Nef: agent of cell subversion
Tài liệu tham khảo
Emerman, 1998, HIV-1 regulatory/accessory genes: keys to unraveling viral and host cell biology, Science, 280, 1880, 10.1126/science.280.5371.1880
Kestler, 1991, Importance of the nef gene for maintenance of high virus loads and for development of AIDS, Cell, 65, 651, 10.1016/0092-8674(91)90097-I
Deacon, 1995, Genomic structure of an attenuated quasi species of HIV-1 from a blood transfusion donor and recipients, Science, 270, 988, 10.1126/science.270.5238.988
Kirchhoff, 1995, Brief report: absence of intact nef sequences in a long-term survivor with nonprogressive HIV-1 infection, N. Engl. J. M, 332, 228, 10.1056/NEJM199501263320405
Learmont, 1999, Immunologic and virologic status after 14 to 18 years of infection with an attenuated strain of HIV-1. A report from the Sydney Blood Bank Cohort, N. Engl. J. M, 340, 1715, 10.1056/NEJM199906033402203
Bonyhadi, 1993, HIV induces thymus depletion in vivo, Nature, 363, 728, 10.1038/363728a0
Jamieson, 1994, Requirement of human immunodeficiency virus type 1 nef for in vivo replication and pathogenicity, J. Virol., 68, 3478, 10.1128/jvi.68.6.3478-3485.1994
Duus, 2001, Separation of human immunodeficiency virus type 1 replication from nef-mediated pathogenesis in the human thymus, J. Virol., 75, 3916, 10.1128/JVI.75.8.3916-3924.2001
Hanna, 1998, Nef harbors a major determinant of pathogenicity for an AIDS-like disease induced by HIV-1 in transgenic mice, Cell, 95, 163, 10.1016/S0092-8674(00)81748-1
Skowronski, 1993, Altered T cell activation and development in transgenic mice expressing the HIV-1 nef gene, EMBO J., 12, 703, 10.1002/j.1460-2075.1993.tb05704.x
Lindemann, 1994, Severe immunodeficiency associated with a human immunodeficiency virus 1 NEF/3'-long terminal repeat transgene, J. Exp. M, 179, 797, 10.1084/jem.179.3.797
Terwilliger, 1986, Effects of mutations within the 3' orf open reading frame region of human T-cell lymphotropic virus type III (HTLV-III/LAV) on replication and cytopathogenicity, J. Virol., 60, 754, 10.1128/jvi.60.2.754-760.1986
Hammes, 1989, Nef protein of human immunodeficiency virus type 1: evidence against its role as a transcriptional inhibitor, Proc. Natl. Acad. Sci. USA, 86, 9549, 10.1073/pnas.86.23.9549
Kim, 1989, Lack of a negative influence on viral growth by the nef gene of human immunodeficiency virus type 1, Proc. Natl. Acad. Sci. USA, 86, 9544, 10.1073/pnas.86.23.9544
Fackler, 2001, Nef from human immunodeficiency virus type 1(f12) inhibits viral production and infectivity, J. Virol., 75, 6601, 10.1128/JVI.75.14.6601-6608.2001
Alexander, 1997, A role for natural simian immunodeficiency virus and human immunodeficiency virus type 1 nef alleles in lymphocyte activation, J. Virol., 71, 6094, 10.1128/jvi.71.8.6094-6099.1997
Messmer, 2000, The decreased replicative capacity of simian immunodeficiency virus SIVmac239Delta(nef) is manifest in cultures of immature dendritic cellsand T cells, J. Virol., 74, 2406, 10.1128/JVI.74.5.2406-2413.2000
Spina, 1994, The importance of nef in the induction of human immunodeficiency virus type 1 replication from primary quiescent CD4 lymphocytes, J. Exp. M, 179, 115, 10.1084/jem.179.1.115
Miller, 1994, The human immunodeficiency virus-1 nef gene product: a positive factor for viral infection and replication in primary lymphocytes and macrophages, J. Exp. M, 179, 101, 10.1084/jem.179.1.101
