Nano strategies for berberine delivery, a natural alkaloid of Berberis

Singh, 2013, Berberine and its derivatives: a patent review (2009–2012), Expert Opin. Ther. Pat., 23, 215, 10.1517/13543776.2013.746314

Tabeshpour, 2017, A review of the effects of Berberis vulgaris and its major component, berberine, in metabolic syndrome, Iran J. Basic Med. Sci., 20, 557

Imanshahidi, 2008, Pharmacological and therapeutic effects of Berberis vulgaris and its active constituent, berberine, Phytother. Res., 22, 999, 10.1002/ptr.2399

Shen, 2016, Development and evaluation of vitamin E D-α-tocopheryl polyethylene glycol 1000 succinate-mixed polymeric phospholipid micelles of berberine as an anticancer nanopharmaceutical, Int. J. Nanomed., 11, 1687

Amin, 1969, Berberine sulfate: antimicrobial activity, bioassay, and mode of action, Can. J. Microbiol., 15, 1067, 10.1139/m69-190

Hayashi, 2007, Antiviral activity of berberine and related compounds against human cytomegalovirus, Bioorg. Med. Chem. Lett., 17, 1562, 10.1016/j.bmcl.2006.12.085

Takase, 1993, Pharmacological studies on antidiarrheal effects of berberine and geranii herba, Nihon yakurigaku zasshi, Folia Pharmacol. Jpn., 102, 101, 10.1254/fpj.102.101

Küpeli, 2002, A comparative study on the anti-inflammatory, antinociceptive and antipyretic effects of isoquinoline alkaloids from the roots of Turkish Berberis species, Life Sci., 72, 645, 10.1016/S0024-3205(02)02200-2

Kuo, 2004, The anti-inflammatory potential of berberine in vitro and in vivo, Cancer Lett., 203, 127, 10.1016/j.canlet.2003.09.002

Khemani, 2012, Encapsulation of berberine in nano-sized PLGA synthesized by emulsification method, ISRN Nanotechnol., 2012, 10.5402/2012/187354

Lin, 2015, Berberine-loaded targeted nanoparticles as specific Helicobacter pylori eradication therapy: in vitro and in vivo study, Nanomedicine, 10, 57, 10.2217/nnm.14.76

Xue, 2015, Berberine-loaded solid lipid nanoparticles are concentrated in the liver and ameliorate hepatosteatosis in db/db mice, Int. J. Nanomed., 10, 5049, 10.2147/IJN.S84565

Lee, 2006, Berberine, a natural plant product, activates AMP-activated protein kinase with beneficial metabolic effects in diabetic and insulin-resistant states, Diabetes, 55, 2256, 10.2337/db06-0006

Wang, 2017, Berberine‐loaded Janus nanocarriers for magnetic field‐enhanced therapy against hepatocellular carcinoma, Chem. Biol. Drug Des., 89, 464, 10.1111/cbdd.12866

Pan, 2017, Berberine reverses hypoxia-induced chemoresistance in breast cancer through the inhibition of AMPK-HIF-1α, Int. J. Biol Sci., 13, 794, 10.7150/ijbs.18969

Yang, 2012, Arachidonic acid metabolism in human prostate cancer, Int. J. Oncol., 41, 1495, 10.3892/ijo.2012.1588

Kurtova, 2015, Blocking PGE 2-induced tumour repopulation abrogates bladder cancer chemoresistance, Nature, 517, 209, 10.1038/nature14034

Li, 2015, Berberine induces apoptosis by suppressing the arachidonic acid metabolic pathway in hepatocellular carcinoma, Mol. Med. Rep., 12, 4572, 10.3892/mmr.2015.3926

Park, 2012, Berberine inhibits human colon cancer cell migration via AMP-activated protein kinase-mediated downregulation of integrin β1 signaling, Biochem. Biophys. Res. Commun., 426, 461, 10.1016/j.bbrc.2012.08.091

