Natural products: An evolving role in future drug discovery

European Journal of Medicinal Chemistry - Tập 46 Số 10 - Trang 4769-4807 - 2011
Bhuwan B. Mishra1, Vinod K. Tiwari1
1Department of Chemistry, Centre of Advanced Study, Banaras Hindu University, Varanasi-221005, India

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Firn, 2003, Nat. Prod. Rep., 20, 382, 10.1039/b208815k

Lee, 2010, J. Nat. Prod., 73, 500, 10.1021/np900821e

Cragg, 1997, J. Nat. Prod., 60, 52, 10.1021/np9604893

Newman, 2003, J. Nat. Prod., 66, 1022, 10.1021/np030096l

Newman, 2007, J. Nat. Prod., 70, 461, 10.1021/np068054v

Kingston, 2005, Curr. Opin. Drug Discov. Dev., 8, 207

Kingston, 2005, IDrugs, 8, 990

Koehn, 2005, Nat. Rev. Drug Discov., 4, 206, 10.1038/nrd1657

Paterson, 2005, Science, 310, 451, 10.1126/science.1116364

Jones, 2006, Curr. Drug Targets, 7, 247, 10.2174/138945006776054915

Gullo, 2006, J. Ind. Microbiol. Biotechnol., 33, 523, 10.1007/s10295-006-0107-2

Wilson, 2006, J. Org. Chem., 71, 8329, 10.1021/jo0610053

Lam, 2007, Trends Microbiol., 15, 279, 10.1016/j.tim.2007.04.001

Baker, 2007, Nat. Prod. Rep., 24, 1225, 10.1039/b602241n

Harvey, 2007, Curr. Opin. Chem. Biol., 11, 480, 10.1016/j.cbpa.2007.08.012

Butler, 2008, Nat. Prod. Rep., 25, 475, 10.1039/b514294f

A.G. Medigene, Press release 1 March 2010. Available at: http://www.medigene.de/.

Wade, 2003, Clin. Rehabil., 17, 21, 10.1191/0269215503cr581oa

Nurmikko, 2007, Pain, 133, 210, 10.1016/j.pain.2007.08.028

Johnson, 2010, J. Pain Symptom Manage., 39, 167, 10.1016/j.jpainsymman.2009.06.008

G.W Pharmaceuticals: Press release 18 March 2010. Available at: http://www.gwpharm.com/.

McCowen, 1951, Science, 113, 202, 10.1126/science.113.2930.202

Lanternier, 2009, Transpl. Infect. Dis., 11, 83, 10.1111/j.1399-3062.2008.00347.x

Shionogi & Co Ltd.: Press release 9 June 2006. Available at: http://www.shionogi.co.jp.

FDA: Press release 17 October 2007. Available at: http://www.fda.gov.

Slover, 2007, Ann. Pharmacother., 41, 965, 10.1345/aph.1H543

Breedt, 2005, Antimicrob. Agents Chemother., 49, 4658, 10.1128/AAC.49.11.4658-4666.2005

Kasbekar, 2006, Am. J. Health-Syst Pharm., 63, 1235, 10.2146/ajhp050487

McGivern, 2007, Neuropsychiatr Dis. Treat., 3, 69, 10.2147/nedt.2007.3.1.69

EMA: Press release 9 July 2007. Available at: http://www.ema.europa.eu/.

Chen, 2007, J. Chromatogr. B., 858, 106, 10.1016/j.jchromb.2007.08.012

Pritchard, 2005, Drug Disc. Today, 10, 688, 10.1016/S1359-6446(05)03395-7

Gershlick, 2007, Am. J. Cardiol., 100, 45M, 10.1016/j.amjcard.2007.08.021

Medtronic: Press release 1 February 2008. Available at: http://wwwp.medtronic.com/.

Cordis: Press release 21 September 2009. Available at: http://www.cordis.com/.

Debono, 1995, J. Med. Chem., 38, 3271, 10.1021/jm00017a012

Torre, 2007, Expert Rev. Anti-Infect. Ther., 5, 45, 10.1586/14787210.5.1.45

Wolfson, 2007, Chem. Biol., 14, 235, 10.1016/j.chembiol.2007.03.005

Barnett, 2007, Expert Opin. Pharmacother., 8, 2593, 10.1517/14656566.8.15.2593

Cvetkovic, 2007, Drugs, 67, 935, 10.2165/00003495-200767060-00008

Blick, 2007, Paediatr. Drugs, 9, 129, 10.2165/00148581-200709020-00007

Jasinski, 2009, J. Psychopharmacol., 23, 410, 10.1177/0269881108093841

Popovic, 2009, Am. J. Health-Sys Pharm., 66, 2005, 10.2146/ajhp080353

Daum, 2007, Nat. Rev. Drug Discov., 7, 865, 10.1038/nrd2442

Jacobs, 2007, Future Microbiol., 2, 591, 10.2217/17460913.2.6.591

Hudes, 2007, New Engl. J. Med., 356, 2271, 10.1056/NEJMoa066838

Wan, 2007, Oncologist, 12, 1007, 10.1634/theoncologist.12-8-1007

Lin, 2006, Ann. Clinical Lab Science, 36, 283

Boni, 2005, Clin. Pharma. Therap., 77, 76, 10.1016/j.clpt.2004.08.025

Soares, 2007, Proc. Natl. Acad. Sci. U.S.A., 104, 13062, 10.1073/pnas.0609877104

EMA: Press release 16 February 2010. Available at: http://www.ema.europa.eu/.

Goodin, 2008, Am. J. Health-Syst Pharm., 65, S10, 10.2146/ajhp080089

Lee, 2008, Cancer Chemother. Pharmacol., 63, 157, 10.1007/s00280-008-0724-8

Conlin, 2008, Eur. J. Cancer, 44, 341, 10.1016/j.ejca.2007.11.019

Guay, 2009, Consult Pharm., 24, 210, 10.4140/TCP.n.2009.210

Slatkin, 2009, J. Support Oncol., 7, 39

.Reichle, 2008, Curr. Opin. Invest. Drugs, 9, 90

Yuan, 2007, Ann. Pharmacother., 41, 984, 10.1345/aph.1K009

Kraft, 2007, Am. J. Health Syst. Pharm., 64, S13, 10.2146/ajhp070430

Novartis: Press release 30 March 2009. Available at: http://www.novartis.com/.

