Neural mechanisms of autonomic, affective, and cognitive integration

Journal of Comparative Neurology - Tập 493 Số 1 - Trang 154-166 - 2005
Hugo Critchley1
1Wellcome Department of Imaging Neuroscience, Institute of Neurology, University College London (UCL) Autonomic Unit, National Hospital for Neurology and Neurosurgery, University College London Hospitals, Institute of Cognitive Neuroscience, UCL, Queen Square, London WC1N 3BG, United Kingdom

Tóm tắt

AbstractInfluential theoretical models propose a central role for afferent information from the body in the expression of emotional feeling states. Feedback representations of changing states of bodily arousal influence learning and facilitate concurrent and prospective decision‐making. Functional neuroimaging studies have increased understanding of brain mechanisms that generate changes in autonomic arousal during behavior and those which respond to internal feedback signals to influence subjective feeling states. In particular, anterior cingulate cortex is implicated in generating autonomic changes, while insula and orbitofrontal cortices may be specialized in mapping visceral responses. Independently, ventromedial prefrontal cortex is recognized to support processes of internal (self‐) reference that predominate in states of rest and disengagement and which putatively serve as a benchmark for dynamic interactions with the environment. Lesion data further highlight the integrated role of these cortical regions in autonomic and motivational control. In computational models of control, forward (efference copies) and inverse models are proposed to enable prediction and correction of action and, by extension, the interpretation of the behavior of others. It is hypothesized that the neural substrate for these processes during motivational and affective behavior lies within the interactions of anterior cingulate, insula, and orbitofrontal cortices. Generation of visceral autonomic correlates of control reinforce experiential engagement in simulatory models and underpin concepts such as somatic markers to bridge the dualistic divide. J. Comp. Neurol. 493:154–166, 2005. © 2005 Wiley‐Liss, Inc.

Từ khóa


Tài liệu tham khảo

10.1016/S0167-8760(02)00123-X

10.1016/S0079-6123(08)63830-3

10.1093/brain/124.2.369

10.1097/00004691-200011000-00006

10.1126/science.7652558

10.1093/cercor/6.2.215

10.1126/science.275.5304.1293

10.1093/brain/120.1.111

Brading A, 1999, The autonomic nervous system and its effectors

10.1016/S0896-6273(00)80476-6

10.2307/1415404

10.1097/00007611-192909000-00037

10.1515/REVNEURO.1999.10.1.49

10.1002/cne.902620104

10.1038/10230

10.1016/S0301-0511(02)00061-3

Cohen JD, 1994, Attention and performance XV, 453

10.1212/WNL.53.4.819

Corricelli G, 2005, Regret and its avoidance: a neuroimaging study of choice behavior, Nat Neurosci, 8, 1255, 10.1038/nn1514

10.1038/nrn894

10.1016/S0959-4388(03)00090-4

10.1073/pnas.0401510101

10.1523/JNEUROSCI.20-08-03033.2000

10.1111/j.1469-7793.2000.t01-1-00259.x

10.1038/84048

10.1016/S0896-6273(01)00225-2

10.1093/brain/124.5.1003

10.1016/S0896-6273(02)00588-3

Critchley HD, 2003, Human cingulate cortex and autonomic cardiovascular control: converging neuroimaging and clinical evidence, Brain, 216, 2139, 10.1093/brain/awg216

10.1038/nn1176

10.1016/j.neuroimage.2004.10.013

10.1016/j.neuroimage.2005.05.047

Damasio AR, 1994, Descartes' error: emotion, reason and the human brain

Damasio AR, 1999, The feeling of what happens: body and emotion in the making of consciousness

Damasio AR, 1991, Frontal lobe function and dysfunction

Darwin C, 1898, The expression of the emotions in man and animals

10.1111/1467-9280.00221

10.1126/science.6612338

10.1093/brain/awh405

10.1093/brain/116.2.397

Frackowiak R, 2004, Human brain function

10.1111/1469-8986.3520179

10.1016/S0028-3932(01)00124-5

10.1016/j.tics.2004.07.002

10.1016/0165-1838(89)90091-X

10.1038/35094500

Harlow JM, 1868, Recovery from the passage of an iron bar through the head, Mass Med Soc, 2, 327

10.1093/brain/124.2.361

10.1037/h0065078

10.1037/0033-295X.101.2.205

Kaada BR, 1951, Somato‐motor, autonomic and electrocorticographic responses to electrical stimulation of rhinencephalic and other structures in primates, cat and dog, Acta Physiol Scand, 24, 1

10.1002/ana.10502

Lange CG, 1885, The classical psychologist, 672

10.1113/jphysiol.1898.sp000726

LeDoux JF, 1992, The amygdala, 339

LeDoux JF, 1996, The emotional brain: the mysterious underpinnings of emotional life

10.1016/0167-8760(96)00022-0

Mathias CJ, 2000, Neurology in clinical practice, 2131

10.1038/30976

10.1152/ajpregu.2001.281.3.R683

10.1016/j.neuroimage.2004.01.019

10.1016/S0079-6123(08)62679-5

10.1016/S0896-6273(03)00169-7

10.1037/0021-843X.102.1.121

10.1002/cne.10609

10.1212/WNL.42.9.1727

10.1093/brain/124.9.1708

10.1006/nimg.2002.1306

10.1097/00001756-199806220-00001

10.1038/39051

Phillips ML, 2000, A differential neural response in obsessive‐compulsive disorder patients with washing compared with checking symptoms to disgust, Psychol Med, 30, 1037, 10.1017/S0033291799002652

10.1111/1469-8986.2004.00170.x

PollatosO AuerDP SchandryRKaufmannC.2004.Autonomic awareness: neural actibity during the perception of cardiovascular stimuli. 10th Annu Meet Organ Hum Brain Mapp. Budapest Hungary. pTU285.

10.1111/j.1469-8986.1995.tb01213.x

Posner MI, 1999, The attention system of the human brain, Annu Rev Neurosci, 13, 25, 10.1146/annurev.ne.13.030190.000325

10.1002/cne.20750

10.1073/pnas.98.2.676

10.1016/S0959-4388(02)00313-6

Rescorla RA, 1972, Classical conditioning II: current research and theory, 64

10.7326/0003-4819-124-11-199606010-00001

10.1146/annurev.neuro.25.032502.111311

10.1037/h0046234

10.1093/cercor/10.3.272

10.1038/nature02581

10.1093/brain/114.2.727

Singer T, 2004, Empathy for pain involves the affective but not sensory components of pain, Science, 30, 1157, 10.1126/science.1093535

Spyer KM, 1999, Autonomic failure: a textbook of clinical disorders of the autonomic nervous system, 45

10.1007/BF00215471

10.1073/pnas.252521499

Tranel D, 2000, Cognitive neuroscience of emotion, 192

10.1016/S0010-9452(08)70155-2

Vuilleumier P, 2004, Distant influences of amygdale lesion on cortical activation during emotional face processing, Nat Neurosci, 7, 1272, 10.1038/nn1341

Wiens S, 2001, Heartbeat detection and the experience of emotions, Cogn Emotion, 14, 417, 10.1080/026999300378905

10.1016/0006-8993(84)90696-6

10.1097/00001756-200009110-00037

10.1152/japplphysiol.00939.2001

10.1098/rstb.2002.1238

Thông tin
Thông tin xuất bản

Journal of Comparative Neurology

Tập 493 Số 1

154-166

Thông tin tác giả