Neuroanatomical Risk Factors for Posttraumatic Stress Disorder in Recent Trauma Survivors

Ziv Ben-Zion1,2, Moran Artzi1,2,3, Dana Niry4,3, Nimrod Jackob Keynan1,5, Yoav Zeevi2,6, Roee Admon7, Haggai Sharon1,8,3,9, Pinchas Halpern10,3, Israel Liberzon11, Arieh Y. Shalev12, Talma Hendler1,2,3,5
1Sagol Brain Institute Tel Aviv, Wohl Institute for Advanced Imaging, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel
2Sagol School of Neuroscience, Tel Aviv University, Tel Aviv, Israel
3Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
4Department of Radiology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel
5School of Psychological Sciences, Faculty of Social Sciences, Tel Aviv University, Tel Aviv, Israel
6Department of Statistics and Operations Research, Tel Aviv University, Tel Aviv, Israel
7Department of Psychology, University of Haifa, Haifa, Israel
8Institute of Pain Medicine, Department of Anesthesiology and Critical Care Medicine, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel
9Pain Management and Neuromodulation Centre, Guy’s and St Thomas’ National Health Service Foundation Trust, London, United Kingdom
10Department of Emergency Medicine, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel
11Department of Psychiatry, Texas A&M Health Science Center, Bryan, Texas
12Department of Psychiatry, New York University Langone Medical Center, New York, New York

Tài liệu tham khảo

Shalev, 2017, Post-traumatic stress disorder, N Engl J Med, 376, 2459, 10.1056/NEJMra1612499 Helpman, 2016, Neural changes in extinction recall following prolonged exposure treatment for PTSD: A longitudinal fMRI study, Neuroimage Clin, 12, 715, 10.1016/j.nicl.2016.10.007 Admon, 2013, A causal model of post-traumatic stress disorder: Disentangling predisposed from acquired neural abnormalities, Trends Cogn Sci, 17, 337, 10.1016/j.tics.2013.05.005 Swartz, 2015, A neural biomarker of psychological vulnerability to future life stress, Neuron, 85, 505, 10.1016/j.neuron.2014.12.055 Galatzer-Levy, 2013, Early PTSD symptom trajectories: Persistence, recovery, and response to treatment: Results from the Jerusalem Trauma Outreach and Prevention Study (J-TOPS), PLoS One, 8, 10.1371/annotation/0af0b6c6-ac23-4fe9-a692-f5c30a3a30b3 Shalev, 2012, Prevention of posttraumatic stress disorder by early treatment: Results from the Jerusalem trauma outreach and prevention study, Arch Gen Psychiatry, 69, 166, 10.1001/archgenpsychiatry.2011.127 Shalev, 2011, Barriers to receiving early care for PTSD: Results from the Jerusalem trauma outreach and prevention study, Psychiatr Serv, 62, 765, 10.1176/ps.62.7.pss6207_0765 Pitman, 2012, Biological studies of post-traumatic stress disorder, Nat Rev Neurosci, 13, 769, 10.1038/nrn3339 Kitayama, 2005, Magnetic resonance imaging (MRI) measurement of hippocampal volume in posttraumatic stress disorder: A meta-analysis, J Affect Disord, 88, 79, 10.1016/j.jad.2005.05.014 Wang, 2010, Magnetic resonance imaging of hippocampal subfields in posttraumatic stress disorder, Arch Gen Psychiatry, 67, 296, 10.1001/archgenpsychiatry.2009.205 Smith, 2005, Bilateral hippocampal volume reduction in adults with post-traumatic stress disorder: A meta-analysis of structural MRI studies, Hippocampus, 15, 798, 10.1002/hipo.20102 Karl, 2006, A meta-analysis of structural brain abnormalities in PTSD, Neurosci Biobehav Rev, 30, 1004, 10.1016/j.neubiorev.2006.03.004 Sapolsky, 1990, Hippocampal damage associated with prolonged glucocorticoid exposure in primates, J Neurosci, 10, 2897, 10.1523/JNEUROSCI.10-09-02897.1990 Gilbertson, 2002, Smaller hippocampal volume predicts pathologic vulnerability to psychological trauma, Nat