Higgins, 2005, Antimicrob. Agents Chemother., 49, 1127, 10.1128/AAC.49.3.1127-1134.2005

Judice, 2003, Bioorg. Med. Chem. Lett., 13, 4165, 10.1016/j.bmcl.2003.08.067

Avaleeson, 2007, Expert Opin. Invest. Drugs, 16, 347, 10.1517/13543784.16.3.347

Theravance: Press release 27 November 2009. Available at: http://investor.theravance.com/.

Piekarz, 2009, J. Clin. Oncol., 27, 5410, 10.1200/JCO.2008.21.6150

Woo, 2009, Clin. Cancer Res., 15, 1496, 10.1158/1078-0432.CCR-08-1215

Thresh, 1876, Analyst, 1, 148, 10.1039/AN8760100025

Knotkova, 2008, Clin. J. Pain, 24, 142, 10.1097/AJP.0b013e318158ed9e

Szallasi, 2007, Nat. Rev. Drug Discov., 6, 357, 10.1038/nrd2280

Gunthorpe, 2008, Curr. Pharm. Des., 14, 32, 10.2174/138161208783330754

Caterina, 1997, Nature, 389, 816, 10.1038/39807

Kissin, 2008, Anesth. Analg., 107, 271, 10.1213/ane.0b013e318162cfa3

Mori, 2006, Am. Assoc. Cancer Res., 66, 3222, 10.1158/0008-5472.CAN-05-0087

McCoy, 2008, Am. J. Respir. Crit. Care Med., 178, 921, 10.1164/rccm.200712-1804OC

Retsch-Bogart, 2008, Pediatr. Pulmonol., 43, 47, 10.1002/ppul.20736

McDevitt, 2001, Trends Microbiol., 9, 611, 10.1016/S0966-842X(01)02235-1

Mills, 2003, J. Antimicrob. Chemother., 51, 749, 10.1093/jac/dkg178

Shea, 2008, J. Med. Chem., 51, 2871, 10.1021/jm700967e

Kishore, 2009, Fitoterapia, 80, 149, 10.1016/j.fitote.2009.01.002

Hebeisen, 2001, Antimicrob. Agents Chemother., 45, 825, 10.1128/AAC.45.3.825-836.2001

Bush, 2007, Expert Opin. Invest. Drugs, 16, 419, 10.1517/13543784.16.4.419

Widmer, 2008, Clin. Infect. Dis., 46, 656, 10.1086/526528

Noel, 2008, Clin. Infect. Dis., 46, 647, 10.1086/526527

Ishikawa, 2003, Bioorg. Med. Chem., 11, 2427, 10.1016/S0968-0896(03)00126-3

Talbot, 2007, Antimicrob. Agents Chemother., 51, 3612, 10.1128/AAC.00590-07

Parish, 2008, Curr. Opin. Invest. Drugs, 9, 201

Kobayashi, 2005, Antimicrob. Agents Chemother., 49, 889, 10.1128/AAC.49.3.889-894.2005

Thomson, 2004, J. Antimicrob. Chemother., 54, 557, 10.1093/jac/dkh328

Macgowan, 2008, Antimicrob. Agents Chemother., 52, 1401, 10.1128/AAC.01153-07

Ueda, 2005, J. Antibiot., 58, 118, 10.1038/ja.2005.15

Sader, 2008, Antimicrob. Agents Chemother., 52, 1153, 10.1128/AAC.01351-07

Gettig, 2008, Ann. Pharmacother., 42, 80, 10.1345/aph.1G232

Schurek, 2007, Expert Rev. Anti-Infect Ther., 5, 185, 10.1586/14787210.5.2.185

Dalhoff, 2006, Biochem. Pharmacol., 71, 1085, 10.1016/j.bcp.2005.12.003

Billeter, 2008, Clin. Infect. Dis., 46, 577, 10.1086/526772

Kim, 2007, Expert Opin. Invest. Drugs, 16, 717, 10.1517/13543784.16.5.717

Targanta Therapeutics: Press release 11 February 2008. Available at: http://www.targanta.com/.

Theravance: Press release 7 July 2007. Available at: http://investor.theravance.com/.

Farver, 2005, Ann. Pharmacother., 39, 863, 10.1345/aph.1E397

Fang, 2006, Mol. Biosystems, 2, 69, 10.1039/B515328J

Breukink, 2006, Nat. Rev. Drug Discov., 5, 321, 10.1038/nrd2004

Scheinfeld, 2007, Drugs Dermatol., 6, 97

Gerding, 2008, Clin. Infect. Dis., 46, S32, 10.1086/521860

Boucher, 2009, Clin. Infect. Dis., 48, 1, 10.1086/595011

Vannuffel, 1996, Drugs, 51, 20, 10.2165/00003495-199600511-00006

Pankuch, 2003, Antimicrob. Agents Chemother., 47, 3270, 10.1128/AAC.47.10.3270-3274.2003

Wecke, 2009, Antimicrob. Agents Chemother., 53, 1619, 10.1128/AAC.01046-08

Aretz, 2000, J. Antibiot. (Tokyo), 53, 807, 10.7164/antibiotics.53.807

Straus, 2006, Biochim. Biophys. Acta, 1758, 1215, 10.1016/j.bbamem.2006.02.009

Grasemann, 2007, Chest, 131, 1461, 10.1378/chest.06-2085

Zeitlin, 2004, Chest, 125, 143, 10.1378/chest.125.1.143

Isaacson, 2003, Curr. Opin. Investig. Drugs, 4, 999

Fritsche, 2008, Antimicrob. Agents Chemother., 52, 1187, 10.1128/AAC.01475-07

Fritsche, 2008, J. Antimicrob. Chemother., 61, 1092, 10.1093/jac/dkn074

Katz, 2005, Chem. Rev., 105, 499, 10.1021/cr030107f

Lawrence, 2001, Curr. Opin. Invest. Drugs, 2, 766

Zhanel, 2003, Expert Opin. Emerg. Drugs, 8, 297, 10.1517/14728214.8.2.297

Hammerschlag, 2008, Expert Opin. Inv. Drugs, 17, 387, 10.1517/13543784.17.3.387

Wang, 2004, Org. Lett., 6, 4455, 10.1021/ol048336r

Stucki, 2008, J. Antimicrob. Chemother., 61, 665, 10.1093/jac/dkm505

Heller, 2007, Antimicrob. Agents Chemother., 51, 1956, 10.1128/AAC.00062-07

Wind, 2007, Rapid Commun. Mass Spectrom., 21, 1093, 10.1002/rcm.2926

Hochlowski, 1987, J. Antibiot. (Tokyo), 40, 575, 10.7164/antibiotics.40.575

Revill, 2006, J. Bolos, Drugs Fut., 31, 494, 10.1358/dof.2006.031.06.1000709

Shue, 2008, Antimicrob. Agents Chemother., 52, 1391, 10.1128/AAC.01045-07

Gerber, 2008, Expert Opin. Inv. Drugs, 17, 547, 10.1517/13543784.17.4.547

Xiao, 2011, J. Am. Chem. Soc., 133, 1092, 10.1021/ja109445q

Credito, 2004, Antimicrob. Agents Chemother., 48, 4430, 10.1128/AAC.48.11.4430-4434.2004

