NRBP1 modulates uric acid transporter ABCG2 expression by activating the Wnt/β-catenin pathway in HK-2 cells

Zhu, 2017, DNA hypomethylation of a transcription factor binding site within the promoter of a gout risk gene nrbp1 upregulates its expression by inhibition of tfap2a binding, Clin Epigenet, 9, 99, 10.1186/s13148-017-0401-z Choi, 2007, Prevalence of the metabolic syndrome in patients with gout: the Third National Health and Nutrition Examination Survey, Arthritis Care Res (Hoboken), 57, 109, 10.1002/art.22466 Keenan, 2016, Causal assessment of serum urate levels in cardiometabolic diseases through a mendelian randomization study, J Am Coll Cardiol, 67, 407, 10.1016/j.jacc.2015.10.086 White, 2016, Plasma urate concentration and risk of coronary heart disease: a mendelian randomisation analysis, Lancet Diabetes Endocrinol, 4, 327, 10.1016/S2213-8587(15)00386-1 Sluijs, 2015, A Mendelian randomization study of circulating uric acid and type 2 diabetes, Diabetes, 64, 3028, 10.2337/db14-0742 Kleber, 2015, Uric acid and cardiovascular events: a Mendelian randomization study, J Am Soc Nephrol, 26, 2831, 10.1681/ASN.2014070660 Grassi, 2014, Hyperuricemia and cardiovascular risk, High Blood Press Cardiovasc Prev, 21, 235, 10.1007/s40292-014-0046-3 Soriano, 2011, Contemporary epidemiology of gout in the UK general population, Arthritis Res Ther, 13, R39, 10.1186/ar3272 Trifir‘o, 2013, Epidemiology of gout and hyperuricaemia in Italy during the years 2005–2009: a nationwide population-based study, Ann Rheum Dis, 72, 694, 10.1136/annrheumdis-2011-201254 Zhu, 2011, Prevalence of gout and hyperuricemia in the US general population: the National Health andNutrition Examination Survey 2007–2008, Arthritis Rheum, 63, 3136, 10.1002/art.30520 Matsuo, 2014, ABCG2 dysfunction causes hyperuricemia due to both renal urate underexcretion and renal urate overload, Sci Rep, 20, 3755, 10.1038/srep03755 Yu, 2020, Uric acid and cardiovascular disease: an update from molecular mechanism to clinical perspective, Front Pharmacol, 11, 582680, 10.3389/fphar.2020.582680 Li, 2014, Hyperuricemia and risk of stroke: a systematic review and meta-analysis of prospective studies, Atherosclerosis, 232, 265, 10.1016/j.atherosclerosis.2013.11.051 Perez-Ruiz, 2002, Renal underexcretion of uric acid is present in patients with apparent high urinary uric acid output, Arthritis Rheum, 47, 610, 10.1002/art.10792 Caulfield, 2008, SLC2A9 is a high-capacity urate transporter in humans, PLoS Med, 5, e197, 10.1371/journal.pmed.0050197 Mithieux, 2006, Contribution of intestine and kidney to glucose fluxes in different nutritional states in rat, Comp Biochem Physiol B: Biochem Mol Biol, 143, 195, 10.1016/j.cbpb.2005.11.007 Ichida, 2003, Urate transport via human PAH transporter hOAT1 and its gene structure, Kidney Int, 63, 143, 10.1046/j.1523-1755.2003.00710.x Hollis-Moffatt, 2009, Role of the urate transporter SLC2A9 gene in susceptibility to gout in New Zealand Maori Pacific Island, and Caucasian case-control sample sets, Arthritis Rheum, 60, 3485, 10.1002/art.24938 Wei, 2015, NRBP1 is downregulated in breast cancer and NRBP1 over expression inhibits cancer cell proliferation through Wnt/beta-catenin signaling pathway, Onco Targets Ther, 8, 3721 Wilson, 2012, Nuclear receptor binding protein 1 regulates intestinal progenitor cell homeostasis and tumour formation, EMBO J, 31, 