Nanoparticle-based bioactive agent release systems for bone and cartilage tissue engineering

Regenerative Therapy - Tập 1 - Trang 109-118 - 2015
Nelson Monteiro1,2, Albino Martins1,2, Rui L. Reis1,3, Nuno M. Neves1,3
13B’s Research Group – Biomaterials, Biodegradables and Biomimetics, Department of Polymer Engineering, University of Minho, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, AvePark, Zona Industrial da Gandra, S. Cláudio do Barco, 4806-909 Caldas das Taipas, Guimarães, Portugal
2ICVS/3B’s – PT Government Associate Laboratory, Braga/Guimarães, Portugal
3ICVS/3B’s - PT Government Associate Laboratory, Braga/Guimarães, Portugal

Tài liệu tham khảo

Santo, 2012, From nano- to macro-scale: nanotechnology approaches for spatially controlled delivery of bioactive factors for bone and cartilage engineering, Nanomed, 7, 1045, 10.2217/nnm.12.78 Liao, 2008, Stem cells and biomimetic materials strategies for tissue engineering, Mater Sci Eng C Biomimetic Supramol Syst, 28, 1189, 10.1016/j.msec.2008.08.015 Chung, 2007, Micro- and nanoscale technologies for tissue engineering and drug discovery applications, Expert Opin Drug Discov, 2, 1653, 10.1517/17460441.2.12.1653 Dvir, 2011, Nanotechnological strategies for engineering complex tissues, Nat Nanotechnol, 6, 13, 10.1038/nnano.2010.246 Ma, 2008, Biomimetic materials for tissue engineering, Adv Drug Deliv Rev, 60, 184, 10.1016/j.addr.2007.08.041 Quaglia, 2008, Bioinspired tissue engineering: the great promise of protein delivery technologies, Int J Pharm, 364, 281, 10.1016/j.ijpharm.2008.04.030 Stevens, 2005, Exploring and engineering the cell surface interface, Science, 310, 1135, 10.1126/science.1106587 Santo, 2012, Enhanced orthotopic bone regeneration promoted by intracellular delivery of dexamethasone, J Tissue Eng Regen Med, 6, 330 Santo, 2012, Enhancement of osteogenic differentiation of human adipose derived stem cells by the controlled release of platelet lysates from hybrid scaffolds produced by supercritical fluid foaming, J Control Release, 162, 19, 10.1016/j.jconrel.2012.06.001 Kim, 2010, Nanomedicine, N Engl J Med, 363, 2434, 10.1056/NEJMra0912273 Hillaireau, 2009, Nanocarriers' entry into the cell: relevance to drug delivery, Cell Mol Life Sci, 66, 2873, 10.1007/s00018-009-0053-z Shi, 2010, Nanotechnology in drug delivery and tissue engineering: from discovery to applications, Nano Lett, 10, 3223, 10.1021/nl102184c Liu, 2008, Polysaccharides-based nanoparticles as drug delivery systems, Adv Drug Deliv Rev, 60, 1650, 10.1016/j.addr.2008.09.001 Zhang, 2009, Nanoparticulate systems for growth factor delivery, Pharm Res, 26, 1561, 10.1007/s11095-009-9897-z Banerjee, 2001, Liposomes: applications in medicine, J Biomater Appl, 16, 3, 10.1106/RA7U-1V9C-RV7C-8QXL Monteiro, 2014, Liposomes in tissue engineering and regenerative medicine, J R Soc Interface, 11, 10.1098/rsif.2014.0459 Mozafari, 2005, Liposomes: an overview of manufacturing techniques, Cell Mol Biol Lett, 10, 711 Matuschek, 2014, Development of the EUCAST disk diffusion antimicrobial susceptibility testing method and its implementation in routine microbiology laboratories, Clin Microbiol Infect, 20, O255, 10.1111/1469-0691.12373 Yang, 2009, Nanotechnology controlled drug delivery for treating bone diseases, Expert Opin Drug Deliv, 6, 851, 10.1517/17425240903044935 Pinto Reis, 2006, Methods for preparation of drug-loaded polymeric nanoparticles, Nanomedicine: Nanotechnol Biol Med, 2, 8, 10.1016/j.nano.2005.12.003 Soppimath, 2001, Biodegradable polymeric nanoparticles as drug delivery devices, J Control Release, 70, 1, 10.1016/S0168-3659(00)00339-4 Adams, 2003, Amphiphilic