Negative symptoms of schizophrenia: Clinical features, relevance to real world functioning and specificity versus other CNS disorders

Aarsland, 2009, Neuropsychiatric symptoms in Parkinson's disease, Mov. Disord., 24, 2175, 10.1002/mds.22589

Addington, 1996, A psychometric comparison of the Calgary depression scale for schizophrenia and the Hamilton depression rating scale, Schizophr. Res., 19, 205, 10.1016/0920-9964(95)00070-4

Addington, 1994, Specificity of the Calgary depression scale for schizophrenics, Schizophr. Res., 11, 239, 10.1016/0920-9964(94)90017-5

Addington, 2000, Cognitive functioning and negative symptoms in schizophrenia, 193

Ahn, 2011, Temporal discounting of rewards in patients with bipolar disorder and schizophrenia, J. Abnorm. Psychol., 120, 911, 10.1037/a0023333

Alphs, 2011, Validation of a 4-item negative symptom assessment (NSA-4): a short, practical clinical tool for the assessment of negative symptoms in schizophrenia, Int. J. Methods Psychiatr. Res., 20, e31, 10.1002/mpr.339

Alphs, 1989, The negative symptom assessment: a new instrument to assess negative symptoms of schizophrenia, Psychopharmacol. Bull., 25, 159

Amador, 1999, Stability of the diagnosis of deficit syndrome in schizophrenia, Am. J. Psychiatry, 156, 637, 10.1176/ajp.156.4.637

Andersson, 1999, Apathy and depressed mood in acquired brain damage: relationship to lesion localization and psychophysiological reactivity, Psychol. Med., 29, 447, 10.1017/S0033291798008046

Andreasen, 1982, Negative symptoms in schizophrenia. Definition and reliability, Arch. Gen. Psychiatry, 39, 784, 10.1001/archpsyc.1982.04290070020005

Andreasen, 1984

Andreasen, 1995, Symptoms of schizophrenia. Methods, meanings, and mechanisms, Arch. Gen. Psychiatry, 52, 341, 10.1001/archpsyc.1995.03950170015003

Andreasen, 1982, Negative v positive schizophrenia. Definition and validation, Arch. Gen. Psychiatry, 39, 789, 10.1001/archpsyc.1982.04290070025006

Averill, 2004, Is schizoaffective disorder a stable diagnostic category: a retrospective examination, Psychiatr. Q., 75, 215, 10.1023/B:PSAQ.0000031792.70861.92

Avery, 2009, The role of effort, cognitive expectancy appraisals and coping style in the maintenance of the negative symptoms of schizophrenia, Psychiatry Res., 167, 36, 10.1016/j.psychres.2008.04.016

Ballmaier, 2008, Regional patterns and clinical correlates of basal ganglia morphology in non-medicated schizophrenia, Schizophr. Res., 106, 140, 10.1016/j.schres.2008.08.025

Barch, 2010, Goal representations and motivational drive in schizophrenia: the role of prefrontal–striatal interactions, Schizophr. Bull., 36, 919, 10.1093/schbul/sbq068

Barch, 2008, Intrinsic motivation in schizophrenia: relationships to cognitive function, depression, anxiety, and personality, J. Abnorm. Psychol., 117, 776, 10.1037/a0013944

Bell, 2006, Does negative symptom change relate to neurocognitive change in schizophrenia? Implications for targeted treatments, Schizophr. Res., 81, 17, 10.1016/j.schres.2005.09.016

Berenbaum, 1992, Emotional experience and expression in schizophrenia and depression, J. Abnorm. Psychol., 101, 37, 10.1037/0021-843X.101.1.37

Berenbaum, 1987, Anhedonia and emotional responses to affect evoking stimuli, Psychol. Med., 17, 677, 10.1017/S0033291700025915

Bermanzohn, 1992, Akinesia: a syndrome common to parkinsonism, retarded depression, and negative symptoms of schizophrenia, Compr. Psychiatry, 33, 221, 10.1016/0010-440X(92)90045-R

Berrios, 1985, Positive and negative symptoms and Jackson. A conceptual history, Arch. Gen. Psychiatry, 42, 95, 10.1001/archpsyc.1985.01790240097011

Bilder, 2000, Neuropsychology of first-episode schizophrenia: initial characterization and clinical correlates, Am. J. Psychiatry, 157, 549, 10.1176/appi.ajp.157.4.549

Blanchard, 2005, Examining the latent structure of negative symptoms: is there a distinct subtype of negative symptom schizophrenia?, Schizophr. Res., 77, 151, 10.1016/j.schres.2005.03.022

Blanchard, 1998, Anhedonia, positive and negative affect, and social functioning in schizophrenia, Schizophr. Bull., 24, 413, 10.1093/oxfordjournals.schbul.a033336

Bleuler, 1950

Bora, 2009, Cognitive functioning in schizophrenia, schizoaffective disorder and affective psychoses: meta-analytic study, Br. J. Psychiatry, 195, 475, 10.1192/bjp.bp.108.055731

