Nanoparticles as drug delivery systems

Agnieszka Z. Wilczewska1, Katarzyna Niemirowicz2, Karolina H. Markiewicz1, Halina Car2
1Institute of Chemistry, University of Bialystok, al. J. Pilsudskiego 11/4, PL 15-433 Białystok, Poland
2Department of Experimental Pharmacology, Medical University of Bialystok, Szpitalna 37, PL 15-295 Białystok, Poland

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Abdel-Mottaleb, 2011, Lipid nanocapsules for dermal application: A comparative study of lipid-based versus polymer-based nanocarriers, Eur J Pharm Biopharm, 79, 36, 10.1016/j.ejpb.2011.04.009

Afergan, 2008, Delivery of serotonin to the brain by monocytes following phagocytosis of liposomes, J Control Release, 132, 84, 10.1016/j.jconrel.2008.08.017

Agnihotri, 2006, Novel interpenetrating network chitosan-poly(ethylene oxide-g-acrylamide)hydrogel microspheres for the controlled release of capecitabine, Int J Pharm, 324, 103, 10.1016/j.ijpharm.2006.05.061

Ahola, 2001, In vitro release of heparin from silica xerogels, Biomaterials, 22, 2163, 10.1016/S0142-9612(00)00407-5

Ai, 2011, Nanotoxicology and nanoparticle safety in biomedical designs, Int J Nanomedicine, 6, 1117

Ajima, 2008, Enhancement of in vivo anticancer effects of cisplatin by incorporation inside singlewall carbon nanohorns, ACS Nano, 2, 2057, 10.1021/nn800395t

Amato, 2010, Silica-encapsulated efficient and stable si quantum dots with high biocompatibility, Nanoscale Res Lett, 5, 1156, 10.1007/s11671-010-9619-9

Arayachukeat, 2011, Retinyl acetate-loaded nanoparticles: Dermal penetration and release of the retinyl acetale, Int J Pharm, 404, 281, 10.1016/j.ijpharm.2010.11.019

Arias, 2010, Iron/ethylcellulose (core/shell) nanoplatform loaded with 5-fluorouracil for cancer targeting, Colloids Surf B Biointerfaces, 77, 111, 10.1016/j.colsurfb.2010.01.030

Arruebo, 2007, Magnetic nanoparticles for drug delivery, Nano Today, 2, 22, 10.1016/S1748-0132(07)70084-1

Arsawang, 2011, How do carbon nanotubes serve as carriers for gemcitabine transport in a drug delivery system?, J Mol Graph Model, 29, 591, 10.1016/j.jmgm.2010.11.002

Asmatulu, 2005, Synthesis, characterization and targeting of biodegradable magnetic nanocomposite particles by external magnetic fields, J Magn Magn Mater, 292, 108, 10.1016/j.jmmm.2004.10.103

Attama, 2007, Solid lipid nanodispersions containing mixed lipid core and a polar heterolipid: characterization, Eur J Pharm Biopharm, 67, 48, 10.1016/j.ejpb.2006.12.004

Bai, 2007, One-pot synthesis of polyacrylamide-gold nanocomposite, Mater Chem Phys, 106, 412, 10.1016/j.matchemphys.2007.06.021

Bajpai, 2011, Magnetically mediated release of ciprofloxacin from polyvinyl alcohol based superparamagnetic nanocomposites, J Mater Sci Mater Med, 22, 357, 10.1007/s10856-010-4214-2

Balogh, 2001, Dendrimer-silver complexes and nanocomposites as antimicrobial agents, Nano Lett, 1, 18, 10.1021/nl005502p

Beg, 2011, Advancement in carbon nanotubes: basics, biomedical applications and toxicity, J Pharm Pharmacol, 63, 141, 10.1111/j.2042-7158.2010.01167.x

Bhirde, 2010, Distribution and clearance of PEG-single-walled carbon nanotube cancer drug delivery vehicles in mice, Nanomedicine, 5, 1535, 10.2217/nnm.10.90

Bhirde, 2009, Targeted killing of cancer cells in vivo and in vitro with EGF-directed carbon nanotube-based drug delivery, ACS Nano, 3, 307, 10.1021/nn800551s

Bilensoy, 2009, Intravesical cationic nanoparticles of chitosan and polycaprolactone for the delivery of Mitomycin C to bladder tumors, Int J Pharm, 371, 170, 10.1016/j.ijpharm.2008.12.015