Ho, 2009, Berberine suppresses in vitro migration and invasion of human SCC-4 tongue squamous cancer cells through the inhibitions of FAK, IKK, NF-κB, u-PA and MMP-2 and-9, Cancer Lett., 279, 155, 10.1016/j.canlet.2009.01.033

Zhao, 2017, Berberine inhibits the chemotherapy‐induced repopulation by suppressing the arachidonic acid metabolic pathway and phosphorylation of FAK in ovarian cancer, Cell Prolif., 50, 10.1111/cpr.12393

Zuo, 2006, Pharmacokinetics of berberine and its main metabolites in conventional and pseudo germ-free rats determined by liquid chromatography ion trap mass spectrometry, Drug Metab. Dispos., 34, 2064, 10.1124/dmd.106.011361

Müller, 1995, Nanosuspensions-a novel formulation for the iv administration of poorly soluble drugs, 491

Müller, 1995, Nanosuspensions for the iv administration of poorly soluble drugs-stability during sterilization and long-term storage, Proc. Int. Symp. Control Rel. Bioact. Mater., 574

Kakran, 2012, Preparation of nanoparticles of poorly water-soluble antioxidant curcumin by antisolvent precipitation methods, J. Nanopart Res., 14, 757, 10.1007/s11051-012-0757-0

Sahibzada, 2018, Berberine nanoparticles with enhanced in vitro bioavailability: characterization and antimicrobial activity, Drug Des. Dev. Ther., 12, 303, 10.2147/DDDT.S156123

Zhang, 2007, Preparation of azithromycin nanosuspensions by high pressure homogenization and its physicochemical characteristics studies, Drug Dev. Ind. Pharm., 33, 569, 10.1080/03639040600975147

Wang, 2015, Berberine nanosuspension enhances hypoglycemic efficacy on streptozotocin induced diabetic C57BL/6 mice, Evid-Based Compl. Alt., 2015

Rouschop, 2008, Ischemia–reperfusion treatment: opportunities point to modulation of the inflammatory response, Kidney Int., 73, 1333, 10.1038/ki.2008.156

Xie, 2017, Berberine nanoparticles protects tubular epithelial cells from renal ischemia-reperfusion injury, Oncotarget, 8, 24154, 10.18632/oncotarget.16530

Pillai, 2001, Polymers in drug delivery, Curr. Opin. Chem. Biol., 5, 447, 10.1016/S1367-5931(00)00227-1

Jain, 2016, 279

Zou, 2009, Antibiotic delivery system using nano‐hydroxyapatite/chitosan bone cement consisting of berberine, J. Biomed. Mater. Res. A, 89, 1108, 10.1002/jbm.a.32199

Wu, 2014, Delivery of berberine using chitosan/fucoidan-taurine conjugate nanoparticles for treatment of defective intestinal epithelial tight junction barrier, Mar. Drugs, 12, 5677, 10.3390/md12115677

Zhou, 2015, In vivo anti-apoptosis activity of novel berberine-loaded chitosan nanoparticles effectively ameliorates osteoarthritis, Int. Immunopharmacol., 28, 34, 10.1016/j.intimp.2015.05.014

Mehra, 2016, Synthesis of berberine loaded polymeric nanoparticles by central composite design, 10.1063/1.4945180

Xu, 2014, Development of poly (N-isopropylacrylamide)/alginate copolymer hydrogel-grafted fabrics embedding of berberine nanosuspension for the infected wound treatment, J. Biomater. Appl., 28, 1376, 10.1177/0885328213509503

Kapoor, 2014, O-hexadecyl-dextran entrapped berberine nanoparticles abrogate high glucose stress induced apoptosis in primary rat hepatocytes, Plos One, 9, 10.1371/journal.pone.0089124

Yu, 2017, PEG–lipid–PLGA hybrid nanoparticles loaded with berberine–phospholipid complex to facilitate the oral delivery efficiency, Drug Delivery, 24, 825, 10.1080/10717544.2017.1321062

