Abnorm Child Psychol 24: 481-498, 1996.

Mikkelsen EJ, Brown GL, Minichiello MD, Millican FK & Rapoport JL: Neurologic status in hyperactive, enuretic, and normal boys,J Am Acad Child Adol Psychiatry 21: 75-81, 1982.

Vitiello B, S toff D, Atkins M, Mahoney A: Soft neurological signs and impulsivity in children. J Dev Beh Pediatr 11: 112-115, 1990.

Gillberg C: Clinical Child Neuropsychiatry. Cambridge: Cambridge University Press, 1995.

Hellgren L, Gillberg C, Bagenholm A, Gillberg C: Children with deficits in attention, motor control, and perception (DAMP) almost grown up: psychiatric and personality disorders at age 16 years. J Child Psychol Psychiatry 35: 1255-1271, 1994.

Landgren M., Pettersson R., Kjellman B. & Gillberg C: ADHD, DAMP and other neurodevelopmental/psychiatric disorders in 6-year-old children: epidemiology and comorbidity. Dev Med Child Neurol 38: 891-906, 1996.

Moffit TE & Silva PA: Neuropsychological deficit and self-report delinquency in an unselected birth cohort. J Am Acad Child Adol Psychiatry 27:233-240, 1987.

Nichols PL: Minimal brain dysfunction and soft signs: The Collaborative Perinatal Project. In Soft Neurological Signs, ed. Tupper DE. New York: Grune and Stratton, pp. 179-200, 1987.

Raine A, Brennan P, Mednick B, Mednick SA: High rates of violence, crime, academic problems, and behavioral problems in males with both early neuromotor deficits and unstable family environments. Arch Gen Psychiatry 53: 544-549, 1996.

McAvay G, Nunes EV, Zaider TI, Goldstein RB & Weissman MM: Physical health problems in depressed and nondepressed children and adolescents of parents with opiate dependence. Depress Anxiety 9:61-69, 1999.

Nunes EV, Weissman MM, Goldstein R, McAvay G, Seracini A, Verdeli H & Wickramaratne PJ: Psychopathology in children of parents with opiate dependence and/ or major depression. J Am Acad Child Adolesc Psychiatry 37:1142-1151, 1998.

Weissman MM, McAvay G, Goldstein RB, Nunes EV, Verdeli H, Wickramaratne PJ: Risk/protective factors among addicted mothers' children: a replication study. Am J Drug Alcohol Abuse 25:661-679, 1999.

Endicott J, Spitzer RL: A diagnostic interview: the Schedule for Affective Disorders and Schizophrenia. Arch Gen Psychiatry 35:773-782, 1978.

Orvaschel H, Puig-Antich J, Chambers W, Tabrizi MA, Johnson R: Retrospective assessment of prepubertal major depression with the Kiddie-SADS-E. Journal of the Am Acad Child Adolesc Psychiatry 21:392-397, 1982.

Goldstein RB, McAvay GJ, Nunes EV, Weissman MM: Maternal life history-vs. gestation-focused assessment of prenatal exposure to substances of abuse. J Sub Abuse 11(4):355-368, 2000.

Dunn LM: Peabody Picture Vocabulary Test-Revised. Circle Pines, MN: American Guidance Service, 1981.

Wechsler D: Wechsler Intelligence Scale for Children Revised. New York, Psychological Corporation, 1974.

Leckman JF, Sholomskas D, Thompson WD, Belanger A, Weissman MM: Best estimate of lifetime psychiatric diagnosis: a methodologic study, Arch Gen Psychiatry 39:879-883, 1982.

Chiriboga CA, Brust JC, Bateman D, Hauser WA: Dose response effect of fetal cocaine exposure on newborn neurologic function, Pediatrics 103:79-85, 1999.

Pine D.S., Scott M.R., Busner C., Davies M., Fried J.A., Parides M. & Shaffer D. Psychometrics of neurological soft signs, J Am Acad Child Adolesc Psychiatry 35: 509-515, 1996.

SAS Institute, Inc. SAS/STAT Software: Changes and Enhancements through Release 6.11. Cary, NC: SAS Institute, 1996.

Cermak TL & Beckman W: Children of alcoholics and other addicts. In: eds. Coombs RH, Ziedonis D: Handbook of Drug Abuse Prevention. Needleham, MA: Allyn and Bacon, pp 361-378, 1995.

Luthar SS, Cushing G, Merikangas K, Rounsaville BJ: Multiple jeopardy: risk/protective factors among addicted mothers' children. Dev Psychopathol 10:117-136, 1998.

Rutter M, Graham P, Yule W: A Neuropsychiatric Study in Childhood. Clinics in Developmental Medicine, Nos. 35/36. London, Henemann Medical Books, 1973.

Crowley TJ, Riggs PD: Adolescent substance use disorder with conduct disorder and comorbid conditions. In: eds. Rahdert E, Czechowicz D: Adolescent Drug Abuse: Clinical assessment and therapeutic interventions (NIDA Research Monograph 156). Rockville, MD, National Institute of Drug Abuse, pp 49-111, 1995.

Webster-Stratton C. Advancing videotape parent training: a comparison study, J Consult Clin Psychol 62:583-593, 1994.