block copolymers for drug delivery, J Pharm Sci, 92, 1343, 10.1002/jps.10397 Gillies, 2005, Dendrimers and dendritic polymers in drug delivery, Drug Discov Today, 10, 35, 10.1016/S1359-6446(04)03276-3 Lee, 2005, Designing dendrimers for biological applications, Nat Biotechnol, 23, 1517, 10.1038/nbt1171 Adler, 2010, Emerging links between surface nanotechnology and endocytosis: Impact on nonviral gene delivery, Nano Today, 5, 553, 10.1016/j.nantod.2010.10.007 Wang, 2008, Recent developments in nanoparticle-based drug delivery and targeting systems with emphasis on protein-based nanoparticles, Expert Opin Drug Deliv, 5, 499, 10.1517/17425247.5.5.499 Fang, 2011, The EPR effect: unique features of tumor blood vessels for drug delivery, factors involved, and limitations and augmentation of the effect, Adv Drug Deliv Rev, 63, 136, 10.1016/j.addr.2010.04.009 Bertrand, 2014, Cancer nanotechnology: the impact of passive and active targeting in the era of modern cancer biology, Adv Drug Deliv Rev, 66, 2, 10.1016/j.addr.2013.11.009 Yin, 2014, Enhanced permeability and retention (EPR) effect based tumor targeting: the concept, application and prospect, JSM Clin Oncol Res, 2 Matsumura, 1986, A new concept for macromolecular therapeutics in cancer chemotherapy: mechanism of tumoritropic accumulation of proteins and the antitumor agent smancs, Cancer Res, 46, 6387 Rothenfluh, 2008, Biofunctional polymer nanoparticles for intra-articular targeting and retention in cartilage, Nat Mater, 7, 248, 10.1038/nmat2116 Garnier, 2012, Development of a platform of antibody-presenting liposomes, Biointerphases, 7, 11, 10.1007/s13758-011-0011-9 Gomes-da-Silva, 2012, Lipid-based nanoparticles for siRNA delivery in cancer therapy: paradigms and challenges, Accounts Chem Res, 45, 1163, 10.1021/ar300048p Motornov, 2010, Stimuli-responsive nanoparticles, nanogels and capsules for integrated multifunctional intelligent systems, Prog Polym Sci, 35, 174, 10.1016/j.progpolymsci.2009.10.004 Ganta, 2008, A review of stimuli-responsive nanocarriers for drug and gene delivery, J Control Release, 126, 187, 10.1016/j.jconrel.2007.12.017 Moura, 2012, Targeted and intracellular triggered delivery of therapeutics to cancer cells and the tumor microenvironment: impact on the treatment of breast cancer, Breast Cancer Res Treat, 133, 61, 10.1007/s10549-011-1688-7 Bessa, 2010, Thermoresponsive self-assembled elastin-based nanoparticles for delivery of BMPs, J Control Release, 142, 312, 10.1016/j.jconrel.2009.11.003 Herbst, 2009, Delivery of stem cells to porcine arterial wall with echogenic liposomes conjugated to antibodies against CD34 and intercellular adhesion molecule-1, Mol Pharm, 7, 3, 10.1021/mp900116r Tanaka, 2005, Efficiency of magnetic liposomal transforming growth factor-beta 1 in the repair of articular cartilage defects in a rabbit model, J Biomed Mater Res A, 73, 255, 10.1002/jbm.a.30187 Matsuo, 2003, Injectable magnetic liposomes as a novel carrier of recombinant human BMP-2 for bone formation in a rat bone-defect model, J Biomed Mater Res A, 66, 747, 10.1002/jbm.a.10002 Dai, 2012, Photo-responsive release of ascorbic acid and catalase in CDBA-liposome for commercial application as a sunscreen cosmetic, RSC Adv, 2, 3340, 10.1039/c2ra01171a Zhang, 2011, Formation, characterization, and fate of inhaled drug nanoparticles, Adv Drug Deliv Rev, 63, 441, 10.1016/j.addr.2010.11.002 Wu, 2011, Physical and chemical stability of drug nanoparticles, Adv Drug Deliv Rev, 63, 456, 10.1016/j.addr.2011.02.001 Sohaebuddin, 2010, Nanomaterial cytotoxicity is composition, size, and cell type dependent, Part Fibre Toxicol, 7 Fischer, 