Julieta Saba1, Federico López Couselo1, Julieta Bruno1, Lila Carniglia1, Daniela Durand1, Mercedes Lasaga1, Carla Caruso1
1Instituto de Investigaciones Biomédicas (INBIOMED), UBA-CONICET, Paraguay 2155, Facultad de Medicina, Universidad de Buenos Aires, Buenos Aires, Argentina
Tóm tắt
:
Huntington’s disease (HD) is a neurodegenerative genetic disorder caused by a CAG repeat
expansion in the huntingtin gene. HD causes motor, cognitive, and behavioral dysfunction.
Since no existing treatment affects the course of this disease, new treatments are needed. Inflammation
is frequently observed in HD patients before symptom onset. Neuroinflammation, characterized
by the presence of reactive microglia, astrocytes and inflammatory factors within the brain, is also
detected early. However, in comparison to other neurodegenerative diseases, the role of neuroinflammation
in HD is much less known. Work has been dedicated to altered microglial and astrocytic
functions in the context of HD, but less attention has been given to glial participation in neuroinflammation.
This review describes evidence of inflammation in HD patients and animal models. It
also discusses recent knowledge on neuroinflammation in HD, highlighting astrocyte and microglia
involvement in the disease and considering anti-inflammatory therapeutic approaches.