Glushakova, 1999, Nef enhances human immunodeficiency virus replication and responsiveness to interleukin-2 in human lymphoid tissue ex vivo, J. Virol., 73, 3968, 10.1128/JVI.73.5.3968-3974.1999
Garcia, 1991, Serine phosphorylation-independent downregulation of cell-surface CD4 by nef, Nature, 350, 508, 10.1038/350508a0
Schwartz, 1996, Endocytosis of major histocompatibility complex class I molecules is induced by the HIV-1 Nef protein, Nat. M, 2, 338, 10.1038/nm0396-338
Simmons, 2001, Nef triggers a transcriptional program in T cells imitating single–signal T cell activation and inducing HIV virulence mediators, Immunity, 14, 763, 10.1016/S1074-7613(01)00158-3
Chowers, 1994, Optimal infectivity in vitro of human immunodeficiency virus type 1 requires an intact nef gene, J. Virol., 68, 2906, 10.1128/jvi.68.5.2906-2914.1994
Collins, 1998, HIV-1 Nef protein protects infected primary cells against killing by cytotoxic T lymphocytes, Nature, 391, 397, 10.1038/34929
Cullen, 1994, The role of Nef in the replication cycle of the human and simian immunodeficiency viruses, Virology, 205, 1, 10.1006/viro.1994.1613
Klotman, 1992, Kinetics of expression of multiply spliced RNA in early human immunodeficiency virus type 1 infection of lymphocytes and monocytes, Proc. Natl. Acad. Sci. USA, 89, 1148, 10.1073/pnas.89.3.1148b
Wu, 2001, Selective transcription and modulation of resting T cell activity by preintegrated HIV DNA, Science, 293, 1503, 10.1126/science.1061548
Luo, 1997, Induction of phosphorylation of human immunodeficiency virus type 1 Nef and enhancement of CD4 downregulation by phorbol myristate acetate, J. Virol., 71, 2535, 10.1128/jvi.71.3.2535-2539.1997
Sawai, 1995, A conserved domain and membrane targeting of Nef from HIV and SIV are required for association with a cellular serine kinase activity, J. Biol. Chem., 270, 15307, 10.1074/jbc.270.25.15307
Aiken, 1994, Nef induces CD4 endocytosis: requirement for a critical dileucine motif in the membrane-proximal CD4 cytoplasmic domain, Cell, 76, 853, 10.1016/0092-8674(94)90360-3
Kaminchik, 1994, Cellular distribution of HIV type 1 Nef protein: identification of domains in Nef required for association with membrane and detergent-insoluble cellular matrix, AIDS Res. Hum. Retroviruses, 10, 1003, 10.1089/aid.1994.10.1003
Niederman, 1993, Myristoylation-enhanced binding of the HIV-1 Nef protein to T cell skeletal matrix, Virology, 197, 420, 10.1006/viro.1993.1605
Fackler, 1997, Association of human immunodeficiency virus Nef protein with actin is myristoylation dependent and influences its subcellular localization, Eur. J. Biochem., 247, 843, 10.1111/j.1432-1033.1997.00843.x
Kotov, 1999, Association of Nef with the human immunodeficiency virus type 1 core, J. Virol., 73, 8824, 10.1128/JVI.73.10.8824-8830.1999
Shugars, 1993, Analysis of human immunodeficiency virus type 1 nef gene sequences present in vivo, J. Virol., 67, 4639, 10.1128/jvi.67.8.4639-4650.1993
Foster, 2001, Genetic and functional diversity of human immunodeficiency virus type 1 subtype B Nef primary isolates, J. Virol., 75, 1672, 10.1128/JVI.75.4.1672-1680.2001
Carl, 2001, Modulation of different human immunodeficiency virus type 1 Nef functions during progression to AIDS, J. Virol., 75, 3657, 10.1128/JVI.75.8.3657-3665.2001