Louie, 2009, Antimicrob. Agents Chemother., 53, 261, 10.1128/AAC.01443-07

Mullarkey, 2003, J. Pharmacol. Exp. Ther., 304, 1093, 10.1124/jpet.102.044487

Rossignol, 2005, Curr. Opin. Invest. Drugs, 6, 496

Kim, 2007, Cell, 130, 906, 10.1016/j.cell.2007.08.002

Robertson, 2008, Antimicrob. Agents Chemother., 52, 2313, 10.1128/AAC.01649-07

Robertson, 2008, Antimicrob. Agents Chemother., 52, 2324, 10.1128/AAC.01651-07

Tidswell, 2010, Crit. Care Med., 38, 72, 10.1097/CCM.0b013e3181b07b78

Nosanchuk, 2006, Rec. Pat. Anti-Infect Drug Discov., 1, 75, 10.2174/157489106775244109

Mishra, 2010, Phytochemistry, 71, 230, 10.1016/j.phytochem.2009.10.013

Mishra, 2010, Fitoterapia, 81, 104, 10.1016/j.fitote.2009.08.009

Cappelletty, 2007, Pharmacotherapy, 27, 369, 10.1592/phco.27.3.369

Turner, 2006, Expert Opin. Emerging Drugs, 11, 231, 10.1517/14728214.11.2.231

Morris, 2006, Am. J. Health Syst. Pharm., 63, 1813, 10.2146/ajhp050464.p2

Brzankalski, 2008, J. Antimicrob. Chemother., 62, 1094, 10.1093/jac/dkn304

Kakeya, 2008, Antimicrob. Agents Chemother., 52, 1868, 10.1128/AAC.01369-07

Kaken Pharmaceutical: Annual Report 2007. Available at: http://www.kaken.co.jp/.

Kasanah, 2005, Curr. Opin. Invest. Drugs, 6, 845

Mishra, 2009, Mini-Rev. Med. Chem., 9, 107, 10.2174/138955709787001758

Andrade-Neto, 2003, J. Ethnopharmacol, 87, 253, 10.1016/S0378-8741(03)00141-7

Vennerstrom, 2004, Nature, 430, 900, 10.1038/nature02779

Ouellet, 2006, Nature, 440, 940, 10.1038/nature04640

Jefford, 2007, Drug Discov. Today, 12, 487, 10.1016/j.drudis.2007.04.009

Davidson, 2009, Roy. Soc. Trop. Med. Hyg., 103, 653, 10.1016/j.trstmh.2008.09.008

Chappuis, 2007, Nat. Rev. Microbiol., 5, 873, 10.1038/nrmicro1748

Sundar, 2007, New Engl. J. Med., 356, 2571, 10.1056/NEJMoa066536

Mishra, 2009, Fitoterapia, 80, 81, 10.1016/j.fitote.2008.10.009

Fujioka, 1994, J. Nat. Prod., 57, 243, 10.1021/np50104a008

Ganguly, 2007, Cancer Res., 67, 11848, 10.1158/0008-5472.CAN-07-1615

Kashiwada, 1996, J. Med. Chem., 39, 1016, 10.1021/jm950922q

Martin, 2007, Antimicrob. Agents Chemother., 51, 3063, 10.1128/AAC.01391-06

Bullock, 2008, Biopharm. Drug Dispos., 29, 396, 10.1002/bdd.625

Yogeeswari, 2005, Curr. Med. Chem., 12, 657, 10.2174/0929867053202214

Heider, 2010, BMC Bioinformatics, 11, 37, 10.1186/1471-2105-11-37

Barnard, 2002, Curr. Opin. Invest. Drugs, 3, 1585

Valeant Pharmaceuticals: Press release 1 June 2009. Available at http://phx.corporate-ir.net/.

Whitby, 2005, J. Virol., 79, 8698, 10.1128/JVI.79.14.8698-8706.2005

Whitby, 2004, Antivir. Chem. Chemother., 15, 141, 10.1177/095632020401500304

Durantel, 2007, Curr. Opin. Invest. Drugs, 8, 125

Borel, 2002, Wien. Klin. Wochenschr., 114, 433

Durantel, 2009, Curr. Opin. Investig. Drugs, 10, 860

Flisiak, 2007, Expert Opin. Invest. Drugs, 16, 1345, 10.1517/13543784.16.9.1345

Manns, 2007, Nat. Rev. Drug Discov., 6, 991, 10.1038/nrd2411

Ma, 2006, Antimicrob. Agents Chemother., 50, 2976, 10.1128/AAC.00310-06

Noser, 2006, J. Virol., 80, 7769, 10.1128/JVI.02427-05

Ptak, 2008, Antimicrob. Agents Chemother., 52, 1302, 10.1128/AAC.01324-07

Coelmont, 2009, Antimicrob. Agents Chemother., 53, 967, 10.1128/AAC.00939-08

Further information on 4-methylumbelliferone clinical trial Available at: http://www.clinicaltrial.gov/ct2/show/NCT00225537/.

Robinson, 1996, Proc. Nat. Acad. Sci. U.S.A., 93, 6326, 10.1073/pnas.93.13.6326

Kakizaki, 2004, J. Biol. Chem., 279, 33281, 10.1074/jbc.M405918200

Gu, 2007, J. Chromatogr. B., 852, 85, 10.1016/j.jchromb.2006.12.055

Yang, 2005, Drug Metab. Dispos, 33, 930, 10.1124/dmd.104.002154

Harad, 2001, J. Chromatogr. A, 932, 75, 10.1016/S0021-9673(01)01235-3

Rigen Pharmaceuticals: Press release 17 August 2009. Available at: http://www.arigen.jp/.

