Bằng Chứng Hóa Học Thần Kinh Về Việc Điều Chỉnh Của Agmatine Đối Với Tính Độc Thần Kinh Của 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine (MPTP)

Neurochemical Research - Tập 30 - Trang 713-719 - 2005
Gad M. Gilad1,2, Varda H. Gilad1, John P. M. Finberg3, Jose M. Rabey4
1Department of Physiology and Pharmacology, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
2Department of Life Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel
3Department of Pharmacology, Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel
4Department of Neurology, Assaf Harofeh Medical Center, and Sackler Faculty of Medicine, Tel Aviv University, Zrifin, Israel

Tóm tắt

Việc điều trị bằng agmatine được biết đến là có tác dụng bảo vệ thần kinh trong nhiều mô hình tổn thương não và tủy sống do độc tố và thiếu máu. Trong nghiên cứu này, chúng tôi muốn tìm hiểu liệu điều trị bằng agmatine có được chứng minh là bảo vệ thần kinh trong mô hình bệnh Parkinson chuột MPTP hay không. Việc điều trị đồng thời hàng ngày (tiêm nội tổn) bằng agmatine (100 mg/kg trong 5 ngày) và MPTP (40 mg/kg trong 2 ngày) đã làm tăng cường tính độc tố liên quan đến MPTP, thể hiện qua việc giảm mạnh khả năng hấp thụ dopamine vào các synaptosome ở hạch nền (42,4% so với 58,3% của nhóm đối chứng). Ngược lại, việc điều trị bằng agmatine bắt đầu sau MPTP, đã cung cấp sự bảo vệ một phần (31%) chống lại độc tính dopaminergic của MPTP. Các phát hiện này gợi ý vai trò của agmatine trong các cơ chế điều chỉnh tính độc tế bào thần kinh của MPTP, nhưng cũng nhấn mạnh hiệu quả bảo vệ thần kinh đặc trưng của agmatine khi được áp dụng sau khi bị tổn thương.

Từ khóa

#Agmatine #MPTP #Bệnh Parkinson #Độc tính thần kinh #Dopamine

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