Nanosized complexation assemblies housed inside reverse micelles churn out monocytic delivery cores for bendamustine hydrochloride

Yuvraj Singh1, Anumandla Chandrashekhar1, Jaya Gopal Meher1, K.K. Durga Rao Viswanadham1, Vivek K. Pawar1, Kavit Raval1, Komal Sharma1, Pankaj K. Singh1, Animesh Kumar1, Manish K. Chourasia1
1Pharmaceutics Division, CSIR-Central Drug Research Institute, Lucknow 226031, India

Tài liệu tham khảo

Cortelezzi, 2014, Bendamustine in combination with ofatumumab in relapsed or refractory chronic lymphocytic leukemia: a GIMEMA Multicenter Phase II Trial, Leukemia, 28, 642, 10.1038/leu.2013.334 Kasa, 2014, Stability-indicating LC method for the estimation of bendamustine hydrochloride and its related impurities, J. Chromatograph. Sci., 52, 573, 10.1093/chromsci/bmt075 Darwish, 2015, Pharmacokinetic and pharmacodynamic profile of bendamustine and its metabolites, Cancer Chemother. Pharmacol., 75, 1143, 10.1007/s00280-015-2727-6 Singh, 2009, Nanoparticle-based targeted drug delivery, Exp. Mol. Pathol., 86, 215, 10.1016/j.yexmp.2008.12.004 Singh, 2016, Subcutaneously administered ultrafine PLGA nanoparticles containing doxycycline hydrochloride target lymphatic filarial parasites, Mol. Pharm., 13, 2084, 10.1021/acs.molpharmaceut.6b00206 Singh, 2015, Reinvestigating nanoprecipitation via Box-Behnken design: a systematic approach, J. Microencapsul., 32, 75, 10.3109/02652048.2014.950710 Pawar, 2014, Immunotherapeutic vitamin E nanoemulsion synergies the antiproliferative activity of paclitaxel in breast cancer cells via modulating Th1 and Th2 immune response, J. Controll. Release: Offic. J. Control. Release Soc., 196, 295, 10.1016/j.jconrel.2014.10.010 Huang, 2015, Self-delivery nanoparticles from an amphiphilic covalent drug couple of irinotecan and bendamustine for cancer combination chemotherapy, RSC Adv., 5, 86254, 10.1039/C5RA16511C Buechler, 2000, Regulation of scavenger receptor CD163 expression in human monocytes and macrophages by pro-and antiinflammatory stimuli, J. Leukoc. Biol., 67, 97, 10.1002/jlb.67.1.97 Chao, 2012, Role of carbohydrate receptors in the macrophage uptake of dextran-coated iron oxide nanoparticles, Adv. Exp. Med. Biol., 733, 115, 10.1007/978-94-007-2555-3_11 Sezer, 1999, Release characteristics of chitosan treated alginate beads: I. Sustained release of a macromolecular drug from chitosan treated alginate beads, J. Microencapsulat., 16, 195, 10.1080/026520499289176 Bhattarai, 2015, Size and diffusion phenomena of AOT/alcohol/water system in the presence of morin by dynamic light scattering, Int. J. Pharm., 478, 610, 10.1016/j.ijpharm.2014.11.037 Daigneault, 2010, The identification of markers of macrophage differentiation in PMA-stimulated THP-1 cells and monocyte-derived macrophages, PLoS ONE, 5, e8668, 10.1371/journal.pone.0008668 Annunziata, 2005, Protein diffusion coefficients determined by macroscopic-gradient Rayleigh interferometry and dynamic light scattering, Langmuir, 21, 12085, 10.1021/la052147f Singh, 2015, Bridging small interfering RNA with giant therapeutic outcomes using nanometric liposomes, J. Controll. Release, 220, 368, 10.1016/j.jconrel.2015.10.050 Wu, 2014, Comparing microspheres with different internal phase of polyelectrolyte as local drug delivery system for bone tuberculosis therapy, BioMed Res. Int., 2014, 8 Singh, 2015, Mucoadhesive gel containing immunotherapeutic nanoparticulate satranidazole for treatment of periodontitis: development and its clinical implications, RSC Adv., 5, 47659, 10.1039/C5RA02350E Pawar, 