Natural Diterpenoid Compound Elevates Expression of Bim Protein, Which Interacts with Antiapoptotic Protein Bcl-2, Converting It to Proapoptotic Bax-like Molecule

Journal of Biological Chemistry - Tập 287 Số 2 - Trang 1054-1065 - 2012
Lixia Zhao1,2, Feng He3, Hai‐Yang Liu4, Yushan Zhu1,2, Weili Tian1,2, Ping Gao1,2, Hong‐Ping He4, Wen Yue1,2, Xiaobo Lei1,2, Biyun Ni1,2, Xiaohui Wang1,2, Haijing Jin1,2, Xiao‐Jiang Hao4, Jialing Lin3, Quan Chen1,2
1College of Life Sciences, Nankai University, Tianjin 300071, China
2Joint Laboratory of Apoptosis and Mitochondrial Biology, The State Key Laboratory of Biomembrane and Membrane Biotechnology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China
3Department of Biochemistry and Molecular Biology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73126
4The State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, China

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