Nanocomposites and bone regeneration

Braddock M, Houston P, Campbell C, et al. Born again bone: tissue engineering for bone repair. News in Physiological Sciences, 2001, 16(5): 208–213

Shors E C. Coralline bone graft substitutes. Orthopedic Clinics of North America, 1999, 30(4): 599–613

Webster T J. Nanophase ceramics as improved bone tissue engineering materials. American Ceramic Society Bulletin, 2003, 82(6): 23–28

Orthopaedic Biomaterials Market Review.

American Academy of Orthopaedic Surgeons. The Evolving Role of Bone-Graft Substitutes. AAOS 77th Annual Meeting, New Orleans, LA, USA, 2010. http://www.aatb.org/aatb/files/ccLibraryFiles/Filename/000000000322/BoneGraftSubstitutes2010.pdf

Tomford W W. Overview. In: Laurencin C T, ed. Bone Graft Substitutes. West Conshohocken, PA, USA: ASTM International, 2003

Khan Y, Laurencin C T. Fracture repair with ultrasound: clinical and cell-based evaluation. The Journal of Bone and Joint Surgery (American Volume), 2008, 90(Suppl 1): 138–144

Laurencin C, Khan Y, El-Amin S F. Bone graft substitutes. Expert Review of Medical Devices, 2006, 3(1): 49–57

Ilan D I, Ladd A L. Bone graft substitutes. Operative Techniques in Plastic and Reconstructive Surgery, 2002, 9(4): 151–160

Laurencin C T, Khan Y. Bone graft substitute materials. http://emedicinemedscapecom/article/1230616-overview

Goulet J A, Senunas L E, DeSilva G L, et al. Autogenous iliac crest bone graft: Complications and functional assessment. Clinical Orthopaedics and Related Research, 1997, 339: 76–81

Berrey B H Jr, Lord C F, Gebhardt M C, et al. Fractures of allografts. Frequency, treatment, and end-results. The Journal of Bone and Joint Surgery (American Volume), 1990, 72(6): 825–833

Ito H, Koefoed M, Tiyapatanaputi P, et al. Remodeling of cortical bone allografts mediated by adherent rAAV-RANKL and VEGF gene therapy. Nature Medicine, 2005, 11(3): 291–297

Laurencin C T, Ambrosio A M A, Borden M D, et al. Tissue engineering: orthopedic applications. Annual Review of Biomedical Engineering, 1999, 1(1): 19–46

Langer R, Vacanti J P. Tissue engineering. Science, 1993, 260(5110): 920–926

Langer R. Tissue engineering. Molecular Therapy, 2000, 1(1): 12–15

Khan Y, Yaszemski M J, Mikos A G, et al. Tissue engineering of bone: material and matrix considerations. The Journal of Bone and Joint Surgery (American Volume), 2008, 90(Suppl 1): 36–42

Athanasiou K A, Zhu C F, Lanctot D R, et al. Fundamentals of biomechanics in tissue engineering of bone. Tissue Engineering, 2000, 6(4): 361–381

Einhorn TA. The cell and molecular biology of fracture healing. Clinical Orthopaedics and Related Research, 1998, 355(Supplement): S7–S21

Schindeler A, McDonald M M, Bokko P, et al. Bone remodeling during fracture repair: The cellular picture. Seminars in Cell and Developmental Biology, 2008, 19(5): 459–466

Nair L S, Laurencin C T. Biodegradable polymers as biomaterials. Progress in Polymer Science, 2007, 32(8–9): 762–798

Deng M, Kumbar S G, Lo KWH, et al. Novel polymer-ceramics for bone repair and regeneration. Recent Patents on Biomedical Engineering, 2011, 4(3) (in press)

Deng M, Kumbar S G, Wan Y, et al. Polyphosphazene polymers for tissue engineering: an analysis of material synthesis, characterization and applications. Soft Matter, 2010, 6(14): 3119–3132

Deng M, Nair L S, Nukavarapu S P, et al. Dipeptide-based polyphosphazene and polyester blends for bone tissue engineering. Biomaterials, 2010, 31(18): 4898–4908

Deng M, Nair L S, Nukavarapu S P, et al. Biomimetic, bioactive etheric polyphosphazene-poly(lactide-co-glycolide) blends for bone tissue engineering. Journal of Biomedical Materials Research Part A, 2010, 92(1): 114–125