Swigut, 2000, Simian and human immunodeficiency virus Nef proteins use different surfaces to downregulate class I major histocompatibility complex antigen expression, J. Virol., 74, 5691, 10.1128/JVI.74.12.5691-5701.2000
Craig, 1999, Analysis of the SH3-binding region of HIV-1 nef: partial functional defects introduced by mutations in the polyproline helix and the hydrophobic pocket, Virology, 262, 55, 10.1006/viro.1999.9897
Garcia, 1996, Structural and functional correlates between HIV-1 and SIV Nef isolates, Virology, 226, 161, 10.1006/viro.1996.0642
Le Gall, 1998, Nef interacts with the mu subunit of clathrin adaptor complexes and reveals a cryptic sorting signal in MHC I molecules, Immunity, 8, 483, 10.1016/S1074-7613(00)80553-1
Anderson, 1993, Nef from primary isolates of human immunodeficiency virus type 1 suppresses surface CD4 expression in human and mouse T cells, J. Virol., 67, 4923, 10.1128/jvi.67.8.4923-4931.1993
Benson, 1993, Downregulation of cell-surface CD4 expression by simian immunodeficiency virus Nef prevents viral super infection, J. Exp. M, 177, 1561, 10.1084/jem.177.6.1561
Garcia, 1993, The negative effect of human immunodeficiency virus type 1 Nef on cell surface CD4 expression is not species specific and requires the cytoplasmic domain of CD4, J. Virol., 67, 1511, 10.1128/jvi.67.3.1511-1516.1993
Mariani, 1993, CD4 down-regulation by nef alleles isolated from human immunodeficiency virus type 1-infected individuals, Proc. Natl. Acad. Sci. USA, 90, 5549, 10.1073/pnas.90.12.5549
Lama, 1999, Cell-surface expression of CD4 reduces HIV-1 infectivity by blocking Env incorporation in a Nef- and Vpu-inhibitable manner, Curr. Biol., 9, 622, 10.1016/S0960-9822(99)80284-X
Ross, 1999, Inhibition of HIV-1 progeny virion release by cell-surface CD4 is relieved by expression of the viral Nef protein, Curr. Biol., 9, 613, 10.1016/S0960-9822(99)80283-8
Foti, 1997, Nef-mediated clathrin-coated pit formation, J. Cell Biol., 139, 37, 10.1083/jcb.139.1.37
Le Gall, 2000, Distinct trafficking pathways mediate Nef-induced and clathrin-dependent major histocompatibility complex class I down-regulation, J. Virol., 74, 9256, 10.1128/JVI.74.19.9256-9266.2000
Luo, 2001, Human immunodeficiency virus type 1 Nef-induced CD4 cell surface downregulation is inhibited by ikarugamycin, J. Virol., 75, 2488, 10.1128/JVI.75.5.2488-2492.2001
Luo, 1996, Inhibition of Nef- and phorbol ester-induced CD4 degradation by macrolide antibiotics, J. Virol., 70, 1527, 10.1128/jvi.70.3.1527-1534.1996
Sanfridson, 1994, The simian immunodeficiency virus Nef protein promotes degradation of CD4 in human T cells, J. Biol. Chem., 269, 3917, 10.1016/S0021-9258(17)41719-4
Rhee, 1994, HIV-1 Nef activity in murine T cells. CD4 modulation and positive enhancement, J. Immunol., 152, 5128, 10.4049/jimmunol.152.10.5128
Rhee, 1994, Human immunodeficiency virus type 1 Nef-induced down-modulation of CD4 is due to rapid internalization and degradation of surface CD4, J. Virol., 68, 5156, 10.1128/jvi.68.8.5156-5163.1994
Mangasarian, 1997, The HIV-1 Nef protein acts as a connector with sorting pathways in the Golgi and at the plasma membrane, Immunity, 6, 67, 10.1016/S1074-7613(00)80243-5
Harris, 1994, Myristoylation-dependent binding of HIV-1 Nef to CD4, J. Mol. Biol., 241, 136, 10.1006/jmbi.1994.1483