Biswas, 2012, Liposomes loaded with paclitaxel and modified with novel triphenylphosphonium-PEG-PE conjugate possess low toxicity, target mitochondria and demonstrate enhanced antitumor effects in vitro and in vivo, J Control Release, 159, 393, 10.1016/j.jconrel.2012.01.009

Biswas, 2011, Development of the novel PEG-PE-based polymer for the reversible attachment of specific ligands to liposomes: synthesis and in vitro characterization, Bioconjug Chem, 22, 2005, 10.1021/bc2002133

Caminade, 2005, Characterization of dendrimers, Adv Drug Deliv Rev, 57, 2130, 10.1016/j.addr.2005.09.011

Cao, 2011, Enhancement of the efficiency of magnetic targeting for drug delivery: Development and evaluation of magnet system, J Magn Magn Mater, 323, 1919, 10.1016/j.jmmm.2010.11.058

Chang, 2008, High efficiency protein separation with organosilane assembled silica coated magnetic nanoparticles, Superlattice Microst, 44, 442, 10.1016/j.spmi.2007.12.006

Chauhan, 2009, Unexpected in vivo anti-inflammatory activity observed for simple, surface functionalized poly(amidoamine) dendrimers, Biomacromolecules, 10, 1195, 10.1021/bm9000298

Chauhan, 2010, Pre-clinical and behavioural toxicity profile of PAMAM dendrimers in mice, Proc R Soc A, 466, 1535, 10.1098/rspa.2009.0448

Chen, 2011, Characterization of chitosan magnetic nanoparticles for in situ delivery of tissue plasminogen activator, Carbohydr Polym, 84, 364, 10.1016/j.carbpol.2010.11.052

Chen, 2005, Formation of nucleoplasmic protein aggregates impairs nuclear function in response to SiO2 nanoparticles, Exp Cell Res, 305, 51, 10.1016/j.yexcr.2004.12.021

Chen, 2008, Age-related differences in pulmonary and cardiovascular responses to SiO2 nanoparticle inhalation: nanotoxicity has susceptible population, Environ Sci Technol, 42, 8985, 10.1021/es800975u

Chen, 2011, Adsorption behavior of epirubicin hydrochloride on carboxylated carbon nanotubes, Int J Pharm, 28, 153, 10.1016/j.ijpharm.2010.11.034

Cho, 2009, The impact of size on tissue distribution and elimination by single intravenous injection of silica nanoparticles, Toxicol Lett, 189, 177, 10.1016/j.toxlet.2009.04.017

Cho, 2007, Inflammatory mediators induced by intratracheal instillation of ultrafine amorphous silica particles, Toxicol Lett, 175, 24, 10.1016/j.toxlet.2007.09.008

Chomoucka, 2010, Magnetic nanoparticles and targeted drug delivering, Pharm Res, 62, 144, 10.1016/j.phrs.2010.01.014

Cole, 2011, Cancer theranostics: the rise of targeted magnetic nanoparticles, Trends Biotechnol, 29, 323, 10.1016/j.tibtech.2011.03.001

Czarnobaj, 2008, Preparation and characterization of silica xerogels as carriers for drugs, Drug Deliv, 15, 485, 10.1080/10717540802321495

Czarnobaj, 2008, Sol-gel processed porous silica carriers for the controlled release of diclofenac diethylamine, J Biomed Mater Res B Appl Biomater, 87, 114, 10.1002/jbm.b.31076

Czarnobaj, 2007, In vitro release of cisplatin from sol-gel processed organically modified silica xerogels, J Mater Sci Mate Med, 18, 2041, 10.1007/s10856-007-3139-x

Czarnobaj K, Sawicki W: The sol-gel prepared SiO2-CaO-P2O5 composites doped with metronidazole for application in local delivery systems. Pharm Dev Technol, 2011, (doi: 10.3109/10837450.2011.572894).

D’Emanuele, 2005, Dendrimer-drug interactions, Adv Drug Deliv Rev, 57, 2147, 10.1016/j.addr.2005.09.012

Daemen, 1995, Liposomal doxorubicin-induced toxicity: depletion and impairment of phagocytic activity of liver macrophages, Int J Cancer, 61, 666, 10.1002/ijc.2910610520

des Rieux, 2006, Nanoparticles as potential oral delivery systems of proteins and vaccines: a mechanistic approach, J Control Release, 116, 1, 10.1016/j.jconrel.2006.08.013

Dev, 2010, Preparation of poly(lactic acid)/chitosan nanoparticles for anti-HIV drug delivery applications, Carbohydr Polym, 80, 833, 10.1016/j.carbpol.2009.12.040

