Neural Crest Cell Implantation Restores Enteric Nervous System Function and Alters the Gastrointestinal Transcriptome in Human Tissue-Engineered Small Intestine

Barthel, 2012, Human tissue-engineered colon forms from postnatal progenitor cells: an in vivo murine model, Regen. Med., 7, 807, 10.2217/rme.12.91

Barthel, 2012, Tissue engineering of the intestine in a murine model, J. Vis. Exp., e4279

Beck, 2009, ChAT and NOS in human myenteric neurons: co-existence and co-absence, Cell Tissue Res., 338, 37, 10.1007/s00441-009-0852-4

Binder, 2015, Enteric neurospheres are not specific to neural crest cultures: implications for neural stem cell therapies, PLoS One, 10, e0119467, 10.1371/journal.pone.0119467

Bohorquez, 2015, Neuroepithelial circuit formed by innervation of sensory enteroendocrine cells, J. Clin. Invest., 125, 782, 10.1172/JCI78361

Bondurand, 2003, Neuron and glia generating progenitors of the mammalian enteric nervous system isolated from foetal and postnatal gut cultures, Development, 130, 6387, 10.1242/dev.00857

Burns, 1998, The sacral neural crest contributes neurons and glia to the post-umbilical gut: spatiotemporal analysis of the development of the enteric nervous system, Development, 125, 4335, 10.1242/dev.125.21.4335

Burns, 2016, White paper on guidelines concerning enteric nervous system stem cell therapy for enteric neuropathies, Dev. Biol., 417, 229, 10.1016/j.ydbio.2016.04.001

Burns, 2009, Development of the enteric nervous system and its role in intestinal motility during fetal and early postnatal stages, Semin. Pediatr. Surg., 18, 196, 10.1053/j.sempedsurg.2009.07.001

Cooper, 2016, In vivo transplantation of enteric neural crest cells into mouse gut; engraftment, functional integration and long-term safety, PLoS One, 11, e0147989, 10.1371/journal.pone.0147989

Costa, 2000, Anatomy and physiology of the enteric nervous system, Gut, 47, iv15

Fattahi, 2016, Deriving human ENS lineages for cell therapy and drug discovery in Hirschsprung disease, Nature, 531, 105, 10.1038/nature16951

Finkbeiner, 2015, Generation of tissue-engineered small intestine using embryonic stem cell-derived human intestinal organoids, Biol. Open, 4, 1462, 10.1242/bio.013235

Friedt, 2013, An update on pediatric endoscopy, Eur. J. Med. Res., 18, 24, 10.1186/2047-783X-18-24

Furness, 2012, The enteric nervous system and neurogastroenterology, Nat. Rev. Gastroenterol. Hepatol., 9, 286, 10.1038/nrgastro.2012.32

Furness, 2014, The enteric nervous system and gastrointestinal innervation: integrated local and central control, Adv. Exp. Med. Biol., 817, 39, 10.1007/978-1-4939-0897-4_3

Furness, 1995, Evidence that enteric motility reflexes can be initiated through entirely intrinsic mechanisms in the guinea-pig small intestine, Neurogastroenterol. Motil., 7, 89, 10.1111/j.1365-2982.1995.tb00213.x

Furness, 2013, The gut as a sensory organ, Nat. Rev. Gastroenterol. Hepatol., 10, 729, 10.1038/nrgastro.2013.180

Goldstein, 2008, A bird's eye view of enteric nervous system development: lessons from the avian embryo, Pediatr. Res., 64, 326, 10.1203/PDR.0b013e31818535e8

Grant, 2015, Human and mouse tissue-engineered small intestine both demonstrate digestive and absorptive function, Am. J. Physiol. Gastrointest. Liver Physiol., 308, G664, 10.1152/ajpgi.00111.2014

Gremel, 2015, The human gastrointestinal tract-specific transcriptome and proteome as defined by RNA sequencing and antibody-based profiling, J. Gastroenterol., 50, 46, 10.1007/s00535-014-0958-7

Grikscheit, 2003, Tissue-engineered large intestine resembles native colon with appropriate in vitro physiology and architecture, Ann. Surg., 238, 35, 10.1097/01.SLA.0000074964.77367.4a

Hetz, 2014, In vivo transplantation of neurosphere-like bodies derived from the human postnatal and adult enteric nervous system: a pilot study, PLoS One, 9, e93605, 10.1371/journal.pone.0093605

Hotta, 2016, Isogenic enteric neural progenitor cells can replace missing neurons and glia in mice with Hirschsprung disease, Neurogastroenterol. Motil., 28, 498, 10.1111/nmo.12744

