Neurocognition as a predictor of transition to psychotic disorder and functional outcomes in ultra-high risk participants: Findings from the NEURAPRO randomized clinical trial

Addington, 2011, At clinical high risk for psychosis: outcome for non-converters, Am. J. Psychiatr., 168, 800, 10.1176/appi.ajp.2011.10081191 Addington, 2017, The role of cognition and social functioning as predictors in the transition to psychosis for youth with attenuated psychotic symptoms, Schizophr. Bull., 43, 57, 10.1093/schbul/sbw152 Allen, 2015, Functional outcome in people at high risk for psychosis predicted by thalamic glutamate levels and prefronto-striatal activation, Schizophr. Bull., 41, 429, 10.1093/schbul/sbu115 Amminger, 2015, Predictors of treatment response in young people at ultra-high risk for psychosis who received long-chain omega-3 fatty acids, Transl. Psychiatry, 5, 1, 10.1038/tp.2014.134 Andreasen, 1982, Negative symptoms in schizophrenia, Arch. Gen. Psychiatry, 39, 784, 10.1001/archpsyc.1982.04290070020005 Armstrong, 2014, When to use the Bonferroni correction, Ophthalmic Physiol. Opt., 34, 502, 10.1111/opo.12131 Blanchard, 2010, Language, motor and speed of processing deficits in adolescents with subclinical psychotic symptoms, Schizophr. Res., 123, 71, 10.1016/j.schres.2010.05.028 Bousman, 2013, Effects of NRG1 and DAOA genetic variation on transition to psychosis in individuals at ultra-high risk for psychosis, Transl. Psychiatry, 3, 251, 10.1038/tp.2013.23 Brewer, 2006, Generalized and specific cognitive performance in clinical high-risk cohorts: a review highlighting potential vulnerability markers for psychosis, Schizophr. Bull., 32, 538, 10.1093/schbul/sbj077 Cannon, 2002, Evidence for early-childhood, pan-developmental impairment specific to schizophreniform disorder: results from a longitudinal birth cohort, Arch. Gen. Psychiatry, 59, 449, 10.1001/archpsyc.59.5.449 Cannon, 2006, Neuropsychological performance at the age of 13 years and adult schizophreniform disorder, Br. J. Psychiatry, 189, 463, 10.1192/bjp.bp.105.020552 Cannon, 2016, An individualized rick calculator for research in prodromal psychosis, Am. J. Psychiatr., 173, 90, 10.1176/appi.ajp.2016.15070890 Carrión, 2013, Prediction of functional outcome in individuals at clinical high risk for psychosis, JAMA Psychiat., 70, 1133, 10.1001/jamapsychiatry.2013.1909 Carrión, 2016, Personalized prediction of psychosis: external validation of the NAPLS2 psychosis risk calculator with the EDIPPP project, Am. J. Psychiatr., 173, 989, 10.1176/appi.ajp.2016.15121565 Cornblatt, 2007, Preliminary findings for two new measures of social and role functioning in the prodromal phase of schizophrenia, Schizophr. Bull., 33, 688, 10.1093/schbul/sbm029 Cornblatt, 2017, Psychosis prevention: a modified clinical high risk perspective from the recognition and prevention (RAP) program, Am. J. Psychiatr., 172, 986, 10.1176/appi.ajp.2015.13121686 Cotter, 2014, What drives poor functioning in the at-risk mental state? A systematic review, Schizophr. Res., 159, 267, 10.1016/j.schres.2014.09.012 Cotter, 2017, Examining the association between social cognition and functioning in individuals at ultra-high risk for psychosis, Aust. N. Z. J. Psychiatry, 51, 83, 10.1177/0004867415622691 Dickson, 2012, Meta-analyses of cognitive and motor function in youth aged 16 years and younger who subsequently develop schizophrenia, Psychol. Med., 42, 743, 10.1017/S0033291711001693 Erlenmeyer-Kimling, 2000, Attention, memory, and motor skills as childhood predictors of schizophrenia-related psychoses: the