Dhar, 2008, Targeted single-wall carbon nanotube-mediated Pt(IV) prodrug delivery using folate as a homing device, J Am Chem Soc, 27, 11467, 10.1021/ja803036e

Di Crescenzo, 2011, Biocompatible dispersions of carbon nanotubes: a potential tool for intracellular transport of anticancer drugs, Nanoscale, 3, 925, 10.1039/C0NR00444H

Di Pasqua, 2009, Adsorption of the Pt(II) anticancer drug carboplatin by mesoporous silica, Chem Biodiv, 6, 1343, 10.1002/cbdv.200900021

Dobrovolskaia, 2007, Immunological properties of engineered nanomaterials, Nat Nano, 2, 469, 10.1038/nnano.2007.223

dos Santos Giuberti, 2011, Study of the pilot production process of long-circulating and pH-sensitive liposomes containing cisplatin, J Liposome Res, 21, 60, 10.3109/08982101003754377

Duncan, 2005, Dendrimer biocompatibility and toxicity, Adv Drug Deliv Rev, 57, 2215, 10.1016/j.addr.2005.09.019

Echeverría, 2010, Synthesis and characterization of ultramicroporous silica xerogels, J Non-Cryst Solids, 356, 378, 10.1016/j.jnoncrysol.2009.11.044

Eom, 2009, Oxidative stress of silica nanoparticles in human bronchial epithelial cell, Beas-2B, Toxicol In Vitro, 23, 1326, 10.1016/j.tiv.2009.07.010

Fidalgo, 2009, Wet sol–gel silica matrices as delivery devices for phenytoin, J Sol-Gel Sci Technol, 49, 320, 10.1007/s10971-008-1880-3

Figuerola, 2010, From iron oxide nanoparticles towards advanced iron-based inorganic materials designed for biomedical applications, Pharmacol Res, 62, 126, 10.1016/j.phrs.2009.12.012

Foldvari, 2008, Carbon nanotubes as functional excipients for nanomedicines: I. Pharmaceutical properties, Nanomedicine, 4, 173, 10.1016/j.nano.2008.04.002

Fritzen-Garcia, 2009, Atomic force microscopy imaging of polyurethane nanoparticles onto different solid, Mater Sci Eng C, 29, 405, 10.1016/j.msec.2008.08.012

Gaihre, 2009, Gelatin-coated magnetic iron oxide nanoparticles as carrier system: drug loading and in vitro drug release study, Int J Pharm, 365, 180, 10.1016/j.ijpharm.2008.08.020

Grassi-Schultheiss, 1997, Analysis of magnetic material in the human heart, spleen and liver, Biometals, 10, 351, 10.1023/A:1018340920329

Hafeli, 2009, Cell uptake and in vitro toxicity of magnetic nanoparticles suitable for drug delivery, Mol Pharm, 6, 1417, 10.1021/mp900083m

Han, 2010, Peptideconjugated PAMAM for targeted doxorubicin delivery to transferrin receptor overexpressed tumors, Mol Pharm, 7, 2156, 10.1021/mp100185f

He, 2011, A pH-responsive mesoporous silica nanoparticles-based multidrug delivery system for overcoming multidrug resistance, Biomaterials, 32, 7711, 10.1016/j.biomaterials.2011.06.066

Heiden, 2007, Developmental toxicity of low generation PAMAM dendrimers in zebrafish, Toxicol Appl Pharmacol, 225, 70, 10.1016/j.taap.2007.07.009

Hocine, 2010, Silicalites and mesoporous silica nanoparticles for photodynamic therapy, Int J Pharm, 402, 221, 10.1016/j.ijpharm.2010.10.004

Hong, 2004, Interaction of poly(amidoamine) dendrimers with supported lipid bilayers and cells: hole formation and the relation to transport, Bioconjug Chem, 15, 774, 10.1021/bc049962b

Hua, 2011, The effectiveness of a magnetic nanoparticle-based delivery system for BCNU in the treatment of gliomas, Biomaterials, 32, 516, 10.1016/j.biomaterials.2010.09.065

Hua, 2010, Magnetic-nanoparticle-modified paclitaxel for targeted therapy for prostate cancer, Biomaterials, 31, 7355, 10.1016/j.biomaterials.2010.05.061

Jain, 2007, Biodistribution, clearance, and biocompatibility of iron oxide magnetic nanoparticles in rats, Mol Pharm, 5, 316, 10.1021/mp7001285

