Nationwide survey of the development of drug-resistant pathogens in the pediatric field: drug sensitivity of Streptococcus pneumoniae in Japan
Tóm tắt
We evaluated the resistance to 20 different antibacterial agents of 362 clinically isolated strains of Streptococcus pneumoniae accumulated from October 2000 to July 2001 (phase 1) and of 332 different strains accumulated from January to June 2004 (phase 2), from institutions throughout Japan that participated in the surveys carried out by the Drug-Resistant Pathogen Surveillance Group in Pediatric Infectious Disease. In phase 1, the proportions of penicillin-sensitive S. pneumoniae (PSSP), penicillin-insensitive S. pneumoniae (PISP), and penicillin-resistant S. pneumoniae (PRSP) were 35.4%, 34.8%, and 29.8%, respectively, and the proportions were almost the same in phase 2: 33.1%, 37.0%, and 29.8%, respectively. Comparison of the MIC90 values of the antibacterial agents for PRSP in phase 1 and phase 2 revealed that these values for cefditoren, cefpodoxime, cefdinir, faropenem, ceftriaxone, cefotaxime, meropenem, and vancomycin increased by twofold to fourfold during the 3 years between phase 1 and phase 2. However the MIC90 of rokitamycin increased more than fourfold. The proportion of S. pneumoniae that were PISP + PRSP remained almost constant over the 3 years between phase 1 and phase 2. The background factors of patient age, previous administration of antibacterial agents, and attendance at a day nursery were examined; we found that in phase 1, the proportion of PISP + PRSP was significantly higher than that of PSSP in patients under 4 years old who had previously received antibacterial agents, but no significant differences were found in any of these background factors in the phase 2 survey. No significant difference was found in the proportions of penicillin-resistant bacteria according to whether or not the child had attended a day nursery.
Tài liệu tham khảo
Konno M, Ubukata K (Penicillin-resistant S. pneumoniae Surveillance Group). Penicillin-resistant S. pneumoniae. Tokyo: Kyowa Kikaku Tsushin; 1997.
Klein JO. Bacterial pneumonias. In: Feigin RD, Cherry J, Demmler GJ, Kaplan S, editors. Textbook of pediatric infectious diseases. 5th ed. Philadelphia: WB Saunders; 2004. p. 299–310.
Dagan R, Greenberg D, Jacobs MR. Pneumococcal Infection. In: Feigin RD, Cherry J, Demmler GJ, Kaplan S, editors. Textbook of pediatric infectious diseases. 5th ed. Philadelphia: WB Saunders;2004. p. 1204–1258.
Japanese Society of Chemotherapy. Committee for Revision of MIC Determination Method. Revision of minimal inhibitory concentration (MIC) determination method. Chemotherapy 1981;29:76–79.
National Committee for Clinical Laboratory Standards. MIC testing supplemental tables. Wayne, Pennsylvania: National Committee for Clinical Laboratory Standards. NCCLS Document M 100-S13 (M7); 2003.
Sato Y, Toyanaga Y, Sunakawa K, et al. Spread of penicillinresistant Streptococcus pneumoniae (PRSP) and beta-lactamasenegative ampicillin-resistant Haemophilus influenzae (BLNAR) in pediatrics. 42nd Annual Interscience Conference on Antimicrobial Agents and Chemotherapy. Washington, DC: American Society of Microbiology; 2002. p. 244.
Matsumoto A, Hosoya M, Katayose M, Murai H, Kawasaki Y, Sato K, et al. Antimicrobial resistance in Streptococcus pneumoniae and Haemophilus influenzae isolated from nasopharynxi in children. Kansenshogaku Zasshi 78:482–489.
Endo H, Kayama Y, Kawamura K, Sato N, Shimoda H, Ubukata K, et al. Bacterial strains isolated from upper pharynx of young children suffering from acute respiratory tract infections. J J Pediatr Soc 2002;106:472–481.
Uno Y. Surveillance based on molecular epidemiology for Streptococcus pneumoniae isolated from the nasopharynx in pediatric patients with acute otitis media. JPN J Chemotherapy 52:68–74.
Uno Y. Surveillance based on molecular epidemiology of Haemophilus influenzae isolated from the nasopharynx of pediatric patients with acute otitis media. JPN J Chemotherapy; 52:163–168.
Ito M, Shirai A, Sakunaka K, Tsukatani T, Shibuya K, Yoshizaki T, et al. Rate of isolation of nasopharyngeal penicillin-resistant Streptococcus pneumoniae from 18-month-old infants. Oto-Rhino-Laryngology, Tokyo 2000;43:540–546.
Ito M, Furukawa M. Survey of the rate of isolation of Haemophilus influenzae in the general population. Journal of Japan Society for Infectious Diseases in Otolaryngology 2002;20:94–97.
Ubukata K, Chiba N, Kobayashi R, Hasegawa K, Konno M. Surveillance based on molecular epidemiology for Haemophilus influenzae isolates between 1998 and 2000 in Japan. Results of clinical isolates of Streptococcus pneumoniae, etc., collected by the Community-Acquired Bacterial Infections Working Group. JPN J Chemotherapy 2002;50:794–804.
Ubukata K, Kobayashi R, Chiba N, Hasegawa K, Konno M. Surveillance based on molecular epidemiology for Streptococcus pneumoniae isolates between 1998 and 2000 in Japan. Results of clinical isolates collected by the Community-Acquired Bacterial Infections Working Group. JPN J Chemotherapy 2003;51:60–70.