Peppas, 2000, Physicochemical foundations and structural design of hydrogels in medicine and biology, Ann. Rev. Biomed. Eng., 2, 9, 10.1146/annurev.bioeng.2.1.9

Al-Awady, 2017, Enhanced antimicrobial effect of berberine in nanogel carriers with cationic surface functionality, J. Mater. Chem. B, 5, 7885, 10.1039/C7TB02262J

Wang, 2016, Berberine‐loaded Janus nanocarriers for magnetic field‐enhanced therapy against hepatocellular carcinoma, Chem. Biol. Drug Des., 89, 464, 10.1111/cbdd.12866

Shrestha, 2014, Lipid-based drug delivery systems, J. Pharmaceutics., 2014, 10.1155/2014/801820

Das, 2011, Recent advances in lipid nanoparticle formulations with solid matrix for oral drug delivery, Aaps PharmSciTech, 12, 62, 10.1208/s12249-010-9563-0

Wang, 2014, Enhancing the antitumor activity of berberine hydrochloride by solid lipid nanoparticle encapsulation, AAPS PharmSciTech, 15, 834, 10.1208/s12249-014-0112-0

Poonia, 2016, Nanostructured lipid carriers: versatile oral delivery vehicle, Future Sci. OA, 2, 10.4155/fsoa-2016-0030

Tiwari, 2011, Nanostructured lipid carrier versus solid lipid nanoparticles of simvastatin: comparative analysis of characteristics, pharmacokinetics and tissue uptake, Int. J. Pharm., 415, 232, 10.1016/j.ijpharm.2011.05.044

Parkin, 2001, Cancer burden in the year 2000, Global Pict. Eur J. Cancer, 37, 4, 10.1016/S0959-8049(01)00267-2

Wang, 2015, In vitro and in vivo antitumor efficacy of berberine-nanostructured lipid carriers against H22 tumor

Meng, 2016

Yin, 2017, Selenium-coated nanostructured lipid carriers used for oral delivery of berberine to accomplish a synergic hypoglycemic effect, Int. J. Nanomed., 12, 8671, 10.2147/IJN.S144615

Wang, 2011, Preparation of an anhydrous reverse micelle delivery system to enhance oral bioavailability and anti-diabetic efficacy of berberine, Eur. J. Pharm. Sci., 44, 127, 10.1016/j.ejps.2011.06.015

Bangham, 1965, Diffusion of univalent ions across the lamellae of swollen phospholipids, J. Mol. Biol., 13, 10.1016/S0022-2836(65)80093-6

Batzri, 1973, Single bilayer liposomes prepared without sonication, BBA)-Biomembranes, 298, 1015, 10.1016/0005-2736(73)90408-2

Deamer, 2010, From “banghasomes” to liposomes: a memoir of Alec Bangham, 1921–2010, FASEB J., 24, 1308, 10.1096/fj.10-0503

Gregoriadis, 1971, Liposomes as carriers of enzymes or drugs: a new approach to the treatment of storage diseases, Biochem. J., 124, 10.1042/bj1240058P

Gregoriadis, 1973, Drug entrapment in liposomes, FEBS Lett., 36, 292, 10.1016/0014-5793(73)80394-1

Allen, 2013, Liposomal drug delivery systems: from concept to clinical applications, Adv. Drug Deliv. Rev., 65, 36, 10.1016/j.addr.2012.09.037

Lin, 2013, Optimizing manufacture of liposomal berberine with evaluation of its antihepatoma effects in a murine xenograft model, Int. J. Pharm., 441, 381, 10.1016/j.ijpharm.2012.11.017

Luo, 2013, Preparation of berberine hydrochloride long-circulating liposomes by ionophore A23187-mediated ZnSO4 gradient method, Asian J. Pharm., 8, 261

