Neurodegeneration and Neuroregeneration in Chagas Disease

Adad, 2001, Neuron count reevaluation in the myenteric plexus of chagasic megacolon after morphometric neuron analysis, Virchows Arch., 438, 254, 10.1007/s004280000319 Adesse, 2010, Transcriptomic signatures of alterations in a myoblast cell line infected with four distinct strains of Trypanosoma cruzi, Am. J. Trop. Med. Hyg., 82, 846, 10.4269/ajtmh.2010.09-0399 Agusti, 1997, The trans-sialidase of Trypanosoma cruzi is anchored by two different lipids, Glycobiology, 7, 731, 10.1093/glycob/7.6.731 Akpan, 2008, Chagas’ disease parasite-derived neurotrophic factor activates cholinergic gene expression in neuronal PC12 cells, Brain Res., 1217, 195, 10.1016/j.brainres.2008.03.082 Aliberti, 1996, Interleukin-12 mediates resistance to Trypanosoma cruzi in mice and is produced by murine macrophages in response to live trypomastigotes, Infect. Immun., 64, 1961, 10.1128/IAI.64.6.1961-1967.1996 Aliberti, 2001, Modulation of chemokine production and inflammatory responses in interferon-gamma- and tumor necrosis factor-R1-deficient mice during Trypanosoma cruzi infection, Am. J. Pathol., 158, 1433, 10.1016/S0002-9440(10)64094-1 Almeida-Leite, 2007, Interferon-gamma induced nitric oxide mediates in vitro neuronal damage by Trypanosoma cruzi-infected macrophages, Neurobiol. Dis., 25, 170, 10.1016/j.nbd.2006.09.003 Alvarez, 2001, Multiple overlapping epitopes in the repetitive unit of the shed acute-phase antigen from Trypanosoma cruzi enhance its immunogenic properties, Infect. Immun., 69, 7946, 10.1128/IAI.69.12.7946-7949.2001 Alves, 2008, Role of the gp85/trans-sialidase superfamily of glycoproteins in the interaction of Trypanosoma cruzi with host structures, Subcell. Biochem., 47, 58, 10.1007/978-0-387-78267-6_4 Alves, 1984, Changes in acetylcholinesterase-positive nerves of the submandibular salivary gland during experimental infection with a protozoon, Trypanosoma cruzi, in rats, Arch. Oral Biol., 29, 647, 10.1016/0003-9969(84)90136-5 Amaya, 2004, Structural insights into the catalytic mechanism of Trypanosoma cruzi trans-sialidase, Structure, 12, 775, 10.1016/j.str.2004.02.036 Amorim, 1995, Functional alterations of the autonomic nervous system in Chagas’ heart disease, Sao Paulo Med. J., 113, 772, 10.1590/S1516-31801995000200007 Andrade, 2005, The Trypanosoma cruzi-host–cell interplay: location, invasion, retention, Nat. Rev. Microbiol., 3, 819, 10.1038/nrmicro1249 Aoki Mdel, 2006, Different signaling pathways are involved in cardiomyocyte survival induced by a Trypanosoma cruzi glycoprotein, Microbes Infect., 8, 1723, 10.1016/j.micinf.2006.02.010 Aoki, 2004, Cruzipain, a major Trypanosoma cruzi antigen, promotes arginase-2 expression and survival of neonatal mouse cardiomyocytes, Am. J. Physiol. Cell Physiol., 286, C206, 10.1152/ajpcell.00282.2003 Arantes, 2004, Interferon-gamma-induced nitric oxide causes intrinsic intestinal denervation in Trypanosoma cruzi-infected mice, Am. J. Pathol., 164, 1361, 10.1016/S0002-9440(10)63222-1 Arevalo, 2006, Neurotrophin signaling: many exciting surprises!, Cell. Mol. Life Sci., 63, 1523, 10.1007/s00018-006-6010-1 Atwood, 2005, The Trypanosoma cruzi proteome, Science, 309, 473, 10.1126/science.1110289 Aukrust, 2005, Inflammatory and anti-inflammatory cytokines in chronic heart failure: potential therapeutic implications, Ann. Med., 37, 74, 10.1080/07853890510007232 Baroldi, 1997, Sudden and unexpected death in clinically ‘silent’ Chagas’ disease. A hypothesis, Int. J. Cardiol., 58, 263, 10.1016/S0167-5273(96)02878-1 Barry, 2009, 14-3-3:Shc scaffolds integrate phosphoserine and phosphotyrosine signaling to regulate phosphatidylinositol 3-kinase activation and cell survival, J. Biol. Chem., 284, 12080, 10.1074/jbc.M807637200 Bassotti, 2007, Enteric glial cells: new players in gastrointestinal motility?, Lab. Invest., 87, 628, 10.1038/labinvest.3700564 Bestetti, 1996, Role of parasites in the pathogenesis of Chagas’ cardiomyopathy, Lancet, 347, 913, 10.1016/S0140-6736(96)91403-8 Bestetti, 1997, Clinical course of Chagas’ heart disease: a comparison with dilated cardiomyopathy, Int. J. Cardiol., 60, 187, 10.1016/S0167-5273(97)00083-1 Beucher, 2008, Sequence diversity of the Trypanosoma cruzi complement regulatory protein family, Infect. Immun., 76, 750, 10.1128/IAI.01104-07 Biolo, 2010, Chagas cardiomyopathy—where do we stand after a hundred years?, Prog. Cardiovasc. Dis., 52, 300, 10.1016/j.pcad.2009.11.008 Bonni, 1995, Serine 133-phosphorylated CREB induces transcription via a cooperative mechanism that may confer specificity to neurotrophin signals, Mol. Cell. Neurosci., 6, 168, 10.1006/mcne.1995.1015 Boyd, 2003, Neurotrophic factors and their receptors in axonal regeneration and functional recovery after peripheral nerve injury, Mol. Neurobiol., 27, 277, 10.1385/MN:27:3:277 Brunet, 2001, Transcription-dependent and -independent control of neuronal survival by the PI3K-Akt signaling pathway, Curr. Opin. Neurobiol., 11, 297, 