Bottlender, 2003, Negative symptoms in depressed and schizophrenic patients: how do they differ?, J. Clin. Psychiatry, 64, 954, 10.4088/JCP.v64n0816

Bottlender, 2003, Does considering duration of negative symptoms increase their specificity for schizophrenia?, Schizophr. Res., 60, 321, 10.1016/S0920-9964(02)00317-1

Brown, 2000, Negative symptoms: the ‘pathology’ of motivation and goal-directed behaviour, Trends Neurosci., 23, 412, 10.1016/S0166-2236(00)01626-X

Buchanan, 2007, Persistent negative symptoms in schizophrenia: an overview, Schizophr. Bull., 33, 1013, 10.1093/schbul/sbl057

Burbridge, 2007, Anhedonia and the experience of emotion in individuals with schizophrenia, J. Abnorm. Psychol., 116, 30, 10.1037/0021-843X.116.1.30

Carpenter, 1988, Deficit and nondeficit forms of schizophrenia: the concept, Am. J. Psychiatry, 145, 578, 10.1176/ajp.145.5.578

Chaturvedi, 1986, Prediction of outcome in depression by negative symptoms, Acta Psychiatr. Scand., 74, 183, 10.1111/j.1600-0447.1986.tb10603.x

Chaturvedi, 1986, Do negative symptoms influence outcome of depression?, Indian J. Psychiatry, 28, 305

Choi, 2010, Intrinsic motivation and learning in a schizophrenia spectrum sample, Schizophr. Res., 118, 12, 10.1016/j.schres.2009.08.001

Ciurli, 2011, Neuropsychiatric disorders in persons with severe traumatic brain injury: prevalence, phenomenology, and relationship with demographic, clinical, and functional features, J. Head Trauma Rehabil., 26, 116, 10.1097/HTR.0b013e3181dedd0e

Clarke, 2008, Apathy in dementia: clinical and sociodemographic correlates, J. Neuropsychiatry Clin. Neurosci., 20, 337, 10.1176/jnp.2008.20.3.337

Cohen, 2010, Emotional experience in patients with schizophrenia revisited: meta-analysis of laboratory studies, Schizophr. Bull., 36, 143, 10.1093/schbul/sbn061

Collins, 1996, Depression in schizophrenia: a comparison of three measures, Schizophr. Res., 20, 205, 10.1016/0920-9964(95)00107-7

Corcoran, 2011, The relationship of social function to depressive and negative symptoms in individuals at clinical high risk for psychosis, Psychol. Med., 41, 251, 10.1017/S0033291710000802

Cornblatt, 2003, The schizophrenia prodrome revisited: a neurodevelopmental perspective, Schizophr. Bull., 29, 633, 10.1093/oxfordjournals.schbul.a007036

Crow, 1980, Molecular pathology of schizophrenia: more than one disease process?, Br. Med. J., 280, 1, 10.1136/bmj.280.6207.66

de Jonghe, 2003, Negative symptoms in Alzheimer's disease: a confirmatory factor analysis, Int. J. Geriatr. Psychiatry, 18, 748, 10.1002/gps.917

Demjaha, 2012, Disorganization/cognitive and negative symptom dimensions in the at-risk mental state predict subsequent transition to psychosis, Schizophr. Bull., 38, 351, 10.1093/schbul/sbq088

Doody, 1995, Positive and negative neuropsychiatric features in Alzheimer's disease, J. Neuropsychiatry Clin. Neurosci., 7, 54, 10.1176/jnp.7.1.54

Drake, 2003, The evolution of symptoms in the early course of non-affective psychosis, Schizophr. Res., 63, 171, 10.1016/S0920-9964(02)00334-1

Duncan, 2005, The impact of cognitive and psychiatric impairment of psychotic disorders on the test of memory malingering (TOMM), Assessment, 12, 123, 10.1177/1073191105275512

Earnst, 1997, Construct validity of negative symptoms: an empirical and conceptual review, Clin. Psychol. Rev., 17, 167, 10.1016/S0272-7358(96)00052-9

Earnst, 1999, Emotional responding in deficit and non-deficit schizophrenia, Psychiatry Res., 88, 191, 10.1016/S0165-1781(99)00083-9

Emsley, 2003, The factor structure for the positive and negative syndrome scale (PANSS) in recent-onset psychosis, Schizophr. Res., 61, 47, 10.1016/S0920-9964(02)00302-X

Evensen, 2012, Apathy in first episode psychosis patients: a ten year longitudinal follow-up study, Schizophr. Res., 136, 19, 10.1016/j.schres.2011.12.019

Faerden, 2010, Apathy in first episode psychosis patients: one year follow up, Schizophr. Res., 116, 20, 10.1016/j.schres.2009.10.014

Faerden, 2009, Apathy and functioning in first-episode psychosis, Psychiatr. Serv., 60, 1495, 10.1176/ps.2009.60.11.1495

Faerden, 2009, Apathy is associated with executive functioning in first episode psychosis, BMC Psychiatry, 9, 1, 10.1186/1471-244X-9-1