Jia, 2005, Cytotoxicity of carbon nanomaterials: singlewall nanotube, multi-wall nanotube, and fullerene, Environ Sci Technol, 39, 1378, 10.1021/es048729l

Jingting, 2011, Preparation and characterization of magnetic nanoparticles containing Fe3O4-dextran-anti-β-human chorionic gonadotropin, a new generation choriocarcinoma-specific gene vector, Int J Nanomedicine, 6, 285

Kale, 2012, Characterization of biocompatible NiCo2O4 nanoparticles for applications in hyperthermia and drug delivery, Nanomedicine, 8, 452, 10.1016/j.nano.2011.07.010

Karlsson, 2008, Copper oxide nanoparticles are highly toxic: a comparison between metal oxide nanoparticles and carbon nanotubes, Chem Res Toxicol, 21, 1726, 10.1021/tx800064j

Kempe, 2010, The use of magnetite nanoparticles for implant-assisted magnetic drug targeting in thrombolytic therapy, Biomaterials, 31, 9499, 10.1016/j.biomaterials.2010.07.107

Kim, 2003, Enhancement of polyethylene glycol (PEG)-modified cationic liposome-mediated gene deliveries: effects on serum stability and transfection efficiency, J Pharm Pharmacol, 55, 453, 10.1211/002235702928

Kim, 2011, Ordered mesoporous polymer-silica hybrid nanoparticles as vehicles for the intracellular controlled release of macro-molecules, ACS Nano, 5, 360, 10.1021/nn101740e

Kitchens, 2006, Transport of poly(amidoamine) dendrimers across Caco-2 cell monolayers: influence of size, charge and fluorescent labeling, Pharm Res, 23, 2818, 10.1007/s11095-006-9122-2

Kojima, 2010, Influence of dendrimer generation and polyethylene glycol length on the biodistribution of PEGylated dendrimers, Int J Pharm, 383, 293, 10.1016/j.ijpharm.2009.09.015

Kovacevic, 2011, Polyhydroxy surfactants for the formulation of lipid nanoparticles (SLN and NLC): Effects on size, physical stability and particle matrix structure, Int J Pharm, 406, 163, 10.1016/j.ijpharm.2010.12.036

Kumar, 2010, In vivo biodistribution and clearance studies using multimodal organically modified silica nanoparticles, ACS Nano, 4, 699, 10.1021/nn901146y

Kumari, 2010, Biodegradable polymeric nanoparticles based drug delivery systems, Colloids Surf B Biointerfaces, 75, 1, 10.1016/j.colsurfb.2009.09.001

Lai, 2010, Pharmacokinetics and enhanced oral bioavailability in beagle dogs of cyclosporine A encapsulated in glyceryl monooleate/poloxamer 407 cubic nanoparticles, Int J Nanomedicine, 5, 13

Lam, 2004, Pulmonary toxicity of single-wall carbon nanotubes in mice 7 and 90 days after intratracheal instillation, Toxicol Sci, 77, 126, 10.1093/toxsci/kfg243

Li, 2010, Organically modified MCM-type material preparation and its usage in controlled amoxicillin delivery, J Colloid Interface Sci, 342, 607, 10.1016/j.jcis.2009.10.073

Lin, 2006, In vitro toxicity of silica nanoparticles in human lung cancer cells, Toxicol Appl Pharmacol, 217, 252, 10.1016/j.taap.2006.10.004

Liu, 2008, Solid lipid nanoparticles for pulmonary delivery of insulin, Int J Pharm, 356, 333, 10.1016/j.ijpharm.2008.01.008

Liu, 2010, Endothelial cells dysfunction induced by silica nanoparticles through oxidative stress via JNK/P53 andNF-κB pathways, Biomaterials, 31, 8198, 10.1016/j.biomaterials.2010.07.069

Lope, 2009, Antibacterial activity and cytotoxicity of PEGylated poly(amidoamine) dendrimers, Mol Biosyst, 5, 1148, 10.1039/b904746h

Losic, 2010, Surface functionalisation of diatoms with dopamine modified iron-oxide nanoparticles: toward magnetically guided drug microcarriers with biologically derived morphologies, Chem Commun (Camb), 46, 6323, 10.1039/c0cc01305f

Luo, 2010, LyP-1-conjugated nanoparticles for targeting drug delivery to lymphatic metastatic tumors, Int J Pharm, 385, 150, 10.1016/j.ijpharm.2009.10.014