Deng M, Nair L S, Nukavarapu S P, et al. Miscibility and in vitro osteocompatibility of biodegradable blends of poly[(ethyl alanato) (p-phenyl phenoxy) phosphazene]_and poly(lactic acid-glycolic acid). Biomaterials, 2008, 29(3): 337–349

Deng M, Nair L S, Nukavarapu S P, et al. In situ porous structures: a unique polymer erosion mechanism in biodegradable dipeptide-based polyphosphazene and polyester blends producing matrices for regenerative engineering. Advanced Functional Materials, 2010, 20(17): 2743–2957

Kierszenbaum A L. Connective tissue. In: Kierszenbaum A L, ed. Histology and Cell Biology: An Introduction to Pathology. St. Louis: Mosby Inc., 2002, 118–129

Jee W S S. Integrated bone tissue physiology: anatomy and physiology. In: Cowin S C, ed. Bone Mechanics Handbook. Boca Raton, FL, USA: CRC Press LLC, 2001

Rho J-Y, Kuhn-Spearing L, Zioupos P. Mechanical properties and the hierarchical structure of bone. Medical Engineering & Physics, 1998, 20(2): 92–102

Murugan R, Ramakrishna S. Development of nanocomposites for bone grafting. Composites Science and Technology, 2005, 65(15–16): 2385–2406

Weiner S, Wagner H D. The material bone: structure-mechanical function relations. Annual Review of Materials Science, 1998, 28(1): 271–298

Marotti G. A new theory of bone lamellation. Calcified Tissue International, 1993, 53(Suppl 1): S47–S56

Bilezikian J P, Raisz L G, Rodan G A. Principles of Bone Biology. San Diego, CA, USA: Academic Press, 1996

Wiesmann H P, Meyer U, Plate U, et al. Aspects of collagen mineralization in hard tissue formation. International Review of Cytology, 2004, 242: 121–156

van der Rest M, Garrone R. Collagen family of proteins. The FASEB Journal, 1991, 5(13): 2814–2823

Weiner S, Traub W. Bone structure: from angstroms to microns. The FASEB Journal, 1992, 6(3): 879–885

Landis W J. The strength of a calcified tissue depends in part on the molecular structure and organization of its constituent mineral crystals in their organic matrix. Bone, 1995, 16(5): 533–544

Ziv V, Weiner S. Bone crystal sizes: a comparison of transmission electron microscopic and X-ray diffraction line width broadening techniques. Connective Tissue Research, 1994, 30(3): 165–175

Rey C, Miquel J L, Facchini L, et al. Hydroxyl groups in bone mineral. Bone, 1995, 16(5): 583–586

Sommerfeldt D, Rubin C. Biology of bone and how it orchestrates the form and function of the skeleton. European Spine Journal, 2001, 10(Suppl 2): S86–S95

Beddington R S, Robertson E J. Axis development and early asymmetry in mammals. Cell, 1999, 96(2): 195–209

Aubin J E. Bone stem cells. Journal of Cellular Biochemistry, Supplement, 1998, 72(Suppl 30–31): 73–82

Ferrari S L, Traianedes K, Thorne M, et al. A role for N-cadherin in the development of the differentiated osteoblastic phenotype. Journal of Bone and Mineral Research, 2000, 15(2): 198–208

Lecanda F, Towler D A, Ziambaras K, et al. Gap junctional communication modulates gene expression in osteoblastic cells. Molecular Biology of the Cell, 1998, 9(8): 2249–2258

Liu X, Ma P X. Polymeric scaffolds for bone tissue engineering. Annals of Biomedical Engineering, 2004, 32(3): 477–486

Li Z, Kong K, Qi W. Osteoclast and its roles in calcium metabolism and bone development and remodeling. Biochemical and Biophysical Research Communications, 2006, 343(2): 345–350

Blair H C, Teitelbaum S L, Ghiselli R, et al. Osteoclastic bone resorption by a polarized vacuolar proton pump. Science, 1989, 245(4920): 855–857

Baroli B. From natural bone grafts to tissue engineering therapeutics: Brainstorming on pharmaceutical formulative requirements and challenges. Journal of Pharmaceutical Sciences, 2009, 98(4): 1317–1375

Veerman E C, Suppers R J, Klein C P, et al. SDS-PAGE analysis of the protein layers adsorbing in vivo and in vitro to bone substituting materials. Biomaterials, 1987, 8(6): 442–448