Fennig, 1996, Diagnosis and six-month stability of negative symptoms in psychotic disorders, Eur. Arch. Psychiatry Clin. Neurosci., 246, 63, 10.1007/BF02274895

Fenton, 1992, Testing systems for assessment of negative symptoms in schizophrenia, Arch. Gen. Psychiatry, 49, 179, 10.1001/archpsyc.1992.01820030011002

Ferguson, 1996, Visceral perception, anhedonia, and emotion, Biol. Psychol., 42, 131, 10.1016/0301-0511(95)05151-1

Fogelson, 2007, Avoidant personality disorder is a separable schizophrenia-spectrum personality disorder even when controlling for the presence of paranoid and schizotypal personality disorders the UCLA family study, Schizophr. Res., 91, 192, 10.1016/j.schres.2006.12.023

Foussias, 2010, Motivational deficits in schizophrenia: cross-sectional and longitudinal relationships with functioning, Schizophr. Res., 117, 303, 10.1016/j.schres.2010.02.506

Foussias, 2009, Motivational deficits as the central link to functioning in schizophrenia: a pilot study, Schizophr. Res., 115, 333, 10.1016/j.schres.2009.09.020

Foussias, 2010, Negative symptoms in schizophrenia: avolition and Occam's razor, Schizophr. Bull., 36, 359, 10.1093/schbul/sbn094

Galderisi, 2013, Categorical and dimensional approaches to negative symptoms of schizophrenia: focus on long-term stability and functional outcome, Schizophr. Res., 147, 157, 10.1016/j.schres.2013.03.020

Galynker, 2000, Negative symptoms in patients with major depressive disorder: a preliminary report, Neuropsychiatry Neuropsychol. Behav. Neurol., 13, 171

Gard, 2009, Motivation and its relationship to neurocognition, social cognition, and functional outcome in schizophrenia, Schizophr. Res., 115, 74, 10.1016/j.schres.2009.08.015

Gard, 2007, Anhedonia in schizophrenia: distinctions between anticipatory and consummatory pleasure, Schizophr. Res., 93, 253, 10.1016/j.schres.2007.03.008

Geary, 2009, Atrophy of basal ganglia nuclei and negative symptoms in temporal lobe epilepsy, J. Neuropsychiatry Clin. Neurosci., 21, 152, 10.1176/jnp.2009.21.2.152

Gerbaldo, 1995, Primary enduring negative symptoms in schizophrenia and major depression, J. Psychiatr. Res., 29, 297, 10.1016/0022-3956(95)00013-U

Gerbaldo, 1994, Subtypes of negative symptoms: the primary subtype in schizophrenic and non-schizophrenic patients, Prog. Neuropsychopharmacol. Biol. Psychiatry, 18, 311, 10.1016/0278-5846(94)90062-0

Germans, 2000, Hedonic deficit in anhedonia: support for the role of approach motivation, Pers. Individ. Differ., 28, 659, 10.1016/S0191-8869(99)00129-4

Getz, 2003, Negative symptoms and psychosocial status in temporal lobe epilepsy, Epilepsy Res., 53, 240, 10.1016/S0920-1211(03)00033-0

Getz, 2002, Negative symptoms in temporal lobe epilepsy, Am. J. Psychiatry, 159, 644, 10.1176/appi.ajp.159.4.644

Gold, 2008, Reward processing in schizophrenia: a deficit in the representation of value, Schizophr. Bull., 34, 835, 10.1093/schbul/sbn068

Gonzalez-Blanch, 2012, Identifying attentional deficits in people with first-episode psychosis with the scale for the assessment of negative symptoms attention subscale: is it possible?, Compr. Psychiatry, 53, 701, 10.1016/j.comppsych.2011.11.007

Gooding, 2002, Normative emotion-modulated startle response in individuals at risk for schizophrenia-spectrum disorders, Schizophr. Res., 57, 109, 10.1016/S0920-9964(01)00295-X

Gooding, 2007, Rates of avoidant, schizotypal, schizoid and paranoid personality disorders in psychometric high-risk groups at 5-year follow-up, Schizophr. Res., 94, 373, 10.1016/j.schres.2007.04.018

Gorissen, 2005, Effort and cognition in schizophrenia patients, Schizophr. Res., 78, 199, 10.1016/j.schres.2005.02.016

Gourzis, 2002, Symptomatology of the initial prodromal phase in schizophrenia, Schizophr. Bull., 28, 415, 10.1093/oxfordjournals.schbul.a006950

Grant, 2009, Defeatist beliefs as a mediator of cognitive impairment, negative symptoms, and functioning in schizophrenia, Schizophr. Bull., 35, 798, 10.1093/schbul/sbn008

Grant, 2012, Randomized trial to evaluate the efficacy of cognitive therapy for low-functioning patients with schizophrenia, Arch. Gen. Psychiatry, 69, 121, 10.1001/archgenpsychiatry.2011.129