Luo, 2011, Carbon nanotube nanoreservior for controlled release of antiinflammatory dexamethasone, Biomaterials, 32, 6316, 10.1016/j.biomaterials.2011.05.020

Mahmoudi, 2010, A new approach for the in vitro identification of the cytotoxicity of super-paramagnetic iron oxide nanoparticles, Colloids Surf B Biointerfaces, 75, 300, 10.1016/j.colsurfb.2009.08.044

Mahmoudi, 2009, Cell toxicity of superparamagnetic iron oxide nanoparticles, J Colloid Interface Sci, 336, 510, 10.1016/j.jcis.2009.04.046

Mainardes, 2010, Intranasal delivery of zidovudine by PLA and PLA–PEG blend nanoparticles, Int J Pharm, 395, 266, 10.1016/j.ijpharm.2010.05.020

Malik, 1999, Dendrimer-platinate: a novel approach to cancer chemotherapy, Anti-Cancer Drugs Des, 10, 767, 10.1097/00001813-199909000-00010

Mao, 2001, Chitosan-DNA nanoparticles as gene carriers: synthesis, characterization and transfection efficiency, J Control Release, 70, 399, 10.1016/S0168-3659(00)00361-8

Martinem, 2011, Synthesis and characterization of thiolated alginate-albumin nanoparticles stabilized by disulfide bonds. Evaluation as drug delivery systems, Carbohydr Polym, 83, 1311, 10.1016/j.carbpol.2010.09.038

Maver, 2007, Novel hybrid silica xerogels for stabilization and controlled release of drug, Int J Pharm, 330, 164, 10.1016/j.ijpharm.2006.09.024

Meng, 2011, Magnetic CoPt nanoparticles as MRI contrast agent for transplanted neural stem cells detection, Nanoscale, 3, 977, 10.1039/c0nr00846j

Menjoge, 2010, Dendrimerbased drug and imaging conjugates: design considerations for nanomedical applications, Drug Discov Today, 15, 171, 10.1016/j.drudis.2010.01.009

Monteiro-Riviere, 2005, Multi-walled carbon nanotube interactions with human epidermal keratinocytes, Toxicol Lett, 155, 377, 10.1016/j.toxlet.2004.11.004

Mora-Huertas, 2010, Polymer-based nanocapsules for drug delivery, Int J Pharm, 385, 113, 10.1016/j.ijpharm.2009.10.018

Muchow, 2008, Lipid nanoparticles with a solid matrix (SLN, NLC LDC) for oral drug delivery, Drug Dev Ind Pharm, 34, 1394, 10.1080/03639040802130061

Muller, 2005, Respiratory toxicity of multi-wall carbon nanotubes, Toxicol Appl Pharmacol, 207, 221, 10.1016/j.taap.2005.01.008

Müller, 2004, Challenges and solutions for the delivery of biotech drugs – a review of drug nanocrystal technology and lipid nanoparticles, J Biotechnol, 113, 151, 10.1016/j.jbiotec.2004.06.007

Müller, 2007, Nanostructured lipid carriers (NLC) in cosmetic dermal products, Adv Drug Deliv Rev, 59, 522, 10.1016/j.addr.2007.04.012

Müller, 2002, Nanostructured lipid matrices for improved microencapsulation of drugs, Int J Pharm, 242, 121, 10.1016/S0378-5173(02)00180-1

Murakami, 2008, Water-dispersed single-wall carbon nano-horns as drug carriers for local cancer chemotherapy, Nanomedicine, 3, 453, 10.2217/17435889.3.4.453

Nanjwade, 2010, Preparation and evaluation of carboplatin biodegradable polymeric nanoparticles, Int J Pharm, 385, 176, 10.1016/j.ijpharm.2009.10.030

Naqvi, 2010, Concentration-dependent toxicity of iron oxide nanoparticles mediated by increased oxidative stress, Int J Nanomedicine, 5, 983, 10.2147/IJN.S13244

Natali, 2010, Dendrimers as drug carriers: dynamics of PEGylated and methotrexate-loaded dendrimers in aqueous solution, Macromolecules, 43, 3011, 10.1021/ma902670q

Nayak, 2010, Curcuminoids-loaded lipid nanoparticles: novel approach towards malaria treatment, Colloids Surf B Biointerfaces, 81, 263, 10.1016/j.colsurfb.2010.07.020

Neuberger, 2005, Superpara-magnetic nanoparticles for biomedical applications: possibilities and limitations of a new drug delivery system, J Magn Magn Mater, 293, 483, 10.1016/j.jmmm.2005.01.064

