Nanomedicine and personalized medicine toward the application of pharmacotyping in clinical practice to improve drug-delivery outcomes

Ioannis S. Vizirianakis1
1Laboratory of Pharmacology, Department of Pharmaceutical Sciences, Aristotle University of Thessaloniki, Thessaloniki, Greece

Tài liệu tham khảo

Housman, 1998, Why pharmacogenomics? Why now?, Nature Biotechnol, 16, 2, 10.1038/5134 Ginsburg, 2001, Personalized medicine: revolutionizing drug discovery and patient care, Trends Biotechnol, 19, 491, 10.1016/S0167-7799(01)01814-5 Vizirianakis, 2004, Challenges in current drug delivery from the potential application of pharmacogenomics and personalized medicine in clinical practice, Curr Drug Deliv, 1, 73, 10.2174/1567201043480009 Sullenger, 2002, Emerging clinical applications of RNA, Nature, 418, 252, 10.1038/418252a Chien, 2002, Optimisation of treatment by applying programmable rate-controlled drug delivery technology, Clin Pharmacokinet, 41, 1267, 10.2165/00003088-200241150-00003 Braeckmans, 2002, Encoding microcarriers: present and future technologies, Nat Rev Drug Disc, 1, 447, 10.1038/nrd817 Collins, 2003, A vision for the future of genomics research, Nature, 422, 835, 10.1038/nature01626 Vizirianakis, 2007, From defining bioinformatics and pharmacogenomics to developing information-based medicine and pharmacotyping in healthcare, 201 Huttenhower, 2010, A quick guide to large-scale genomic data mining, PLoS Comput Biol, 6, e1000779, 10.1371/journal.pcbi.1000779 Roses, 2000, Pharmacogenetics and the practice of medicine, Nature, 405, 857, 10.1038/35015728 Evans, 1999, Pharmacogenomics: translating functional genomics into rational therapeutics, Science, 286, 487, 10.1126/science.286.5439.487 McLeod, 2001, Pharmacogenomics: unlocking the human genome for better drug therapy, Annu Rev Pharmacol Toxicol, 41, 101, 10.1146/annurev.pharmtox.41.1.101 Vizirianakis, 2007, The transformation of pharmacogenetics into pharmacogenomics reinforces personalized medicine towards pharmacotyping for improved patient care, 1 Vizirianakis, 2005, Improving pharmacotherapy outcomes by pharmacogenomics: From expectation to reality?, Pharmacogenomics, 6, 701, 10.2217/14622416.6.7.701 Manasco, 2002, Pharmacogenetics and the genetic basis of ADRs, 516 Weinshilboum, 2003, Inheritance and drug response, N Engl J Med, 348, 529, 10.1056/NEJMra020021 Meyer, 2000, Pharmacogenetics and adverse drug reactions, Lancet, 356, 1667, 10.1016/S0140-6736(00)03167-6 Silber, 2003, Pharmacogenomics, biomarkers, and the promise of personalized medicine, 11 Spear, 2001, Clinical application of pharmacogenetics, Trends Mol Med, 7, 201, 10.1016/S1471-4914(01)01986-4 Lazarou, 1998, Incidence of adverse drug reactions in hospitalized patients: a meta-analysis of prospective studies, JAMA, 279, 1200, 10.1001/jama.279.15.1200 2000, 1 Flockhart, 2002, Implications of cytochrome P450 interactions when prescribing medication for hypertension, Arch Intern Med, 162, 405, 10.1001/archinte.162.4.405 Ingelman-Sundberg, 2004, Pharmacogenetics of cytochrome P450 and its applications in drug therapy: the past, present and future, Trends Pharmacol Sci, 25, 193, 10.1016/j.tips.2004.02.007 Ebbesen, 2001, Drug-related deaths in a department of internal medicine, Arch Intern Med, 61, 2317, 10.1001/archinte.161.19.2317 Evans, 2003, Drug disposition, drug targets, and side effects, N Engl J Med, 348, 538, 10.1056/NEJMra020526 Robertson, 2000, DNA methylation in health and disease, Nat Rev Genet, 1, 11, 10.1038/35049533 Johnstone, 2002, Histone-deacetylase inhibitors: novel drugs for the treatment of cancer, Nature Rev Drug Disc, 1, 287, 10.1038/nrd772 Ingelman-Sundberg, 2010, The past, present and future of pharmacoepigenomics, Pharmacogenomics, 11, 625, 10.2217/pgs.10.59 Goldstein, 2003, Pharmacogenetics in the laboratory and the clinic, N Engl J Med, 348, 553, 10.1056/NEJMe020173 International Transporter Consortium, 2010, Membrane transporters in drug development, Nat Rev Drug Discov, 9, 215, 10.1038/nrd3028 Phillips, 2001, Potential role of pharmacogenomics in reducing adverse drug reactions: a systematic review, JAMA, 286, 2270, 10.1001/jama.286.18.2270 Vizirianakis, 2010, Clinical and pharmacogenomic assessment of herb-drug interactions to improve drug delivery and pharmacovigilance, 199 Vizirianakis, 2007, Clinical translation of genotyping and haplotyping data: implementation of in vivo pharmacology experience leading drug prescription to pharmacotyping, Clin Pharmacokinet, 46, 807, 10.2165/00003088-200746100-00001 Vizirianakis, 2010, Toward the development of innovative bi-functional agents