Neurokinin-1 Receptor as a potential drug target for COVID-19 treatment

Biomedicine & Pharmacotherapy - Tập 143 - Trang 112159 - 2021
Riffat Mehboob1,2
1Faculty of Allied Health Sciences, The University of Lahore, Lahore, Pakistan
2Lahore Medical Research Center, LLP, Lahore, Pakistan

Tài liệu tham khảo

McGonagle, 2020, The role of cytokines including interleukin-6 in COVID-19 induced pneumonia and macrophage activation syndrome-like disease, Autoimmun. Rev., 19, 10.1016/j.autrev.2020.102537 WHO, Director-General's opening remarks at the media briefing on COVID-19 - 11 March 2020. https://www.who.int/dg/speeches/detail/who-director-general-s-opening-remarks-at-the-media-briefing-on-covid-19---11-march-2020, 2020. Zheng, 2020, Clinical characteristics of 161 cases of corona virus disease 2019 (COVID-19) in Changsha, Eur. Rev. Med. Pharmacol. Sci., 24, 3404 B. insider, A day-by-day breakdown of coronavirus symptoms shows how the disease COVID-19 goes from bad to worse. https://www.businessinsider.com/coronavirus-covid19-day-by-day-symptoms-patients-2020–2, 2020. Lindsey, 2020, Covid-19 — the search for effective therapy, N. Eng. J. Med. US, 1931, An unidentified depressor substance in certain tissue extracts, J. Physiol., 72, 74, 10.1113/jphysiol.1931.sp002763 S. Graefe, S.S. Mohiuddin, Biochemistry, Substance P, in StatPearls, 2020: Treasure Island (FL). Cuello, 1979, Detection of substance P in the central nervous system by a monoclonal antibody, Proc. Natl. Acad. Sci. USA, 76, 3532, 10.1073/pnas.76.7.3532 Ho, 1997, Human monocytes and macrophages express substance P and neurokinin-1 receptor, J. Immunol., 159, 5654, 10.4049/jimmunol.159.11.5654 Chernova, 2009, Substance P (SP) enhances CCL5-induced chemotaxis and intracellular signaling in human monocytes, which express the truncated neurokinin-1 receptor (NK1R), J. Leukoc. Biol., 85, 154, 10.1189/jlb.0408260 O’Connor, 2004, The role of substance P in inflammatory disease, J. Cell Physiol., 201, 167, 10.1002/jcp.20061 Saito, 1991, Pharmacological properties of the tachykinin receptor subtype in the endothelial cell and vasodilation, Ann. N. Y. Acad. Sci., 632, 457, 10.1111/j.1749-6632.1991.tb33155.x Mazzone, 2000, Respiratory actions of tachykinins in the nucleus of the solitary tract: effect of neonatal capsaicin pretreatment, Br. J. Pharmacol., 129, 1132, 10.1038/sj.bjp.0703173 Ramkissoon, 2006, G protein-coupled receptors in haematopoietic disruption, Expert Opin. Biol. Ther., 6, 109, 10.1517/14712598.6.2.109 Bost, 2004, Tachykinin-mediated modulation of the immune response, Front. Biosci., 9, 3331, 10.2741/1484 Mehboob, 2017, Substance P/Neurokinin 1 and trigeminal system: a possible link to the pathogenesis in sudden perinatal deaths, Front. Neurol., 8, 82, 10.3389/fneur.2017.00082 Badri, 2019, Emerging targets for cough therapies; NK1 receptor antagonists, Pulm. Pharmacol. Ther., 59, 10.1016/j.pupt.2019.101853 Smith, 2020, The Neurokinin-1 Receptor antagonist orvepitant is a novel antitussive therapy for chronic refractory cough: results from a phase 2 pilot study (VOLCANO-1), Chest, 157, 111, 10.1016/j.chest.2019.08.001 Otsuka, 2011, Plasma substance P levels in patients with persistent cough, Respiration, 82, 431, 10.1159/000330419 Lavezzi, 2011, Developmental alterations of the spinal