Nevozhay, 2007, Current status of research on conjugates and related drug delivery systems in the treatment of cancer and other diseases (Polish), Postepy Hig Med Dosw, 61, 350

Nishimori, 2009, Silica nanoparticles as hepatotoxicants, Eur J Pharm Biopharm, 72, 496, 10.1016/j.ejpb.2009.02.005

Paavola, 2000, Controlled release injectable liposomal gel of ibuprofen for epidural analgesia, Int J Pharm, 199, 85, 10.1016/S0378-5173(00)00376-8

Pan, 2005, Dendrimer modified magnetite nanoparticles for protein immobilization, J Colloid Interface Sci, 284, 1, 10.1016/j.jcis.2004.09.073

Pandey, 2005, Nanoencapsulation of azole antifungals: Potential applications to improve oral drug delivery, Int J Pharm, 301, 268, 10.1016/j.ijpharm.2005.05.027

Panyam, 2003, Biodegradable nanoparticles for drug and gene delivery to cells and tissue, Adv Drug Deliv Rev, 55, 329, 10.1016/S0169-409X(02)00228-4

Park, 2009, Oxidative stress and pro-inflammatory responses induced by silica nanoparticles in vivo and in vitro, Toxicol Lett, 184, 18, 10.1016/j.toxlet.2008.10.012

Park, 2009, PEGylated PLGA nanoparticles for the improved delivery of doxorubicin, Nanomedicine, 5, 410, 10.1016/j.nano.2009.02.002

Perry, 2011, Drug-delivery strategies by using template-synthesized nanotubes, Chemistry, 17, 6296, 10.1002/chem.201002835

Poland, 2008, Carbon nanotubes introduced into the abdominal cavity of mice show asbestoslike pathogenicity in a pilot study, Nat Nanotechnol, 3, 423, 10.1038/nnano.2008.111

Popovici, 2011, Controlled drug delivery system based on ordered mesoporous silica matrices of captopril as angiotensin-converting enzyme inhibitor drug, J Pharm Sci, 100, 704, 10.1002/jps.22308

Prajapati, 2009, Dendimer-mediated solubilization, formulation development and in vitro-in vivo assessment of piroxicam, Mol Pharm, 6, 940, 10.1021/mp8002489

Prajapati, 2011, Targeted killing of Leishmania donovani in vivo and in vitro with amphotericin B attached to functionalized carbon nanotubes, J Antimicrob Chemother, 66, 874, 10.1093/jac/dkr002

Prokopowicz, 2010, Synthesis and in vitro characterization of freeze-dried doxorubicin-loaded silica xerogels, J Sol-Gel Sci Technol, 53, 525, 10.1007/s10971-009-2126-8

Puglia, 2008, Lipid nanoparticles for prolonged topical delivery: an in vitro and in vivo investigation, Int J Pharm, 357, 295, 10.1016/j.ijpharm.2008.01.045

Quintanar-Guerrero, 2009, Silica xerogels as pharmaceutical drug carriers, Expert Opin Drug Deliv, 6, 485, 10.1517/17425240902902307

Radomski, 2005, Nanoparticleinduced platelet aggregation and vascular thrombosis, Br J Pharmacol, 146, 882, 10.1038/sj.bjp.0706386

Rejinold, 2011, Biodegradable and thermo-sensitive chitosan-g-poly(N-vinylcaprolactam) nanoparticles as a 5-fluorouracil carrier, Carbohydr Polym, 83, 776, 10.1016/j.carbpol.2010.08.052

Roberts, 1996, Preliminary biological evaluation of polyamidoamine (PAMAM) Starburst dendrimers, J Biomed Mater Res, 30, 53, 10.1002/(SICI)1097-4636(199601)30:1<53::AID-JBM8>3.0.CO;2-Q

Safdar, 2010, Drug-induced nephro-toxicity caused by amphotericin B lipid complex and liposomal amphotericin B: a review and meta-analysis, Medicine (Baltimore), 89, 236, 10.1097/MD.0b013e3181e9441b

Saraog, 2010, Gelatin nanocarriers as potential vectors for effective management of tuberculosis, Int J Pharm, 385, 143, 10.1016/j.ijpharm.2009.10.004

Sayed, 2011, Possible weak ferromagnetism in pure and M (Mn, Cu, Co, Fe and Tb) doped NiGa2O4 nanoparticles, J Nanosci Nanotechnol, 11, 3363, 10.1166/jnn.2011.3731