Neurosci, 5, 1242, 10.1038/nn958 Gurvits, 2006, Subtle neurologic compromise as a vulnerability factor for combat-related posttraumatic stress disorder: Results of a twin study, Arch Gen Psychiatry, 63, 571, 10.1001/archpsyc.63.5.571 Acheson, 2012, Hippocampal dysfunction effects on context memory: Possible etiology for posttraumatic stress disorder, Neuropharmacology, 62, 674, 10.1016/j.neuropharm.2011.04.029 Admon, 2013, Stress-induced reduction in hippocampal volume and connectivity with the ventromedial prefrontal cortex are related to maladaptive responses to stressful military service, Hum Brain Mapp, 34, 2808, 10.1002/hbm.22100 Woon, 2010, Hippocampal volume deficits associated with exposure to psychological trauma and posttraumatic stress disorder in adults: A meta-analysis, Prog Neuropsychopharmacol Biol Psychiatry, 34, 1181, 10.1016/j.pnpbp.2010.06.016 Levy-Gigi, 2013, Association among clinical response, hippocampal volume, and FKBP5 gene expression in individuals with posttraumatic stress disorder receiving cognitive behavioral therapy, Biol Psychiatry, 74, 793, 10.1016/j.biopsych.2013.05.017 Bolsinger, 2018, Neuroimaging correlates of resilience to traumatic events—A comprehensive review, Front Psychiatry, 9, 693, 10.3389/fpsyt.2018.00693 Bodensteiner, 1990, Wide cavum septum pellucidum: A marker of disturbed brain development, Pediatr Neurol, 6, 391, 10.1016/0887-8994(90)90007-N Jurjus, 1993, Cavum septum pellucidum in schizophrenia, affective disorder and healthy controls: A magnetic resonance imaging study, Psychol Med, 23, 319, 10.1017/S0033291700028403 Rakic, 1968, Development of the corpus callosum and cavum septi in man, J Comp Neurol, 132, 45, 10.1002/cne.901320103 Sarwar, 1989, The septum pellucidum: Normal and abnormal, AJNR Am J Neuroradiol, 10, 989 de Souza Crippa, 2006, Cavum septum pellucidum and adhesio interthalamica in schizophrenia: An MRI study, Eur Psychiatry, 21, 291, 10.1016/j.eurpsy.2005.09.010 Takahashi, 2007, Prevalence of large cavum septi pellucidi and its relation to the medial temporal lobe structures in schizophrenia spectrum, Prog Neuropsychopharmacol Biol Psychiatry, 31, 1235, 10.1016/j.pnpbp.2007.04.019 Degreef, 1992, Abnormalities of the septum pellucidum on MR scans in first-episode schizophrenic patients, Am J Neuroradiol, 13, 835 Nopoulos, 1997, Cavum septi pellucidi in normals and patients with schizophrenia as detected by magnetic resonance imaging, Biol Psychiatry, 41, 1102, 10.1016/S0006-3223(96)00209-0 Scott, 1993, Midline cerebral malformations and schizophrenia, J Neuropsychiatry Clin Neurosci, 5, 287, 10.1176/jnp.5.3.287 Shioiri, 1996, Prevalence of cavum septum pellucidum detected by MRI in patients with bipolar disorder, major depression and schizophrenia, Psychol Med, 26, 431, 10.1017/S0033291700034838 DeLisi, 1993, Increased prevalence of cavum septum pellucidum in schizophrenia, Psychiatry Res Neuroimaging, 50, 193, 10.1016/0925-4927(93)90030-L Hagino, 2001, Magnetic resonance imaging study of the cavum septi pellucidi in patients with schizophrenia, Am J Psychiatry, 158, 1717, 10.1176/appi.ajp.158.10.1717 Fukuzako, 1996, Cavum septum pellucidum in schizophrenia: A magnetic resonance imaging study, Psychiatry Clin Neurosci, 50, 125, 10.1111/j.1440-1819.1996.tb01675.x Kwon, 1998, MRI study of cavum septi pellucidi in schizophrenia, affective disorder, and schizotypal personality disorder, Am J Psychiatry, 155, 509, 10.1176/ajp.155.4.509 Nopoulos, 1998, Frequency and severity of enlarged cavum septi pellucidi in childhood- onset schizophrenia, Am J Psychiatry, 155, 1074, 10.1176/ajp.155.8.1074 Rajarethinam, 2001, Prevalence of cavum septum pellucidum in schizophrenia