2007, Nanotoxicity: the growing need for in vivo study, Curr Opin Biotechnol, 18, 565, 10.1016/j.copbio.2007.11.008 Monopoli, 2012, Biomolecular coronas provide the biological identity of nanosized materials, Nat Nanotechnol, 7, 779, 10.1038/nnano.2012.207 Pighinelli, 2013, Chitosan-hydroxyapatite composites, Carbohydr Polym, 93, 256, 10.1016/j.carbpol.2012.06.004 Kataoka, 2001, Block copolymer micelles for drug delivery: design, characterization and biological significance, Adv Drug Deliv Rev, 47, 113, 10.1016/S0169-409X(00)00124-1 Baoum, 2010, Cationic surface modification of PLC nanoparticles offers sustained gene delivery to pulmonary epithelial cells, J Pharm Sci, 99, 2413, 10.1002/jps.21994 Gonçalves, 2012, Chitosan coated liposomes as an innovative nanocarrier for drugs, J Biomed Nanotechnol, 8, 240, 10.1166/jbn.2012.1375 Monopoli, 2013, Formation and characterization of the nanoparticle-protein corona, Methods Mol Biol (Clifton, NJ), 1025, 137, 10.1007/978-1-62703-462-3_11 Vetten, 2014, Challenges facing sterilization and depyrogenation of nanoparticles: effects on structural stability and biomedical applications, Nanomed, 10, 1391, 10.1016/j.nano.2014.03.017 Rabanel, 2012, Drug-loaded nanocarriers: passive targeting and crossing of biological barriers, Curr Med Chem, 19, 3070, 10.2174/092986712800784702 Lee, 2008, Controlled dual release of basic fibroblast growth factor and indomethacin from heparin-conjugated polymeric micelle, Int J Pharm, 346, 57, 10.1016/j.ijpharm.2007.06.025 Oliveira, 2010, Ex vivo culturing of stromal cells with dexamethasone-loaded carboxymethylchitosan/poly(amidoamine) dendrimer nanoparticles promotes ectopic bone formation, Bone, 46, 1424, 10.1016/j.bone.2010.02.007 Oliveira, 2009, The osteogenic differentiation of rat bone marrow stromal cells cultured with dexamethasone-loaded carboxymethylchitosan/poly(amidoamine) dendrimer nanoparticles, Biomaterials, 30, 804, 10.1016/j.biomaterials.2008.10.024 Oliveira, 2008, Surface engineered carboxymethylchitosan/poly(amidoamine) dendrimer nanoparticles for intracellular targeting, Adv Funct Mater, 18, 1840, 10.1002/adfm.200800165 Zaki, 2010, Gateways for the intracellular access of nanocarriers: a review of receptor-mediated endocytosis mechanisms and of strategies in receptor targeting, Expert Opin Drug Deliv, 7, 895, 10.1517/17425247.2010.501792 Sahay, 2010, Endocytosis of nanomedicines, J Control Release, 145, 182, 10.1016/j.jconrel.2010.01.036 Dash, 2010, The influence of size and charge of chitosan/polyglutamic acid hollow spheres on cellular internalization, viability and blood compatibility, Biomaterials, 31, 8188, 10.1016/j.biomaterials.2010.07.067 Ge, 2009, Effect of surface charge and agglomerate degree of magnetic iron oxide nanoparticles on KB cellular uptake in vitro, Colloid Surf B Biointerfaces, 73, 294, 10.1016/j.colsurfb.2009.05.031 Patil, 2007, Protein adsorption and cellular uptake of cerium oxide nanoparticles as a function of zeta potential, Biomaterials, 28, 4600, 10.1016/j.biomaterials.2007.07.029 Harush-Frenkel, 2007, Targeting of nanoparticles to the clathrin-mediated endocytic pathway, Biochem Biophys Res Commun, 353, 26, 10.1016/j.bbrc.2006.11.135 Roger, 2009, Lipid nanocarriers improve paclitaxel transport throughout human intestinal epithelial cells by using vesicle-mediated transcytosis, J Control Release, 140, 174, 10.1016/j.jconrel.2009.08.010 Kulkarni, 2010, Liposomal gene delivery mediated by tissue-engineered scaffolds, Trends Biotechnol, 28, 28, 10.1016/j.tibtech.2009.10.003 Chung, 2007, Surface engineered and drug releasing pre-fabricated scaffolds for tissue engineering, Adv Drug Deliv