Sayes, 2006, Functionalization density dependence of single-walled carbon nanotubes cytotoxicity in vitro, Toxicol Lett, 161, 135, 10.1016/j.toxlet.2005.08.011

Shah, 2011, Low-generation asymmetric dendrimers exhibit minimal toxicity and effectively complex DANN, J Pept Sci, 17, 470, 10.1002/psc.1347

Shi L, Fleming CJ, Riechers SL, Yin N-N, Luo J, Lam KS, Liu GY: High-resolution imaging of dendrimers used in drug delivery via scanning probe microscopy. J Drug Deliv, 2011, (doi:10.1155/2011/254095).

Shiba, 2006, Carbon nanohorns as a novel drug carrier, Nihon Rinsho, 64, 239

Shin US, Yoon IK, Lee GS, Jang WC, Knowles JC, Kim HW: Carbon nanotubes in nanocomposites and hybrids with hydroxyapatite for bone replacements. J Tissue Eng, 2011, (doi:10.4061/2011/674287).

Shubayev, 2009, Magnetic nanopar-ticles for theragnostics, Adv Drug Deliv Rev, 61, 467, 10.1016/j.addr.2009.03.007

Silva, 2011, Sonoproduction of liposomes and protein particles as templates for delivery purposes, Biomacromolecules, 12, 3353, 10.1021/bm200658b

Singh, 2008, Folate and Folate-PEG-PAMAM dendrimers: synthesis, characterization, and targeted anticancer drug delivery potential in tumor bearing mice, Bioconjugate Chem, 19, 2239, 10.1021/bc800125u

Slowing, 2007, Mesoporous silica nanoparticles for drug delivery and biosensing applications, Adv Funct Mater, 17, 1225, 10.1002/adfm.200601191

Slowing, 2008, Mesoporous silica nanoparticles as controlled release drug delivery and gene transfection carriers, Adv Drug Deliv Rev, 60, 1278, 10.1016/j.addr.2008.03.012

Smolensky, 2011, Surface functionalization of magnetic iron oxide nanoparticles for MRI applications - effect of anchoring group and ligand exchange protocol, Contrast Media Mol Imaging, 6, 189

Sunderland, 2006, Targeted nanoparticles for detecting and treating cancer, Drug Dev Res, 67, 70, 10.1002/ddr.20069

Suri, 2007, Nanotechnology-based drug delivery systems, J Occup Med Toxicol, 2, 16, 10.1186/1745-6673-2-16

Svenson, 2005, Dendrimers in biomedical applications – reflections on the field, Adv Drug Deliv Rev, 57, 2106, 10.1016/j.addr.2005.09.018

Sznitowska, 2001, Bioavailability of diazepam from aqueous-organic solution, submicron emulsion and solid lipid nanoparticles after rectal administration in rabbits, Eur J Pharm Biopharm, 52, 159, 10.1016/S0939-6411(01)00157-6

Tamer, 2010, Synthesis of magnetic core-shell Fe3O4 – Au, nanoparticles for biomolecule immobilization and detection, J Nanopart Res, 12, 1187, 10.1007/s11051-009-9749-0

Tanis, 2009, Association of a weakly acidic anti-inflammatory drug (Ibuprofen) with a poly(amidoamine) dendrimer as studied by molecular dynamics simulations, J Phys Chem B, 113, 10984, 10.1021/jp9039176

Tomalia, 2005, Birth of a new macromolecular architecture: dendrimers as quantized building blocks for nanoscale synthetic organic chemistry, Prog Polym Sci, 30, 294, 10.1016/j.progpolymsci.2005.01.007

Tong, 2011, In vitro and in vivo anti-tumor effects of gemcitabine loaded with a new drug delivery system, J Nanosci Nanotechnol, 11, 3651, 10.1166/jnn.2011.3804

Torchilin, 2008

Tosh, 2010, Polyamidoamine (PAMAM) dendrimer conjugates of “clickable” agonists of the A3 adenosine receptor and coactivation of the P2Y14 receptor by a tethered nucleotide, Bioconjug Chem, 21, 372, 10.1021/bc900473v

Tripisciano, 2010, Cisplatin filled multiwalled carbon nanotubes – a novel molecular hybrid of anticancer drug container, Eur Phys J B, 75, 141, 10.1140/epjb/e2010-00037-2

Turkova, 2011, Amphotericin B in neonates: deoxycholate or lipid formulation as first-line therapy – is there a ‘right’ choice?, Curr Opin Infect Dis, 24, 163, 10.1097/QCO.0b013e328343614e