studied with MRI, Schizophr Res, 48, 201, 10.1016/S0920-9964(00)00110-9 Ferrari, 2008, Structural magnetic ressonance imaging in anxiety disorders: An update of research findings, Braz J Psychiatry, 30, 251, 10.1590/S1516-44462008000300013 Kim, 2007, The occurrence of cavum septi pellucidi enlargement is increased in bipolar disorder patients, Bipolar Disord, 9, 274, 10.1111/j.1399-5618.2007.00442.x Beraldi, 2018, Meta-analyses of cavum septum pellucidum in mood disorders in comparison with healthy controls or schizophrenia, Eur Neuropsychopharmacol, 28, 1325, 10.1016/j.euroneuro.2018.10.001 Chun, 2003, Diffusion changes in the aging human brain, AJNR Am J Neuroradiol, 21, 1078 Nopoulos, 2000, Enlarged cavum septi pellucidi in patients with schizophrenia: Clinical and cognitive correlates, J Neuropsychiatry Clin Neurosci, 12, 344, 10.1176/jnp.12.3.344 Flashman, 2007, Cavum septum pellucidum in schizophrenia: Clinical and neuropsychological correlates, Psychiatry Res, 154, 147, 10.1016/j.pscychresns.2006.09.001 Trzesniak, 2011, Are cavum septum pellucidum abnormalities more common in schizophrenia spectrum disorders? A systematic review and meta-analysis, Schizophr Res, 125, 1, 10.1016/j.schres.2010.09.016 Rajarethinam, 2008, No difference in the prevalence of cavum septum pellucidum (CSP) between first-episode schizophrenia patients, offspring of schizophrenia patients and healthy controls, Schizophr Res, 103, 22, 10.1016/j.schres.2007.11.031 Takahashi, 2010, Midline brain abnormalities in established bipolar affective disorder, J Affect Disord, 122, 301, 10.1016/j.jad.2009.09.003 Chon, 2010, MRI study of the cavum septum pellucidum in obsessive–compulsive disorder, Eur Arch Psychiatry Clin Neurosci, 260, 337, 10.1007/s00406-009-0081-6 Takahashi, 2009, Midline brain structures in patients with current and remitted major depression, Prog Neuropsychopharmacol Biol Psychiatry, 33, 1058, 10.1016/j.pnpbp.2009.05.020 Nopoulos, 2000, Developmental brain anomalies in children with attention-deficit hyperactivity disorder, J Child Neurol, 15, 102, 10.1177/088307380001500208 Myslobodsky, 1995, Changes of brain anatomy in patients with posttraumatic stress disorder: A pilot magnetic resonance imaging study, Psychiatry Res, 58, 259, 10.1016/0165-1781(95)02708-5 May, 2004, Cavum septum pellucidum in monozygotic twins discordant for combat exposure: Relationship to posttraumatic stress disorder, Biol Psychiatry, 55, 656, 10.1016/j.biopsych.2003.09.018 Morey, 2009, A comparison of automated segmentation and manual tracing for quantifying hippocampal and amygdala volumes, Neuroimage, 45, 855, 10.1016/j.neuroimage.2008.12.033 Tae, 2008, Validation of hippocampal volumes measured using a manual method and two automated methods (FreeSurfer and IBASPM) in chronic major depressive disorder, Neuroradiology, 50, 569, 10.1007/s00234-008-0383-9 Mulder, 2014, Hippocampal volume change measurement: Quantitative assessment of the reproducibility of expert manual outlining and the automated methods FreeSurfer and FIRST, Neuroimage, 92, 169, 10.1016/j.neuroimage.2014.01.058 Ben-Zion, 2019, Neurobehavioral moderators of post-traumatic stress disorder (PTSD) trajectories: Study protocol of a prospective MRI study of recent trauma survivors, Eur J Psychotraumatol, 10, 1683941, 10.1080/20008198.2019.1683941 Fine, 2018, Evaluating web-based cognitive-affective remediation in recent trauma survivors: Study rationale and protocol, Eur J Psychotraumatol, 9, 1442602, 10.1080/20008198.2018.1442602 Blake, 1995, The development of a Clinician-Administered PTSD Scale, J Trauma Stress, 8, 75, 10.1002/jts.2490080106 Weathers, 2018, The Clinician-Administered