Neuroinflammation in intracerebral haemorrhage: immunotherapies with potential for translation

The Lancet Neurology - Tập 19 - Trang 1023-1032 - 2020
Mengzhou Xue1, V Wee Yong2
1The Second Affiliated Hospital of Zhengzhou University, Zhengzhou, China
2The Hotchkiss Brain Institute and the Department of Clinical Neurosciences, University of Calgary, Calgary, AB, Canada

Tài liệu tham khảo

Gross, 2019, Cerebral intraparenchymal hemorrhage: a review, JAMA, 321, 1295, 10.1001/jama.2019.2413 Wan, 2019, Iron toxicity, lipid peroxidation and ferroptosis after intracerebral haemorrhage, Stroke Vasc Neurol, 4, 93, 10.1136/svn-2018-000205 Bai, 2020, Microglia and macrophage phenotypes in intracerebral haemorrhage injury: therapeutic opportunities, Brain, 143, 1297, 10.1093/brain/awz393 Tschoe, 2020, Neuroinflammation after intracerebral hemorrhage and potential therapeutic targets, J Stroke, 22, 29, 10.5853/jos.2019.02236 Shtaya, 2019, Rapid neuroinflammatory changes in human acute intracerebral hemorrhage, Ann Clin Transl Neurol, 6, 1465, 10.1002/acn3.50842 Jiang, 2020, Immune changes in peripheral blood and hematoma of patients with intracerebral hemorrhage, FASEB J, 34, 2774, 10.1096/fj.201902478R Yong, 2005, Metalloproteinases: mediators of pathology and regeneration in the CNS, Nat Rev Neurosci, 6, 931, 10.1038/nrn1807 Lattanzi, 2020, Matrix metalloproteinases in acute intracerebral hemorrhage, Neurotherapeutics, 17, 484, 10.1007/s13311-020-00839-0 Zhang, 2015, Nuclear factor-κB activation in perihematomal brain tissue correlates with outcome in patients with intracerebral hemorrhage, J Neuroinflammation, 12, 53, 10.1186/s12974-015-0277-9 Rodríguez-Yáñez, 2012, Increased expression of toll-like receptors 2 and 4 is associated with poor outcome in intracerebral hemorrhage, J Neuroimmunol, 247, 75, 10.1016/j.jneuroim.2012.03.019 Mackenzie, 1999, Early cellular events in the penumbra of human spontaneous intracerebral hemorrhage, J Stroke Cerebrovasc Dis, 8, 1, 10.1016/S1052-3057(99)80032-9 Kayhanian, 2017, Prognostic value of peripheral leukocyte counts and plasma glucose in intracerebral haemorrhage, J Clin Neurosci, 41, 50, 10.1016/j.jocn.2017.03.032 Wimmer, 2018, Neuroinflammatory responses in experimental and human stroke lesions, J Neuroimmunol, 323, 10, 10.1016/j.jneuroim.2018.07.003 Mracsko, 2014, Leukocyte invasion of the brain after experimental intracerebral hemorrhage in mice, Stroke, 45, 2107, 10.1161/STROKEAHA.114.005801 Zhang, 2018, Organ- and cell-specific immune responses are associated with the outcomes of intracerebral hemorrhage, FASEB J, 32, 220, 10.1096/fj.201700324r Dong, 2019, When encephalitogenic T cells collaborate with microglia in multiple sclerosis, Nat Rev Neurol, 15, 704, 10.1038/s41582-019-0253-6 Liddelow, 2017, Neurotoxic reactive astrocytes are induced by activated microglia, Nature, 541, 481, 10.1038/nature21029 Li, 2010, Perihematomal pathological changes in neurons and astrocytes following acute cerebral hemorrhage, Int J Neurosci, 120, 683, 10.3109/00207454.2010.513460 Katsanos, 2017, Plasma glial fibrillary acidic protein in the differential diagnosis of intracerebral hemorrhage, Stroke, 48, 2586, 10.1161/STROKEAHA.117.018409 Luger, 2017, Glial fibrillary acidic protein serum