2486, 10.1038/emboj.2012.91 Liao, 2017, Regulation of stem-like cancer cells by glutamine through β-catenin pathway mediated by redox signaling, Mol Cancer, 16, 51, 10.1186/s12943-017-0623-x Dharmapuri, 2015, Celecoxib sensitizes imatinib-resistant K562 cells to imatinib by inhibiting MRP1-5 ABCA2 and ABCG2 transporters via Wnt and Ras signaling pathways, Leuk Res, 39, 696, 10.1016/j.leukres.2015.02.013 Xu, 2015, The WNT/β-catenin pathway is involved in the anti-adipogenic activity of cerebrosides from the sea cucumber Cucumaria frondosa, Food Funct, 6, 2396, 10.1039/C5FO00273G Chen, 2019, Dihydrotestosterone regulates hair growth through the Wnt/β-catenin pathway in C57BL/6 mice and in vitro organ culture, Front Pharmacol, 10, 1528, 10.3389/fphar.2019.01528 Le, 2020, Anti-hyperuricemic effects of astaxanthin by regulating xanthine oxidase. Adenosine deaminase and urate transporters in rats, Mar Drugs, 18, 10.3390/md18120610 Taniguchi, 2020, Pharmacological properties and clinical efficacy of dotinurad (URECE® tablets), a novel hypouricemic agent, Nihon Yakurigaku Zasshi, 155, 426, 10.1254/fpj.20047 Chen, 2020, Dendrobium officinalis six nostrum ameliorates urate under-excretion and protects renal dysfunction in lipid emulsion-induced hyperuricemic rats, Biomed Pharmacother, 132, 110765, 10.1016/j.biopha.2020.110765 Lukkunaprasit, 2020, The association between genetic polymorphisms in ABCG2 and SLC2A9 and urate: an updated systematic review and meta-analysis, BMC Med Genet, 21, 210, 10.1186/s12881-020-01147-2 Pang, 2017, Gypenosides inhibits xanthine oxidoreductase and ameliorates urate excretion in hyperuricemic rats induced by high cholesterol and high fat food (lipid emulsion), Med Sci Monit, 23, 1129, 10.12659/MSM.903217 Mandal, 2015, The molecular physiology of uric acid homeostasis, Annu Rev Physiol, 77, 323, 10.1146/annurev-physiol-021113-170343 Guo, 2020, Effects and mechanisms of Dendrobium officinalis Six nostrum for treatment of hyperuricemia with hyperlipidemia, Evid Based Complement Alternat Med, 2020, 2914019, 10.1155/2020/2914019 Wang, 2016, Siwu decoction attenuates oxonate-induced hyperuricemia and kidney inflammation in mice, Chin J Nat Med, 14, 499 Shen, 2019, Study on anti-trioxypurine effect and mechanism of dendrobium candidum simiao prescription on hyperuricemia rats, Chin J Mod Appl Pharm, 36, 157 Ichida, 2012, Decreased extra-renal urate excretion is a common cause of hyperuricemia, Nat Commun, 3, 764, 10.1038/ncomms1756 Zhang, 2020, Study on mechanism of compound qiling formula granules in treatment of hyperuricemia in rats, Chin J Mod Appl Pharm, 37, 1825 Kerr, 2013, Nuclear receptor-binding protein 1: a novel tumour suppressor and pseudokinase, Biochem Soc Trans, 41, 1055, 10.1042/BST20130069 Wei, 2015, NRBP1 is downregulated in breast cancer and NRBP1 overexpression inhibits cancer cell proliferation through Wnt/β-catenin signaling pathway, Onco Targets Ther, 8, 3721 Vesel, 2017, ABCB1 and ABCG2 drug transporters are differentially expressed in non-small cell lung cancers (NSCLC) and expression is modified by cisplatin treatment via altered Wnt signaling, Respir Res, 18, 52, 10.1186/s12931-017-0537-6 Tao, 2019, Blockade of ERK1/2 by U0126 alleviates uric acid-induced EMT and tubular cell injury in rats with hyperuricemic nephropathy, Am J Physiol Renal Physiol, 316, F660, 10.1152/ajprenal.00480.2018