Rev, 59, 249, 10.1016/j.addr.2007.03.015 Dawson, 2008, Biomaterials for stem cell differentiation, Adv Drug Deliv Rev, 60, 215, 10.1016/j.addr.2007.08.037 Fu, 2010, Mechanical regulation of cell function with geometrically modulated elastomeric substrates, Nat Methods, 7, 10.1038/nmeth.1487 Evans, 2009, Substrate stiffness affects early differentiation events in embryonic stem cells, Eur Cell Mater, 18, 1, 10.22203/eCM.v018a01 Kawano, 2013, Mechanical regulation of cellular adhesion onto honeycomb-patterned porous scaffolds by altering the elasticity of material surfaces, Biomacromolecules, 14, 1208, 10.1021/bm400202d Engler, 2006, Matrix elasticity directs stem cell lineage specification, Cell, 126, 677, 10.1016/j.cell.2006.06.044 Peyton, 2006, The use of poly(ethylene glycol) hydrogels to investigate the impact of ECM chemistry and mechanics on smooth muscle cells, Biomaterials, 27, 4881, 10.1016/j.biomaterials.2006.05.012 Santo, 2012, Controlled release strategies for bone, cartilage and osteochondral engineering. Part I: recapitulation of tissue healing and variables for the design of delivery systems, Tissue Eng Part B Rev, 19, 308, 10.1089/ten.teb.2012.0138 Habraken, 2007, Ceramic composites as matrices and scaffolds for drug delivery in tissue engineering, Adv Drug Deliv Rev, 59, 234, 10.1016/j.addr.2007.03.011 Luz, 2012, Chitosan/bioactive glass nanoparticles composites for biomedical applications, Biomed Mater, 7 Martins, 2008, Electrospinning: processing technique for tissue engineering scaffolding, Int Mater Rev, 53, 257, 10.1179/174328008X353547 Hutmacher, 2001, An introduction to biodegradable materials for tissue engineering applications, Ann Acad Med Singap, 30, 183 Martins, 2009, Hierarchical starch-based fibrous scaffold for bone tissue engineering applications, J Tissue Eng Regen Med, 3, 37, 10.1002/term.132 Gloria, 2012, Three-dimensional poly(epsilon-caprolactone) bioactive scaffolds with controlled structural and surface properties, Biomacromolecules, 13, 3510, 10.1021/bm300818y Gillette, 2011, Engineering extracellular matrix structure in 3D multiphase tissues, Biomaterials, 32, 8067, 10.1016/j.biomaterials.2011.05.043 Kelleher, 2010, Engineering extracellular matrix through nanotechnology, J R Soc Interface, 7, S717, 10.1098/rsif.2010.0345.focus Alexander, 2008, Stimuli-responsive hydrogels – drugs take control, Nat Mater, 7, 767, 10.1038/nmat2281 Ulijn, 2007, Bioresponsive hydrogels, Mater Today, 10, 40, 10.1016/S1369-7021(07)70049-4 Kim, 2006, Surface functionalized electrospun biodegradable nanofibers for immobilization of bioactive molecules, Biotechnol Prog, 22, 1108, 10.1021/bp060039t Yoo, 2009, Surface-functionalized electrospun nanofibers for tissue engineering and drug delivery, Adv Drug Deliv Rev, 61, 1033, 10.1016/j.addr.2009.07.007 Martins, 2009, Surface modification of electrospun polycaprolactone nanofiber meshes by plasma treatment to enhance biological performance, Small, 5, 1195 Darain, 2011, Performance of surface-modified polycaprolactone on growth factor binding, release, and proliferation of smooth muscle cells, Soft Mater, 9, 64, 10.1080/1539445X.2010.520797 Pashkuleva, 2010, Surface modification of starch based biomaterials by oxygen plasma or UV-irradiation, J Mater Sci Mater Med, 21, 21, 10.1007/s10856-009-3831-0 Mattanavee, 2009, Immobilization of biomolecules on the surface of electrospun polycaprolactone fibrous scaffolds for tissue engineering, ACS Appl Mater Interfaces, 1, 1076, 10.1021/am900048t Mori, 1994, Surface modification of polyethylene fiber by graft-poymerization, J Polym Sci Part A Polymer Chem, 32, 1683, 10.1002/pola.1994.080320910 