10.1016/S0959-4388(00)00211-7 Burkauskiene, 2006, Age-related changes in myocardial nerve and collagen networks of the auricle of the right atrium, Acta Cardiol., 61, 513, 10.2143/AC.61.5.2017765 Buscaglia, 2006, Trypanosoma cruzi surface mucins: host-dependent coat diversity, Nat. Rev. Microbiol., 4, 229, 10.1038/nrmicro1351 Buschiazzo, 2002, The crystal structure and mode of action of trans-sialidase, a key enzyme in Trypanosoma cruzi pathogenesis, Mol. Cell, 10, 757, 10.1016/S1097-2765(02)00680-9 Caetano, 2006, Influence of Trypanosoma cruzi chronic infection in the depletion of esophageal neurons in Calomys callosus, Dig. Dis. Sci., 51, 1796, 10.1007/s10620-006-9186-1 Caetano, 2008, Does cyclophosphamide play a protective role against neuronal loss in chronic T. cruzi infection?, Dig. Dis. Sci., 53, 2929, 10.1007/s10620-008-0260-8 Camargos, 1996, Preganglionic fibres of the adrenal medulla and cervical sympathetic ganglia: differential involvement during experimental American trypanosomiasis in rats, Int. J. Exp. Pathol., 77, 115, 10.1046/j.1365-2613.1996.00971.x Camargos, 2000, Infection with different Trypanosoma cruzi populations in rats: myocarditis, cardiac sympathetic denervation, and involvement of digestive organs, Am. J. Trop. Med. Hyg., 62, 604, 10.4269/ajtmh.2000.62.604 Campos, 1973, Chagas enteropathy, Gut, 14, 910, 10.1136/gut.14.11.910 Caradonna, 2009, Preferential brain homing following intranasal administration of Trypanosoma cruzi, Infect. Immun., 77, 1349, 10.1128/IAI.01434-08 Carmen, 2007, Suicide prevention: disruption of apoptotic pathways by protozoan parasites, Mol. Microbiol., 64, 904, 10.1111/j.1365-2958.2007.05714.x Cavallesco, 1988, Antibody to Trypanosoma cruzi neuraminidase enhances infection in vitro and identifies a subpopulation of trypomastigotes, J. Immunol., 140, 617, 10.4049/jimmunol.140.2.617 Chernousov, 2000, Schwann cell extracellular matrix molecules and their receptors, Histol. Histopathol., 15, 593 Cheung, 2004, Emerging role for ERK as a key regulator of neuronal apoptosis, Sci. STKE, 10.1126/stke.2512004pe45 Chimelli, 1997, Trypanosomiasis, Brain Pathol., 7, 599, 10.1111/j.1750-3639.1997.tb01077.x Chuenkova, 2000, A trypanosomal protein synergizes with the cytokines ciliary neurotrophic factor and leukemia inhibitory factor to prevent apoptosis of neuronal cells, Mol. Biol. Cell, 11, 1487, 10.1091/mbc.11.4.1487 Chuenkova, 2001, The T. cruzi trans-sialidase induces PC12 cell differentiation via MAPK/ERK pathway, Neuroreport, 12, 3715, 10.1097/00001756-200112040-00022 Chuenkova, 2003, PDNF, a human parasite-derived mimic of neurotrophic factors, prevents caspase activation, free radical formation, and death of dopaminergic cells exposed to the Parkinsonism-inducing neurotoxin MPP+, Brain Res. Mol. Brain Res., 119, 50, 10.1016/j.molbrainres.2003.08.012 Chuenkova, 2004, Chagas’ disease parasite promotes neuron survival and differentiation through TrkA nerve growth factor receptor, J. Neurochem., 91, 385, 10.1111/j.1471-4159.2004.02724.x Chuenkova, 2005, A synthetic peptide modeled on PDNF, Chagas’ disease parasite neurotrophic factor, promotes survival and differentiation of neuronal cells through TrkA receptor, Biochemistry, 44, 15685, 10.1021/bi0512039 Chuenkova, 2006, Enhancement of tyrosine hydroxylase expression and activity by Trypanosoma cruzi parasite-derived neurotrophic factor, Brain Res., 1099, 167, 10.1016/j.brainres.2006.04.128 Chuenkova, 2009, Trypanosoma cruzi targets Akt in host cells as an intracellular antiapoptotic strategy, Sci. Signal., 2, 10.1126/scisignal.2000374 Chuenkova, 1999, trans-sialidase of Trypanosoma cruzi: location of galactose-binding site(s), Biochem. Biophys. Res. Commun., 262, 549, 10.1006/bbrc.1999.1154 Chuenkova, 2001, Trypanosoma cruzi trans-sialidase: a potent and specific survival factor for human Schwann cells by means of phosphatidylinositol 3-kinase/Akt signaling, Proc. Natl. Acad. Sci. USA, 98, 9936, 10.1073/pnas.161298398 Cole, 2002, Poly(ADP-ribose) polymerase inhibition prevents both apoptotic-like delayed neuronal death and necrosis after H(2)O(2) injury, J. Neurochem., 82, 19, 10.1046/j.1471-4159.2002.00935.x Conti, 2004, Inducible nitric oxide synthase (iNOS) in immune-mediated demyelination and Wallerian degeneration of the rat peripheral nervous system, Exp. Neurol., 187, 350, 10.1016/j.expneurol.2004.01.026 Correia, 2007, Cardiac autonomic modulation evaluated by heart interval variability is unaltered but subtly widespread in the indeterminate Chagas’ disease, Pacing Clin. Electrophysiol., 30, 772, 10.1111/j.1540-8159.2007.00749.x Coura, 2007, Chagas disease: what is known and what is needed–a background article, Mem. Inst. Oswaldo. Cruz., 102, 113, 10.1590/S0074-02762007000900018 Cunha, 2003, Norepinephrine and heart rate variability: a marker of dysautonomia in chronic Chagas cardiopathy, Rev. Port. Cardiol., 22, 29 da Silveira, 2005, Comparative study of the presence of Trypanosoma cruzi kDNA, inflammation and denervation in chagasic