Narrative role of vitamin D receptor with osteoporosis and obesity in a sample of Egyptian females: a pilot study
Tóm tắt
Vitamin D receptor (VDR) is known as one of the cellular regulators for several metabolic pathways indicating its pivotal role in the pathological pathway of numerous diseases. Considering the high frequency of osteoporosis and obesity among women, the current study aimed to explore the prospective assembly of the most frequent two VDR loci, single nucleotide polymorphism SNPs rs731236 (TaqI) and rs7975232 (ApaI) with a genetic predisposition to osteoporosis (skeletal) and obesity (chronic non-skeletal disorders), in Egyptian women. This was a cross-sectional study, including 97 Egyptian females (25–65 years), randomly chosen, from all employees and workers of the National Research Centre, Egypt. Anthropometric measurements (weight, height, BMI), dual-energy X-ray absorptiometry (DEXA), and molecular genetic analysis were done. The variation of ApaI genotype between the normal and osteoporotic groups denotes a remarkable association of the homozygote ApaI genotype with osteoporosis risk. Among the normal weight group, bone mineral density (BMD) was significantly associated with TaqI VDR gene polymorphism as the presence of the heterozygote genotype was accompanied with higher BMD while the homozygote one was detected with lower BMD. Also, TaqI VDR gene polymorphism was significantly associated with BMI when participants were divided according to the presence of osteoporosis; increased BMI was expressed in the non-osteoporotic women group carrying the homozygote genotype of Taq I VDR gene while the presence of the heterozygote genotype (TaqI) in the osteoporotic group was associated with increased BMI. The heterozygote TaqI genotype is protective against the osteoporosis phenotype and accompanied with increased BMI among osteoporotic women, while the homozygote ApaI genotype has a significant association with osteoporosis risk.
Tài liệu tham khảo
Greco EA, Lenzi A, Migliaccio S (2015) The obesity of bone. Ther Adv Endocrinol Metab. 6(6):273–286
Trevisan C, Alessi A, Girotti G, Zanforlini BM, Bertocco A, Mazzochin M, Zoccarato F, Piovesan F, Dianin M, Giannini S, Manzato E, Sergi G (2020) The impact of smoking on bone metabolism, bone mineral density and vertebral fractures in postmenopausal women. J Clin Densitom 23(3):381–389
El-Zanaty and Associates [Egypt], International I (2015) Egypt demographic and health survey 2014. Ministry of Health and Population and ICF International, Cairo and Rockville
Horowitz MC, Lorenzo JA (2004) The origin of osteoclasts. Curr Opin Rheumatol. 16:464–468
Nakamura T (2004) WHO diagnostic criteria for osteoporosis and trends in Europe and USA. Nihon Rinsho 62(Suppl 2):235–239
Lyon HN, Hirschhorn JN (2005) Genetics of common forms of obesity: a brief overview. Am J Clin Nutr 82(1):215S–217S. https://doi.org/10.1093/ajcn/82.1.215S
Carlberg C (2019) Nutrigenomics of vitamin D. Nutrients 11(3):676. https://doi.org/10.3390/nu11030676
Hewison M, Zehnder D, Chakraverty R, Adams JS (2004) Vitamin D and barrier function: a novel role for extra-renal 1α-hydroxylase. Mol Cell Endocrinol 215(1-2):31–38. https://doi.org/10.1016/j.mce.2003.11.017
Uitterlinden AG, Fang Y, Van Meurs JB, Pols HA, Van Leeuwen JP (2004) Genetics and biology of vitamin D receptor polymorphisms. Gene. 338(2):143–156. https://doi.org/10.1016/j.gene.2004.05.014
Banjabi AA, Al-Ghafari AB, Kumosani TA, Kannan K, Fallatah SM (2020) Genetic influence of vitamin D receptor gene polymorphisms on osteoporosis risk. Int J Health Sci (Qassim) 14(4):22–28
Al-Hazmi AS, Al-Mehmadi MM, Al-Bogami SM et al (2017) Vitamin D receptor gene polymorphisms as a risk factor for obesity in Saudi men. Electron Physician 9(10):5427–5433. https://doi.org/10.19082/5427
Man H, Yu Z, Dan L et al (2018) Association between −174G>C polymorphism in the IL-6 promoter region and the risk of obesity: a meta-analysis. Medicine. 97:e11773
Shab-Bidar S, Neyestani TR, Djazayery A (2017) Vitamin D receptor gene polymorphisms, metabolic syndrome, and type 2 diabetes in Iranian subjects: no association with observed SNPs. Int J Vitam Nutr Res 10:1–10
Hasan HA, AbuOdeh RO, Muda WAMBW, Mohamed HJBJ, Samsudin AR (2017) Association of vitamin D receptor gene polymorphisms with metabolic syndrome and its components among adult Arabs from the United Arab Emirates. Diabetes Metab Syndr 11(Suppl. 2):531–537
Correa-Rodriguez M, Carrillo-Avila JA, Schmidt-RioValle J, Gonzalez-Jimenez E, Vargas S, Martin J et al (2018) Genetic association analysis of vitamin D receptor gene polymorphisms and obesity-related phenotypes. Gene. 640:51–56. https://doi.org/10.1016/j.gene.2017.10.029
Hiernaux J, Tanner JM (1969) Growth and physical studies. In: Weiner JS, Lourie SA (eds) Biology human. A guide to field methods. IBP. London, Blackwell Scientific Publications; 1969, Oxford
WHO Scientific Group on the Prevention and Management of Osteoporosis: Geneva, Switzerland (2003). Prevention and management of osteoporosis: report of a WHO scientific group. World Health Organization. Tech Rep Ser 2003;921:1–164. https://apps.who.int/iris/handle/10665/42841.