trigeminal nucleus disclosed by substance P immunohistochemistry in fetal and infant sudden unexplained deaths, Neuropathology, 31, 405, 10.1111/j.1440-1789.2010.01190.x Hayashi, 2016, Immunohistochemical analysis of brainstem lesions in the autopsy cases with severe motor and intellectual disabilities showing sudden unexplained death, Front. Neurol., 7, 93, 10.3389/fneur.2016.00093 A.C, 2020, Treating COVID-19 - off-label drug use, compassionate use, and randomized clinical trials during pandemics, JAMA, 323, 1897, 10.1001/jama.2020.4742 Devin, 2014, Substance P increases sympathetic activity during combined angiotensin-converting enzyme and dipeptidyl peptidase-4 inhibition, Hypertension, 63, 951, 10.1161/HYPERTENSIONAHA.113.02767 Kierszenbaum, 2007, An introduction to pathology Touyz, 2020, ACE2 the Janus-faced protein - from cardiovascular protection to severe acute respiratory syndrome-coronavirus and COVID-19, Clin. Sci., 134, 747, 10.1042/CS20200363 Zhu, 2018, Correlation between the levels of serum cystatin C and substance P in peripheral blood in diabetes mellitus patients complicated with hypertension, Exp. Ther. Med., 16, 1159 Manak, 2010, Anti-HIV-1 activity of the neurokinin-1 receptor antagonist aprepitant and synergistic interactions with other antiretrovirals, AIDS, 24, 2789, 10.1097/QAD.0b013e3283405c33 Ho, 2004, Substance P and neurokinin-1 receptor modulation of HIV, J. Neuroimmunol., 157, 48, 10.1016/j.jneuroim.2004.08.022 Mashaghi, 2016, Neuropeptide substance P and the immune response, Cell Mol. Life Sci., 73, 4249, 10.1007/s00018-016-2293-z Johnson, 2016, The therapeutic potential of targeting substance P/NK-1R interactions in inflammatory CNS disorders, Front. Cell Neurosci., 10, 296 Marriott, 2001, Substance P receptor mediated macrophage responses, Adv. Exp. Med. Biol., 493, 247, 10.1007/0-306-47611-8_30 Marriott, 1998, Substance P diminishes lipopolysaccharide and interferon-gamma-induced TGF-beta 1 production by cultured murine macrophages, Cell Immunol., 183, 113, 10.1006/cimm.1998.1248 Covas, 1994, Disturbed immunoregulatory properties of the neuropeptide substance P on lymphocyte proliferation in HIV infection, Clin. Exp. Immunol., 96, 384, 10.1111/j.1365-2249.1994.tb06039.x Marriott, 2000, IL-4 and IFN-gamma up-regulate substance P receptor expression in murine peritoneal macrophages, J. Immunol., 165, 182, 10.4049/jimmunol.165.1.182 Bozic, 1996, Neurogenic amplification of immune complex inflammation, Science, 273, 1722, 10.1126/science.273.5282.1722 Leng, 2020, Transplantation of ACE2(-) mesenchymal stem cells improves the outcome of patients with COVID-19 pneumonia, Aging Dis., 11, 216, 10.14336/AD.2020.0228 Sarzi-Puttini, 2020, COVID-19, cytokines and immunosuppression: what can we learn from severe acute respiratory syndrome?, Clin. Exp. Rheumatol., 38, 337, 10.55563/clinexprheumatol/xcdary Borson, 1985, Neutral endopeptidase and neurogenic inflammation in rats with respiratory infections, J. Appl. Physiol., 66, 2653, 10.1152/jappl.1989.66.6.2653 Song, 2014, Inhibitors of endopeptidase and angiotensin-converting enzyme lead to an amplification of the morphological changes and an upregulation of the substance P system in a muscle overuse model, BMC Musculoskelet. Disord., 15, 126, 10.1186/1471-2474-15-126 Geppetti, 