National Wilms Tumor Study: An Update for Pathologists

SAGE Publications - 1998
Beckwith Jb1
1Department of Pathology and Human Anatomy, Division of Pediatric Pathology, AH 327, Loma Linda University, Loma Linda, CA 92350, USA

Tóm tắt

The National Wilms Tumor Study (NWTS)-5, begun in August 1995, incorporates some important new definitions and concepts that have critical importance in determining therapy and prognosis. The criteria for stage 1 were refined to accommodate an important subset of stage 1 Wilms tumors that are being managed by nephrectomy alone, without the use of adjuvant therapy. The distinction between stages 1 and 2 in the renal sinus is no longer defined by the hilar plane but by the presence or absence of venous or lymphatic invasion. Specific problems encountered in the interpretation of the renal sinus are discussed here. The topographical definition of focal anaplasia has proven to be of prognostic value and is incorporated into the NWTS-5 study design.

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Tài liệu tham khảo

10.1002/cncr.1980.45.s7.1791

10.1002/1097-0142(19810501)47:9<2302::AID-CNCR2820470933>3.0.CO;2-K

Breslow N, 1985, Results of the National Wilms tumor Study. J Clin Oncol, 3, 521

10.1002/mpo.2950130202

10.1002/1097-0142(19861201)58:11<2501::AID-CNCR2820581125>3.0.CO;2-V

10.1016/S0031-3955(16)38088-9

GreenDM, GrundyPE, BreslowNE, RitcheyML, BeckwithJB, CoppesMJ, ThomasPRM, D'AngioGJ: Wilms Tumor. In: PizzoPA, PoplackDG, eds. Principles and Practice of Pediatric Oncology. 2nd ed. Philadelphia and New York: Lippincott-Raven, 1997;733–759.

10.1200/JCO.1993.11.1.91

10.1002/1097-0142(19940915)74:6<1817::AID-CNCR2820740626>3.0.CO;2-X

Beckwith JB, 1994, Atlas of Tumor Pathology, Third Series, Fascicle 11. Tumors of the Kidney, Bladder, and Related Urinary Structures, 5

Beckwith JB, 1993, Histology for Pathologists, 669

10.1002/1097-0142(197805)41:5<1937::AID-CNCR2820410538>3.0.CO;2-U

10.1016/S0046-8177(88)80152-7

Faria P, 1996, A report from the National Wilms Tumor Study Group. Am J Surg Pathol, 20, 909

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