Nojiri C, Okano T, Koyanagi H, et al. In vivo protein adsorption on polymers: visualization of adsorbed proteins on vascular implants in dogs. Journal of Biomaterials Science, Polymer Edition, 1993, 4(2): 75–88

Davies J E. Mechanisms of endosseous integration. The International Journal of Prosthodontics, 1998, 11(5): 391–401

Soultanis K, Pyrovolou N, Karamitros A, et al. Instrumentation loosening and material of implants as predisposal factors for late postoperative infections in operated idiopathic scoliosis. Studies in Health Technology and Informatics, 2006, 123: 559–564

Kirkpatrick J S, Venugopalan R, Beck P, et al. Corrosion on spinal implants. Journal of Spinal Disorders & Techniques, 2005, 18(3): 247–251

Laurencin C T, Khan Y, Kofron M, et al. The ABJS Nicolas Andry Award: Tissue engineering of bone and ligament: a 15-year perspective. Clinical Orthopaedics and Related Research, 2006, 447: 221–236

Sung H J, Meredith C, Johnson C, et al. The effect of scaffold degradation rate on three-dimensional cell growth and angiogenesis. Biomaterials, 2004, 25(26): 5735–5742

Kuboki Y, Takita H, Kobayashi D, et al. BMP-induced osteogenesis on the surface of hydroxyapatite with geometrically feasible and nonfeasible structures: topology of osteogenesis. Journal of Biomedical Materials Research, 1998, 39(2): 190–199

D’Lima D D, Lemperle S M, Chen P C, et al. Bone response to implant surface morphology. The Journal of Arthroplasty, 1998, 13(8): 928–934

Sul Y-T, Johansson C B, Petronis S, et al. Characteristics of the surface oxides on turned and electrochemically oxidized pure titanium implants up to dielectric breakdown: the oxide thickness, micropore configurations, surface roughness, crystal structure and chemical composition. Biomaterials, 2002, 23(2): 491–501

Jarcho M. Calcium phosphate ceramics as hard tissue prosthetics. Clinical Orthopaedics and Related Research, 1981, 157: 259–278

Ducheyne P, de Groot K. In vivo surface activity of a hydroxyapatite alveolar bone substitute. Journal of Biomedical Materials Research, 1981, 15(3): 441–445

Webster T J, Ergun C, Doremus R H, et al. Enhanced functions of osteoblasts on nanophase ceramics. Biomaterials, 2000, 21(17): 1803–1810

Lee C H, Singla A, Lee Y. Biomedical applications of collagen. International Journal of Pharmaceutics, 2001, 221(1–2): 1–22

Miyata T, Taira T, Noishiki Y. Collagen engineering for biomaterial use. Clinical Materials, 1992, 9(3–4): 139–148

Rao K P. Recent developments of collagen-based materials for medical applications and drug delivery systems. Journal of Biomaterials Science, Polymer Edition, 1995, 7(7): 623–645

Urist M R, Nilsson O, Rasmussen J, et al. Bone regeneration under the influence of a bone morphogenetic protein (BMP) beta tricalcium phosphate (TCP) composite in skull trephine defects in dogs. Clinical Orthopaedics and Related Research, 1987, 214: 295–304

Urist M R, Peltier L F. Bone: formation by autoinduction. Clinical Orthopaedics and Related Research, 2002, 395: 4–10

Sandhu H S, Boden S D. Biologic enhancement of spinal fusion. Orthopedic Clinics of North America, 1998, 29(4): 621–631

Wang E A, Rosen V, D’Alessandro J S, et al. Recombinant human bone morphogenetic protein induces bone formation. Proceedings of the National Academy of Sciences of the United States of America, 1990, 87(6): 2220–2224

Bianco P, Riminucci M, Gronthos S, et al. Bone marrow stromal stem cells: nature, biology, and potential applications. Stem Cells, 2001, 19(3): 180–192

Tiedeman J J, Connolly J F, Strates B S, et al. Treatment of nonunion by percutaneous injection of bone marrow and demineralized bone matrix. An experimental study in dogs. Clinical Orthopaedics and Related Research, 1991, 268: 294–302

Grauer J N, Beiner J M, Kwon B K, et al. Bone graft alternatives for spinal fusion. BioDrugs, 2003, 17(6): 391–394

Chan C K, Kumar T S, Liao S, et al. Biomimetic nanocomposites for bone graft applications. Nanomedicine, 2006, 1(2): 177–188