patients with and without megaesophagus, Parasitology, 131, 627, 10.1017/S0031182005008061 da Silveira, 2007, Neurochemical coding of the enteric nervous system in chagasic patients with megacolon, Dig. Dis. Sci., 52, 2877, 10.1007/s10620-006-9680-5 da Silveira, 2007, Megacolon in Chagas disease: a study of inflammatory cells, enteric nerves, and glial cells, Hum. Pathol., 38, 1256, 10.1016/j.humpath.2007.01.020 da Silveira, 2008, Neuronal plasticity of the enteric nervous system is correlated with chagasic megacolon development, Parasitology, 135, 1337, 10.1017/S0031182008004770 da Silveira, 2009, Glial fibrillary acidic protein and S-100 colocalization in the enteroglial cells in dilated and nondilated portions of colon from chagasic patients, Hum. Pathol., 40, 244, 10.1016/j.humpath.2008.04.025 Dantas, 1990, Lower esophageal sphincter pressure in Chagas’ disease, Dig. Dis. Sci., 35, 508, 10.1007/BF01536927 Datta, 1997, Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery, Cell, 91, 231, 10.1016/S0092-8674(00)80405-5 Davila, 1991, Cardiac parasympathetic innervation in Chagas’ heart disease, Med. Hypotheses, 35, 80, 10.1016/0306-9877(91)90027-V Davila, 1995, Cardiac sympathetic–parasympathetic balance in rats with experimentally-induced acute chagasic myocarditis, Rev. Inst. Med. Trop. Sao Paulo, 37, 155, 10.1590/S0036-46651995000200011 Davila, 1998, Chagas’ heart disease and the autonomic nervous system, Int. J. Cardiol., 66, 123, 10.1016/S0167-5273(98)00212-5 Davila, 2004, A modified and unifying neurogenic hypothesis can explain the natural history of chronic Chagas heart disease, Int. J. Cardiol., 96, 191, 10.1016/j.ijcard.2003.06.015 de Lima, 2008, Interstitial cells of Cajal in chagasic megaesophagus, Ann. Diagn. Pathol., 12, 271, 10.1016/j.anndiagpath.2007.12.002 de Melo-Jorge, 2007, The Chagas’ disease parasite Trypanosoma cruzi exploits nerve growth factor receptor TrkA to infect mammalian hosts, Cell Host Microbe, 1, 251, 10.1016/j.chom.2007.05.006 de Oliveira, 1995, The spectrum of esophageal motor disorders in Chagas’ disease, Am. J. Gastroenterol., 90, 1119 de Souza, 1996, Trypanosoma cruzi strains and autonomic nervous system pathology in experimental Chagas disease, Mem. Inst. Oswaldo Cruz, 91, 217, 10.1590/S0074-02761996000200018 Diazgranados, 2009, Chagasic encephalitis in HIV patients: common presentation of an evolving epidemiological and clinical association, Lancet Infect. Dis., 9, 324, 10.1016/S1473-3099(09)70088-X Dutra, 2008, Current concepts in immunoregulation and pathology of human Chagas disease, Curr. Opin. Infect. Dis., 21, 287, 10.1097/QCO.0b013e3282f88b80 El-Sayed, 2005, The genome sequence of Trypanosoma cruzi, etiologic agent of Chagas disease, Science, 309, 409, 10.1126/science.1112631 Fazan, 1997, Qualitative and quantitative morphology of the vagus nerve in experimental Chagas’ disease in rats: a light microscopy study, Am. J. Trop. Med. Hyg., 57, 672, 10.4269/ajtmh.1997.57.672 Feldman, 1999, Evidence that antisulfatide autoantibodies from rats experimentally infected with Trypanosoma cruzi bind to homologous neural tissue, Parasitol. Res., 85, 446, 10.1007/s004360050576 Frasch, 2000, Functional diversity in the trans-sialidase and mucin families in Trypanosoma cruzi, Parasitol. Today, 16, 282, 10.1016/S0169-4758(00)01698-7 Freire-de-Lima, 2010, Trypanosoma cruzi subverts host cell sialylation and may compromise antigen-specific CD8+ T cell responses, J. Biol. Chem., 285, 13388, 10.1074/jbc.M109.096305 Frevert, 1992, Stage-specific expression and intracellular shedding of the cell surface trans-sialidase of Trypanosoma cruzi, Infect. Immun., 60, 2349, 10.1128/IAI.60.6.2349-2360.1992 Gao, 2001, Trypanosoma cruzi trans-sialidase potentiates T cell activation through antigen-presenting cells: role of IL-6 and Bruton's tyrosine kinase, Eur. J. Immunol., 31, 1503, 10.1002/1521-4141(200105)31:5<1503::AID-IMMU1503>3.0.CO;2-W Gao, 2002, Interleukin-6 is required for parasite specific response and host resistance to Trypanosoma cruzi, Int. J. Parasitol., 32, 167, 10.1016/S0020-7519(01)00322-8 Gao, 2002, The Trypanosoma cruzi trans-sialidase is a T cell-independent B cell mitogen and an inducer of non-specific Ig secretion, Int. Immunol., 14, 299, 10.1093/intimm/14.3.299 Gao, 2003, Immunological tolerance and its breakdown in Chagas’ heart disease: role of parasitokines, Front. Biosci., 8, e218, 10.2741/1004 Gao, 2004, Activated CREB is sufficient to overcome inhibitors in myelin and promote spinal axon regeneration in vivo, Neuron, 44, 609, 10.1016/j.neuron.2004.10.030 Garcia, 1999, Nitric oxide is involved in the lesions of the peripheral autonomic neurons observed in the acute phase of experimental Trypanosoma cruzi infection, Exp. Parasitol., 93, 191, 10.1006/expr.1999.4451 Garg, 1997, Glycosylphosphatidylinositols are required for the development of Trypanosoma cruzi amastigotes, Infect. Immun., 65, 4055, 10.1128/IAI.65.10.4055-4060.1997 Gazzinelli, 2006, Protozoan encounters with Toll-like