Green, 2012, From perception to functional outcome in schizophrenia: modeling the role of ability and motivation, Arch. Gen. Psychiatry, 69, 1216, 10.1001/archgenpsychiatry.2012.652

Green, 2000, Neurocognitive deficits and functional outcome in schizophrenia: are we measuring the “right stuff”?, Schizophr. Bull., 26, 119, 10.1093/oxfordjournals.schbul.a033430

Green, 2008, Social cognition in schizophrenia: an NIMH workshop on definitions, assessment, and research opportunities, Schizophr. Bull., 34, 1211, 10.1093/schbul/sbm145

Gruzelier, 1996, The factorial structure of schizotypy: Part I. Affinities with syndromes of schizophrenia, Schizophr. Bull., 22, 611, 10.1093/schbul/22.4.611

Gur, 2006, Flat affect in schizophrenia: relation to emotion processing and neurocognitive measures, Schizophr. Bull., 32, 279, 10.1093/schbul/sbj041

Harvey, 2006, Negative symptoms and cognitive deficits: what is the nature of their relationship?, Schizophr. Bull., 32, 250, 10.1093/schbul/sbj011

Hawkins, 2004, Factorial structure of the scale of prodromal symptoms, Schizophr. Res., 68, 339, 10.1016/S0920-9964(03)00053-7

Heerey, 2007, Patients with schizophrenia demonstrate dissociation between affective experience and motivated behavior, J. Abnorm. Psychol., 116, 268, 10.1037/0021-843X.116.2.268

Heerey, 2007, Delay discounting in schizophrenia, Cogn. Neuropsychiatry, 12, 213, 10.1080/13546800601005900

Herbener, 2001, Longitudinal assessment of negative symptoms in schizophrenia/schizoaffective patients, other psychotic patients, and depressed patients, Schizophr. Bull., 27, 527, 10.1093/oxfordjournals.schbul.a006893

Herbener, 2004, Are negative symptoms associated with functioning deficits in both schizophrenia and nonschizophrenia patients? A 10-year longitudinal analysis, Schizophr. Bull., 30, 813, 10.1093/oxfordjournals.schbul.a007134

Herbener, 2005, Change in the relationship between anhedonia and functional deficits over a 20-year period in individuals with schizophrenia, Schizophr. Res., 75, 97, 10.1016/j.schres.2004.12.013

Ho, 1998, Two-year outcome in first-episode schizophrenia: predictive value of symptoms for quality of life, Am. J. Psychiatry, 155, 1196, 10.1176/ajp.155.9.1196

Horan, 2006, Anhedonia in schizophrenia: a review of assessment strategies, Schizophr. Bull., 32, 259, 10.1093/schbul/sbj009

Horan, 2011, Development and psychometric validation of the clinical assessment interview for negative symptoms (CAINS), Schizophr. Res., 132, 140, 10.1016/j.schres.2011.06.030

Hovington, 2012, Identifying persistent negative symptoms in first episode psychosis, BMC Psychiatry, 12, 224, 10.1186/1471-244X-12-224

Hunter, 2012, Negative symptoms and psychosocial functioning in schizophrenia: neglected but important targets for treatment, Eur. Psychiatry, 27, 432, 10.1016/j.eurpsy.2011.02.015

Jackson, 1958

Jager, 2003, On the descriptive validity of ICD-10 schizophrenia: empirical analyses in the spectrum of non-affective functional psychoses, Psychopathology, 36, 152, 10.1159/000071260

Jobe, 2005, Long-term outcome of patients with schizophrenia: a review, Can. J. Psychiatry, 50, 892, 10.1177/070674370505001403

Juckel, 2006, Dysfunction of ventral striatal reward prediction in schizophrenic patients treated with typical, not atypical, neuroleptics, Psychopharmacology, 187, 222, 10.1007/s00213-006-0405-4

Juckel, 2006, Dysfunction of ventral striatal reward prediction in schizophrenia, NeuroImage, 29, 409, 10.1016/j.neuroimage.2005.07.051

Kaiser, 2011, The negative symptoms of schizophrenia: category or continuum?, Psychopathology, 44, 345, 10.1159/000325912

Katsanis, 1992, Clinical correlates of anhedonia and perceptual aberration in first-episode patients with schizophrenia and affective disorder, J. Abnorm. Psychol., 101, 184, 10.1037/0021-843X.101.1.184

Kay, 1987, The positive and negative syndrome scale (PANSS) for schizophrenia, Schizophr. Bull., 13, 261, 10.1093/schbul/13.2.261

Keefe, 1992, Empirical assessment of the factorial structure of clinical symptoms in schizophrenia: negative symptoms, Psychiatry Res., 44, 153, 10.1016/0165-1781(92)90049-9

Kelley, 1999, Empirical validation of primary negative symptoms: independence from effects of medication and psychosis, Am. J. Psychiatry, 156, 406, 10.1176/ajp.156.3.406