PTSD Scale for DSM–5 (CAPS-5): Development and initial psychometric evaluation in military veterans, Psychol Assess, 30, 383, 10.1037/pas0000486 Fischl, 2012, FreeSurfer. Neuroimage, 62, 774, 10.1016/j.neuroimage.2012.01.021 Sánchez-Benavides, 2010, Manual validation of FreeSurfer’s automated hippocampal segmentation in normal aging, mild cognitive impairment, and Alzheimer Disease subjects, Psychiatry Res, 181, 219, 10.1016/j.pscychresns.2009.10.011 Wenger, 2014, Comparing manual and automatic segmentation of hippocampal volumes: Reliability and validity issues in younger and older brains, Hum Brain Mapp, 35, 4236, 10.1002/hbm.22473 Preacher, 2008, Asymptotic and resampling strategies for assessing and comparing indirect effects in multiple mediator models, Behav Res Methods, 40, 879, 10.3758/BRM.40.3.879 Hayes, 2013 Feng, 2014, Log-transformation and its implications for data analysis, Shanghai Arch Psychiatry, 26, 105 Aiken, 1991 Bremner, 1995, MRI-based measurement of hippocampal volume in patients with combat-related posttraumatic stress disorder, Am J Psychiatry, 152, 973, 10.1176/ajp.152.7.973 Bremner, 1997, Magnetic resonance imaging-based measurement of hippocampal volume in posttraumatic stress disorder related to childhood physical and sexual abuse—A preliminary report, Biol Psychiatry, 41, 23, 10.1016/S0006-3223(96)00162-X Gurvits, 1996, Magnetic resonance imagine study of hippocampal volume in chronic, combat-related PTSD, Biol Psychiatry, 40, 1091, 10.1016/S0006-3223(96)00229-6 Stein, 1997, Hippocampal volume in women victimized by childhood sexual abuse, Psychol Med, 27, 951, 10.1017/S0033291797005242 Yehuda, 2001, Are glucocortoids responsible for putative hippocampal damage in PTSD? How and when to decide, Hippocampus, 11, 85, 10.1002/hipo.1025 McEwen, 2001, Commentary on PTSD discussion, Hippocampus, 11, 82, 10.1002/hipo.1024 Bremner, 2001, Hypotheses and controversies related to effects of stress on the hippocampus: An argument for stress-induced damage to the hippocampus in patients with posttraumatic stress disorder, Hippocampus, 11, 75, 10.1002/hipo.1023 Pitman, 2001, Hippocampal diminution in PTSD: More (or less?) than meets the eye, Hippocampus, 11, 73, 10.1002/hipo.1022 Dremmen, 2019, Cavum septum pellucidum in the general pediatric population and its relation to surrounding brain structure volumes, cognitive function, and emotional or behavioral problems, AJNR Am J Neuroradiol, 40, 340, 10.3174/ajnr.A5939 Yehuda, 1998, Predicting the development of posttraumatic stress disorder from the acute response to a traumatic event, Biol Psychiatry, 44, 1305, 10.1016/S0006-3223(98)00276-5 Koren, 2001, Long term course of chronic posttraumatic stress disorder in traffic accident victims: A three-year prospective follow-up study, Behav Res Ther, 39, 1449, 10.1016/S0005-7967(01)00025-0 Hepp, 2008, Post-traumatic stress disorder in serious accidental injury: 3-year follow-up study, Br J Psychiatry, 192, 376, 10.1192/bjp.bp.106.030569 Perkonigg, 2005, Longitudinal course of posttraumatic stress disorder and posttraumatic stress disorder symptoms in a community sample of adolescents and young adults, Am J Psychiatry, 162, 1320, 10.1176/appi.ajp.162.7.1320 Kessler, 1995, Posttraumatic stress disorder in the National Comorbidity Survey, Arch Gen Psychiatry, 52, 1048, 10.1001/archpsyc.1995.03950240066012 Shalev, 2005, PTSD following terrorist attacks: A prospective evaluation, Am J Psychiatry, 162, 1188, 10.1176/appi.ajp.162.6.1188 Takahashi, 2008, Prevalence of large cavum septi pellucidi in ultra high-risk individuals and patients with psychotic disorders, Schizophr Res, 105, 236, 10.1016/j.schres.2008.06.021