Rossi, 1996, Nef-CD4 physical interaction sensed with the yeast two-hybrid system, Virology, 217, 397, 10.1006/viro.1996.0130
Grzesiek, 1996, The CD4 determinant for downregulation by HIV-1 Nef directly binds to Nef. Mapping of the Nef binding surface by NMR, Biochemistry, 35, 10256, 10.1021/bi9611164
Preusser, 2001, Direct in vitro binding of full-length human immunodeficiency virus type 1 Nef protein to CD4 cytoplasmic domain, J. Virol., 75, 3960, 10.1128/JVI.75.8.3960-3964.2001
Anderson, 1994, The cytoplasmic domain of CD4 is sufficient for its down-regulation from the cell surface by human immunodeficiency virus type 1 Nef, J. Virol., 68, 3092, 10.1128/jvi.68.5.3092-3101.1994
Hua, 1997, Human immunodeficiency virus types 1 and 2 and simian immunodeficiency virus Nef use distinct but overlapping target sites for downregulation of cell surface CD4, J. Virol., 71, 6742, 10.1128/jvi.71.9.6742-6748.1997
Mangasarian, 1999, Nef-induced CD4 and major histocompatibility complex class I (MHC-I) down-regulation are governed by distinct determinants: N-terminal alpha helix and proline repeat of Nef selectively regulate MHC-I trafficking, J. Virol., 73, 1964, 10.1128/JVI.73.3.1964-1973.1999
Greenberg, 1997, Co-localization of HIV-1 Nef with the AP-2 adaptor protein complex correlates with Nef-induced CD4 down-regulation, EMBO J., 16, 6964, 10.1093/emboj/16.23.6964
Greenberg, 1998, A dileucine motif in HIV-1 Nef is essential for sorting into clathrin-coated pits and for downregulation of CD4, Curr. Biol., 8, 1239, 10.1016/S0960-9822(07)00518-0
Bresnahan, 1999, Cutting edge: SIV Nef protein utilizes both leucine- and tyrosine-based protein sorting pathways for down-regulation of CD4, J. Immunol., 163, 2977, 10.4049/jimmunol.163.6.2977
Craig, 1998, Interaction of HIV-1 Nef with the cellular dileucine-based sorting pathway is required for CD4 down-regulation and optimal viral infectivity, Proc. Natl. Acad. Sci. USA, 95, 11229, 10.1073/pnas.95.19.11229
Craig, 2000, Interactions of HIV-1 nef with the mu subunits of adaptor protein complexes 1, 2, and 3: role of the dileucine-based sorting motif, Virology, 271, 9, 10.1006/viro.2000.0277
Lock, 1999, Two elements target SIV Nef to the AP-2 clathrin adaptor complex, but only one is required for the induction of CD4 endocytosis, EMBO J., 18, 2722, 10.1093/emboj/18.10.2722
Piguet, 1998, Mechanism of Nef-induced CD4 endocytosis: Nef connects CD4 with the mu chain of adaptor complexes, EMBO J., 17, 2472, 10.1093/emboj/17.9.2472
Xu, 1999, Subunit interactions in the clathrin-coated vesicle vacuolar (H(+))-ATPase complex, J. Biol. Chem., 274, 28909, 10.1074/jbc.274.41.28909
Lu, 1998, Interactions between HIV1 Nef and vacuolar ATPase facilitate the internalization of CD4, Immunity, 8, 647, 10.1016/S1074-7613(00)80569-5
Mandic, 2001, Negative factor from siv binds to the catalytic subunit of the v-atpase to internalize cd4 and to increase viral infectivity, Mol. Biol. Cell, 12, 463, 10.1091/mbc.12.2.463
Erdtmann, 2000, Two independent regions of HIV-1 Nef are required for connection with the endocytic pathway through binding to the mu 1 chain of AP1 complex, Traffic, 1, 871, 10.1034/j.1600-0854.2000.011106.x
Piguet, 1999, Nef-induced CD4 degradation: a diacidic-based motif in Nef functions as a lysosomal targeting signal through the binding of beta-COP in endosomes, Cell, 97, 63, 10.1016/S0092-8674(00)80715-1