receptor signalling pathways: implications for host parasitism, Nat. Rev. Immunol., 6, 895, 10.1038/nri1978 Gazzinelli, 1992, The microbicidal activity of interferon-gamma-treated macrophages against Trypanosoma cruzi involves an l-arginine-dependent, nitrogen oxide-mediated mechanism inhibitable by interleukin-10 and transforming growth factor-beta, Eur. J. Immunol., 22, 2501, 10.1002/eji.1830221006 Gea, 1993, Chagas’ disease cardioneuropathy: association of anti-Trypanosoma cruzi and anti-sciatic nerve antibodies, Am. J. Trop. Med. Hyg., 49, 581, 10.4269/ajtmh.1993.49.581 Ginty, 1994, Nerve growth factor activates a Ras-dependent protein kinase that stimulates c-fos transcription via phosphorylation of CREB, Cell, 77, 713, 10.1016/0092-8674(94)90055-8 Gu, 2010, Redox reactions induced by nitrosative stress mediate protein misfolding and mitochondrial dysfunction in neurodegenerative diseases, Mol. Neurobiol., 41, 55, 10.1007/s12035-010-8113-9 Guerra, 2001, Cyclophosphamide-induced immunosuppression protects cardiac noradrenergic nerve terminals from damage by Trypanosoma cruzi infection in adult rats, Trans. R. Soc. Trop. Med. Hyg., 95, 505, 10.1016/S0035-9203(01)90021-5 Gutierrez, 2009, Molecular characterization and intracellular distribution of the alpha 5 subunit of Trypanosoma cruzi 20S proteasome, Parasitol. Int., 58, 367, 10.1016/j.parint.2009.07.012 Gutierrez, 2009, The effects of nitric oxide on the immune system during Trypanosoma cruzi infection, Mem. Inst. Oswaldo Cruz, 104, 236, 10.1590/S0074-02762009000900030 Ha, 2008, ERK mediates activity dependent neuronal complexity via sustained activity and CREB-mediated signaling, Dev. Neurobiol., 68, 1565, 10.1002/dneu.20682 Hagger, 2000, A deficiency of interstitial cells of Cajal in Chagasic megacolon, J. Auton. Nerv. Syst., 80, 108, 10.1016/S0165-1838(00)00076-X Haolla, 2009, Strain-specific protective immunity following vaccination against experimental Trypanosoma cruzi infection, Vaccine, 27, 5644, 10.1016/j.vaccine.2009.07.013 Hashimoto, 2005, Trypanosoma cruzi posttranscriptionally up-regulates and exploits cellular FLIP for inhibition of death-inducing signal, Mol. Biol. Cell, 16, 3521, 10.1091/mbc.E04-12-1051 Herbella, 2008, Treatment of achalasia: lessons learned with Chagas’ disease, Dis. Esophagus, 21, 461, 10.1111/j.1442-2050.2008.00811.x Hernandez, 2003, Human chagasic IgGs bind to cardiac muscarinic receptors and impair L-type Ca2+ currents, Cardiovasc. Res., 58, 55, 10.1016/S0008-6363(02)00811-8 Hoff, 1978, Trypanosoma cruzi in the cerebrospinal fluid during the acute stage of Chagas’ disease, N. Engl. J. Med., 298, 604, 10.1056/NEJM197803162981106 Howlett, 2009, Cytokine signalling via gp130 in gastric cancer, Biochim. Biophys. Acta, 1793, 1623, 10.1016/j.bbamcr.2009.07.009 Huang, 2001, Neurotrophins: roles in neuronal development and function, Annu. Rev. Neurosci., 24, 677, 10.1146/annurev.neuro.24.1.677 Iantorno, 2007, The enteric nervous system in chagasic and idiopathic megacolon, Am. J. Surg. Pathol., 31, 460, 10.1097/01.pas.0000213371.79300.a8 Imai, 2005, Microarray analysis of host gene-expression during intracellular nests formation of Trypanosoma cruzi amastigotes, Microbiol. Immunol., 49, 623, 10.1111/j.1348-0421.2005.tb03654.x Iosa, 1989, Plasma norepinephrine in Chagas’ cardioneuromyopathy: a marker of progressive dysautonomia, Am. Heart J., 117, 882, 10.1016/0002-8703(89)90627-3 James, 2005, Postmortem studies of the intertruncal plexus and cardiac conduction system from patients with Chagas disease who died suddenly, Prog. Cardiovasc. Dis., 47, 258, 10.1016/j.pcad.2005.01.003 Johnson, 2008, Nerve repair: experimental and clinical evaluation of neurotrophic factors in peripheral nerve regeneration, Injury, 39, S37, 10.1016/j.injury.2008.06.015 Junqueira, 2002, Impaired autonomic control of heart interval changes to Valsalva manoeuvre in Chagas’ disease without overt manifestation, Auton. Neurosci., 97, 59, 10.1016/S1566-0702(02)00014-0 Knott, 2009, Nitric oxide in health and disease of the nervous system, Antioxid. Redox Signal., 11, 541, 10.1089/ars.2008.2234 Koberle, 1968, Chagas’ disease and Chagas’ syndromes: the pathology of American trypanosomiasis, Adv. Parasitol., 6, 63, 10.1016/S0065-308X(08)60472-8 Koberle, 1970, The causation and importance of nervous lesions in American trypanosomiasis, Bull. World Health Organ., 42, 739 Koeberle, 1963, Enteromegaly and cardiomegaly in chagas disease, Gut, 4, 399, 10.1136/gut.4.4.399 Koon, 2006, Immunomodulatory properties of substance P: the gastrointestinal system as a model, Ann. N. Y. Acad. Sci., 1088, 23, 10.1196/annals.1366.024 Lai, 1996, Structural determinants of Trk receptor specificities using BDNF-based neurotrophin chimeras, J. Neurosci. Res., 46, 618, 10.1002/(SICI)1097-4547(19961201)46:5<618::AID-JNR10>3.0.CO;2-T Laranjeira, 2009, Enteric nervous system development: recent progress and future challenges, Auton. Neurosci., 151, 61, 10.1016/j.autneu.2009.09.001 Lenzi, 1996, Trypanosoma