Kendler, 2003, The genetics of schizophrenia: chromosomal deletions, attentional disturbances, and spectrum boundaries, Am. J. Psychiatry, 160, 1549, 10.1176/appi.ajp.160.9.1549

Kendler, 1997, The risk for psychiatric disorders in relatives of schizophrenic and control probands: a comparison of three independent studies, Psychol. Med., 27, 411, 10.1017/S003329179600445X

Kendler, 1995, Examining the validity of DSM-III-R schizoaffective disorder and its putative subtypes in the roscommon family study, Am. J. Psychiatry, 152, 755, 10.1176/ajp.152.5.755

Kiang, 2003, Apathy in schizophrenia: clinical correlates and association with functional outcome, Schizophr. Res., 63, 79, 10.1016/S0920-9964(02)00433-4

Kimhy, 2006, The factorial structure of the schedule for the deficit syndrome in schizophrenia, Schizophr. Bull., 32, 274, 10.1093/schbul/sbi064

Kirkpatrick, 1989, The schedule for the deficit syndrome: an instrument for research in schizophrenia, Psychiatry Res., 30, 119, 10.1016/0165-1781(89)90153-4

Kirkpatrick, 2001, A separate disease within the syndrome of schizophrenia, Arch. Gen. Psychiatry, 58, 165, 10.1001/archpsyc.58.2.165

Kirkpatrick, 2006, The NIMH-MATRICS consensus statement on negative symptoms, Schizophr. Bull., 32, 214, 10.1093/schbul/sbj053

Kirkpatrick, 2011, The brief negative symptom scale: psychometric properties, Schizophr. Bull., 37, 300, 10.1093/schbul/sbq059

Kirsch-Darrow, 2006, Dissociating apathy and depression in Parkinson disease, Neurology, 67, 33, 10.1212/01.wnl.0000230572.07791.22

Kitamura, 1991, Depressive and negative symptoms in major psychiatric disorders, Compr. Psychiatry, 32, 88, 10.1016/0010-440X(91)90074-M

Klosterkotter, 1995, Positive or negative symptoms – which are more appropriate as diagnostic criteria for schizophrenia?, Acta Psychiatr. Scand., 92, 321, 10.1111/j.1600-0447.1995.tb09592.x

Konstantakopoulos, 2011, Apathy, cognitive deficits and functional impairment in schizophrenia, Schizophr. Res., 133, 193, 10.1016/j.schres.2011.07.003

Kopelowicz, 2008, Consistency of brief psychiatric rating scale factor structure across a broad spectrum of schizophrenia patients, Psychopathology, 41, 77, 10.1159/000111551

Kraepelin, 1919

Kring, 2000, Anhedonia, 174

Kring, 2013, The clinical assessment interview for negative symptoms (CAINS): final development and validation, Am. J. Psychiatry, 170, 165, 10.1176/appi.ajp.2012.12010109

Kring, 1993, Flat affect in schizophrenia does not reflect diminished subjective experience of emotion, J. Abnorm. Psychol., 102, 507, 10.1037/0021-843X.102.4.507

Kring, 2008, Emotional response deficits in schizophrenia: insights from affective science, Schizophr. Bull., 34, 819, 10.1093/schbul/sbn071

Leak, 1991, An examination of the construct validity of the social anhedonia scale, J. Pers. Assess., 56, 84, 10.1207/s15327752jpa5601_8

Leifker, 2009, Determinants of everyday outcomes in schizophrenia: the influences of cognitive impairment, functional capacity, and symptoms, Schizophr. Res., 115, 82, 10.1016/j.schres.2009.09.004

Leventhal, 2006, Measuring hedonic capacity in depression: a psychometric analysis of three anhedonia scales, J. Clin. Psychol., 62, 1545, 10.1002/jclp.20327

Levy, 1998, Apathy is not depression, J. Neuropsychiatry Clin. Neurosci., 10, 314, 10.1176/jnp.10.3.314

Lewine, 1990, A discriminant validity study of negative symptoms with a special focus on depression and antipsychotic medication, Am. J. Psychiatry, 147, 1463, 10.1176/ajp.147.11.1463

Lipkovich, 2009, Relationships among neurocognition, symptoms and functioning in patients with schizophrenia: a path-analytic approach for associations at baseline and following 24 weeks of antipsychotic drug therapy, BMC Psychiatry, 9, 44, 10.1186/1471-244X-9-44

Llerena, 2012, Looking at the other side of the coin: a meta-analysis of self-reported emotional arousal in people with schizophrenia, Schizophr. Res., 142, 65, 10.1016/j.schres.2012.09.005

Loas, 1996, Anhedonia and negative symptomatology in chronic schizophrenia, Compr. Psychiatry, 37, 5, 10.1016/S0010-440X(96)90043-7

Makris, 2010, White matter volume abnormalities and associations with symptomatology in schizophrenia, Psychiatry Res., 183, 21, 10.1016/j.pscychresns.2010.04.016

Malla, 2005, First-episode psychosis: psychopathology, quality of life, and functional outcome, Schizophr. Bull., 31, 650, 10.1093/schbul/sbi031