levels distinguish between intracerebral hemorrhage and cerebral ischemia in the early phase of stroke, Clin Chem, 63, 377, 10.1373/clinchem.2016.263335 Duan, 2016, Intracerebral hemorrhage, oxidative stress, and antioxidant therapy, Oxid Med Cell Longev, 2016, 10.1155/2016/1203285 Lorente, 2018, Serum malondialdehyde levels and mortality in patients with spontaneous intracerebral hemorrhage, World Neurosurg, 113, e542, 10.1016/j.wneu.2018.02.085 Chang, 2014, Matrix metalloproteinase-9: dual role and temporal profile in intracerebral hemorrhage, J Stroke Cerebrovasc Dis, 23, 2498, 10.1016/j.jstrokecerebrovasdis.2014.07.005 Rosell, 2006, Increased brain expression of matrix metalloproteinase-9 after ischemic and hemorrhagic human stroke, Stroke, 37, 1399, 10.1161/01.STR.0000223001.06264.af Zhang, 2010, Exploring the optimal operation time for patients with hypertensive intracerebral hemorrhage: tracking the expression and progress of cell apoptosis of prehematomal brain tissues, Chin Med J (Engl), 123, 1246 Wu, 2008, Expression of matrix metalloproteinase MMP-9 in the plasma and hematoma fluid of intracerebral hemorrhage patients, Zhonghua Yi Xue Za Zhi, 88, 174 Abilleira, 2003, Matrix metalloproteinase-9 concentration after spontaneous intracerebral hemorrhage, J Neurosurg, 99, 65, 10.3171/jns.2003.99.1.0065 Lorente, 2020, High serum tissue inhibitor of matrix metalloproteinase-1 levels and mortality in patients with spontaneous intracerebral hemorrhage, World Neurosurg, 134, e476, 10.1016/j.wneu.2019.10.106 Zhao, 2006, Role of matrix metalloproteinases in delayed cortical responses after stroke, Nat Med, 12, 441, 10.1038/nm1387 Zhu, 2019, Role and mechanisms of cytokines in the secondary brain injury after intracerebral hemorrhage, Prog Neurobiol, 178, 10.1016/j.pneurobio.2019.03.003 Malone, 2019, Immunomodulatory therapeutic strategies in stroke, Front Pharmacol, 10, 630, 10.3389/fphar.2019.00630 Yong, 2019, The benefits of neuroinflammation for the repair of the injured central nervous system, Cell Mol Immunol, 16, 540, 10.1038/s41423-019-0223-3 Sansing, 2011, Toll-like receptor 4 contributes to poor outcome after intracerebral hemorrhage, Ann Neurol, 70, 646, 10.1002/ana.22528 Taylor, 2017, TGF-β1 modulates microglial phenotype and promotes recovery after intracerebral hemorrhage, J Clin Invest, 127, 280, 10.1172/JCI88647 Shi, 2015, Increased frequency of circulating regulatory T cells in patients with acute cerebral hemorrhage, Neurosci Lett, 591, 115, 10.1016/j.neulet.2015.02.042 Faissner, 2018, Unexpected additive effects of minocycline and hydroxychloroquine in models of multiple sclerosis: Prospective combination treatment for progressive disease?, Mult Scler, 24, 1543, 10.1177/1352458517728811 Sheng, 2018, Efficacy of minocycline in acute ischemic stroke: a systematic review and meta-analysis of rodent and clinical studies, Front Neurol, 9, 10.3389/fneur.2018.01103 Yrjänheikki, 1998, Tetracyclines inhibit microglial activation and are neuroprotective in global brain ischemia, Proc Natl Acad Sci USA, 95, 15769, 10.1073/pnas.95.26.15769 Yong, 2004, The promise of minocycline in neurology, Lancet Neurol, 3, 744, 10.1016/S1474-4422(04)00937-8 Naderi, 2020, Neuroprotective effects of minocycline on focal