cruzi: paninfectivity of CL strain during murine acute infection, Exp. Parasitol., 84, 16, 10.1006/expr.1996.0086 Leon, 2003, The significance of autoimmunity in the pathogenesis of Chagas heart disease, Front. Biosci., 8, e315, 10.2741/1023 Letai, 2006, Growth factor withdrawal and apoptosis: the middle game, Mol. Cell, 21, 728, 10.1016/j.molcel.2006.03.005 Lo Presti, 2009, Involvement of the beta-adrenergic system in the cardiac chronic form of experimental Trypanosoma cruzi infection, Parasitology, 136, 905, 10.1017/S0031182009006337 Lo, 2008, Ventricular arrhythmias in heart failure patients, Cardiol. Clin., 26, 381, 10.1016/j.ccl.2008.03.009 Long, 1980, The peptidergic system in Chagas's disease, Trans. R. Soc. Trop. Med. Hyg., 74, 273 Losavio, 1989, A sequential study of the peripheral nervous system involvement in experimental Chagas’ disease, Am. J. Trop. Med. Hyg., 41, 539, 10.4269/ajtmh.1989.41.539 Losavio, 1993, Functional changes of the sciatic nerve in mice chronically infected with Trypanosoma cruzi, Medicina (B Aires), 53, 129 Lu, 2008, Human autoantibodies specific for neurotrophin receptors TrkA, TrkB, and TrkC protect against lethal Trypanosoma cruzi infection in mice, Am. J. Pathol., 173, 1406, 10.2353/ajpath.2008.080514 Lu, 2008, Auto-antibodies to receptor tyrosine kinases TrkA, TrkB and TrkC in patients with chronic Chagas’ disease, Scand. J. Immunol., 67, 603, 10.1111/j.1365-3083.2008.02102.x Luther, 2009, Neurotrophins and target interactions in the development and regulation of sympathetic neuron electrical and synaptic properties, Auton. Neurosci., 151, 46, 10.1016/j.autneu.2009.08.009 Machado, 1989, Experimental American trypanomiasis in rats: sympathetic denervation, parasitism and inflammatory process, Mem. Inst. Oswaldo Cruz, 84, 549, 10.1590/S0074-02761989000400013 Machado, 1979, Trypanosoma cruzi: acetylcholine content and cholinergic innervation of the heart in rats, Exp. Parasitol., 47, 107, 10.1016/0014-4894(79)90012-2 Machado, 1987, Changes in choline acetyltransferase activity of rat tissues during Chagas’ disease, Braz. J. Med. Biol. Res., 20, 697 Machado, 1994, Trypanosoma cruzi infection in rats induced early lesion of the heart noradrenergic nerve terminals by a complement-independent mechanism, J. Neural Transm. Gen. Sect., 97, 149, 10.1007/BF01277950 Machado, 1998, Heart autonomic innervation during the acute phase of experimental American trypanosomiasis in the dog, Am. J. Trop. Med. Hyg., 59, 492, 10.4269/ajtmh.1998.59.492 Machado, 2001, Morphometry of submucous and myenteric esophagic plexus of dogs experimentally reinfected with Trypanosoma cruzi, Mem. Inst. Oswaldo Cruz, 96, 545, 10.1590/S0074-02762001000400017 Madison, 1994, Point sources of Schwann cells result in growth into a nerve entubulation repair site in the absence of axons: effects of freeze-thawing, Exp. Neurol., 128, 266, 10.1006/exnr.1994.1136 Mady, 1994, Survival and predictors of survival in patients with congestive heart failure due to Chagas’ cardiomyopathy, Circulation, 90, 3098, 10.1161/01.CIR.90.6.3098 Maifrino, 1999, Vasoactive-intestinal-peptide- and substance-P-immunoreactive nerve fibres in the myenteric plexus of mouse colon during the chronic phase of Trypanosoma cruzi infection, Ann. Trop. Med. Parasitol., 93, 49, 10.1080/00034989958799 Maifrino, 1999, Morphometry and acetylcholinesterase activity of the myenteric neurons of the mouse colon in the chronic phase of experimental Trypanosoma cruzi infection, Am. J. Trop. Med. Hyg., 60, 721, 10.4269/ajtmh.1999.60.721 Manning, 2007, AKT/PKB signaling: navigating downstream, Cell, 129, 1261, 10.1016/j.cell.2007.06.009 Manning-Cela, 2001, LYT1 protein is required for efficient in vitro infection by Trypanosoma cruzi, Infect. Immun., 69, 3916, 10.1128/IAI.69.6.3916-3923.2001 Margolis, 2009, Neuropeptides and inflammatory bowel disease, Curr. Opin. Gastroenterol., 25, 503, 10.1097/MOG.0b013e328331b69e Marin-Neto, 1998, Cardiac dysautonomia and pathogenesis of Chagas’ heart disease, Int. J. Cardiol., 66, 129 Marin-Neto, 2007, Pathogenesis of chronic Chagas heart disease, Circulation, 115, 1109, 10.1161/CIRCULATIONAHA.106.624296 Martinelli, 2006, Cardiac NGF and GDNF expression during Trypanosoma cruzi infection in rats, Auton. Neurosci., 130, 32, 10.1016/j.autneu.2006.05.004 Matsuda, 1995, Effect of isosorbide dinitrate on gastroesophageal reflux in healthy volunteers and patients with Chagas’ disease, Dig. Dis. Sci., 40, 177, 10.1007/BF02063962 Matsuda, 2009, The chronic gastrointestinal manifestations of Chagas disease, Clinics (Sao Paulo), 64, 1219, 10.1590/S1807-59322009001200013 Maurer, 2006, Glycogen synthase kinase-3 regulates mitochondrial outer membrane permeabilization and apoptosis by destabilization of MCL-1, Mol. Cell, 21, 749, 10.1016/j.molcel.2006.02.009 Melo, 1998, Depletion of radiosensitive leukocytes exacerbates the heart sympathetic denervation and parasitism in experimental Chagas’ disease in rats, J. Neuroimmunol., 84, 151, 