Benichou, 1994, Physical interaction of the HIV-1 Nef protein with beta-COP, a component of non-clathrin-coated vesicles essential for membrane traffic, J. Biol. Chem., 269, 30073, 10.1016/S0021-9258(18)43773-8
Luo, 1996, The association of Nef with a cellular serine/threonine kinase and its enhancement of infectivity are viral isolate dependent, J. Virol., 70, 6493, 10.1128/jvi.70.9.6493-6496.1996
Janvier, 2001, Nef-induced CD4 downregulation: a diacidic sequence in human immunodeficiency virus type 1 Nef does not function as a protein sorting motif through direct binding to beta-COP, J. Virol., 75, 3971, 10.1128/JVI.75.8.3971-3976.2001
Liu, 1997, Binding of HIV-1 Nef to a novel thioesterase enzyme correlates with Nef-mediated CD4 down-regulation, J. Biol. Chem., 272, 13779, 10.1074/jbc.272.21.13779
Cohen, 2000, The human thioesterase II protein binds to a site on HIV-1 Nef critical for CD4 down-regulation, J. Biol. Chem., 275, 23097, 10.1074/jbc.M000536200
Cohen, 1999, The selective downregulation of class I major histocompatibility complex proteins by HIV-1 protects HIV-infected cells from NK cells, Immunity, 10, 661, 10.1016/S1074-7613(00)80065-5
Betts, 2000, Putative immunodominant human immunodeficiency virus-specific CD8(+) T-cell responses cannot be predicted by major histocompatibility complex class I haplotype, J. Virol., 74, 9144, 10.1128/JVI.74.19.9144-9151.2000
Riggs, 1999, The dileucine-based sorting motif in HIV-1 Nef is not required for down-regulation of class I MHC, Virology, 258, 203, 10.1006/viro.1999.9736
Swann, 2001, HIV-1 Nef blocks transport of MHC class I molecules to the cell surface via a PI 3-kinase-dependent pathway, Virology, 282, 267, 10.1006/viro.2000.0816
Greenberg, 1998, The SH3 domain-binding surface and an acidic motif in HIV-1 Nef regulate trafficking of class I MHC complexes, EMBO J., 17, 2777, 10.1093/emboj/17.10.2777
Piguet, 2000, HIV-1 Nef protein binds to the cellular protein PACS-1 to downregulate class I major histocompatibility complexes, Nat. Cell. Biol., 2, 163, 10.1038/35004038
Wan, 1998, PACS-1 defines a novel gene family of cytosolic sorting proteins required for trans-Golgi network localization, Cell, 94, 166, 10.1016/S0092-8674(00)81420-8
Bell, 1998, Association of simian immunodeficiency virus Nef with the T-cell receptor (TCR) zeta chain leads to TCR down-modulation, J. Gen. Virol., 79, 2717, 10.1099/0022-1317-79-11-2717
Swigut, 2001, Mechanism for down-regulation of CD28 by Nef, EMBO J., 20, 1593, 10.1093/emboj/20.7.1593
Bell, 2001, Down-modulation of the costimulatory molecule, Virology, 283, 148, 10.1006/viro.2001.0872
Swingler, 1999, HIV-1 Nef mediates lymphocyte chemotaxis and activation by infected macrophages, Nat. M, 5, 103, 10.1038/12433
Iafrate, 1997, Separable functions of Nef disrupt two aspects of T cell receptor machinery: CD4 expression and CD3 signaling, EMBO J., 16, 673, 10.1093/emboj/16.4.673
Schrager, 1999, HIV-1 Nef increases T cell activation in a stimulus-dependent manner, Proc. Natl. Acad. Sci. USA, 96, 8167, 10.1073/pnas.96.14.8167
Wang, 2000, The Nef protein of HIV-1 associates with rafts and primes T cells for activation, Proc. Natl. Acad. Sci. USA, 97, 394, 10.1073/pnas.97.1.394
Page, 1997, Human immunodeficiency virus type 1 Nef does not alter T-cell sensitivity to antigen-specific stimulation, J. Virol., 71, 3776, 10.1128/jvi.71.5.3776-3787.1997
