Neonatal Exposure to Diethylstilbestrol Alters the Expression of DNA Methyltransferases and Methylation of Genomic DNA in the Epididymis of Mice

Endocrine Journal - Tập 53 Số 3 - Trang 331-337 - 2006
Koji Sato1,2,3, Hideki Fukata1,3, Yasushi Kogo4, Jun Ohgane4, Kunio Shiota4, Chisato Mori1,2,3
1Center of Environmental Health Science for Future Generations (NPO)
2Department of Bioenvironmental Medicine, Graduate School of Medicine, Chiba University
3Environmental Health Science Project for Future Generations, Graduate School of Medicine, Chiba University
4Laboratory of Cellular Biochemistry, Animal Resource Science/Veterinary Medical Sciences, Graduate School of Agriculture and Life Science, The University of Tokyo

Tóm tắt

Từ khóa


Tài liệu tham khảo

1. Herbst AL, Ulfelder H, Poskanzer DC (1971) Adenocarcinoma of the vagina. Association of maternal stilbestrol therapy with tumor appearance in young women. N Engl J Med 284: 878-881.

2. Newbold RR (2004) Lessons learned from perinatal exposure to diethylstilbestrol. Toxicol Appl Pharmacol 199: 142-150.

3. McLachlan JA, Newbold RR, Bullock B (1975) Reproductive tract lesions in male mice exposed prenatally to diethylstilbestrol. Science 190: 991-992.

1986, 181, 59

5. Newbold R (1995) Cellular and molecular effects of developmental exposure to diethylstilbestrol: implications for other environmental estrogens. Environ Health Perspect 103 (Suppl 7): 83-87.

6. Adachi T, Matsuno Y, Sugimura A, Takano K, Koh KB, Sakurai K, Shibayama T, Iguchi T, Mori C, Komiyama M (2003) ADAM7 (a disintegrin and metalloprotease 7) mRNA is suppressed in mouse epididymis by neonatal exposure to diethylstilbestrol. Mol Reprod Dev 64: 414-421.

7. Adachi T, Ono Y, Koh KB, Takashima K, Tainaka H, Matsuno Y, Nakagawa S, Todaka E, Sakurai K, Fukata H, Iguchi T, Komiyama M, Mori C (2004) Long-term alteration of gene expression without morphological change in testis after neonatal exposure to genistein in mice: toxicogenomic analysis using cDNA microarray. Food Chem Toxicol 42: 445-452.

8. Matsuno Y, Adachi T, Koh KB, Fukata H, Sugimura A, Sakurai K, Shibayama T, Iguchi T, Komiyama M, Mori C (2004) Effect of neonatal exposure to diethylstilbestrol on testicular gene expression in adult mouse: comprehensive analysis with cDNA subtraction method. Int J Androl 27: 115-122.

SHIBAYAMA T, 2001, 48, 655, 10.1507/endocrj.48.655

10.1007/s002040050285

1997, 57, 4356

12. Li S, Hansman R, Newbold R, Davis B, McLachlan JA, Barrett JC (2003) Neonatal diethylstilbestrol exposure induces persistent elevation of c-fos expression and hypomethylation in its exon-4 in mouse uterus. Mol Carcinog 38: 78-84.

13. Nakagawa T, Kanai Y, Ushijima S, Kitamura T, Kakizoe T, Hirohashi S (2005) DNA hypermethylation on multiple CpG islands associated with increased DNA methyltransferase DNMT1 protein expression during multistage urothelial carcinogenesis. J Urol 173: 1767-1771.

14. Etoh T, Kanai Y, Ushijima S, Nakagawa T, Nakanishi Y, Sasako M, Kitano S, Hirohashi S (2004) Increased DNA methyltransferase 1 (DNMT1) protein expression correlates significantly with poorer tumor differentiation and frequent DNA hypermethylation of multiple CpG islands in gastric cancers. Am J Pathol 164: 689-699.

15. Dahl C, Guldberg P (2003) DNA methylation analysis techniques. Biogerontology 4: 233-250.

1991, 88, 9523, 10.1073/pnas.88.21.9523

10.1016/j.ydbio.2003.12.031

10.1002/(SICI)1520-6408(1998)22:2<132::AID-DVG3>3.0.CO;2-7

10.1002/gene.1031

10.1006/geno.2001.6607

1995, 16, 203

10.1016/0022-2836(87)90689-9

10.1016/S0006-291X(02)00228-0

10.1073/pnas.022637199

10.1046/j.1432-1033.2002.02972.x

10.1042/BJ20040684

27. Shigeta H, Zuo W, Yang N, DiAugustine R, Teng CT (1997) The mouse estrogen receptor-related orphan receptor alpha 1: molecular cloning and estrogen responsiveness. J Mol Endocrinol 19: 299-309.

10.1016/j.bbrc.2004.12.165

10.1016/j.bbrc.2004.10.002

10.1038/327336a0

10.1046/j.1432-0436.2002.690406.x

10.1046/j.1365-2443.2002.00574.x

10.1101/gr.2431504

34. Wu Q, Ohsako S, Ishimura R, Suzuki JS, Tohyama C (2004) Exposure of mouse preimplantation embryos to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) alters the methylation status of imprinted genes H19 and Igf2. Biol Reprod 70: 1790-1797.

10.1126/science.1108190

1992, 50, 131, 10.1002/ijc.2910500126

1997, 18, 791, 10.1093/carcin/18.4.791

NEWBOLD R R, 2000, 21, 1355, 10.1093/carcin/21.7.1355

39. Watson RE, Goodman JI (2002) Epigenetics and DNA methylation come of age in toxicology. Toxicol Sci 67: 11-16.

40. Fukata H, Mori C (2004) Epigenetic alteration by the chemical substances, food and environmental factors. Reprod Med Biol 3: 115-121.