to induce differentiation and promote apoptosis in leukemia: clinical candidates and perspectives, J Med Chem, 53, 6779, 10.1021/jm100189a Ahn, 2010, Functional mapping of drug response with pharmacodynamic-pharmacokinetic principles, Trends Pharmacol Sci, 31, 306, 10.1016/j.tips.2010.04.004 Caruthers, 2007, Nanotechnological applications in medicine, Curr Opin Biotechnol, 18, 26, 10.1016/j.copbio.2007.01.006 Davis, 2008, Nanoparticle therapeutics: an emerging treatment modality for cancer, Nat Rev Drug Discov, 7, 771, 10.1038/nrd2614 Debbage, 2009, Targeted drugs and nanomedicine: present and future, Curr Pharm Des, 5, 153, 10.2174/138161209787002870 Lammers, 2010, Nanotheranostics and image-guided drug delivery: current concepts and future directions, Mol Pharm, 10.1021/mp100228v Marchant, 2009, Small is beautiful: what can nanotechnology do for personalized medicine?, Curr Pharmacogenomics Personalized Med, 7, 231, 10.2174/187569209790112346 Jain, 2010, Innovative diagnostic technologies and their significance for personalized medicine, Mol Diagn Ther, 14, 141, 10.1007/BF03256366 van den Akker-van Marle, 2006, Cost-effectiveness of pharmacogenomics in clinical practice: a case study of thiopurine methyltransferase genotyping in acute lymphoblastic leukemia in Europe, Pharmacogenomics, 7, 783, 10.2217/14622416.7.5.783 Gurwitz, 2009, Improving pharmacovigilance in Europe: TPMT genotyping and phenotyping in the UK and Spain, Eur J Hum Genet, 17, 991, 10.1038/ejhg.2009.10 Fleeman, 2010, The clinical effectiveness and cost-effectiveness of testing for cytochrome P450 polymorphisms in patients with schizophrenia treated with antipsychotics: a systematic review and economic evaluation, Health Technol Assess, 14, 1, 10.3310/hta14030 McKinnon, 2007, A critical analysis of barriers to the clinical implementation of pharmacogenomics, Ther Clin Risk Manag, 3, 751 Wu, 2009, Implementation of pharmacogenomics into the clinical practice of therapeutics: issues for the clinician and the laboratorian, Personalized Med, 6, 315, 10.2217/pme.09.1 Flowers, 2004, The role of cost-effectiveness analysis in the era of pharmacogenomics, Pharmacoeconomics, 22, 481, 10.2165/00019053-200422080-00001 Payne, 2010, Cost-effectiveness analysis in pharmacogenomics, Pharmacogenomics, 11, 643, 10.2217/pgs.10.45 Wong, 2010, Cost effectiveness of pharmacogenomics: a critical and systematic review, Pharmacoeconomics, 28, 1001, 10.2165/11537410-000000000-00000 Halapi, 2002, Advances in the development of genetic markers for the diagnosis of disease and drug response, Expert Rev Mol Diagn, 2, 411, 10.1586/14737159.2.5.411 Johnson, 2002, Molecular diagnostics as a predictive tool: genetics of drug efficacy and toxicity, Trends Mol Med, 8, 300, 10.1016/S1471-4914(02)02354-7 Dequeker, 2001, Quality control in molecular genetic testing, Nat Rev Genet, 2, 717, 10.1038/35088588 Lewin, 2004, Molecular biomarkers in drug development, Drug Discov Today, 9, 976, 10.1016/S1359-6446(04)03272-6 Hall, 2003, Molecular diagnostics: a healthcare perspective, Expert Rev Mol Diagn, 3, 13, 10.1586/14737159.3.1.13 Sangkuhl, 2008, PharmGKB: understanding the effects of individual genetic variants, Drug Metab Rev, 40, 539, 10.1080/03602530802413338 Weinshilboum, 2004, Pharmacogenomics: bench to bedside, Nat Rev Drug Discov, 3, 739, 10.1038/nrd1497 Vizirianakis, 2002, Pharmaceutical education in the wake of genomic technologies for drug development and personalized medicine, Eur J Pharm Sci, 15, 243, 10.1016/S0928-0987(02)00013-1 Gurwitz, 2003, Education: teaching pharmacogenomics to prepare future physicians and researchers for personalized medicine, Trends Pharmacol Sci, 24, 122, 10.1016/S0165-6147(03)00024-5 Henry, 2008, Drug interactions and pharmacogenomics in the treatment of breast cancer and depression, Am J Psychiatry, 165, 1251, 10.1176/appi.ajp.2008.08040482 Hoskins, 2009, CYP2D6 and tamoxifen: DNA matters in breast cancer, Nat Rev Cancer, 9, 576, 10.1038/nrc2683 Kelly, 2010, Selective serotonin reuptake inhibitors and breast cancer mortality in women receiving tamoxifen: a population based cohort study, Br Med J, 340, c693, 10.1136/bmj.c693 Sideras, 2010, Co-prescription of tamoxifen and medications that inhibit CYP2D6, J Clin Oncol, 28, 2768, 10.1200/JCO.2009.23.8931 Lash, 2010, Evidence and practice regarding the role for CYP2D6 inhibition in decisions about tamoxifen therapy, J Clin Oncol, 28, 1273, 10.1200/JCO.2009.26.7906 Keller, 2010, Coriell Personalized Medicine Collaborative: a prospective study of the utility of personalized medicine, Personalized Med, 7, 310, 10.2217/pme.10.13