NIH Consensus Statement (2000). Osteoporosis prevention, diagnosis, and therapy. NIH Consens Statement 2000;17(1):1–45.
Mohamed S, El-Askary A (2017) Vitamin D receptor gene polymorphism among Egyptian obese children. Asian J Clin Nutr 9:24–29
Pludowski P, Holick MF, Grant WB, Konstantynowicz J, Mascarenhas MR, Haq A (2018) Vitamin D supplementation guidelines. J Steroid BiochemMol Biol 175:125–135. https://doi.org/10.1016/j.jsbmb.2017.01.021
Sirajudeen S, Shah I, Al MA (2019) A narrative role of vitamin D and its receptor: with current evidence on the gastric tissues. Int J Mol Sci 20(15):3832. https://doi.org/10.3390/ijms20153832
Zhang L, Yin X, Wang J, Xu D, Wang Y, Yang J, Tao Y, Zhang S, Feng X, Yan C (2018) Associations between VDR gene polymorphisms and osteoporosis risk and bone mineral density in postmenopausal women: a systematic review and meta-analysis. Sci Rep 17(1):981
Marozik P, Mosse I, Alekna V, Rudenko E, Tamulaitienė M, Ramanau H et al (2013) Association between polymorphisms of VDR, COL1A1, and LCT genes and bone mineral density in Belarusian women with severe postmenopausal osteoporosis. Medicina (Kaunas) 49:177–184 [PubMed] [Google Scholar]
Shen H, Xie J, Lu H (2014) Vitamin D receptor gene and risk of fracture in postmenopausal women: a meta-analysis. Climacteric. 17(4):319–324. https://doi.org/10.3109/13697137.2013.856401
Wang QX, Zhao SM, Zhou YB, Zhang C (2018) Lack of association between vitamin D receptor genes BsmI as well as ApaI polymorphisms and osteoporosis risk: a pooled analysis on Chinese individuals. Int J Rheum Dis 21(5):967–974. https://doi.org/10.1111/1756-185X.13282
Yadav U, Kumar P, Rai V (2020) Vitamin D receptor (VDR) gene FokI, BsmI, ApaI, and TaqI polymorphisms and osteoporosis risk: a meta-analysis. Egypt J Med Human Genet 21(1):15. https://doi.org/10.1186/s43042-020-00057-5
Sakamoto Y, Oono F, Iida K, Wang PL, Tachi Y (2021) Relationship between vitamin D receptor gene polymorphisms (BsmI, TaqI, ApaI, and FokI) and calcium intake on bone mass in young Japanese women. BMC Womens Health 21(1):76. https://doi.org/10.1186/s12905-021-01222-7
Chen X, Wang W, Yanyan Wang Y, Han X, Gao L (2019) Vitamin D receptor polymorphisms associated with susceptibility to obesity: a meta-analysis. Med SciMonit 25:8297–8305
Fan HR, Lin LQ, Hao MA et al (2015) Association between vitamin D receptor gene polymorphism (TaqI) and obesity in Chinese population. J Genet 94(3):473–478. https://doi.org/10.1007/s12041-015-0541-x
Bienertova-Vasku J, Zlamal F, Pohorala A, Mikes O, Goldbergova-Pavkova M, Novak J et al (2017) Allelic variants in vitamin D receptor gene are associated with adiposity measures in the central-European population. BMC Med Genet 18(1):90. https://doi.org/10.1186/s12881-017-0454-z
Yiannis V, Theologia S, Kalliopi K et al (2013) VDR TaqI is associated with obesity in the Greek population. Gene. 512:237–239
Ruiz-Ojeda FJ, Anguita-Ruiz A, Leis R, Aguilera CM (2018) Genetic factors and molecular mechanisms of vitamin D and obesity relationship. Ann Nutr Metab 73:89–99
Karonova T, Grineva E, Belyaeva O, Bystrova A, Jude EB, Andreeva A, Kostareva A, Pludowski P (2018) Relationship between vitamin D status and vitamin D receptor gene polymorphisms with markers of metabolic syndrome among adults. Front Endocrinol (Lausanne) 9:448
Nam SW, Choi J, Jeon HJ, Oh TK, Lee DH (2021) The associations between vitamin D receptor BsmI and ApaI polymorphisms and obesity in Korean patients with type 2 diabetes mellitus. Diabetes Metab Syndr Obes 14:557–564