Funderburk BW, Eyberg SM, Newcomb K, et. al.: Parent-child interaction therapy with behavior problem children: maintenance of treatment effects in the school setting. Child and Family Behavior Therapy 20:17-38, 1998.

Patterson GR: Coercive Family Process. Eugene, OR: Castalia, 1982.

Pine DS, Shaffer D, Schonfeld IS, Davies M: Minor physical anomalies: modifiers of environmental risk for psychiatric impairment? J Am Acad Child Adoles Psychiatry 36:395-403, 1997.

Raine A, Brennan P, Farrington D: Biosocial bases of violence: conceptual and theoretical issues. In: eds. A Raine, P Brennan, DP Farrington, SA Mednick: Biosocial Bases of Violence. New York, NY: Plenum Press, 2001.

Obiols JE, Serrano F, Caparros B, Subira S, Barrantes N: Neurological soft signs in adolescents with poor performance on the continous performance test: markers of liability for schizophrenia spectrum disorders?. Psychiatry Res 86(3):217-28, 1999.

Keenan E, O'Donnell C, Sinanan K, O'Callaghan E: Severity of alcohol dependence and its relationship to neurological soft signs, neuropsychological impairment and family history. Acta Psychiatr Scand 95(4):272-6, 1997.

McGee R, Williams S, Silva PA:Behavioral and developmental characteristics of aggressive, hyperactive, and aggressive-hyperactive boys. J AmAcad Child Adolesc Psychiatry 21: 270-279, 1984.

Sandberg ST, Wieselberg M, Shaffer D: Hyperkinetic and conduct problem children Child Psychiatry and Human Development 34 in a primary school population: Some epidemiological considerations. J Child Psychol Psychiatry 21: 293-311, 1980.

Gillberg IC, Gillberg C: Three-year follow-up at age 10 of children with minor neurodevelopmental disorders, I: Behavioral problems. Dev Med Child Neurol 25: 438-449, 1983.

Paul R, Cohen D, Klin A, Volkmar F. Multiplex developmental disorders: the role of communication in the construction of the self. Psychiatr Clin North Am. 1999; 8: 189-202.

Cummings JL: The neuroanatomy of depression.Journal of Clinical Psychiatry 54; Suppl: 14-20, 1993.

Cummings JL: Frontal-subcortical circuits and human behavior, Arch Neurol 50: 873-880, 1993.

Insel T: Toward a neuroanatomy of obsessive-compulsive disorder, Arch Gen Psychiatry, 49: 553-557, 1992.

Peterson BS: Neuroimaging in child and adolescent psychiatry. J Am Acad Child Adolesc Psychiatry 34: 1560-1576, 1995.

Pine DS, Shaffer D, Shonfeld IS: Persistent emotional disorders in children with neurological soft signs. J Am Acad Child Adolesc Psychiatry 32: 1229-1236, 1993.

Rosenberg D, Keshavan M, Bagwell W, Seymour A, O'Hearn, K, Dick E, Birmaher B, Sweeney J: Caudate nucleus and putamen abnormalities in pediatric OCD. Biol Psychiatry 39: 606, 1996.

Swedo SE, Leonard HL, Garvey M, et. al.: Pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections: clinical description of the first 50 cases. Am J Psychiatry 155: 264-271, 1998.

Middelton FA, Strick PL: Anatomical evidence for cerebellar and basal ganglia involvement in higher cognitive function. Science 266: 458-461, 1994.

Castellanos FX, Elia J, Kruesi MJP, Marsh WL, Gulotta CS, Potter WZ, Ritchie GF, Hamburger SD, Rapaport JL: Cerebrospinal fluid homovanillic acid predicts behavioral response to stimulants in 45 boys with attention deficit hyperactivity disorder, Neuropsychopharmacology, 14: 125-137, 1996.

Dray A: Serotonin in the basal ganglia: functions and interactions with other neuronal pathways, J Physiol 77: 393-403, 1981.

Wasserman GA, Kline J K, Bateman DA, et al.: Prenatal cocaine exposure and school age intelligence, Drug and Alcohol Dependence 50: 203-210, 1998.

Clark DB, Kirisci L, Moss HB (1998), Early adolescent gateway drug use in sons of fathers with substance use disorders. Addictive Behaviors 23: 561-566.

Tarter R, Vanyukov M, Giancoila P, Dawes M, Blackson T, Mezzich A & Clark DB (1999). Etiology of early age onset substance use disorder: a maturational perspective. Development and Psychopathology 11: 657-683.

Iacono WG, Carlson SR, Taylor J, Elkins IJ & McGue M (1999). Behavioral disinhibition and the development of substance use disorders: findings from the Minnesota twin family study. Development and Psychopathology 11:869-900.

Shaffer D, Schonfeld I, O'Connor et al.:Neurological soft signs; their relationship to psychiatric disorder and intelligence in childhood and adolescence. Arch Gen Psychiatry 42:342-351, 1985.

Pincus JH. Neurological meaning of soft signs, in Lewis M. (ed.) Child and Adolescent Psychiatry: A Comprehensive Textbook. Lippincott, Williams and Winkins (2002) pp. 573-581.