Malla, 2002, Negative symptoms in first episode non-affective psychosis, Acta. Psychiatr. Scand., 105, 431, 10.1034/j.1600-0447.2002.02139.x

Marder, 2011, Methodological issues in negative symptom trials, Schizophr. Bull., 37, 250, 10.1093/schbul/sbq161

Marder, 1997, The effects of risperidone on the five dimensions of schizophrenia derived by factor analysis: combined results of the North American trials, J. Clin. Psychiatry, 58, 538, 10.4088/JCP.v58n1205

Marin, 1991, Reliability and validity of the apathy evaluation scale, Psychiatry Res., 38, 143, 10.1016/0165-1781(91)90040-V

McGlashan, 1988, A selective review of recent North American long-term followup studies of schizophrenia, Schizophr. Bull., 14, 515, 10.1093/schbul/14.4.515

McGlashan, 1992, The positive–negative distinction in schizophrenia. Review of natural history validators, Arch. Gen. Psychiatry, 49, 63, 10.1001/archpsyc.1992.01820010063008

Meehl, 1962, Schizotaxia, schizotypy, schizophrenia, Am. Psychol., 17, 827, 10.1037/h0041029

Messinger, 2011, Avolition and expressive deficits capture negative symptom phenomenology: implications for DSM-5 and schizophrenia research, Clin. Psychol. Rev., 31, 161, 10.1016/j.cpr.2010.09.002

Milev, 2005, Predictive values of neurocognition and negative symptoms on functional outcome in schizophrenia: a longitudinal first-episode study with 7-year follow-up, Am. J. Psychiatry, 162, 495, 10.1176/appi.ajp.162.3.495

Miller, 1993, Alogia, attentional impairment, and inappropriate affect: their status in the dimensions of schizophrenia, Compr. Psychiatry, 34, 221, 10.1016/0010-440X(93)90002-L

Minas, 1994, Positive and negative symptoms in the psychoses: principal components analysis of items from the scale for the assessment of positive symptoms and the scale for the assessment of negative symptoms, Compr. Psychiatry, 35, 135, 10.1016/0010-440X(94)90059-Q

Moller, 2002, The Kraepelinian dichotomy: preliminary results of a 15-year follow-up study on functional psychoses: focus on negative symptoms, Schizophr. Res., 56, 87, 10.1016/S0920-9964(01)00252-3

Moller, 2000, Long-term course of schizophrenic, affective and schizoaffective psychosis: focus on negative symptoms and their impact on global indicators of outcome, Acta Psychiatr. Scand., 54, 10.1034/j.1600-0447.2000.00010.x

Mueser, 1994, A multisite investigation of the reliability of the scale for the assessment of negative symptoms, Am. J. Psychiatry, 151, 1453, 10.1176/ajp.151.10.1453

Murray, 2008, Incentive motivation in first-episode psychosis: a behavioural study, BMC Psychiatry, 8, 34, 10.1186/1471-244X-8-34

Nakagami, 2010, The prospective relationships among intrinsic motivation, neurocognition, and psychosocial functioning in schizophrenia, Schizophr. Bull., 36, 935, 10.1093/schbul/sbq043

Nakagami, 2008, Intrinsic motivation, neurocognition and psychosocial functioning in schizophrenia: testing mediator and moderator effects, Schizophr. Res., 105, 95, 10.1016/j.schres.2008.06.015

Nakaya, 2008, A two-factor structure for the schedule for the deficit syndrome in schizophrenia, Psychiatry Res., 158, 256, 10.1016/j.psychres.2007.10.008

Nielsen, 2012, Alterations of the brain reward system in antipsychotic naive schizophrenia patients, Biol. Psychiatry, 71, 898, 10.1016/j.biopsych.2012.02.007

Niendam, 2006, Neurocognitive performance and functional disability in the psychosis prodrome, Schizophr. Res., 84, 100, 10.1016/j.schres.2006.02.005

Ojeda, 2012, An explanatory model of quality of life in schizophrenia: the role of processing speed and negative symptoms, Actas Esp. Psiquiatr., 40, 10

Overall, 1962, The brief psychiatric rating scale, Psychol. Rep., 10, 799, 10.2466/pr0.1962.10.3.799

Pearce, 2004, Positive and negative cerebral symptoms: the roles of Russell Reynolds and Hughlings Jackson, J. Neurol. Neurosurg. Psychiatry, 75, 1148, 10.1136/jnnp.2004.038422

Peralta, 1995, Negative symptoms in schizophrenia: a confirmatory factor analysis of competing models, Am. J. Psychiatry, 152, 1450, 10.1176/ajp.152.10.1450

Peralta, 1999, Dimensional structure of psychotic symptoms: an item-level analysis of SAPS and SANS symptoms in psychotic disorders, Schizophr. Res., 38, 13, 10.1016/S0920-9964(99)00003-1

Peralta, 1997, Factor structure of symptoms in functional psychoses, Biol. Psychiatry, 42, 806, 10.1016/S0006-3223(96)00496-9