10.1016/S0165-5728(97)00248-8 Melo, 2001, Trypanosoma cruzi: peripheral blood monocytes and heart macrophages in the resistance to acute experimental infection in rats, Exp. Parasitol., 97, 15, 10.1006/expr.2000.4576 Meneghelli, 2004, Chagasic enteropathy, Rev. Soc. Bras. Med. Trop., 37, 252, 10.1590/S0037-86822004000300012 Meyer, 1982, On the cultivation of Trypanosoma cruzi in tissue cultures of the spinal and sympathetic ganglion from the chick embryo, An Acad. Bras. Cienc., 54, 739 Meyer, 1992, Enhanced synthesis of brain-derived neurotrophic factor in the lesioned peripheral nerve: different mechanisms are responsible for the regulation of BDNF and NGF mRNA, J. Cell Biol., 119, 45, 10.1083/jcb.119.1.45 Ming, 1993, Mediation of Trypanosoma cruzi invasion by sialic acid on the host cell and trans-sialidase on the trypanosome, Mol. Biochem. Parasitol., 59, 243, 10.1016/0166-6851(93)90222-J Mizuno, 2008, Interferon-gamma directly induces neurotoxicity through a neuron specific, calcium-permeable complex of IFN-gamma receptor and AMPA GluR1 receptor, FASEB J., 22, 1797, 10.1096/fj.07-099499 Molina, 1987, The neuromuscular pathology of experimental Chagas’ disease, J. Neurol. Sci., 81, 287, 10.1016/0022-510X(87)90104-3 Mucci, 2006, The trans-sialidase from Trypanosoma cruzi triggers apoptosis by target cell sialylation, Cell. Microbiol., 8, 1086, 10.1111/j.1462-5822.2006.00689.x Mukherjee, 2003, Role of vasoactive mediators in the pathogenesis of Chagas’ disease, Front. Biosci., 8, e410, 10.2741/1103 Mukherjee, 2004, Trypanosoma cruzi infection activates extracellular signal-regulated kinase in cultured endothelial and smooth muscle cells, Infect. Immun., 72, 5274, 10.1128/IAI.72.9.5274-5282.2004 Mukherjee, 2008, Alterations in myocardial gene expression associated with experimental Trypanosoma cruzi infection, Genomics, 91, 423, 10.1016/j.ygeno.2008.01.008 Murata, 2008, Interaction between cFLIP and Itch, a ubiquitin ligase, is obstructed in Trypanosoma cruzi-infected human cells, Microbiol. Immunol., 52, 539, 10.1111/j.1348-0421.2008.00073.x Nagata, 2010, Studies of the structure–activity relationships of peptides and proteins involved in growth and development based on their three-dimensional structures, Biosci. Biotechnol. Biochem., 74, 462, 10.1271/bbb.90678 Nascimento, 2010, Characterization of enteroglial cells and denervation process in chagasic patients with and without megaesophagus, Hum. Pathol., 41, 528, 10.1016/j.humpath.2009.05.018 Navarro, 2007, Neural plasticity after peripheral nerve injury and regeneration, Prog. Neurobiol., 82, 163, 10.1016/j.pneurobio.2007.06.005 O'Connell, 2000, TrkA amino acids controlling specificity for nerve growth factor, J. Biol. Chem., 275, 7870, 10.1074/jbc.275.11.7870 Oliveira, 1985, A natural human model of intrinsic heart nervous system denervation: Chagas’ cardiopathy, Am. Heart J., 110, 1092, 10.1016/0002-8703(85)90222-4 Oliveira, 2009, Neuropathy of gastrointestinal Chagas’ disease: immune response to myelin antigens, Neuroimmunomodulation, 16, 54, 10.1159/000179667 Olshansky, 2008, Parasympathetic nervous system and heart failure: pathophysiology and potential implications for therapy, Circulation, 118, 863, 10.1161/CIRCULATIONAHA.107.760405 Parodi, 1992, Identification of the gene(s) coding for the trans-sialidase of Trypanosoma cruzi, EMBO J., 11, 1705, 10.1002/j.1460-2075.1992.tb05221.x Peraza-Cruces, 2008, Trypanosoma cruzi infection induces up-regulation of cardiac muscarinic acetylcholine receptors in vivo and in vitro, Braz. J. Med. Biol. Res., 41, 796, 10.1590/S0100-879X2008000900009 Pereira, 1983, A developmentally regulated neuraminidase activity in Trypanosoma cruzi, Science, 219, 1444, 10.1126/science.6338592 Perez-Fuentes, 1998, Humoral nitric oxide levels and antibody immune response of symptomatic and indeterminate Chagas’ disease patients to commercial and autochthonous Trypanosoma cruzi antigen, Am. J. Trop. Med. Hyg., 58, 715, 10.4269/ajtmh.1998.58.715 Petersen, 2006, Trypanosoma cruzi infection and nuclear factor kappa B activation prevent apoptosis in cardiac cells, Infect. Immun., 74, 1580, 10.1128/IAI.74.3.1580-1587.2006 Pinto, 2002, Immune response, nitric oxide, autonomic dysfunction and stroke: a puzzling linkage on Trypanosoma cruzi infection, Med. Hypotheses, 58, 374, 10.1054/mehy.2001.1401 Pittella, 1993, Central nervous system involvement in Chagas’ disease. An updating, Rev. Inst. Med. Trop. Sao Paulo, 35, 111, 10.1590/S0036-46651993000200001 Punukollu, 2007, Clinical aspects of the Chagas’ heart disease, Int. J. Cardiol., 115, 279, 10.1016/j.ijcard.2006.03.004 Rassi, 2000, Chagas' heart disease, Clin. Cardiol., 23, 883, 10.1002/clc.4960231205 Ratier, 2008, Relevance of the diversity among members of the Trypanosoma cruzi trans-sialidase family analyzed with camelids single-domain antibodies, PLoS One, 3, e3524, 10.1371/journal.pone.0003524 Ribeiro, 1998, Effect of Chagas’ disease on nitric oxide-containing neurons in severely affected and unaffected