Nanocomposite hydrogels for biomedical applications

Biotechnology and Bioengineering - Tập 111 Số 3 - Trang 441-453 - 2014
Akhilesh K. Gaharwar1, Nicholas A. Peppas2, Ali Khademhosseini3,4,5
1Department of Biomedical Engineering, Texas A&M University, College Station, Texas 77843
2Departments of Chemical Engineering, Biomedical Engineering and Pharmacy, The University of Texas at Austin, Austin, Texas, 78712
3Department of Medicine, Center for Biomedical Engineering, Brigham and Women's Hospital, Harvard Medical School, Cambridge, Massachusetts, 02139
4Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139
5Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, Massachusetts, 02115

Tóm tắt

ABSTRACTHydrogels mimic native tissue microenvironment due to their porous and hydrated molecular structure. An emerging approach to reinforce polymeric hydrogels and to include multiple functionalities focuses on incorporating nanoparticles within the hydrogel network. A wide range of nanoparticles, such as carbon‐based, polymeric, ceramic, and metallic nanomaterials can be integrated within the hydrogel networks to obtain nanocomposites with superior properties and tailored functionality. Nanocomposite hydrogels can be engineered to possess superior physical, chemical, electrical, and biological properties. This review focuses on the most recent developments in the field of nanocomposite hydrogels with emphasis on biomedical and pharmaceutical applications. In particular, we discuss synthesis and fabrication of nanocomposite hydrogels, examine their current limitations and conclude with future directions in designing more advanced nanocomposite hydrogels for biomedical and biotechnological applications. Biotechnol. Bioeng. 2014;111: 441–453. © 2013 Wiley Periodicals, Inc.

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Thông tin xuất bản

Biotechnology and Bioengineering

Tập 111 Số 3

441-453

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