1993, Characterization of tachykinin receptors in ferret trachea by peptide agonists and nonpeptide antagonists, Am. J. Physiol., 265, L164 Nieber, 1992, Substance P and beta-endorphin-like immunoreactivity in lavage fluids of subjects with and without allergic asthma, J. Allergy Clin. Immunol., 90, 646, 10.1016/0091-6749(92)90138-R Tomaki, 1995, Elevated substance P content in induced sputum from patients with asthma and patients with chronic bronchitis, Am. J. Respir. Crit. Care Med., 151, 613, 10.1164/ajrccm/151.3_Pt_1.613 Adcock, 1993, Increased tachykinin receptor gene expression in asthmatic lung and its modulation by steroids, J. Mol. Endocrinol., 11, 1, 10.1677/jme.0.0110001 Bertrand, 1996, Tachykinin and kinin receptor antagonists: therapeutic perspectives in allergic airway disease, Trends Pharmacol. Sci., 17, 255, 10.1016/0165-6147(96)10027-4 Kaczyńska, 2018, Neuropeptides and breathing in health and disease, Pulm. Pharm. Ther., 48, 217, 10.1016/j.pupt.2017.12.001 Szereda-Przestaszewska, 2020, Serotonin and substance P: synergy or competition in the control of breathing, Auton. Neurosci., 225, 10.1016/j.autneu.2020.102658 Bright, 2017, Abnormalities in substance P neurokinin-1 receptor binding in key brainstem nuclei in sudden infant death syndrome related to prematurity and sex, PLoS One, 12, 0184958, 10.1371/journal.pone.0184958 Parameswaran, 2002, Airway hyperresponsiveness and calcium handling by smooth muscle: a “deeper look”, Chest, 121, 621, 10.1378/chest.121.2.621 Mehboob, 2014, Vertebrate specific oncogenic TAC1 has unconventional networking properties, Healthmed, 8, 843 Lorente, 2019, Persistently high serum substance P levels and early mortality in patients with severe traumatic brain injury, World Neurosurg., 132, 613, 10.1016/j.wneu.2019.08.064 Muhammad, 2018, Neurochemical alterations in sudden unexplained perinatal deaths-a review, Front. Pediatr., 6, 6, 10.3389/fped.2018.00006 Mehboob, 2017, Towards better understanding of the pathogenesis of neuronal respiratory network in sudden perinatal death, Front. Neurol., 8, 320, 10.3389/fneur.2017.00320 Mehboob, 2015, Role of neurotransmitter substance P in progression of oral squamous cell carcinoma, Pathol. Res. Pract., 211, 203, 10.1016/j.prp.2014.09.016 Dehlin, 2014, Substance P in heart failure: the good and the bad, Int. J. Cardiol., 170, 270, 10.1016/j.ijcard.2013.11.010 Dehlin, 2013, Substance P acting via the neurokinin-1 receptor regulates adverse myocardial remodeling in a rat model of hypertension, Int. J. Cardiol., 168, 4643, 10.1016/j.ijcard.2013.07.190 Widiapradja, 2019, Regulation of cardiac mast cell maturation and function by the Neurokinin-1 Receptor in the fibrotic heart, Sci. Rep., 9, 11004, 10.1038/s41598-019-47369-0 Mistrova, 2016, Role of substance P in the cardiovascular system, Neuropeptides, 58, 41, 10.1016/j.npep.2015.12.005 D’Souza, 2007, Substance P is associated with heart enlargement and apoptosis in murine dilated cardiomyopathy induced by Taenia crassiceps infection, J. Parasitol., 93, 1121, 10.1645/GE-596R1.1 Meléndez, 2011, Substance P induces adverse myocardial remodelling via a mechanism involving cardiac mast cells, Cardiovasc Res., 92, 420, 10.1093/cvr/cvr244 Meléndez, 2019, Substance P as a potential biomarker of pain assessment in dogs, Iran. J. Vet. Res., 