Turos, 2007, Antibiotic-conjugated polyacrylate nanoparticles: New opportunities for development of anti-MRSA agents, Bioorg Med Chem Lett, 17, 53, 10.1016/j.bmcl.2006.09.098

Üner, 2007, Importance of solid lipid nanoparticles (SLN) in various administration routes and future perspectives, Int J Nanomedicine, 2, 289

van den Hoven, 2011, Liposomal drug formulations in the treatment of rheumatoid arthritis, Mol Pharm, 8, 1002, 10.1021/mp2000742

Waite, 2009, PAMAM-RGD conjugates enhance siRNA delivery through a multicellular spheroid model of malignant glioma, Bioconjug Chem, 20, 1908, 10.1021/bc900228m

Wang, 2010, Pharmacokinetic parameters and tissue distribution of magnetic Fe3O4 nanoparticles in mice, Int J Nanomedicine, 5, 861

Wängler, 2008, Antibody-dendrimer conjugates: the number, not the size of the dendrimers, determines the imunore-activity, Bioconjug Chem, 19, 813, 10.1021/bc700308q

Waters, 2009, Macrophage responses to silica nanoparticles are highly conserved across particle sizes, Toxicol Sci, 107, 553, 10.1093/toxsci/kfn250

Wei, 2010, Synthesis of polymer-mesoporous silica nanocomposites, Materials, 3, 4066, 10.3390/ma3074066

Wilson, 2010, Chitosan nanoparticles as a new delivery system for the anti-Alzheimer drug tacrine, Nanomedicine, 6, 144, 10.1016/j.nano.2009.04.001

Wissing, 2004, Solid lipid nanopartic les for parenteral drug delivery, Adv Drug Deliv Rev, 56, 1257, 10.1016/j.addr.2003.12.002

Wu, 2010, Biocompatibility of Fe3O4/DNR magnetic nanoparticles in the treatment of hematologic malignancies, Int J Nanomedicine, 5, 1079

Xiong, 2011, Cationic liposomes as gene delivery system: transfection efficiency and new application, Pharmazie, 66, 158

Yallapu, 2011, Multi-functional magnetic nanoparticles for magnetic resonance imaging and cancer therapy, Biomaterials, 32, 1890, 10.1016/j.biomaterials.2010.11.028

Yang, 2009, Cell membrane injury induced by silica nanoparticles in mouse macrophage, J Biomed Nanotechnol, 5, 528, 10.1166/jbn.2009.1061

Yang, 2006, Preparation of poly ε-caprolactone nanoparticles containing magnetite for magnetic drug carrier, Int J Pharm, 324, 185, 10.1016/j.ijpharm.2006.06.029

Yeung, 2011, Liposome-encapsulated 0.5% 5-aminolevulinic acid with intense pulsed light for the treatment of inflammatory facial acne: apilot study, Dermatol Surg, 37, 450, 10.1111/j.1524-4725.2011.01929.x

Yoo, 2010, Factors that control the circulation time of nanoparticles in blood: challenges, solutions and future prospects, Curr Pharm Des, 16, 2298, 10.2174/138161210791920496

Yu, 2011, Epidermal growth factor-PEG functionalized PAMAM-pentaethylenehexamine dendron for targeted gene delivery produced by click chemistry, Biomacromolecules, 12, 2039, 10.1021/bm101464n

Yu, 2009, Toxicity of amorphous silica nanoparticles in mouse keratinocytes, J Nanopart Res, 11, 15, 10.1007/s11051-008-9417-9

Yukihara, 2011, Effective drug delivery system for duchenne muscular dystrophy using hybrid liposomes including gentamicin along with reduced toxicity, Biol Pharm Bull, 34, 712, 10.1248/bpb.34.712

Zhang, 2010, Characterization of and biomolecule immobilization on the biocompatible multi-walled carbon nanotubes generated by functionalization with polyamidoamine dendrimers, Colloids Surf B Biointerfaces, 80, 18, 10.1016/j.colsurfb.2010.05.023

Zhang, 2011, Adsorption of sulfamethoxazole on functionalized carbon nanotubes as affected by cations and anions, Environ Pollut, 159, 2616, 10.1016/j.envpol.2011.05.036

Zhao, 2011, Interaction of mesoporous silica nanoparticles with human red blood cell membranes: size and surface effects, ACS Nano, 5, 1366, 10.1021/nn103077k