Rothstein, 2003, Expert Opin. Invest. Drugs, 12, 255, 10.1517/13543784.12.2.255

Rothstein, 2006, Expert Opin. Invest. Drugs, 15, 603, 10.1517/13543784.15.6.603

Rothstein, 2007, Arch. Pharm. (Weinheim), 340, 517, 10.1002/ardp.200700080

Haynes, 2006, Curr. Top. Med. Chem., 6, 509, 10.2174/156802606776743129

Vivas, 2007, J. Antimicrob. Chemother., 59, 658, 10.1093/jac/dkl563

Alessandro, 2007, Toxicology, 241, 66, 10.1016/j.tox.2007.08.084

Haynes, 2006, Angew. Chem., 45, 2082, 10.1002/anie.200503071

Currens, 1996, J. Pharmacol. Exp. Ther., 279, 645

Kashman, 1993, J. Med. Chem., 36, 1110, 10.1021/jm00060a020

Yang, 2001, J. Nat. Prod., 64, 265, 10.1021/np0003995

Coleman, 2008, Chem-biol Interact, 175, 387, 10.1016/j.cbi.2008.05.023

Kozikowski, 1999, Acc. Chem. Res., 32, 641, 10.1021/ar9800892

Bai, 2000, Curr. Med. Chem., 7, 355, 10.2174/0929867003375281

Wang, 2009, J. Neural Transm., 116, 457, 10.1007/s00702-009-0189-x

Dahan, 2008, Eur. J. Pain, 12, 403, 10.1016/j.ejpain.2007.07.009

Xu, 1995, Zhongguo Yao Li Xue Bao, 16, 391

PAION: Press release 3 November 2008. Available at: http://www.paion.com/.

Hayakawa, 1983, J. Antibiot. (Tokyo), 36, 934, 10.7164/antibiotics.36.934

Kobierski, 2003, Anesth. Analg, 97, 174, 10.1213/01.ANE.0000066359.83348.F1

Wei, 2006, J.Chromatogr. B., 830, 120, 10.1016/j.jchromb.2005.10.027

Supko, 2003, Clin. Cancer Res., 9, 5178

Press release 8th Sep 2010. Available at: http://www.darabiosciences.com/.

Marlow, 2003, Respir. Care, 48, 1238

Buchhalter, 2008, Drugs, 68, 1067, 10.2165/00003495-200868080-00005

Zheng, 2006, AAPS J., 8, E682, 10.1208/aapsj080478

Zheng, 2007, Bioorg. Med. Chem., 15, 2975, 10.1016/j.bmc.2007.02.013

Zheng, 2005, J. Med. Chem., 48, 5551, 10.1021/jm0501228

Kem, 1971, Toxicon, 9, 23, 10.1016/0041-0101(71)90040-7

Neugebauer, 2007, Eur. J. Pharmacol., 571, 33, 10.1016/j.ejphar.2007.06.003

Eyerman, 2005, J. Pharmacol. Exp. Therap., 312, 160, 10.1124/jpet.104.072264

Polston, 2006, Life Sci., 79, 981, 10.1016/j.lfs.2006.05.006

Kem, 2006, Marine Drugs, 4, 255, 10.3390/md403255

Kem, 1997, J. Pharmacol. Exp. Ther., 283, 979

Martin, 2004, Psychopharmacology (Berlin), 174, 54, 10.1007/s00213-003-1750-1

Olincy, 2007, Biochem. Pharmacol., 74, 1192, 10.1016/j.bcp.2007.07.015

Kitagawa, 2003, Neuropsychopharmacology, 28, 542, 10.1038/sj.npp.1300028

Olincy, 2006, Arch. Gen. Psychiatry, 63, 630, 10.1001/archpsyc.63.6.630

Hwang, 2007, Adv. Food Nutr. Res., 52, 141, 10.1016/S1043-4526(06)52004-2

Hagen, 2007, J. Pain Symptom Manage., 34, 171, 10.1016/j.jpainsymman.2006.11.008

Hagen, 2008, J. Pain Symptom Manage., 35, 420, 10.1016/j.jpainsymman.2007.05.011

Terlau, 2004, Physiol. Rev., 84, 41, 10.1152/physrev.00020.2003

Norton, 2006, Toxicon, 48, 780, 10.1016/j.toxicon.2006.07.022

Olivera, 2007, Mol. Intervention, 7, 251, 10.1124/mi.7.5.7

Sharpe, 2001, Nat. Neurosci., 4, 902, 10.1038/nn0901-902

Lovelace, 2006, J. Med. Chem., 49, 6561, 10.1021/jm060299h

Paczkowski, 2007, J. Biol. Chem., 282, 17837, 10.1074/jbc.M610813200

Fraenkel, 2004, Arch. Intern. Med., 164, 1299, 10.1001/archinte.164.12.1299

Glinski, 1991, Acta Derm. Venereol., 71, 51, 10.2340/00015555715154

Razavi, 2006, Cell, 127, 1123, 10.1016/j.cell.2006.10.038

Remadevi, 2008, IDrugs, 11, 120

Winston Pharmaceuticals: Press release 19 October 2009. Available at: http://www.winstonlabs.com/.

Rossetti, 1987, J. Clin. Invest., 79, 1510, 10.1172/JCI112981

White, 2010, Clin. Diabetes, 28, 5, 10.2337/diaclin.28.1.5

Meng, 2008, J. Med. Chem., 51, 1145, 10.1021/jm701272q

BMS: Press release 2 October 2009. Available at: http://www.bms.com/.