cerebral ischemia injury: a systematic review, Neural Regen Res, 15, 773, 10.4103/1673-5374.268898 Kobayashi, 2013, Minocycline selectively inhibits M1 polarization of microglia, Cell Death Dis, 4, e525, 10.1038/cddis.2013.54 Power, 2003, Intracerebral hemorrhage induces macrophage activation and matrix metalloproteinases, Ann Neurol, 53, 731, 10.1002/ana.10553 Xue, 2010, Improving outcomes of neuroprotection by minocycline: guides from cell culture and intracerebral hemorrhage in mice, Am J Pathol, 176, 1193, 10.2353/ajpath.2010.090361 Selim, 2019, Deferoxamine mesylate in patients with intracerebral haemorrhage (i-DEF): a multicentre, randomised, placebo-controlled, double-blind phase 2 trial, Lancet Neurol, 18, 428, 10.1016/S1474-4422(19)30069-9 Fouda, 2017, Minocycline in acute cerebral hemorrhage: an early phase randomized trial, Stroke, 48, 2885, 10.1161/STROKEAHA.117.018658 Chang, 2017, Minocycline and matrix metalloproteinase inhibition in acute intracerebral hemorrhage: a pilot study, Eur J Neurol, 24, 1384, 10.1111/ene.13403 Casha, 2012, Results of a phase II placebo-controlled randomized trial of minocycline in acute spinal cord injury, Brain, 135, 1224, 10.1093/brain/aws072 Lampl, 2007, Minocycline treatment in acute stroke: an open-label, evaluator-blinded study, Neurology, 69, 1404, 10.1212/01.wnl.0000277487.04281.db Padma Srivastava, 2012, Efficacy of minocycline in acute ischemic stroke: a single-blinded, placebo-controlled trial, Neurol India, 60, 23, 10.4103/0028-3886.93584 Cudkowicz, 2010, A futility study of minocycline in Huntington's disease, Mov Disord, 25, 2219, 10.1002/mds.23236 Gordon, 2007, Efficacy of minocycline in patients with amyotrophic lateral sclerosis: a phase III randomised trial, Lancet Neurol, 6, 1045, 10.1016/S1474-4422(07)70270-3 Howard, 2020, Minocycline at 2 different dosages vs placebo for patients with mild Alzheimer disease: a randomized clinical trial, JAMA Neurol, 77, 164, 10.1001/jamaneurol.2019.3762 Metz, 2017, Trial of minocycline in a clinically isolated syndrome of multiple sclerosis, N Engl J Med, 376, 2122, 10.1056/NEJMoa1608889 O'Sullivan, 2016, Sphingosine-1-phosphate receptor therapies: advances in clinical trials for CNS-related diseases, Neuropharmacology, 113, 597, 10.1016/j.neuropharm.2016.11.006 Noda, 2013, Fingolimod phosphate promotes the neuroprotective effects of microglia, J Neuroimmunol, 256, 13, 10.1016/j.jneuroim.2012.12.005 Rolland, 2013, Fingolimod reduces cerebral lymphocyte infiltration in experimental models of rodent intracerebral hemorrhage, Exp Neurol, 241, 45, 10.1016/j.expneurol.2012.12.009 Lu, 2014, Fingolimod exerts neuroprotective effects in a mouse model of intracerebral hemorrhage, Brain Res, 1555, 89, 10.1016/j.brainres.2014.01.048 Zhang, 2017, T lymphocytes infiltration promotes blood-brain barrier injury after experimental intracerebral hemorrhage, Brain Res, 1670, 96, 10.1016/j.brainres.2017.06.019 Fu, 2014, Fingolimod for the treatment of intracerebral hemorrhage: a 2-arm proof-of-concept study, JAMA Neurol, 71, 1092, 10.1001/jamaneurol.2014.1065 Li, 2015, Fingolimod alters inflammatory mediators and vascular permeability in intracerebral hemorrhage, Neurosci Bull, 31, 755, 10.1007/s12264-015-1532-2 Zhu, 2015, Combination