Peterson, 1983, Anhedonia: a construct validation approach, J. Pers. Assess., 47, 539, 10.1207/s15327752jpa4705_16

Pini, 2004, Cross-sectional similarities and differences between schizophrenia, schizoaffective disorder and mania or mixed mania with mood-incongruent psychotic features, Eur. Psychiatry, 19, 8, 10.1016/j.eurpsy.2003.07.007

Piskulic, 2012, Negative symptoms in individuals at clinical high risk of psychosis, Psychiatry Res., 196, 220, 10.1016/j.psychres.2012.02.018

Pluck, 2002, Apathy in Parkinson's disease, J. Neurol. Neurosurg. Psychiatry, 73, 636, 10.1136/jnnp.73.6.636

Rabinowitz, 2012, Negative symptoms have greater impact on functioning than positive symptoms in schizophrenia: analysis of CATIE data, Schizophr. Res., 137, 147, 10.1016/j.schres.2012.01.015

Raine, 2006, Schizotypal personality: neurodevelopmental and psychosocial trajectories, Annu. Rev. Clin. Psychol., 2, 291, 10.1146/annurev.clinpsy.2.022305.095318

Rao, 2007, Apathy syndrome after traumatic brain injury compared with deficits in schizophrenia, Psychosomatics, 48, 217, 10.1176/appi.psy.48.3.217

Rector, 2001, Cognitive behavioral therapy for schizophrenia: an empirical review, J. Nerv. Ment. Dis., 189, 278, 10.1097/00005053-200105000-00002

Rector, 2005, The negative symptoms of schizophrenia: a cognitive perspective, Can. J. Psychiatry, 50, 247, 10.1177/070674370505000503

Reichman, 1996, Negative symptoms in Alzheimer's disease, Am. J. Psychiatry, 153, 424, 10.1176/ajp.153.3.424

Reichman, 2001, Negative symptoms in the elderly patient with dementia, Int. J. Geriatr. Psychiatry, 16, S7, 10.1002/1099-1166(200112)16:1+<::AID-GPS566>3.0.CO;2-S

Rosenheck, 2006, Barriers to employment for people with schizophrenia, Am. J. Psychiatry, 163, 411, 10.1176/appi.ajp.163.3.411

Roth, 2004, Apathy in schizophrenia: reduced frontal lobe volume and neuropsychological deficits, Am. J. Psychiatry, 161, 157, 10.1176/appi.ajp.161.1.157

Salem, 1999, Flat affect and social skills in schizophrenia: evidence for their independence, Psychiatry Res., 87, 159, 10.1016/S0165-1781(99)00068-2

Sayers, 1996, Factor structure and construct validity of the scale for the assessment of negative symptoms, Psychol. Assess., 8, 269, 10.1037/1040-3590.8.3.269

Schlagenhauf, 2008, Reward system activation in schizophrenic patients switched from typical neuroleptics to olanzapine, Psychopharmacology, 196, 673, 10.1007/s00213-007-1016-4

Schmidt, 2011, Social cognition as a mediator variable between neurocognition and functional outcome in schizophrenia: empirical review and new results by structural equation modeling, Schizophr. Bull., 37, S41, 10.1093/schbul/sbr079

Schroeder, 2011, Evaluation of the appropriateness of multiple symptom validity indices in psychotic and non-psychotic psychiatric populations, Clin. Neuropsychol., 25, 437, 10.1080/13854046.2011.556668

Sergi, 2007, Social cognition in schizophrenia: relationships with neurocognition and negative symptoms, Schizophr. Res., 90, 316, 10.1016/j.schres.2006.09.028

Siever, 2004, The pathophysiology of schizophrenia disorders: perspectives from the spectrum, Am. J. Psychiatry, 161, 398, 10.1176/appi.ajp.161.3.398

Simon, 2010, Neural correlates of reward processing in schizophrenia – relationship to apathy and depression, Schizophr. Res., 118, 154, 10.1016/j.schres.2009.11.007

Starkstein, 2006, A prospective longitudinal study of apathy in Alzheimer's disease, J. Neurol. Neurosurg. Psychiatry, 77, 8, 10.1136/jnnp.2005.069575

Starkstein, 2009, The syndromal validity and nosological position of apathy in Parkinson's disease, Mov. Disord., 24, 1211, 10.1002/mds.22577

Stolar, 1994, Neuropsychological correlates of alogia and affective flattening in schizophrenia, Biol. Psychiatry, 35, 164, 10.1016/0006-3223(94)91148-7

Strauss, 2011, Deficits in positive reinforcement learning and uncertainty-driven exploration are associated with distinct aspects of negative symptoms in schizophrenia, Biol. Psychiatry, 69, 424, 10.1016/j.biopsych.2010.10.015

Strauss, 2012, A new perspective on anhedonia in schizophrenia, Am. J. Psychiatry, 169, 364, 10.1176/appi.ajp.2011.11030447