Christenson E M, Anseth K S, van den Beucken J J J P, et al. Nanobiomaterial applications in orthopedics. Journal of Orthopaedic Research, 2007, 25(1): 11–22

Webster T J, Ahn E S. Nanostructured biomaterials for tissue engineering bone. Advances in Biochemical Engineering/Biotechnology, 2007, 103: 275–308

Webster T J, Siegel R W, Bizios R. Osteoblast adhesion on nanophase ceramics. Biomaterials, 1999, 20(13): 1221–1227

Webster T J, Ergun C, Doremus R H, et al. Enhanced osteoclastlike cell functions on nanophase ceramics. Biomaterials, 2001, 22(11): 1327–1333

Liao S S, Cui F Z. In vitro and in vivo degradation of mineralized collagen-based composite scaffold: nanohydroxyapatite/collagen/poly(L-lactide). Tissue Engineering, 2004, 10(1–2): 73–80

Liao S S, Cui F Z, Zhang W, et al. Hierarchically biomimetic bone scaffold materials: nano-HA/collagen/PLA composite. Journal of Biomedical Materials Research Part B: Applied Biomaterials, 2004, 69(2): 158–165

Laurencin C T, Attawia M A, Elgendy H E, et al. Tissue engineered bone-regeneration using degradable polymers: The formation of mineralized matrices. Bone, 1996, 19(1 Suppl): S93–S99

Zhang P, Hong Z, Yu T, et al. In vivo mineralization and osteogenesis of nanocomposite scaffold of poly(lactide-coglycolide) and hydroxyapatite surface-grafted with poly(Llactide). Biomaterials, 2009, 30(1): 58–70

Elias K L, Price R L, Webster T J. Enhanced functions of osteoblasts on nanometer diameter carbon fibers. Biomaterials, 2002, 23(15): 3279–3287

Price R L, Waid M C, Haberstroh K M, et al. Selective bone cell adhesion on formulations containing carbon nanofibers. Biomaterials, 2003, 24(11): 1877–1887

Mistry A S, Mikos A G, Jansen J A. Degradation and biocompatibility of a poly(propylene fumarate)-based/alumoxane nanocomposite for bone tissue engineering. Journal of Biomedical Materials Research Part A, 2007, 83(4): 940–953

Horch R A, Shahid N, Mistry A S, et al. Nanoreinforcement of poly(propylene fumarate)-based networks with surface modified alumoxane nanoparticles for bone tissue engineering. Biomacromolecules, 2004, 5(5): 1990–1998

Shi X, Hudson J L, Spicer P P, et al. Injectable nanocomposites of single-walled carbon nanotubes and biodegradable polymers for bone tissue engineering. Biomacromolecules, 2006, 7(7): 2237–2242

Liu H, Slamovich E B, Webster T J. Increased osteoblast functions on nanophase titania dispersed in poly-lactic-coglycolic acid composites. Nanotechnology, 2005, 16(7): S601–S608

Webster T J, Smith T A. Increased osteoblast function on PLGA composites containing nanophase titania. Journal of Biomedical Materials Research Part A, 2005, 74(4): 677–686

Li W J, Laurencin C T, Caterson E J, et al. Electrospun nanofibrous structure: a novel scaffold for tissue engineering. Journal of Biomedical Materials Research, 2002, 60(4): 613–621

Nair L S, Laurencin C T. Nanofibers and nanoparticles for orthopaedic surgery applications. The Journal of Bone and Joint Surgery (American Volume), 2008, 90(Suppl 1): 128–131

Nair L S, Bhattacharyya S, Laurencin C T. Development of novel tissue engineering scaffolds via electrospinning. Expert Opinion on Biological Therapy, 2004, 4(5): 659–668

Woo K M, Chen V J, Ma P X. Nano-fibrous scaffolding architecture selectively enhances protein adsorption contributing to cell attachment. Journal of Biomedical Materials Research Part A, 2003, 67(2): 531–537

Pelled G, Tai K, Sheyn D, et al. Structural and nanoindentation studies of stem cell-based tissue-engineered bone. Journal of Biomechanics, 2007, 40(2): 399–411

Huang Z-M, Zhang Y-Z, Kotaki M, et al. A review on polymer nanofibers by electrospinning and their applications in nanocomposites. Composites Science and Technology, 2003, 63(15): 2223–2253

Ma P X, Zhang R. Synthetic nano-scale fibrous extracellular matrix. Journal of Biomedical Materials Research, 1999, 46(1): 60–72