20, 289 Caroleo, 2020, Targeting neuropathic pain: pathobiology, current treatment and peptidomimetics as a new therapeutic opportunity, Curr. Med. Chem., 27, 1469, 10.2174/0929867326666190530121133 Zieglgansberger, 2019, Substance P and pain chronicity, Cell Tissue Res., 375, 227, 10.1007/s00441-018-2922-y Han, 2019, Involvement of substance P in the analgesic effect of low-level laser therapy in a mouse model of chronic widespread muscle pain, Pain. Med., 20, 1963, 10.1093/pm/pnz056 Zhang, 2019, Activation of mitogen-activated protein kinases in satellite glial cells of the trigeminal ganglion contributes to substance P-mediated inflammatory pain, Int. J. Oral. Sci., 11, 24, 10.1038/s41368-019-0055-0 Casault, 2019, Cytokine responses in severe traumatic brain injury: where there is smoke, is there fire?, Neurocrit Care, 30, 22, 10.1007/s12028-018-0522-z Wang, 2014, Aprepitant in the prevention of vomiting induced by moderately and highly emetogenic chemotherapy, Asian Pac. J. Cancer Prev., 15, 10045, 10.7314/APJCP.2014.15.23.10045 Okafor, 2017, The role of neurokinin-1 (substance P) antagonists in the prevention of postoperative nausea and vomiting, J. Anaesthesiol. Clin. Pharmacol., 33, 441, 10.4103/0970-9185.222511 Tuluc, 2014, HIV infection of macrophages is enhanced in the presence of increased expression of CD163 induced by substance P, J. Leukoc. Biol., 96, 143, 10.1189/jlb.4AB0813-434RR Robinson, 2015, Substance P receptor antagonism: a potential novel treatment option for viral-myocarditis, Biomed. Res. Int., 2015, 10.1155/2015/645153 Robinson, 2009, Substance P is required for the pathogenesis of EMCV infection in mice, Int. J. Clin. Exp. Med., 2, 76 Hamza, 2007, Herpes simplex virus type-1 latency-associated transcript-induced immunoreactivity of substance P in trigeminal neurons is reversed by bone morphogenetic protein-7, Neurosci. Lett., 413, 31, 10.1016/j.neulet.2006.11.063 Bossaller, 1992, In vivo measurement of endothelium-dependent vasodilation with substance P in man, Herz, 17, 284 Dalzell, 2014, Effects of neutral endopeptidase (neprilysin) inhibition on the response to other vasoactive peptides in small human resistance arteries: studies with thiorphan and omapatrilat, Cardiovasc Ther., 32, 13, 10.1111/1755-5922.12053 Wang, 2011, Hypoxia-induced down-regulation of neprilysin by histone modification in mouse primary cortical and hippocampal neurons, PLoS One, 6, 19229, 10.1371/journal.pone.0019229 M.A. Ibrahim, Preuss C.V., Antiemetic Neurokinin-1 Receptor Blockers, in StatPearls 2020: Treasure Island (FL). https://www.ncbi.nlm.nih.gov/books/NBK470394/. Quartara, 2006, Tachykinin receptors antagonists: from research to clinic, Curr. Drug Targets, 7, 975, 10.2174/138945006778019381 Munoz, 2013, Involvement of substance P and the NK-1 receptor in cancer progression, Peptides, 48, 1, 10.1016/j.peptides.2013.07.024 Mehboob, 2020, Aprepitant as a combinant with Dexamethasone reduces the inflammation via Neurokinin 1 Receptor Antagonism in severe to critical Covid-19 patients and potentiates respiratory recovery: A novel therapeutic approach, MedRxiv Shoenfeld, 2020, Corona (COVID-19) time musings: our involvement in COVID-19 pathogenesis, diagnosis, treatment and vaccine planning, Autoimmun. Rev., 19, 10.1016/j.autrev.2020.102538