Nguyen, 2014, Chitosan-coated nano-liposomes for the oral delivery of berberine hydrochloride, J. Mater. Chem. B, 2, 7149, 10.1039/C4TB00876F

Sailor, 2015, Formulation and in vitro evaluation of berberine containing liposome optimized by 32 full factorial designs, J. App. Pharm. Sci., 5, 23, 10.7324/JAPS.2015.50704

Choudhary, 2017, Impact of dendrimers on solubility of hydrophobic drug molecules, Front. Pharmacol., 8, 10.3389/fphar.2017.00261

Gupta, 2017, Dendrimer encapsulated and conjugated delivery of berberine: a novel approach mitigating toxicity and improving in vivo pharmacokinetics, Int. J. Pharm., 528, 88, 10.1016/j.ijpharm.2017.04.073

Novoselov, 2007, The rise of graphene, Nat. Mater., 6, 183, 10.1038/nmat1849

Liu, 2013, Graphene and graphene oxide as new nanocarriers for drug delivery applications, Acta Biomater., 9, 9243, 10.1016/j.actbio.2013.08.016

Yang, 2013, Nano-graphene in biomedicine: theranostic applications, Chem. Soc. Rev., 42, 530, 10.1039/C2CS35342C

Pan, 2012, The application of graphene oxide in drug delivery, Expert Opin. Drug. Del., 9, 1365, 10.1517/17425247.2012.729575

BAO, 2012, Recent advances in graphene-based nanomaterials for biomedical applications, Nano Life., 2, 10.1142/S179398441100030X

You, 2015, Graphene oxide-based nanocarriers for cancer imaging and drug delivery, Curr. Pharm. Des., 21, 3215, 10.2174/1381612821666150531170832

Yu, 2015, The structure‐dependent electric release and enhanced oxidation of drug in graphene oxide‐based nanocarrier loaded with anticancer herbal drug Berberine, J. Pharm. Sci., 104, 2489, 10.1002/jps.24491

Faraday, 1857, The Bakerian lecture: experimental relations of gold (and other metals) to light, Philos. Trans. Soc. Lond., 147, 145

Jain, 2012, Gold nanoparticles as novel agents for cancer therapy, Br. J. Radiol., 85, 101, 10.1259/bjr/59448833

Souza, 2015, Gold nanoparticle and berberine entrapped into hydrogel matrix as drug delivery system, J. Biomater. Nanobiotechnol., 6, 53, 10.4236/jbnb.2015.61006

Pandey, 2013, Biogenic gold nanoparticles as fotillas to fire berberine hydrochloride using folic acid as molecular road map, Mater. Sci. Eng. C, 33, 3716, 10.1016/j.msec.2013.05.007

Zhang, 2016, Silver nanoparticles: synthesis, characterization, properties, applications, and therapeutic approaches, Int. J. Mol. Sci., 17, 1534, 10.3390/ijms17091534

Dziedzic, 2016, Silver nanoparticles exhibit the dose-dependent anti-proliferative effect against human squamous carcinoma cells attenuated in the presence of Berberine, Molecules, 21, 365, 10.3390/molecules21030365

Bhanumathi, 2017, Bioformulation of silver nanoparticles as berberine carrier cum anticancer agent against breast cancer, New J. Chem., 41, 14466, 10.1039/C7NJ02531A

Guo, 2013, The applications of vitamin E TPGS in drug delivery, Eur. J. Pharm. Sci., 49, 175, 10.1016/j.ejps.2013.02.006

Vuddanda, 2014, Investigations on agglomeration and haemocompatibility of vitamin E TPGS surface modified berberine chloride nanoparticles, Biomed. Res. Int., 2014, 10.1155/2014/951942

Zhang, 2014, Solid dispersion of berberine–phospholipid complex/TPGS 1000/SiO2: preparation, characterization and in vivo studies, Int. J. Pharm., 465, 306, 10.1016/j.ijpharm.2014.01.023