Whitesides G M, Grzybowski B. Self-assembly at all scales. Science, 2002, 295(5564): 2418–2421

Zeleny J. The electrical discharge from liquid points, and a hydrostatic method of measuring the electric intensity at their surfaces. Physical Review, 1914, 3(2): 69–91

Formhals A. Process and apparatus for preparing artificial threads. US Patent, 1975504, 1934

Kumbar S G, James R, Nukavarapu S P, et al. Electrospun nanofiber scaffolds: engineering soft tissues. Biomedical Materials, 2008, 3(3): 034002

Li D, Wang Y, Xia Y. Electrospinning of polymeric and ceramic nanofibers as uniaxially aligned arrays. Nano Letters, 2003, 3(8): 1167–1171

Patel S, Kurpinski K, Quigley R, et al. Bioactive nanofibers: synergistic effects of nanotopography and chemical signaling on cell guidance. Nano Letters, 2007, 7(7): 2122–2128

Ma Z, Kotaki M, Inai R, et al. Potential of nanofiber matrix as tissue-engineering scaffolds. Tissue Engineering, 2005, 11(1–2): 101–109

Deng M, James R, Laurencin C T, et al. Nanostructured polymeric scaffolds for orthopaedic regenerative engineering. IEEE Transactions on Nanobioscience, 2011 (in press)

Kumbar S G, Nukavarapu S P, James R, et al. Recent patents on electrospun biomedical nanostructures: an overview. Recent Patents on Biomedical Engineering, 2008, 1(1): 68–78

Bhattarai N, Edmondson D, Veiseh O, et al. Electrospun chitosan-based nanofibers and their cellular compatibility. Biomaterials, 2005, 26(31): 6176–6184

Zhang Y, Venugopal J R, El-Turki A, et al. Electrospun biomimetic nanocomposite nanofibers of hydroxyapatite/chitosan for bone tissue engineering. Biomaterials, 2008, 29(32): 4314–4322

Yang D, Jin Y, Zhou Y, et al. In situ mineralization of hydroxyapatite on electrospun chitosan-based nanofibrous scaffolds. Macromolecular Bioscience, 2008, 8(3): 239–246

Schneider O D, Weber F, Brunner T J, et al. In vivo and in vitro evaluation of flexible, cottonwool-like nanocomposites as bone substitute material for complex defects. Acta Biomaterialia, 2009, 5(5): 1775–1784

Kim H-W, Kim H-E, Knowles J C. Production and potential of bioactive glass nanofibers as a next-generation biomaterial. Advanced Functional Materials, 2006, 16(12): 1529–1535

Kim H-W, Song J-H, Kim H-E. Nanofiber generation of gelatin-hydroxyapatite biomimetics for guided tissue regeneration. Advanced Functional Materials, 2005, 15(12): 1988–1994

Nair L S, Bhattacharyya S, Bender J D, et al. Fabrication and optimization of methylphenoxy substituted polyphosphazene nanofibers for biomedical applications. Biomacromolecules, 2004, 5(6): 2212–2220

Bhattacharyya S, Kumbar S G, Khan Y M, et al. Biodegradable polyphosphazene-nanohydroxyapatite composite nanofibers: scaffolds for bone tissue engineering. Journal of Biomedical Nanotechnology, 2009, 5(1): 69–75

Bhattacharyya S, Nair L S, Singh A, et al. Electrospinning of poly[bis(ethyl alanato) phosphazene] nanofibers. Journal of Biomedical Nanotechnology, 2006, 2(1): 36–45

Conconi M T, Lora S, Menti A M, et al. In vitro evaluation of poly[bis(ethyl alanato)phosphazene] as a scaffold for bone tissue engineering. Tissue Engineering, 2006, 12(4): 811–819

Laurencin C T, Kumbar S G, Deng M, et al. Nano-structured scaffolds for regenerative engineering. In: Honorary Series in Translational Research in Biomaterials, 2010 AICHE Annual Meeting, Salt Lake City, Utah, USA, 2010

Deng M, Kumbar S G, Nair L S, et al. Biomimetic structures: biological implications of dipeptide-substituted polyphosphazene-polyester blend nanofiber matrices for loadbearing bone regeneration. Advanced Functional Materials, 2011, 21(14): 2641–2651

Place E S, Evans N D, Stevens M M. Complexity in biomaterials for tissue engineering. Nature Materials, 2009, 8(6): 457–470