intestine, Dis. Colon Rectum, 41, 1411, 10.1007/BF02237058 Ribeiro, 2001, Parasympathetic dysautonomia precedes left ventricular systolic dysfunction in Chagas disease, Am. Heart J., 141, 260, 10.1067/mhj.2001.111406 Ribeiro, 2005, Vagal dysfunction in Chagas disease, Int. J. Cardiol., 103, 225, 10.1016/j.ijcard.2004.11.007 Rocha, 2006, Characterization of cardiopulmonary function and cardiac muscarinic and adrenergic receptor density adaptation in C57BL/6 mice with chronic Trypanosoma cruzi infection, Parasitology, 133, 729, 10.1017/S0031182006001193 Rodrigues, 2002, Cardiac denervation in mice infected with Trypanosoma cruzi, Ann. Trop. Med. Parasitol., 96, 125, 10.1179/000349802125000583 Roux, 2002, Neurotrophin signaling through the p75 neurotrophin receptor, Prog. Neurobiol., 67, 203, 10.1016/S0301-0082(02)00016-3 Rubin-de-Celis, 2006, Expression of trypomastigote trans-sialidase in metacyclic forms of Trypanosoma cruzi increases parasite escape from its parasitophorous vacuole, Cell. Microbiol., 8, 1888, 10.1111/j.1462-5822.2006.00755.x Ruhl, 2006, Glial regulation of neuronal plasticity in the gut: implications for clinicians, Gut, 55, 600, 10.1136/gut.2005.084426 Saavedra, 1999, The Trypanosoma cruzi trans-sialidase, through its COOH-terminal tandem repeat, upregulates interleukin 6 secretion in normal human intestinal microvascular endothelial cells and peripheral blood mononuclear cells, J. Exp. Med., 190, 1825, 10.1084/jem.190.12.1825 Sahenk, 2010, TrkB and TrkC agonist antibodies improve function, electrophysiologic and pathologic features in Trembler J mice, Exp. Neurol., 224, 495, 10.1016/j.expneurol.2010.05.013 Sakamoto, 2009, CREB in the pathophysiology of cancer: implications for targeting transcription factors for cancer therapy, Clin. Cancer Res., 15, 2583, 10.1158/1078-0432.CCR-08-1137 Schenkman, 1992, Trypanosoma cruzi trans-sialidase and neuraminidase activities can be mediated by the same enzymes, J. Exp. Med., 175, 567, 10.1084/jem.175.2.567 Scudder, 1993, Enzymatic characterization of beta-d-galactoside alpha 2,3-trans-sialidase from Trypanosoma cruzi, J. Biol. Chem., 268, 9886, 10.1016/S0021-9258(18)98428-0 Seeburg, 2005, Polo-like kinases in the nervous system, Oncogene, 24, 292, 10.1038/sj.onc.1208277 Segal, 2003, Selectivity in neurotrophin signaling: theme and variations, Annu. Rev. Neurosci., 26, 299, 10.1146/annurev.neuro.26.041002.131421 Shen, 2006, TNF receptor superfamily-induced cell death: redox-dependent execution, FASEB J., 20, 1589, 10.1096/fj.05-5603rev Sheu, 2000, Differential patterns of ERK and STAT3 phosphorylation after sciatic nerve transection in the rat, Exp. Neurol., 166, 392, 10.1006/exnr.2000.7508 Silva, 2003, The role of nitric oxide in the pathogenesis of Chagas disease, Front. Biosci., 8, s314, 10.2741/1012 Silveira, 2008, Novel protective antigens expressed by Trypanosoma cruzi amastigotes provide immunity to mice highly susceptible to Chagas’ disease, Clin. Vaccine Immunol., 15, 1292, 10.1128/CVI.00142-08 Simeonidis, 2003, Regulation of the NK-1 receptor gene expression in human macrophage cells via an NF-kappa B site on its promoter, Proc. Natl. Acad. Sci. USA, 100, 2957, 10.1073/pnas.0530112100 Simoes, 2000, Relation of regional sympathetic denervation and myocardial perfusion disturbance to wall motion impairment in Chagas’ cardiomyopathy, Am. J. Cardiol., 86, 975, 10.1016/S0002-9149(00)01133-4 Skoff, 1998, TNF-alpha and TGF-beta act synergistically to kill Schwann cells, J. Neurosci. Res., 53, 747, 10.1002/(SICI)1097-4547(19980915)53:6<747::AID-JNR12>3.0.CO;2-V Soares, 1999, Immunopathology of cardiomyopathy in the experimental Chagas disease, Mem. Inst. Oswaldo Cruz, 94, 257, 10.1590/S0074-02761999000700043 Sofroniew, 2001, Nerve growth factor signaling, neuroprotection, and neural repair, Annu. Rev. Neurosci., 24, 1217, 10.1146/annurev.neuro.24.1.1217 Sterin-Borda, 2000, Role of neurotransmitter autoantibodies in the pathogenesis of chagasic peripheral dysautonomia, Ann. N. Y. Acad. Sci., 917, 273, 10.1111/j.1749-6632.2000.tb05393.x Sterin-Borda, 1997, Participation of nitric oxide signaling system in the cardiac muscarinic cholinergic effect of human chagasic IgG, J. Mol. Cell. Cardiol., 29, 1851, 10.1006/jmcc.1997.0424 Tafuri, 1970, On the behavior of the neurosecretory vesicular component of the mega-esophagus in human Trypanosomiasis cruzi, Rev. Inst. Med. Trop. Sao Paulo, 12, 298 Tanowitz, 1982, Infection of organotypic cultures of spinal cord and dorsal root ganglia with Trypanosoma cruzi, Am. J. Trop. Med. Hyg., 31, 1090, 10.4269/ajtmh.1982.31.1090 Tanowitz, 2009, Perspectives on Trypanosoma cruzi-induced heart disease (Chagas disease), Prog. Cardiovasc. Dis., 51, 524, 10.1016/j.pcad.2009.02.001 Tarleton, 2001, Parasite persistence in the aetiology of Chagas disease, Int. J. Parasitol., 31, 550, 10.1016/S0020-7519(01)00158-8 Tekiel, 1997, Chagas’ disease: reactivity against homologous tissues induced by different strains of Trypanosoma cruzi, Parasitology, 