He, 2005, Fabrication and endothelialization of collagen-blended biodegradable polymer nanofibers: potential vascular graft for blood vessel tissue engineering, Tissue Eng, 11, 1574, 10.1089/ten.2005.11.1574 Malynych, 2002, Poly(vinyl pyridine) as a universal surface modifier for immobilization of nanoparticles, J Phys Chem B, 106, 1280, 10.1021/jp013236d Zhu, 2004, Immobilization of biomacromolecules onto aminolyzed poly(L-lactic acid) toward acceleration of endothelium regeneration, Tissue Eng, 10, 53, 10.1089/107632704322791691 Mourtas, 2011, Covalent immobilization of liposomes on plasma functionalized metallic surfaces, Colloid Surf B Biointerfaces, 84, 214, 10.1016/j.colsurfb.2011.01.002 Yoon, 2004, Immobilization of cell adhesive RGD peptide onto the surface of highly porous biodegradable polymer scaffolds fabricated by a gas foaming/salt leaching method, Biomaterials, 25, 5613, 10.1016/j.biomaterials.2004.01.014 Curran, 2006, The guidance of human mesenchymal stem cell differentiation in vitro by controlled modifications to the cell substrate, Biomaterials, 27, 4783, 10.1016/j.biomaterials.2006.05.001 Bengali, 2005, Gene delivery by immobilization to cell-adhesive substrates, MRS Bull, 30, 659, 10.1557/mrs2005.193 Andersen, 2010, siRNA nanoparticle functionalization of nanostructured scaffolds enables controlled multilineage differentiation of stem cells, Mol Ther, 18, 2018, 10.1038/mt.2010.166 De Laporte, 2007, Matrices and scaffolds for DNA delivery in tissue engineering, Adv Drug Deliv Rev, 59, 292, 10.1016/j.addr.2007.03.017 Yamauchi, 2005, Layer-by-layer assembly of poly(ethyleneimine) and plasmid DNA onto transparent indium-tin oxide electrodes for temporally and spatially specific gene transfer, Langmuir, 21, 8360, 10.1021/la0505059 Chan, 2009, Early adhesive behavior of bone-marrow-derived mesenchymal stem cells on collagen electrospun fibers, Biomed Mater, 4 Santo, 2012, Controlled release strategies for bone, cartilage and osteochondral engineering. Part II: challenges on the evolution from single towards multiple bioactive factor delivery, Tissue Eng Part B Rev, 19, 327, 10.1089/ten.teb.2012.0727 Park, 2009, In vitro and in vivo chondrogenesis of rabbit bone marrow-derived stromal cells in fibrin matrix mixed with growth factor loaded in nanoparticles, Tissue Eng Part A, 15, 2163, 10.1089/ten.tea.2008.0532 Deng, 2011, Application of decellularized scaffold combined with loaded nanoparticles for heart valve tissue engineering in vitro, J Huazhong Univ Sci Technol Med Sci, 31, 88, 10.1007/s11596-011-0156-2 Pulavendran, 2011, Three-dimensional scaffold containing EGF incorporated biodegradable polymeric nanoparticles for stem cell based tissue engineering applications, Biotechnol Bioprocess Eng, 16, 393, 10.1007/s12257-009-3155-4 Tan, 2011, Controlled release of chitosan/heparin nanoparticle-delivered VEGF enhances regeneration of decellularized tissue-engineered scaffolds, Int J Nanomedicine, 6, 929, 10.2147/IJN.S18753 Wang, 2008, Liposomes/chitosan scaffold/human fibrin gel composite systems for delivering hydrophilic drugs – release behaviors of tirofiban in vitro, Drug Deliv, 15, 149, 10.1080/10717540801952456 Meyenburg, 2000, Fibrin encapsulated liposomes as protein delivery system – studies on the in vitro release behavior, J Control Release, 69, 159, 10.1016/S0168-3659(00)00295-9 Chung, 2006, A fibrin encapsulated liposomes-in-chitosan matrix (FLCM) for delivering water-soluble drugs – influences of the surface properties of liposomes and the crosslinked fibrin network, Int J Pharm, 311, 122, 10.1016/j.ijpharm.2005.12.038 Wang, 2011, Bisphosphonate-derivatized liposomes