Huang, 2016, Generating trunk neural crest from human pluripotent stem cells, Sci. Rep., 6, 19727, 10.1038/srep19727

Johann, 2007, Time of transplantation and cell preparation determine neural stem cell survival in a mouse model of Huntington's disease, Exp. Brain Res., 177, 458, 10.1007/s00221-006-0689-y

Kruger, 2002, Neural crest stem cells persist in the adult gut but undergo changes in self-renewal, neuronal subtype potential, and factor responsiveness, Neuron, 35, 657, 10.1016/S0896-6273(02)00827-9

Kunze, 1999, The enteric nervous system and regulation of intestinal motility, Annu. Rev. Physiol., 61, 117, 10.1146/annurev.physiol.61.1.117

Lake, 2013, Enteric nervous system development: migration, differentiation, and disease, Am. J. Physiol. Gastrointest. Liver Physiol., 305, G1, 10.1152/ajpgi.00452.2012

Laughlin, 2012, Total colonic aganglionosis: a systematic review and meta-analysis of long-term clinical outcome, Pediatr. Surg. Int., 28, 773, 10.1007/s00383-012-3117-3

Lee, 2007, The mechanism and spread of pacemaker activity through myenteric interstitial cells of Cajal in human small intestine, Gastroenterology, 132, 1852, 10.1053/j.gastro.2007.02.049

Lindley, 2008, Human and mouse enteric nervous system neurosphere transplants regulate the function of aganglionic embryonic distal colon, Gastroenterology, 135, 205, 10.1053/j.gastro.2008.03.035

Liu, 1994, Selective lesioning of interstitial cells of Cajal by methylene blue and light leads to loss of slow waves, Am. J. Physiol., 266, G485

McCracken, 2011, Generating human intestinal tissue from pluripotent stem cells in vitro, Nat. Protoc., 6, 1920, 10.1038/nprot.2011.410

Metzger, 2009, Expansion and differentiation of neural progenitors derived from the human adult enteric nervous system, Gastroenterology, 137, 2063, 10.1053/j.gastro.2009.06.038

Metzger, 2009, Enteric nervous system stem cells derived from human gut mucosa for the treatment of aganglionic gut disorders, Gastroenterology, 136, 2214, 10.1053/j.gastro.2009.02.048

Qu, 2008, Immunohistochemical analysis of neuron types in the mouse small intestine, Cell Tissue Res., 334, 147, 10.1007/s00441-008-0684-7

Schneider, 2012, NIH Image to ImageJ: 25 years of image analysis, Nat. Methods, 9, 671, 10.1038/nmeth.2089

Spence, 2011, Directed differentiation of human pluripotent stem cells into intestinal tissue in vitro, Nature, 470, 105, 10.1038/nature09691

Sulkowski, 2014, Single-stage versus multi-stage pull-through for Hirschsprung's disease: practice trends and outcomes in infants, J. Pediatr. Surg., 49, 1619, 10.1016/j.jpedsurg.2014.06.002

Takahashi, 2003, Pathophysiological significance of neuronal nitric oxide synthase in the gastrointestinal tract, J. Gastroenterol., 38, 421, 10.1007/s00535-003-1094-y

Timmermans, 1994, Nitric oxide synthase immunoreactivity in the enteric nervous system of the developing human digestive tract, Cell Tissue Res., 275, 235, 10.1007/BF00319421

Uesaka, 2016, Development of the intrinsic and extrinsic innervation of the gut, Dev. Biol., 417, 158, 10.1016/j.ydbio.2016.04.016

Watson, 2014, An in vivo model of human small intestine using pluripotent stem cells, Nat. Med., 20, 1310, 10.1038/nm.3737

Wieck, 2016, Human and murine tissue-engineered colon exhibit diverse neuronal subtypes and can be populated by enteric nervous system progenitor cells when donor colon is aganglionic, Tissue Eng. Part A., 22, 53, 10.1089/ten.tea.2015.0120

Wilkinson, 2015, Isolation of enteric nervous system progenitor cells from the aganglionic gut of patients with Hirschsprung's disease, PLoS One, 10, e0125724, 10.1371/journal.pone.0125724

Workman, 2017, Engineered human pluripotent-stem-cell-derived intestinal tissues with a functional enteric nervous system, Nat. Med., 23, 49, 10.1038/nm.4233

Zhou, 2016, Neurosphere based differentiation of human iPSC improves astrocyte differentiation, Stem Cells Int., 2016, 4937689, 10.1155/2016/4937689