Baur, 2006, Nat. Rev. Drug Disc., 5, 493, 10.1038/nrd2060

Howitz, 2003, Nature, 425, 191, 10.1038/nature01960

Wood, 2004, Nature, 430, 686, 10.1038/nature02789

Valenzano, 2006, Curr. Biol., 16, 296, 10.1016/j.cub.2005.12.038

Elliott, 2009, Drugs Fut, 34, 291, 10.1358/dof.2009.034.04.1360696

Lambert, 2005, J. Med. Chem., 48, 5059, 10.1021/jm058183t

Burstein, 2004, Life Sci., 75, 1513, 10.1016/j.lfs.2004.04.010

Burstein, 1992, J. Med. Chem., 35, 3135, 10.1021/jm00095a007

Kaneko, 1997, J. Med. Chem., 40, 1863, 10.1021/jm970031d

Yasuzawa, 1986, J. Antibiot. (Tokyo), 39, 1072, 10.7164/antibiotics.39.1072

Maroney, 2001, J. Biol. Chem., 276, 25302, 10.1074/jbc.M011601200

Liesch, 1985, J. Antibiot. (Tokyo), 38, 1638, 10.7164/antibiotics.38.1638

Goetz, 1988, J. Antibiot. (Tokyo), 41, 875, 10.7164/antibiotics.41.875

Sandall, 2003, Biochemistry, 42, 6904, 10.1021/bi034043e

Metabolic Pharmaceuticals: Press release 14 August 2007. Available at: http://www.metabolic.com.au/.

Brossi, 1996, Aust. J. Chem., 49, 171, 10.1071/CH9960171

Shaw, 2001, Proc. Natl. Acad. Sci. U.S.A., 98, 7605, 10.1073/pnas.131152998

Boros, 1999, J. Med. Chem., 42, 206, 10.1021/jm980597h

Gyermek, 2005, Med. Res. Rev., 25, 610, 10.1002/med.20036

Savarese, 2004, Anesthesiology, 100, 835, 10.1097/00000542-200404000-00013

Karcioglu, 2006, Int. J. Clin. Pract., 60, 1638, 10.1111/j.1742-1241.2006.00685.x

Further information Available on: http://www.astellas.com/.

Barbier, 1987, Helv. Chim. Act., 70, 196, 10.1002/hlca.19870700124

Wihler, 2005, Diabetologia, 48, 1645, 10.1007/s00125-005-1837-9

Quaschning, 2006, Kidney Blood Press. Res., 29, 351, 10.1159/000097625

Davidson, 2007, Diabetes, 56, 355, 10.2337/db06-1180

Lieberman, 2007, Nat. Chem. Biol., 2, 101, 10.1038/nchembio850

Steet, 2007, Biochem. Pharmacol., 73, 1376, 10.1016/j.bcp.2006.12.015

Steet, 2006, Proc. Natl. Acad. Sci. U.S.A., 103, 13813, 10.1073/pnas.0605928103

Dulsat, 2009, Drugs Fut., 34, 23, 10.1358/dof.2009.034.01.1323946

Amicus Therapeutics: Press release 2 October 2009. Available at: http://www.amicustherapeutics.com/.

Jirousek, 1996, J. Med. Chem., 39, 2664, 10.1021/jm950588y

Joy, 2005, Ann. Pharmacother., 39, 1693, 10.1345/aph.1E572

Clarke, 2007, Best Pract. Res. Clin. Endocrinol. Metab., 21, 573, 10.1016/j.beem.2007.09.007

Chackalamannil, 2008, J. Med. Chem., 51, 3061, 10.1021/jm800180e

Clasby, 2007, J. Med. Chem., 50, 129, 10.1021/jm061043e

Chelliah, 2007, J. Med. Chem., 50, 5147, 10.1021/jm070704k

Clasby, 2007, Bioorg. Med. Chem. Lett., 17, 3647, 10.1016/j.bmcl.2007.04.061

Ahima, 2002, Diabetes, 51, 2099, 10.2337/diabetes.51.7.2099

Chernova, 2005, Am. J. Physiol. Regul. Integr. Comp. Physiol., 289, R1644, 10.1152/ajpregu.00098.2005

Ferrari, 2007, Med. Hypotheses, 68, 1307, 10.1016/j.mehy.2006.07.058

Hollman, 1996, Br. Med. J., 312, 912, 10.1136/bmj.312.7035.912

Ferrari, 1998, J. Pharmacol. Exp. Ther., 285, 83

Schoner, 2007, Am. J. Physiol. Cell Physiol., 293, C509, 10.1152/ajpcell.00098.2007

Staessen, 2005, Pharmacogenomics, 6, 755, 10.2217/14622416.6.7.755

Onoma, 2008, Clin. Exp. Pharmacol. Physiol., 35, 35, 10.1111/j.1440-1681.2007.04744.x

Roje, 2007, Phytochemistry, 68, 1904, 10.1016/j.phytochem.2007.03.038

Williams, 2007, Am. J. Nephrol., 27, 605, 10.1159/000108104

Inouye, 1966, J. Antibiot. (Tokyo), 19, 288

Hughes, 1994, Nat. Prod. Rep., 11, 135, 10.1039/np9941100135

Nuengchamnong, 2007, J. Pharm. Biomed. Anal., 44, 853, 10.1016/j.jpba.2007.03.031

Parenti, 2007, Mol. Ther., 15, 508, 10.1038/sj.mt.6300074

Saunier, 1982, J. Biol. Chem., 257, 14155, 10.1016/S0021-9258(19)45358-1

Amicus Press release 27 February 2009. Available at: http://ir.amicustherapeutics.com/.

Amicus Press release 30 September 2009. Available at: http://ir.amicustherapeutics.com/releases.cfm.

Trezise, 1994, Eur. J. Pharmacol., 259, 295, 10.1016/0014-2999(94)90656-4

Kandzari, 2005, Expert Opin. Invest. Drugs, 14, 1435, 10.1517/13543784.14.11.1435

Anglade, 2007, Expert Opin. Invest. Drugs, 16, 1525, 10.1517/13543784.16.10.1525

Lux Biosciences: Press release 30 March 2010. Available at: http://www.luxbio.com/.

Isotechnika: Further information Available at: http://www.isotechnika.com/.

Seo, 2001, Mutat. Res., 496, 191, 10.1016/S1383-5718(01)00234-0

Kim, 2004, Biochem. Pharmacol., 68, 1081, 10.1016/j.bcp.2004.04.027

Novogen: Further information Available at: http://www.novogen.com/.

St-Jacques, 1973, J. Org. Chem., 38, 1253, 10.1021/jo00947a001

Kiuchi, 2000, J. Med. Chem., 43, 2946, 10.1021/jm000173z

Baumruker, 2007, Expert Opin. Invest. Drugs, 16, 283, 10.1517/13543784.16.3.283

Rosen, 2005, Nat. Rev. Immunol., 5, 560, 10.1038/nri1650

Ewart, 1970, Biochem. J., 118, 603, 10.1042/bj1180603

Hennerici, 2006, Lancet, 368, 1871, 10.1016/S0140-6736(06)69776-6

Neurobiological Technologies: Further information Available at: http://www.ntii.com/.

