Naturally occurring systemic immune responses to HPV antigens do not predict regression of CIN2/3

Springer Science and Business Media LLC - Tập 59 - Trang 799-803 - 2009
Cornelia L. Trimble1, Shiwen Peng2, Christopher Thoburn3, Ferdynand Kos3, T. C. Wu2
1Department of Gynecology and Obstetrics, Johns Hopkins University School of Medicine, Baltimore, USA
2Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, USA
3Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, USA

Tóm tắt

Essentially all squamous cervical cancers and their precursor lesions, high grade cervical intraepithelial neoplasia (CIN2/3), are caused by persistent human papillomavirus (HPV) infection. However, not all CIN2/3 lesions progress to cancer. In a brief, observational study window monitoring subjects with CIN2/3 from protocol entry (biopsy diagnosis) to definitive therapy (cervical conization) at week 15, in a cohort of 50 subjects, we found that 26% of CIN2/3 lesions associated with HPV16, the genotype most commonly associated with disease, underwent complete histologic regression. Nonetheless, HPV16-specific T cell responses measured in peripheral blood obtained at the time of study entry and at the time of conization were marginally detectable directly ex vivo, and did not correlate with lesion regression. This finding suggests that, in the setting of natural infection, immune responses which are involved in elimination of cervical dysplastic epithelium are not represented to any great extent in the systemic circulation.

Tài liệu tham khảo

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