Neuroinflammation in Alzheimer's disease

The Lancet Neurology - Tập 14 Số 4 - Trang 388-405 - 2015
Michael T. Heneka1,2, Monica J. Carson3, Joseph El Khoury4, Gary E. Landreth5, Frederic Brosseron2, Douglas L. Feinstein6, Andréas H. Jacobs7,8, Tony Wyss‐Coray9,10, Javier Vitórica11, Richard M. Ransohoff12, Karl Herrup13, Sally A. Frautschy14, Bente Finsen15, Guy C. Brown16, Alexei Verkhratsky17,18,19, Koji Yamanaka20, Jari Koistinaho21, Eicke Latz22,2,23, Annett Halle24, Gabor C. Petzold1,2, Terrence Town25, Dave Morgan26, Mari L. Shinohara27, V. Hugh Perry28, Clive Holmes29,30, Nicolás G. Bazán31, David J. Brooks32, Stéphane Hunot33, Bertrand Joseph34, Nikolaus Deigendesch35, Olga Garaschuk36, Erik Boddeke37, Charles A. Dinarello38, John C.S. Breitner39, Greg M. Cole14, Douglas T. Golenbock22, Markus P. Kummer1
1Department of Neurology, University Hospital Bonn, University of Bonn, Bonn, Germany
2German Center for Neurodegnerative Diseases (DZNE), Bonn, Germany
3Division of Biomedical Sciences, Center for Glial-Neuronal Interactions, University of California, Riverside, CA, USA
4Division of Infectious Diseases, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA
5Alzheimer Research Laboratory, Department of Neurosciences, Case Western Reserve University School of Medicine, Cleveland, OH, USA
6Department of Anesthesiology, University of Illinois, Chicago, IL, USA
7Department of Geriatrics, Johanniter Hospital, Bonn, Germany
8European Institute for Molecular Imaging (EIMI) at the Westfalian Wilhelms University (WWU), Münster, Germany
9Center for Tissue Regeneration, Repair, and Restoration, VA Palo Alto Health Care System, Palo Alto, CA, USA
10Department of Neurology and Neurological Sciences Stanford University School of Medicine, Stanford, CA. USA
11Instituto de Biomedicina de Sevilla (IBIS), Hospital Universitario Virgen del Rocio, Consejo Superior de Investigaciones Cientificas Universidad de Sevilla, Sevilla, Spain
12Department of Neuroscience, Neuroinflammation Research Center, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA
13Division of Life Science, Hong Kong University of Science and Technology, Hong Kong
14Department of Neurology, David Geffen School of Medicine at the University of California, Los Angeles, the Geriatric, Research, and Clinical Center, Greater Los Angeles Veterans Affairs Healthcare System, Los Angeles, CA, USA
15Institute of Molecular Medicine, University of Southern Denmark, Odense, Denmark
16Department of Biochemistry, University of Cambridge, Cambridge, UK
17Achucarro Center for Neuroscience, Basque Foundation for Science (IKERBASQUE), Bilbao, Spain
18Department of Neurosciences, University of the Basque Country UPV/EHU (Euskal Herriko Unibertsitatea/Universidad del País Vasco) and CIBERNED (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas), Leioa, Spain
19Faculty of Life Sciences, The University of Manchester, Manchester, UK
20Research Institute of Environmental Medicine, Nagoya University/RIKEN Brain Science Institute, Wako-shi, Japan
21Department of Neurobiology, AI Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland
22Department of InfectiousDiseases and Immunology, University of Massachusetts Medical School, Worcester, MA, USA
23Institute of Innate Immunity, University of Bonn, Bonn, Germany
24Max-Planck Research Group Neuroimmunology, Center of Advanced European Studies and Research (CAESAR), Bonn, Germany
25Zilkha Neurogenetic Institute, Keck School of Medicine of the University of Southern California, Los Angeles, CA, USA
26Department of Molecular Pharmacology and Physiology, Byrd Alzheimer's Institute, University of South Florida College of Medicine, Tampa, FL, USA
27Department of Immunology, Duke University Medical Center, Durham, NC, USA
28School of Biological Sciences, Southampton General Hospital, Southampton, UK
29Clinical and Experimental Science, University of Southampton, Southampton, UK
30Memory Assessment and Research Centre, Moorgreen Hospital, Southern Health Foundation Trust, Southampton, UK
31Louisiana State University Neuroscience Center of Excellence, Louisiana State University Health Sciences Center School of Medicine in New Orleans, LA, USA
32Division of Experimental Medicine, Imperial College London, Hammersmith Hospital, London, UK
33Centre National de la Recherche Scientifique (CNRS), UMR 7225, Experimental Therapeutics of Neurodegeneration, Paris, France
34Department of Oncology–Pathology, Cancer Centrum Karolinska, Karolinska Institutet, Stockholm, Sweden
35Department of Cellular Microbiology, Max Planck Institute for Infection Biology, Berlin, Germany
36Institute of Physiology II, Eberhard Karls University of Tübingen, Tübingen, Germany
37Department of Neuroscience, University of Groningen, University Medical Centre Groningen, Groningen, Netherlands
38Department of Medicine, University of Colorado Denver, Aurora, CO, USA
39Centre for Studies on Prevention of Alzheimer's Disease, Douglas Mental Health University Institute, and the McGill University Faculty of Medicine, Montreal, Quebec, Canada

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