Oberlies, 2004, J. Nat. Prod., 67, 129, 10.1021/np030498t

Pommier, 2006, Nat. Rev. Cancer, 6, 789, 10.1038/nrc1977

Teicher, 2008, Biochem. Pharmacol., 75, 1262, 10.1016/j.bcp.2007.10.016

Grossman, 2008, Neuro-Oncology, 10, 608, 10.1215/15228517-2008-030

Daud, 2005, Clin. Cancer Res., 11, 3009, 10.1158/1078-0432.CCR-04-1722

Kroep, 2009, Expert Opin. Inv. Drugs, 18, 69, 10.1517/13543780802571674

Nitiss, 2005, IDrugs, 8, 578

Sessa, 2007, Ann. Oncol., 18, 561, 10.1093/annonc/mdl418

Pecorelli, 2010, Ann. Oncol., 21, 759, 10.1093/annonc/mdp514

Chatterjee, 2004, J. Clin. Pharmacol., 44, 723, 10.1177/0091270004265647

Chatterjee, 2005, J. Clin. Pharmacol., 45, 453, 10.1177/0091270004270225

Escalona-Benz, 2005, Invest. Ophthalmol. Vis. Sci., 46, 8, 10.1167/iovs.04-0751

Aprile, 2010, Drug Metab. Dispos

Pettit, 1995, Anticancer Drug Des., 10, 299

Young, 2004, Invest. Drugs, 13, 1171, 10.1517/13543784.13.9.1171

Mahindroo, 2006, Expert Opin. Ther. Pat., 16, 647, 10.1517/13543776.16.5.647

Hinnen, 2007, Br. J. Cancer, 96, 1159, 10.1038/sj.bjc.6603694

Sanofi-Aventis: Further information Available at: http://www.oncology.sanofi-aventis.com/.

Pettit, 2000, Anti-Cancer Drug Des., 15, 203

Salmon, 2006, Clin. Cancer Res., 12, 4090, 10.1158/1078-0432.CCR-06-0163

Chan, 2008, Anti-Cancer Drugs, 19, 17, 10.1097/CAD.0b013e3282f077a1

Aneja, 2007, Cancer Chemother. Pharmacol., 60, 831, 10.1007/s00280-007-0430-y

Jackson, 2008, Cancer Chemother. Pharmacol., 63, 117, 10.1007/s00280-008-0720-z

Makarov, 2007, Biochemistry, 46, 14899, 10.1021/bi701803s

Bennouna, 2005, Expert Opin. Invest. Drugs, 14, 1259, 10.1517/13543784.14.10.1259

Kruczynski, 1998, Biochem. Pharmacol., 55, 635, 10.1016/S0006-2952(97)00505-4

Laboratoires Pierre Fabre: Press relaease 26 June 2009. Available at: http://www.pierre-fabre.com/.

Kingston, 2007, Curr. Opin. Drug Discov. Dev., 10, 130

Cisternino, 2003, Br. J. Pharmacol., 138, 1367, 10.1038/sj.bjp.0705150

Engels, 2005, Br. J. Cancer, 93, 173, 10.1038/sj.bjc.6602698

Brooks, 2003, Mol. Cancer Ther., 2, 1195

Sessa, 2002, Ann. Oncol., 13, 1140, 10.1093/annonc/mdf174

Gelmon, 2000, J. Clin. Oncol., 18, 4098, 10.1200/JCO.2000.18.24.4098

Kurata, 2000, J. Clin. Oncol., 18, 3164, 10.1200/JCO.2000.18.17.3164

Bradley, 2001, Clin. Cancer Res., 7, 3229

Jones, 2008, Cancer Chemother. Pharmacol., 61, 435, 10.1007/s00280-007-0486-8

Geney, 2005, Med. Chem., 1, 125, 10.2174/1573406053175292

Sano, 2006, Oncol. Rep., 15, 329

Sampath, 2003, Mol. Cancer Ther., 2, 873

Ramanathan, 2008, Cancer Chemother. Pharmacol., 61, 453, 10.1007/s00280-007-0489-5

Shionoya, 2003, Cancer Sci., 94, 459, 10.1111/j.1349-7006.2003.tb01465.x

Ono, 2004, Biol. Pharm. Bull., 27, 345, 10.1248/bpb.27.345

Roche, 2006, Curr. Opin. Invest. Drugs, 7, 1092

Safarpour, 2009, J. Pharm. Biomed. Anal., 49, 774, 10.1016/j.jpba.2008.12.034

Advani, 2003, Clin. Cancer Res., 9, 5187

Fishman, 2006, Clin. Cancer Res., 12, 523, 10.1158/1078-0432.CCR-05-0928

de Bois, 2006, Br. J. Cancer, 94, 79, 10.1038/sj.bjc.6602886

Michel, 2004, Eur. J. Med. Chem., 39, 649, 10.1016/j.ejmech.2004.05.001

Garrett, 2005, Clin. Cancer Res., 11, 3335, 10.1158/1078-0432.CCR-04-1494

Tillequin, 2007, Phytochem. Rev., 6, 65, 10.1007/s11101-006-9010-8

Leonce, 2006, Cancer Res., 66, 7203, 10.1158/0008-5472.CAN-05-3946

Quintas-Cardama, 2007, Cancer, 109, 248, 10.1002/cncr.22398

ChemGenex: Press release 23 March 2010. Available at: http://www.chemgenex.com/.

Youngren, 2005, Breast Cancer Res. Treat., 94, 37, 10.1007/s10549-005-6939-z

Khanna, 2007, Gynecol. Oncol., 107, 554, 10.1016/j.ygyno.2007.08.074

Hwu, 1998, J. Med. Chem., 41, 2994, 10.1021/jm970819w

Chen, 1998, J. Med. Chem., 41, 3001, 10.1021/jm980182w

Chang, 2004, Proc. Natl. Acad. Sci. U.S.A., 101, 13239, 10.1073/pnas.0405407101

Lopez, 2007, Anti-Cancer Drugs, 18, 933, 10.1097/CAD.0b013e32813148e0

Smolewski, 2008, IDrugs, 11, 204

Liu, 2007, Curr. Bioactive Compounds, 3, 37, 10.2174/157340707780126499

Barret, 2002, Cancer Chemother. Pharmacol., 49, 479, 10.1007/s00280-002-0451-5

Sargent, 2003, Anti-Cancer Drugs, 14, 467, 10.1097/00001813-200307000-00013

Kluza, 2006, Anti-Cancer Drugs, 17, 155, 10.1097/00001813-200602000-00006

Challacombe, 2006, J. Immunol., 177, 8123, 10.4049/jimmunol.177.11.8123

Ogbourne, 2007, Anti-Cancer Drugs, 18, 357, 10.1097/CAD.0b013e3280149ec5

Ersvaer, 2010, Toxins, 2, 174, 10.3390/toxins2010174

LEO Pharma: Press release 1 February 2010. Available at: http://www.leo-pharma.com/.