115, 495, 10.1017/S0031182097001625 Tekiel, 2001, Changes in the mouse sciatic nerve action potential after epineural injection of sera from Trypanosoma cruzi infected mice, Parasite Immunol., 23, 533, 10.1046/j.1365-3024.2001.00415.x Todeschini, 2004, Enzymatically inactive trans-sialidase from Trypanosoma cruzi binds sialyl and beta-galactopyranosyl residues in a sequential ordered mechanism, J. Biol. Chem., 279, 5323, 10.1074/jbc.M310663200 Tracey, 2007, Physiology and immunology of the cholinergic antiinflammatory pathway, J. Clin. Invest., 117, 289, 10.1172/JCI30555 Tucker, 2001, Neurotrophins are required for nerve growth during development, Nat. Neurosci., 4, 29, 10.1038/82868 Twiss, 2006, Pathophysiological mechanisms for actions of the neurotrophins, Brain Pathol., 16, 320, 10.1111/j.1750-3639.2006.00039.x Urfer, 1995, An immunoglobulin-like domain determines the specificity of neurotrophin receptors, EMBO J., 14, 2795, 10.1002/j.1460-2075.1995.tb07279.x Vaillant, 2002, Signaling mechanisms underlying reversible, activity-dependent dendrite formation, Neuron, 34, 985, 10.1016/S0896-6273(02)00717-1 Van Voorhis, 1991, Molecular mimicry by Trypanosoma cruzi: the F1-160 epitope that mimics mammalian nerve can be mapped to a 12-amino acid peptide, Proc. Natl. Acad. Sci. USA, 88, 5993, 10.1073/pnas.88.14.5993 Vasconcelos, 2009, Distinctive impaired cardiac autonomic modulation of heart rate variability in chronic Chagas’ indeterminate and heart diseases, J. Electrocardiol., 42, 281, 10.1016/j.jelectrocard.2008.10.007 Vawter, 1996, Human olfactory neuroepithelial cells: tyrosine phosphorylation and process extension are increased by the combination of IL-1beta, IL-6, NGF, and bFGF, Exp. Neurol., 142, 179, 10.1006/exnr.1996.0189 Villalta, 1999, Signal transduction in human macrophages by gp83 ligand of Trypanosoma cruzi: trypomastigote gp83 ligand up-regulates trypanosome entry through protein kinase C activation, Mol. Cell Biol. Res. Commun., 2, 64, 10.1006/mcbr.1999.0150 Villar, 2004, Cardiovascular autonomic function testing in asymptomatic T. cruzi carriers: a sensitive method to identify subclinical Chagas’ disease, Int. J. Cardiol., 93, 189, 10.1016/j.ijcard.2003.03.002 Vo, 1999, The regeneration of peripheral noradrenergic nerves after chemical sympathectomy in diabetic rats: effects of nerve growth factor, Exp. Neurol., 157, 127, 10.1006/exnr.1999.7018 von Boyen, 2006, Proinflammatory cytokines induce neurotrophic factor expression in enteric glia: a key to the regulation of epithelial apoptosis in Crohn's disease, Inflamm. Bowel Dis., 12, 346, 10.1097/01.MIB.0000219350.72483.44 Vyas, 2002, Molecular mechanisms of neuronal cell death: implications for nuclear factors responding to cAMP and phorbol esters, Mol. Cell. Neurosci., 21, 1, 10.1006/mcne.2002.1170 Weinkauf, 2009, Trypanosoma cruzi promotes neuronal and glial cell survival through the neurotrophic receptor TrkC, Infect. Immun., 77, 1368, 10.1128/IAI.01450-08 Wen, 2006, Increased oxidative stress is correlated with mitochondrial dysfunction in chagasic patients, Free Radic. Biol. Med., 41, 270, 10.1016/j.freeradbiomed.2006.04.009 Wiesmann, 1999, Crystal structure of nerve growth factor in complex with the ligand-binding domain of the TrkA receptor, Nature, 401, 184, 10.1038/43705 Wong, 1997, Hepatocyte growth factor promotes motor neuron survival and synergizes with ciliary neurotrophic factor, J. Biol. Chem., 272, 5187, 10.1074/jbc.272.8.5187 Woronowicz, 2004, Trypanosome trans-sialidase targets TrkA tyrosine kinase receptor and induces receptor internalization and activation, Glycobiology, 14, 987, 10.1093/glycob/cwh123 Woronowicz, 2007, Trypanosome trans-sialidase mediates neuroprotection against oxidative stress, serum/glucose deprivation, and hypoxia-induced neurite retraction in Trk-expressing PC12 cells, Glycobiology, 17, 725, 10.1093/glycob/cwm034 Yaffe, 2001, Phosphoserine/threonine-binding domains, Curr. Opin. Cell Biol., 13, 131, 10.1016/S0955-0674(00)00189-7 Yuan, 2000, Apoptosis in the nervous system, Nature, 407, 802, 10.1038/35037739 Yuan, 2002, Inhibition of JNK by cellular stress- and tumor necrosis factor alpha-induced AKT2 through activation of the NF kappa B pathway in human epithelial cells, J. Biol. Chem., 277, 29973, 10.1074/jbc.M203636200 Zhang, 1999, Parasite persistence correlates with disease severity and localization in chronic Chagas’ disease, J. Infect. Dis., 180, 480, 10.1086/314889 Zheng, 2000, Guidance of regenerating motor axons in vivo by gradients of diffusible peripheral nerve-derived factors, J. Neurobiol., 42, 212, 10.1002/(SICI)1097-4695(20000205)42:2<212::AID-NEU5>3.0.CO;2-C Zheng, 2002, FKHRL1 and its homologs are new targets of nerve growth factor Trk receptor signaling, J. Neurochem., 80, 1049, 10.1046/j.0022-3042.2002.00783.x Zhou, 2004, NGF-induced axon growth is mediated by localized inactivation of GSK-3beta and functions of the microtubule plus end binding protein APC, Neuron, 42, 897, 10.1016/j.neuron.2004.05.011