to control drug release from Collagen/Hydroxyapatite scaffolds, Mol Pharm, 8, 1025, 10.1021/mp200028w Bengali, 2005, Gene delivery through cell culture substrate adsorbed DNA complexes, Biotechnol Bioeng, 90, 290, 10.1002/bit.20393 Abrams, 2010, Evaluation of efficacy, biodistribution, and inflammation for a potent siRNA nanoparticle: effect of dexamethasone co-treatment, Mol Ther, 18, 171, 10.1038/mt.2009.208 Bengali, 2009, Efficacy of immobilized polyplexes and lipoplexes for substrate-mediated gene delivery, Biotechnol Bioeng, 102, 1679, 10.1002/bit.22212 De Laporte, 2009, Local gene delivery from ECM-coated poly(lactide-co-glycolide) multiple channel bridges after spinal cord injury, Biomaterials, 30, 2361, 10.1016/j.biomaterials.2008.12.051 He, 2011, Effective gene delivery to mesenchymal stem cells based on the reverse transfection and three-dimensional cell culture system, Pharm Res, 28, 1577, 10.1007/s11095-011-0390-0 Wei, 2007, The enhancement of osteogenesis by nano-fibrous scaffolds incorporating rhBMP-7 nanospheres, Biomaterials, 28, 2087, 10.1016/j.biomaterials.2006.12.028 Xing, 2010, Adhesion force studies of nanofibers and nanoparticles, Langmuir, 26, 11809, 10.1021/la100443d Yilgor, 2010, Effect of scaffold architecture and BMP-2/BMP-7 delivery on in vitro bone regeneration, J Mater Sci Mater Med, 21, 2999, 10.1007/s10856-010-4150-1 Jung, 2009, In situ chondrogenic differentiation of human adipose tissue-derived stem cells in a TGF-beta(1) loaded fibrin-poly(lactide-caprolactone) nanoparticulate complex, Biomaterials, 30, 4657, 10.1016/j.biomaterials.2009.05.034 Chen, 2010, Toward delivery of multiple growth factors in tissue engineering, Biomaterials, 31, 6279, 10.1016/j.biomaterials.2010.04.053 Gurkan, 2010, The sequential production profiles of growth factors and their relations to bone volume in ossifying bone marrow explants, Tissue Eng Part A, 16, 2295, 10.1089/ten.tea.2009.0565 Biondi, 2008, Controlled drug delivery in tissue engineering, Adv Drug Deliv Rev, 60, 229, 10.1016/j.addr.2007.08.038 Guldberg, 2009, Spatiotemporal delivery strategies for promoting musculoskeletal tissue regeneration, J Bone Min Res, 24, 1507, 10.1359/jbmr.090801 Kulkarni, 2009, Fibrin−lipoplex system for controlled Topical delivery of multiple genes, Biomacromolecules, 10, 1650, 10.1021/bm900248n Houchin-Ray, 2009, Spatially patterned gene expression for guided neurite extension, J Neurosci Res, 87, 844, 10.1002/jnr.21908 Lim, 2010, Dual growth factor-releasing nanoparticle/hydrogel system for cartilage tissue engineering, J Mater Sci Mater Med, 21, 2593, 10.1007/s10856-010-4118-1 Guo-ping, 2010, Influence on the osteogenic activity of the human bone marrow mesenchymal stem cells transfected by liposome-mediated recombinant plasmid pIRES-hBMP2-hVEGF165 in vitro, Ann Plast Surg, 65, 80, 10.1097/SAP.0b013e3181b4bc5d da Silva, 2010, Impact of biological agents and tissue engineering approaches on the treatment of rheumatic diseases, Tissue Eng Part B-Rev, 16, 331, 10.1089/ten.teb.2009.0536 Puppi, 2010, Polymeric materials for bone and cartilage repair, Prog Polym Sci, 35, 403, 10.1016/j.progpolymsci.2010.01.006 Chung, 2007, Enhanced bone regeneration with BMP-2 loaded functional nanoparticle-hydrogel complex, J Control Release, 121, 91, 10.1016/j.jconrel.2007.05.029 Nie, 2007, Fabrication and characterization of PLGA/HAp scaffolds for delivery of BMP-2 plasmid composite DNA, J Control Release, 120, 111, 10.1016/j.jconrel.2007.03.018 Hosseinkhani, 2008, DNA nanoparticles encapsulated in 3D tissue-engineered scaffolds enhance osteogenic differentiation of mesenchymal stem cells, J Biomed Mater Res