2015, Pluronic F-127 stabilised docetaxel nanocrystals improve apoptosis by mitochondrial depolarization in breast cancer cells: pharmacokinetics and toxicity assessment, J. Biomed. Nanotechnol., 11, 1747, 10.1166/jbn.2015.2158 Lunov, 2011, Differential uptake of functionalized polystyrene nanoparticles by human macrophages and a monocytic cell line, ACS Nano, 5, 1657, 10.1021/nn2000756 Myers, 2011, Comparative evaluation of different cell lysis and extraction methods for studying benzo(a)pyrene metabolism in HT-29 colon cancer cell cultures, Cellular Physiol. Biochem.: Int. J. Exper. Cellular Physiol., Biochem., Pharmacol., 28, 209, 10.1159/000331732 Singh, 2016, Novel validated RP-HPLC method for bendamustine hydrochloride based on ion-pair chromatography: application in determining infusion stability and pharmacokinetics, J. Chromatogr. Sci., 55, 30, 10.1093/chromsci/bmw145 Spehr, 2011, Dynamics of water confined to reverse AOT micelles, Soft Matter, 7, 5745, 10.1039/c1sm05204g Menger, 1978, Adsorption, displacement, and ionization in water pools, J. Am. Chem. Soc., 100, 4376, 10.1021/ja00482a010 Shukla, 2004, Observation of two diffusive relaxation modes in microemulsions by dynamic light scattering, Langmuir, 20, 8526, 10.1021/la048883l M.P. Pileni, Structure and Reactivity in Reverse Micelles, 1989. Rinaudc, 1999, Solubilization of chitosan in strong acid medium, Int. J. Polym. Anal. Charact., 5, 267, 10.1080/10236669908009742 Sze, 2003, Zeta-potential measurement using the Smoluchowski equation and the slope of the current–time relationship in electroosmotic flow, J. Colloid Interface Sci., 261, 402, 10.1016/S0021-9797(03)00142-5 Brugger, 2013, Bendamustine in indolent non-hodgkin's lymphoma: a practice guide for patient management, Oncologist, 18, 954, 10.1634/theoncologist.2013-0079 Gaul, 2008, Bendamustine induces G2 cell cycle arrest and apoptosis in myeloma cells: the role of ATM-Chk2-Cdc25A and ATM-p53-p21-pathways, J. Cancer Res. Clin. Oncol., 134, 245, 10.1007/s00432-007-0278-x Gordon, 2005, Monocyte and macrophage heterogeneity, Nat. Rev. Immunol., 5, 953, 10.1038/nri1733 Grunwald, 1996, Monocytes can phagocytose Gram-negative bacteria by a CD14-dependent mechanism, J. Immunol. (Baltimore, Md.: 1950), 157, 4119, 10.4049/jimmunol.157.9.4119 Cline, 1968, Phagocytosis by human monocytes, Blood, 32, 423, 10.1182/blood.V32.3.423.423 Hillaireau, 2009, Nanocarriers' entry into the cell: relevance to drug delivery, Cellular Mole. Life Sci.: CMLS, 66, 2873, 10.1007/s00018-009-0053-z Doi, 1993, Charged collagen structure mediates the recognition of negatively charged macromolecules by macrophage scavenger receptors, J. Biol. Chem., 268, 2126, 10.1016/S0021-9258(18)53971-5 Zamze, 2002, Recognition of bacterial capsular polysaccharides and lipopolysaccharides by the macrophage mannose receptor, J. Biol. Chem., 277, 41613, 10.1074/jbc.M207057200 Kuhn, 2014, Different endocytotic uptake mechanisms for nanoparticles in epithelial cells and macrophages, Beilst. J. Nanotechnol., 5, 1625, 10.3762/bjnano.5.174 Kim, 2014, Red Si-rhodamine drug conjugates enable imaging in GFP cells, Chem. Commun., 50, 4504, 10.1039/c4cc00144c Hiraoka, 2014, Purine analog-like properties of bendamustine underlie rapid activation of DNA damage response and synergistic effects with pyrimidine analogues in lymphoid malignancies, PLoS ONE, 9, e90675, 10.1371/journal.pone.0090675 Brookes, 1961, The reaction of mono- and di-functional alkylating agents with nucleic acids, Biochem. J., 80, 496, 10.1042/bj0800496