Djebbi, 2016, Preparation and optimization of a drug delivery system based on berberine chloride-immobilized MgAl hydrotalcite, Int. J. Pharm., 506, 438, 10.1016/j.ijpharm.2016.04.048

Djebbi, 2016, Delivery system for berberine chloride based on the nanocarrier ZnAl-layered double hydroxide: physicochemical characterization, release behavior and evaluation of anti-bacterial potential, Int. J. Pharm., 515, 422, 10.1016/j.ijpharm.2016.09.089

Zhu, 2015, The photoluminescence mechanism in carbon dots (graphene quantum dots, carbon nanodots, and polymer dots): current state and future perspective, Nano Res., 8, 355, 10.1007/s12274-014-0644-3

Hola, 2014, Carbon dots—Emerging light emitters for bioimaging, cancer therapy and optoelectronics, Nano Today, 9, 590, 10.1016/j.nantod.2014.09.004

Zhu, 2016, Beyond bottom-up carbon nanodots: citric-acid derived organic molecules, Nano Today, 11, 128, 10.1016/j.nantod.2015.09.002

Zheng, 2015, Single and repeated dose toxicity of citric acid-based carbon dots and a derivative in mice, RSC Adv., 5, 91398, 10.1039/C5RA18391J

Zeng, 2016, Carbon dots as a trackable drug delivery carrier for localized cancer therapy in vivo, J. Mater. Chem. B, 4, 5119, 10.1039/C6TB01259K

Shao, 2017, Carbon dots for tracking and promoting the osteogenic differentiation of mesenchymal stem cells, Biomater Sci., 5, 1820, 10.1039/C7BM00358G

Song, 2014, Bioimaging based on fluorescent carbon dots, Rsc Adv., 4, 27184, 10.1039/c3ra47994c

Lu, 2017, Piezochromic carbon dots with two‐photon fluorescence, Angew. Chem., 129, 6283, 10.1002/ange.201700757

Huang, 2014, A facile, green, and solvent-free route to nitrogen–sulfur-codoped fluorescent carbon nanoparticles for cellular imaging, RSC Adv., 4, 11872, 10.1039/C4RA00012A

Wang, 2014, Facile synthesis of water-soluble and biocompatible fluorescent nitrogen-doped carbon dots for cell imaging, Analyst, 139, 1692, 10.1039/C3AN02098C

Wang, 2014, Common origin of green luminescence in carbon nanodots and graphene quantum dots, ACS Nano, 8, 2541, 10.1021/nn500368m

Yang, 2013, Bottom-up fabrication of photoluminescent carbon dots with uniform morphology via a soft–hard template approach, Chem. Commun., 49, 4920, 10.1039/c3cc38815h

Lim, 2015, Carbon quantum dots and their applications, Chem. Soc. Rev., 44, 362, 10.1039/C4CS00269E

Tao, 2017, The polymeric characteristics and photoluminescence mechanism in polymer carbon dots: a review, Mater. Today Chem., 6, 13, 10.1016/j.mtchem.2017.09.001

Feng, 2016, Charge-convertible carbon dots for imaging-guided drug delivery with enhanced in vivo cancer therapeutic efficiency, ACS Nano, 10, 4410, 10.1021/acsnano.6b00043

Ge, 2016, Carbon dots with intrinsic theranostic properties for bioimaging, red‐light‐triggered photodynamic/photothermal simultaneous therapy in vitro and in vivo, Adv. Healthcare Mater., 5, 665, 10.1002/adhm.201500720

Zhang, 2018, Berberine-based carbon dots for selective and safe cancer theranostics, RSC Adv., 8, 1168, 10.1039/C7RA12069A

Pund, 2014, Improvement of anti-inflammatory and anti-angiogenic activity of berberine by novel rapid dissolving nanoemulsifying technique, Phytomedicine, 21, 307, 10.1016/j.phymed.2013.09.013