New York high-risk project, Am. J. Psychiatr., 157, 1416, 10.1176/appi.ajp.157.9.1416 Eslami, 2011, Disorganized symptoms and executive functioning predict impaired social functioning in subjects at risk for psychosis, J. Neuropsychiatry Clin. Neurosci., 23, 457, 10.1176/jnp.23.4.jnp457 Fett, 2011, The relationship between neurocognition and social cognition with functional outcomes in schizophrenia: a meta-analysis, Neurosci. Biobehav. Rev., 35, 573, 10.1016/j.neubiorev.2010.07.001 Fusar-Poli, 2012, Predicting psychosis: meta-analysis of transition outcomes in individuals at clinical high risk, Arch. Gen. Psychiatry, 69, 220, 10.1001/archgenpsychiatry.2011.1472 Fusar-Poli, 2012, Cogntive functioning in prodromal psychosis: a meta-analysis, Arch. Gen. Psychiatry, 69, 562, 10.1001/archgenpsychiatry.2011.1592 Giuliano, 2012, Neurocognition in the psychosis risk syndrome: a quantitative and qualitative review, Curr. Pharm. Des., 18, 399, 10.2174/138161212799316019 Glenthøj, 2016, Social cognition in patients at ultra-high risk for psychosis: what is the relation to social skills and functioning?, Schizophr. Res. Cogn., 5, 21, 10.1016/j.scog.2016.06.004 Goghari, 2014, Spatial working memory ability in individuals at ultra high risk for psychosis, J. Psychiatr. Res., 50, 100, 10.1016/j.jpsychires.2013.12.010 Goldman, 1992, Revising axis v for DSM-IV: a review of measures of social functioning, Am. J. Psychiatr., 149, 1148, 10.1176/ajp.149.9.1148 Hair, 1995 Hauser, 2017, Neuropsychological test performance to enhance identification of subjects at clinical high risk for psychosis and to be most promising for predictive algorithms for conversion to psychosis: a meta-analysis, J. Clin. Psychiatry, 78, 28, 10.4088/JCP.15r10197 Keefe, 2004, The brief assessment of cognition in schizophrenia: reliability, sensitivity, and comparison with a standard neurocognitive battery, Schizophr. Res., 68, 283, 10.1016/j.schres.2003.09.011 Keefe, 2008, Norms and standardization of the brief assessment of cognition in schizophrenia (BACS), Schizophr. Res., 102, 108, 10.1016/j.schres.2008.03.024 Lichtenberger, 2012 Lin, 2011, Neurocognitive predictors of functional outcome two to 13 years after identification as ultra-high risk for psychosis, Schizophr. Res., 132, 1, 10.1016/j.schres.2011.06.014 Mam-Lam-Fook, 2017, Neuropsychology of subjects with ultra-high risk (UHR) of psychosis: a critical analysis of the literature, L'Encéphale, 43, 241, 10.1016/j.encep.2017.02.001 Mancuso, 2011, Social cognition in psychosis: multidimensional structure, clinical correlates, and relationship with functional outcome, Schizophr. Res., 125, 143, 10.1016/j.schres.2010.11.007 Markulev, 2015, NEURAPRO-E study protocol: a multicentre randomized controlled trial of omega-3 fatty acids and cognitive-behavioural case management for patients at ultra high risk of schizophrenia and other psychotic disorders, Early Interv. Psychiatry, 11, 418, 10.1111/eip.12260 McDonald, 2018, Using online screening in the general population to detect participants at clinical high-risk for psychosis, Schizophr. Bull., sby069 McGorry, 2017, Effect of ω-3 polyunsaturated fatty acids in young people at ultrahigh risk for psychotic disorders: the NEURAPRO randomised clinical trial, JAMA Psychiatry, 74, 19, 10.1001/jamapsychiatry.2016.2902 Mesholam-Gately, 2009, Neurocognition in first-episode schizophrenia: a meta-analytic review, Neuropsychology, 23, 315, 10.1037/a0014708 Meyer, 2014, The relationship of neurocognition and negative symptoms to social and role functioning over time in individuals at