Coward, 1993, J. Agric. Food Chem., 41, 1961, 10.1021/jf00035a027

Constantinou, 2002, Anticancer Res., 22, 2581

Constantinou, 2003, Eur. J. Cancer, 39, 1012, 10.1016/S0959-8049(03)00124-2

Morre, 2007, Oncol. Res., 16, 299, 10.3727/000000006783980973

Mor, 2006, Curr. Opin. Invest. Drugs, 7, 542

Mortio, 2001, Biol. Pharm. Bull., 24, 351, 10.1248/bpb.24.351

Hwang, 2009, Nutr. Cancer, 61, 598, 10.1080/01635580902825639

Kim, 2009, Ann. N. Y Acad. Sci., 1171, 495, 10.1111/j.1749-6632.2009.04899.x

Nakamura, 2009, Mol. Cancer, 8, 100, 10.1186/1476-4598-8-100

Rewcastle, 1989, J. Med. Chem., 32, 793, 10.1021/jm00124a012

Wallace, 2007, Cancer Res., 67, 7011, 10.1158/0008-5472.CAN-06-3757

McKeage, 2008, Expert Opin. Invest. Drugs, 17, 23, 10.1517/13543784.17.1.23

Choi, 2003, J. Biochem. Mol. Biol., 36, 223, 10.5483/BMBRep.2003.36.2.223

Pardee, 2002, Curr. Cancer Drug Targets, 2, 227, 10.2174/1568009023333854

Bey, 2007, Proc. Natl. Acad. Sci. U.S.A., 104, 11832, 10.1073/pnas.0702176104

Bentle, 2007, Cancer Res., 6, 6936, 10.1158/0008-5472.CAN-07-0935

Patel, 2010, Fitoterapia, 81, 145, 10.1016/j.fitote.2009.08.010

Sanofi-Aventis: Further information Available at: http://en.sanofi-aventis.com/.

Athar, 2007, Toxicol. Appl. Pharmacol., 224, 274, 10.1016/j.taap.2006.12.025

Lastra, 2007, Biochem. Soc. Trans., 35, 1156, 10.1042/BST0351156

Hatcher, 2008, Cell Mol. Life Sc, 65, 1631, 10.1007/s00018-008-7452-4

Ahmad, 2006, J. Biol. Chem., 281, 35764, 10.1074/jbc.M607160200

RITA: Further information Available at: http://www.reatapharma.com/.

Chowdhury, 2002, Med. Sci. Monitor, 8, BR254

Alakurtti, 2006, Eur. J. Pharm. Sci., 29, 1, 10.1016/j.ejps.2006.04.006

Chintharlapalli, 2007, Cancer Res., 67, 2816, 10.1158/0008-5472.CAN-06-3735

Provinciali, 2007, Cancer Res., 67, 2022, 10.1158/0008-5472.CAN-06-2601

Gazak, 2007, Curr. Med. Chem., 14, 315, 10.2174/092986707779941159

Mokhtari, 2008, Cell. Biol. Int., 32, 888, 10.1016/j.cellbi.2008.03.019

Hogan, 2007, J. Surg. Res., 143, 58, 10.1016/j.jss.2007.03.080

Sharma, 2003, Anticancer Res., 23, 2649

Sakai, 2004, J. Antibiot. (Tokyo), 57, 173, 10.7164/antibiotics.57.173

Sakai, 2004, J. Antibiot. (Tokyo), 57, 180, 10.7164/antibiotics.57.180

Kotake, 2007, Nat. Chem. Biol., 3, 570, 10.1038/nchembio.2007.16

Konishi, 1986, J. Antibiot. (Tokio), 39, 784, 10.7164/antibiotics.39.784

Trevino, 2004, Mol. Cancer Ther., 3, 1403, 10.1158/1535-7163.1403.3.11

Callisto Pharmaceuticals: Further information available at http://www.callistopharma.com/.

Bos, 2001, Cancer Chemother. Pharmacol., 48, 361, 10.1007/s002800100350

Caponigro, 2005, Invest. New Drugs, 23, 85, 10.1023/B:DRUG.0000047110.36382.45

Fraier, 2002, J. Pharm. Biomed. Anal., 30, 377, 10.1016/S0731-7085(02)00222-4

Quintieri, 2005, Clin. Cancer Res., 11, 1608, 10.1158/1078-0432.CCR-04-1845

Bellorini, 1995, Nucleic Acids Res., 23, 1657, 10.1093/nar/23.10.1657

Geroni, 2002, Cancer Res., 62, 2332

Cozzi, 2000, Bioorg. Med. Chem. Lett., 10, 1269, 10.1016/S0960-894X(00)00204-3

Cozzi, 2003, Farmaco, 58, 213, 10.1016/S0014-827X(03)00014-4

Broggini, 2004, Anti-Cancer Drugs, 15, 1, 10.1097/00001813-200401000-00001

Leahy, 2007, Eur. J. Cancer, 43, 308, 10.1016/j.ejca.2006.09.014

Bedin, 2004, Int. J. Cancer, 109, 643, 10.1002/ijc.20010

Schnur, 1995, J. Med. Chem., 38, 3806, 10.1021/jm00019a010

Modi, 2007, J. Clin. Oncol., 25, 5410, 10.1200/JCO.2007.11.7960

Neckers, 2006, Curr. Top. Med. Chem., 6, 1163, 10.2174/156802606777811979

Waza, 2005, Nat. Med., 11, 1088, 10.1038/nm1298

Jez, 2003, Chem. Biol., 10, 361, 10.1016/S1074-5521(03)00075-9

Hanson, 2009, Expert Opin. Inv. Drugs, 18, 1375, 10.1517/13543780903158934

Elit, 2006, IDrugs, 9, 636

Mita, 2008, Expert Opin. Inv. Drugs, 17, 1947, 10.1517/13543780802556485

Mita, 2008, J. Clin. Oncol., 26, 361, 10.1200/JCO.2007.12.0345

Feling, 2003, Angew. Chem. Int. Ed. Engl., 42, 355, 10.1002/anie.200390115

Chauhan, 2005, Cancer Cell, 8, 407, 10.1016/j.ccr.2005.10.013

Nereus Pharmaceuticals: Further information Available at: http://www.nereuspharm.com/.