Renkema, 1999, Identification of the Nef-associated kinase as p21-activated kinase 2, Curr. Biol., 9, 1407, 10.1016/S0960-9822(00)80086-X
Arora, 2000, Lentivirus Nef specifically activates Pak2, J. Virol., 74, 11081, 10.1128/JVI.74.23.11081-11087.2000
Salojin, 1999, TCR and CD28 are coupled via ZAP-70 to the activation of the Vav/Rac-1-/PAK-1/p38 MAPK signaling pathway, J. Immunol., 163, 844, 10.4049/jimmunol.163.2.844
Yablonski, 1998, A Nck-Pak1 signaling module is required for T-cell receptor-mediated activation of NFAT, but not of JNK, EMBO J., 17, 5647, 10.1093/emboj/17.19.5647
Manninen, 2001, Activation of NFAT-dependent gene expression by Nef: conservation among divergent Nef alleles, dependence on SH3 binding and membrane association, and cooperation with protein kinase C-theta, J. Virol., 75, 3034, 10.1128/JVI.75.6.3034-3037.2001
Manninen, 1998, SH3-Domain binding function of HIV-1 Nef is required for association with a PAK-related kinase, Virology, 250, 273, 10.1006/viro.1998.9381
Khan, 1998, Role of the SH3-ligand domain of simian immunodeficiency virus Nef in interaction with Nef-associated kinase and simian AIDS in rhesus macaques, J. Virol., 72, 5820, 10.1128/JVI.72.7.5820-5830.1998
Fackler, 1999, Activation of Vav by Nef induces cytoskeletal rearrangements and downstream effector functions, Mol. Cell, 3, 729, 10.1016/S1097-2765(01)80005-8
Brown, 1999, Activation of the PAK-related kinase by human immunodeficiency virus type 1 Nef in primary human peripheral blood lymphocytes and macrophages leads to phosphorylation of a PIX-p95 complex, J. Virol., 73, 9899, 10.1128/JVI.73.12.9899-9907.1999
Xu, 1999, Induction of Fas ligand expression by HIV involves the interaction of Nef with the T cell receptor zeta chain, J. Exp. M, 189, 1489, 10.1084/jem.189.9.1489
Herna, 2000, Interactions of HIV-1 NEF with cellular signal transducing proteins, Front. Biosci., 5, D268, 10.2741/Renkema
Gallina, 2001, Rack1 binds HIV-1 Nef and can act as a Nef-protein kinase C adaptor, Virology, 283, 7, 10.1006/viro.2001.0855
Briggs, 1997, SH3-mediated Hck tyrosine kinase activation and fibroblast transformation by the Nef protein of HIV-1, J. Biol. Chem., 272, 17899, 10.1074/jbc.272.29.17899
Moarefi, 1997, Activation of the Src-family tyrosine kinase Hck by SH3 domain displacement, Nature, 385, 650, 10.1038/385650a0
Briggs, 2001, HIV-1 Nef promotes survival of myeloid cells by a Stat3-dependent pathway, J Biol. Chem., 10.1074/jbc.M103244200
Miller, 1995, Expression of the human immunodeficiency virus type 1 (HIV-1) nef gene during HIV-1 production increases progeny particle infectivity independently of gp160 or viral entry, J. Virol., 69, 579, 10.1128/jvi.69.1.579-584.1995
Goldsmith, 1995, Dissociation of the CD4 downregulation and viral infectivity enhancement functions of human immunodeficiency virus type 1 Nef, J. Virol., 69, 4112, 10.1128/jvi.69.7.4112-4121.1995
Aiken, 1995, Nef stimulates human immunodeficiency virus type 1 proviral DNA synthesis, J. Virol., 69, 5048, 10.1128/jvi.69.8.5048-5056.1995
Chowers, 1995, The growth advantage conferred by HIV-1 nef is determined at the level of viral DNA formation and is independent of CD4 downregulation, Virology, 212, 451, 10.1006/viro.1995.1502
Schwartz, 1995, Human immunodeficiency virus type 1 Nef increases the efficiency of reverse transcription in the infected cell, J. Virol., 69, 4053, 10.1128/jvi.69.7.4053-4059.1995