clinical high risk in the first phase of the North American prodrome longitudinal study, Schizophr. Bull., 40, 1452, 10.1093/schbul/sbt235 Mittal, 2007, Movement abnormalities predict conversion to Axis I psychosis among prodromal adolescents, J. Abnorm. Psychol., 116, 796, 10.1037/0021-843X.116.4.796 Mollon, 2018, Course of cognitive development from infancy to early adulthood in the psychosis spectrum, JAMA Psychiat., 75, 270, 10.1001/jamapsychiatry.2017.4327 Morrison, 2012, Early detection and intervention evaluation for people at risk of psychosis: multisite randomised controlled trial, BMJ, 5, 24 Nelson, 2013, Long-term follow-up of a group at ultra high risk ("prodromal") for psychosis: the PACE 400 study, JAMA Psychiat., 70, 793, 10.1001/jamapsychiatry.2013.1270 Nelson, 2018, NEURAPRO: a multi-centre RCT of omega-3 polyunsaturated fatty acids versus placebo in young people at ultra-high risk of psychotic disorders – medium term follow up and clinical course, NPJ Schizophr., 4, 10.1038/s41537-018-0052-x Niendam, 2009, Exploring predictors of outcome in the psychosis prodrome: implications for early identification and intervention, Neuropsychol. Rev., 19, 280, 10.1007/s11065-009-9108-z Overall, 1962, The brief psychiatric rating scale, Psychol. Rep., 10, 799, 10.2466/pr0.1962.10.3.799 de Paula, 2015, Cognition in at-risk mental states for psychosis, Neurosci. Biobehav. Rev., 57, 199, 10.1016/j.neubiorev.2015.09.006 Perneger, 1998, What's wrong with Bonferroni adjustments, BMJ, 316, 1236, 10.1136/bmj.316.7139.1236 Rakhshan, 2016, Childhood pegboard task predicts adult-onset psychosis-spectrum disorder among a genetic high-risk sample, Schizophr. Res., 178, 68, 10.1016/j.schres.2016.08.017 Rapado-Castro, 2015, Sources of clinical distress in young people at ultra high risk of psychosis, Schizophr. Res., 165, 15, 10.1016/j.schres.2015.03.022 Reilly, 2014, Generalized and specific neurocognitive deficits in psychotic disorders: utility for evaluating pharmacological treatment effects and as intermediate phenotypes for gene discovery, Schizophr. Bull., 40, 516, 10.1093/schbul/sbu013 Sawada, 2017, Identifying neurocognitive markers for outcome prediction of global functioning in individuals with first-episode and ultra-high-risk for psychosis, Psychiatry Clin. Neurosci., 71, 318, 10.1111/pcn.12522 Seidman, 2010, Neuropsychology of the prodrome to psychosis in the NAPLS consortium: relationship to family history and conversion to psychosis, Arch. Gen. Psychiatry, 67, 578, 10.1001/archgenpsychiatry.2010.66 Seidman, 2016, Association of neurocognition with transition to psychosis: baseline functioning in the second phase of the North American prodrome longitudinal study, JAMA Psychiat., 73, 1239, 10.1001/jamapsychiatry.2016.2479 Seligman, 2001 Sommer, 2016, Early interventions in risk groups for schizophrenia: what are we waiting for?, NPJ Schizophr., 2, 10.1038/npjschz.2016.3 Tabachnick, 2013 Wechsler, 1997 Yung, 2003, Psychosis prediction: 12-month follow up of a high-risk ("prodromal") group, Schizophr. Res., 60, 21, 10.1016/S0920-9964(02)00167-6 Yung, 2004, Risk factors for psychosis in an ultra high-risk group: psychopathology and clinical features, Schizophr. Res., 67, 131, 10.1016/S0920-9964(03)00192-0 Yung, 2005, Mapping the onset of psychosis: the comprehensive assessment of at-risk mental states, Aust. N. Z. J. Psychiatry, 39, 964, 10.1080/j.1440-1614.2005.01714.x Yung, 2007, Declining transition rate in ultra high risk (prodromal) services: dilution or reduction of risk?, Schizophr. Bull., 33, 673, 10.1093/schbul/sbm015