Omura, 1977, J. Antibiot. (Tokyo), 30, 275, 10.7164/antibiotics.30.275

Wang, 2008, J. Clin. Pharmacol., 48, 763, 10.1177/0091270008318006

Chen, 2008, Expert Opin. Inv. Drugs, 17, 939, 10.1517/13543784.17.6.939

Robertson, 2007, J. Clin. Oncol., 25, 1741, 10.1200/JCO.2006.09.3146

Propper, 2001, J. Clin. Oncol., 19, 1485, 10.1200/JCO.2001.19.5.1485

Knapper, 2006, Blood, 108, 3262, 10.1182/blood-2006-04-015560

Revill, 2007, Drugs Fut., 32, 215, 10.1358/dof.2007.032.03.1084137

Press release 6th June 2009. Available at: http://www.cephalon.com/.

Takahashi, 1989, J. Antibiot. (Tokyo), 42, 571, 10.7164/antibiotics.42.571

Fuse, 2005, J. Clin. Pharmacol., 45, 394, 10.1177/0091270005274549

Tse, 2007, Clin. Cancer Res., 13, 1955, 10.1158/1078-0432.CCR-06-2793

Charan, 2004, J. Nat. Prod., 67, 1431, 10.1021/np040042r

McAlpine, 2008, J. Nat. Prod., 71, 1585, 10.1021/np800376n

Gourdeau, 2008, Cancer Chemother. Pharmacol., 61, 911, 10.1007/s00280-007-0544-2

Campas, 2009, Drugs Fut., 34, 349, 10.1358/dof.2009.034.05.1370797

Bennett, 2000, Adv. Appl. Microbiol., 47, 1, 10.1016/S0065-2164(00)47000-0

X. Gemin, Further information Available at: http://www.geminx.com/.

Galmarini, 2003, Idrugs, 6, 1182

Rothermel, 2003, Semin. Oncol., 30, 51, 10.1016/S0093-7754(03)70025-6

Alexander, 2008, Drugs Fut., 33, 496, 10.1358/dof.2008.033.06.1213136

Pronzato, 2008, Drugs, 68, 139, 10.2165/00003495-200868020-00001

Klar, 2006, Angew. Chem. Int. Ed., 45, 7942, 10.1002/anie.200602785

White, 2002, Org. Lett., 4, 995, 10.1021/ol020023d

Kanoh, 1999, J. Antibiot. (Tokyo), 52, 134, 10.7164/antibiotics.52.134

Nicholson, 2006, Anticancer Drugs, 17, 25, 10.1097/01.cad.0000182745.01612.8a

McMorris, 1992, J. Org. Chem., 57, 6876, 10.1021/jo00051a037

Kelner, 1996, Invest. New Drugs, 14, 161, 10.1007/BF00210787

Wang, 2007, Biochem. Pharmacol., 73, 469, 10.1016/j.bcp.2006.10.023

Escargueil, 2008, J. Cell Sci., 121, 1275, 10.1242/jcs.023259

Moneo, 2007, Mol. Cancer Ther., 6, 1310, 10.1158/1535-7163.MCT-06-0729

Towle, 2001, Cancer Res., 61, 1013

Seletsky, 2004, Bioorg. Med. Chem. Lett., 14, 5547, 10.1016/j.bmcl.2004.08.068

Zheng, 2004, Bioorg. Med. Chem. Lett., 14, 5551, 10.1016/j.bmcl.2004.08.069

Kuznetsov, 2004, Cancer Res., 64, 5760, 10.1158/0008-5472.CAN-04-1169

Newman, 2007, Curr. Opin. Invest. Drugs, 8, 1057

George, 2005, Blood, 105, 1768, 10.1182/blood-2004-09-3413

Revill, 2007, Drugs Fut., 32, 315, 10.1358/dof.2007.032.04.1094476

Schaufelberger, 1991, J. Nat. Prod., 54, 1265, 10.1021/np50077a004

Sudek, 2007, J. Nat. Prod., 70, 67, 10.1021/np060361d

Banerjee, 2008, J. Nat. Prod., 71, 492, 10.1021/np0705716

Leal, 2009, Biochem. Pharmacol., 78, 162, 10.1016/j.bcp.2009.04.003

PharmaMar: Press release 21 April 2010. Available at: http://www.pharmamar.com/.

Bai, 1992, Biochem. Pharmacol., 43, 2637, 10.1016/0006-2952(92)90153-A

Ray, 2007, Cancer Res., 67, 3767, 10.1158/0008-5472.CAN-06-3065

Mita, 2006, Clin. Cancer Res., 12, 5207, 10.1158/1078-0432.CCR-06-0179

Watanabe, 2007, Anti-Cancer Drugs, 18, 905, 10.1097/CAD.0b013e3280dce1d1

Sewell, 2005, Eur. J. Cancer, 41, 1637, 10.1016/j.ejca.2005.04.015

PharmaMar: Press release 10 June 2009. Available at: http://www.pharmamar.com/.

Duncan, 2006, Nat. Rev. Cancer, 6, 688, 10.1038/nrc1958

Masuda, 1995, Cancer Immunol. Immun., 40, 329, 10.1007/BF01519634

Bross, 2001, Clin. Cancer Res., 7, 1490

DiJoseph, 2007, Leukemia, 21, 2240, 10.1038/sj.leu.2404866

DiJoseph, 2006, Clin. Cancer Res., 12, 242, 10.1158/1078-0432.CCR-05-1905

Fanale, 2007, Drugs, 67, 333, 10.2165/00003495-200767030-00002

Erickson, 2006, Cancer Res., 66, 4426, 10.1158/0008-5472.CAN-05-4489

Widdison, 2006, J. Med. Chem., 49, 4392, 10.1021/jm060319f