Part A, 85A, 47, 10.1002/jbm.a.31327 Park, 2009, Bone morphogenic protein-2 (BMP-2) loaded nanoparticles mixed with human mesenchymal stem cell in fibrin hydrogel for bone tissue engineering, J Biosci Bioeng, 108, 530, 10.1016/j.jbiosc.2009.05.021 Yilgor, 2009, Incorporation of a sequential BMP-2/BMP-7 delivery system into chitosan-based scaffolds for bone tissue engineering, Biomaterials, 30, 3551, 10.1016/j.biomaterials.2009.03.024 Zhang, 2009, Pharmacokinetics and bone formation by BMP-2 entrapped in polyethylenimine-coated albumin nanoparticles, Biomaterials, 30, 5143, 10.1016/j.biomaterials.2009.05.060 Zhang, 2010, Polyethylenimine-PEG coated albumin nanoparticles for BMP-2 delivery, Biomaterials, 31, 952, 10.1016/j.biomaterials.2009.10.011 Ratanavaraporn, 2012, Local suppression of pro-inflammatory cytokines and the effects in BMP-2-induced bone regeneration, Biomaterials, 33, 304, 10.1016/j.biomaterials.2011.09.050 Eibl, 1995, Medical application of synthetic phospholipids as liposomes and drugs, J Liposome Res, 5, 131, 10.3109/08982109509039914 Monteiro, 2014, Immobilization of bioactive factor-loaded liposomes at the surface of electrospun nanofibers targeting tissue engineering, Biomater Sci, 2, 1195, 10.1039/C4BM00069B Monteiro, 2014, Instructive nanofibrous scaffold comprising runt-related transcription factor 2 gene delivery for bone tissue engineering, ACS Nano, 8, 8082, 10.1021/nn5021049 Park, 2008, PLGA microsphere construct coated with TGF-beta 3 loaded nanoparticles for neocartilage formation, Biomacromolecules, 9, 2162, 10.1021/bm800251x Mickova, 2012, Core/Shell nanofibers with embedded liposomes as a drug delivery system, Biomacromolecules, 13, 952, 10.1021/bm2018118 Cao, 2012, Incorporating ptgf-beta 1/calcium phosphate nanoparticles with fibronectin into 3-dimensional collagen/chitosan scaffolds: efficient, sustained gene delivery to stem cells for chondrogenic differentiation, Eur Cell Mater, 23, 81, 10.22203/eCM.v023a06 Ertan, 2013, Effect of double growth factor release on cartilage tissue engineering, J Tissue Eng Regen Med, 7, 149, 10.1002/term.509 Shi, 2013, Nanoparticle delivery of the bone morphogenetic protein 4 gene to adipose-derived stem cells promotes articular cartilage repair in vitro and in Vivo, Arthrosc, 29, 10.1016/j.arthro.2013.09.076 Lu, 2013, Porous chitosan scaffolds with embedded hyaluronic acid/chitosan/plasmid-DNA nanoparticles encoding TGF-beta 1 induce DNA controlled release, transfected chondrocytes, and promoted cell proliferation, PLoS One, 8 Kim, 2008, Enhancement of ectopic bone formation by bone morphogenetic protein-2 delivery using heparin-conjugated PLGA nanoparticles with transplantation of bone marrow-derived mesenchymal stem cells, J Biomed Sci, 15, 771, 10.1007/s11373-008-9277-4 Bakhshandeh, 2011, Effective combination of aligned nanocomposite nanofibers and human unrestricted somatic stem cells for bone tissue engineering, Acta Pharmacol Sin, 32, 626, 10.1038/aps.2011.8 Pathi, 2011, Hydroxyapatite nanoparticle-containing scaffolds for the study of breast cancer bone metastasis, Biomaterials, 32, 5112, 10.1016/j.biomaterials.2011.03.055 Bonadio, 1999, Localized, direct plasmid gene delivery in vivo: prolonged therapy results in reproducible tissue regeneration, Nat Med, 5, 753, 10.1038/10473 Oliveira, 2011, Polysaccharide-based materials for cartilage tissue engineering applications, J Tissue Eng Regen Med, 5, 421, 10.1002/term.335 Park, 2011, Chondrogenesis of human mesenchymal stem cells in fibrin constructs evaluated in vitro and in nude mouse and rabbit defects models, Biomaterials, 32, 1495, 10.1016/j.biomaterials.2010.11.003