of the immune modulator fingolimod with alteplase in acute ischemic stroke: a pilot trial, Circulation, 132, 1104, 10.1161/CIRCULATIONAHA.115.016371 Bobinger, 2019, Siponimod (BAF-312) attenuates perihemorrhagic edema and improves survival in experimental intracerebral hemorrhage, Stroke, 50, 3246, 10.1161/STROKEAHA.119.027134 Shakeri-Nejad, 2020, Safety, tolerability, pharmacodynamics and pharmacokinetics of intravenous siponimod: a randomized, open-label study in healthy subjects, Clin Ther, 42, 175, 10.1016/j.clinthera.2019.11.014 Arefieva, 2018, Immunotropic effects and proposed mechanism of action for 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors (Statins), Biochemistry (Mosc), 83, 874, 10.1134/S0006297918080023 Ewen, 2013, Neuroprotective effect of atorvastatin involves suppression of TNF-α and upregulation of IL-10 in a rat model of intracerebral hemorrhage, Cell Biochem Biophys, 66, 337, 10.1007/s12013-012-9453-z Wang, 2018, The evolving role of neuro-immune interaction in brain repair after cerebral ischemic stroke, CNS Neurosci Ther, 24, 1100, 10.1111/cns.13077 Tapia-Perez, 2009, Use of statins for the treatment of spontaneous intracerebral hemorrhage: results of a pilot study, Cent Eur Neurosurg, 70, 15, 10.1055/s-0028-1082064 Chen, 2019, Statins for neuroprotection in spontaneous intracerebral hemorrhage, Neurology, 93, 1056, 10.1212/WNL.0000000000008627 Ribe, 2019, Statins and risk of intracerebral haemorrhage in a stroke-free population: a nationwide Danish propensity score matched cohort study, EClinicalMedicine, 8, 78, 10.1016/j.eclinm.2019.02.007 Åsberg, 2020, Statins as secondary preventives in patients with intracerebral hemorrhage, Int J Stroke, 15, 61, 10.1177/1747493018816476 Yadav, 2019, Insight into the mechanism of action of dimethyl fumarate in multiple sclerosis, J Mol Med (Berl), 97, 463, 10.1007/s00109-019-01761-5 Zhao, 2015, Dimethyl fumarate protects brain from damage produced by intracerebral hemorrhage by mechanism involving Nrf2, Stroke, 46, 1923, 10.1161/STROKEAHA.115.009398 Elkins, 2017, Safety and efficacy of natalizumab in patients with acute ischaemic stroke (ACTION): a randomised, placebo-controlled, double-blind phase 2 trial, Lancet Neurol, 16, 217, 10.1016/S1474-4422(16)30357-X Elkind, 2020, Natalizumab in acute ischemic stroke (ACTION II): a randomized, placebo-controlled trial, Neurology, 95, e1091, 10.1212/WNL.0000000000010038 Lei, 2016, Neuroprotective pentapeptide CN-105 improves functional and histological outcomes in a murine model of intracerebral hemorrhage, Sci Rep, 6, 10.1038/srep34834 Xu, 2019, Glibenclamide ameliorates the disrupted blood-brain barrier in experimental intracerebral hemorrhage by inhibiting the activation of NLRP3 inflammasome, Brain Behav, 9, 10.1002/brb3.1254 Liddle, 2020, Translational intracerebral hemorrhage research: has current neuroprotection research ARRIVEd at a standard for experimental design and reporting?, Transl Stroke Res, 10.1007/s12975-020-00824-x Lively, 2012, Age-related comparisons of evolution of the inflammatory response after intracerebral hemorrhage in rats, Transl Stroke Res, 3, 132, 10.1007/s12975-012-0151-3 Fu, 2015, Immune interventions in stroke, Nat Rev Neurol, 11, 524, 10.1038/nrneurol.2015.144