Strauss, 2010, Periods of recovery in deficit syndrome schizophrenia: a 20-year multi-follow-up longitudinal study, Schizophr. Bull., 36, 788, 10.1093/schbul/sbn167

Strauss, 2012, Factor structure of the brief negative symptom scale, Schizophr. Res., 142, 96, 10.1016/j.schres.2012.09.007

Strauss, 2013, Deconstructing negative symptoms of schizophrenia: avolition-apathy and diminished expression clusters predict clinical presentation and functional outcome, J. Psychiatr. Res., 47, 783, 10.1016/j.jpsychires.2013.01.015

Strauss, 2011, Anticipatory vs. consummatory pleasure: what is the nature of hedonic deficits in schizophrenia?, Psychiatry Res., 187, 36, 10.1016/j.psychres.2011.01.012

Strauss, 1974, The diagnosis and understanding of schizophrenia. Part III. Speculations on the processes that underlie schizophrenic symptoms and signs, Schizophr. Bull., 61, 10.1093/schbul/1.11.61

Sumiyoshi, 2005, Disorganization of semantic memory underlies alogia in schizophrenia: an analysis of verbal fluency performance in Japanese subjects, Schizophr. Res., 74, 91, 10.1016/j.schres.2004.05.011

Svirskis, 2007, Quality of life and functioning ability in subjects vulnerable to psychosis, Compr. Psychiatry, 48, 155, 10.1016/j.comppsych.2006.10.008

Szendi, 2006, Correlations between clinical symptoms, working memory functions and structural brain abnormalities in men with schizophrenia, Psychiatry Res., 147, 47, 10.1016/j.pscychresns.2005.05.014

Szeszko, 2008, Clinical and neuropsychological correlates of white matter abnormalities in recent onset schizophrenia, Neuropsychopharmacology, 33, 976, 10.1038/sj.npp.1301480

Tandon, 2009, Schizophrenia, “just the facts” 4. Clinical features and conceptualization, Schizophr. Res., 110, 1, 10.1016/j.schres.2009.03.005

Tienari, 2003, Genetic boundaries of the schizophrenia spectrum: evidence from the Finnish adoptive family study of schizophrenia, Am. J. Psychiatry, 160, 1587, 10.1176/appi.ajp.160.9.1587

Vadhan, 2001, Convergent validity and neuropsychological correlates of the schedule for the assessment of negative symptoms (SANS) attention subscale, J. Nerv. Ment. Dis., 189, 637, 10.1097/00005053-200109000-00011

Ventura, 2009, Symptoms as mediators of the relationship between neurocognition and functional outcome in schizophrenia: a meta-analysis, Schizophr. Res., 113, 189, 10.1016/j.schres.2009.03.035

Ventura, 2000, Symptom dimensions in recent-onset schizophrenia and mania: a principal components analysis of the 24-item brief psychiatric rating scale, Psychiatry Res., 97, 129, 10.1016/S0165-1781(00)00228-6

Vercelletto, 2002, Negative symptoms, depression and Alzheimer's disease, Int. J. Geriatr. Psychiatry, 17, 383, 10.1002/gps.620

Verma, 2012, Symptomatic and functional remission in patients with first-episode psychosis, Acta Psychiatr. Scand., 126, 282, 10.1111/j.1600-0447.2012.01883.x

Vollema, 1995, The multidimensionality of schizotypy, Schizophr. Bull., 21, 19, 10.1093/schbul/21.1.19

Wallwork, 2012, Searching for a consensus five-factor model of the positive and negative syndrome scale for schizophrenia, Schizophr. Res., 137, 246, 10.1016/j.schres.2012.01.031

Waltz, 2007, Selective reinforcement learning deficits in schizophrenia support predictions from computational models of striatal–cortical dysfunction, Biol. Psychiatry, 62, 756, 10.1016/j.biopsych.2006.09.042

Waltz, 2009, Patients with schizophrenia have a reduced neural response to both unpredictable and predictable primary reinforcers, Neuropsychopharmacology, 34, 1567, 10.1038/npp.2008.214

White, 1997, Empirical assessment of the factorial structure of clinical symptoms in schizophrenia. A multisite, multimodel evaluation of the factorial structure of the positive and negative syndrome scale. The PANSS study group, Psychopathology, 30, 263, 10.1159/000285058

Wing, 1989, The concept of negative symptoms, Br. J. Psychiatry Suppl, 7, 10, 10.1192/S000712500029140X

Winograd-Gurvich, 2006, Negative symptoms: a review of schizophrenia, melancholic depression and Parkinson's disease, Brain Res. Bull., 70, 312, 10.1016/j.brainresbull.2006.06.007

Yee, 2010, Integrity of emotional and motivational states during the prodromal, first-episode, and chronic phases of schizophrenia, J. Abnorm. Psychol., 119, 71, 10.1037/a0018475

Yung, 1996, The prodromal phase of first-episode psychosis: past and current conceptualizations, Schizophr. Bull., 22, 353, 10.1093/schbul/22.2.353