Chazal, 2001, Human immunodeficiency virus type 1 particles pseudotyped with envelope proteins that fuse at low pH no longer require Nef for optimal infectivity, J. Virol., 75, 4014, 10.1128/JVI.75.8.4014-4018.2001
Aiken, 1997, Pseudotyping human immunodeficiency virus type 1 (HIV-1) by the glycoprotein of vesicular stomatitis virus targets HIV-1 entry to an endocytic pathway and suppresses both the requirement for Nef and the sensitivity to cyclosporin A, J. Virol., 71, 5871, 10.1128/jvi.71.8.5871-5877.1997
Luo, 1998, Infectivity enhancement by HIV-1 Nef is dependent on the pathway of virus entry: implications for HIV-based gene transfer systems, Virology, 241, 224, 10.1006/viro.1997.8966
Schaeffer, 2001, Human immunodeficiency virus type 1 Nef functions at the level of virus entry by enhancing cytoplasmic delivery of virions, J. Virol., 75, 2993, 10.1128/JVI.75.6.2993-3000.2001
Zhou, 2001, Nef enhances human immunodeficiency virus type 1 infectivity resulting from intervirion fusion: evidence supporting a role for nef at the virion envelope, J. Virol., 75, 5851, 10.1128/JVI.75.13.5851-5859.2001
Luo, 1997, Infectivity enhancement by human immunodeficiency virus type 1 Nef is independent of its association with a cellular serine/threonine kinase, J. Virol., 71, 9524, 10.1128/jvi.71.12.9524-9530.1997
Iafrate, 2000, Disrupting surfaces of nef required for downregulation of CD4 and for enhancement of virion infectivity attenuates simian immunodeficiency virus replication in vivo, J. Virol., 74, 9836, 10.1128/JVI.74.21.9836-9844.2000
Yoon, 2001, Stable expression of human immunodeficiency virus type 1 Nef confers resistance against Fas-mediated apoptosis, AIDS Res. Hum. Retroviruses, 17, 99, 10.1089/08892220150217184
Geleziunas, 2001, HIV-1 Nef inhibits ASK1-dependent death signalling providing a potential mechanism for protecting the infected host cell, Nature, 410, 834, 10.1038/35071111
Rasola, 2001, Apoptosis enhancement by the HIV-1 Nef protein, J. Immunol., 166, 81, 10.4049/jimmunol.166.1.81
Kirchhoff, 1999, The human immunodeficiency virus type 1 nef gene can to a large extent replace simian immunodeficiency virus nef in vivo, J. Virol., 73, 8371, 10.1128/JVI.73.10.8371-8383.1999
Alexander, 1999, Induction of AIDS in rhesus monkeys by a recombinant simian immunodeficiency virus expressing nef of human immunodeficiency virus type 1, J. Virol., 73, 5814, 10.1128/JVI.73.7.5814-5825.1999
Carl, 2000, Simian immunodeficiency virus containing mutations in N-terminal tyrosine residues and in the PxxP motif in Nef replicates efficiently in rhesus macaques, J. Virol., 74, 4155, 10.1128/JVI.74.9.4155-4164.2000
Lang, 1997, Association of simian immunodeficiency virus Nef with cellular serine/threonine kinases is dispensable for the development of AIDS in rhesus macaques, Nat. M, 3, 860, 10.1038/nm0897-860
Sawai, 1996, Activation of PAK by HIV and SIV Nef: importance for AIDS in rhesus macaques, Curr. Biol., 6, 1519, 10.1016/S0960-9822(96)00757-9
Liu, 2000, Mutation of a conserved residue (D123) required for oligomerization of human immunodeficiency virus type 1 Nef protein abolishes interaction with human thioesterase and results in impairment of Nef biological functions, J. Virol., 74, 5310, 10.1128/JVI.74.11.5310-5319.2000