NME1 functions as a metastasis suppressor in pancreatic cancer

Molecular & Cellular Toxicology - Tập 19 - Trang 767-773 - 2022
Do Yeon Kim1,2, Hyeseon Yun1,2, Ji-Eun You1,2, Dong-In Koh1, Yea Seong Ryu1, Dong-Il Yoon1,2, Chul Hee Kim1,2, Ji-U Lee1,2, Dong- Hee Kang1, Dong-Hoon Jin1,2,3
1Asan Institute for Life Science, Asan Medical Center, Seoul, Republic of Korea
2Department of Medical Science, Asan Medical Institute of Convergence Science and Technology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea
3Department of Convergence Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea

Tóm tắt

A known metastasis suppressor gene, NME1 (Nm23), downregulated in melanoma, breast cancer, and other cancers, suppresses migration and invasion of tumor cells. However, in pancreatic cancer (PC), one of the common and deadly cancers worldwide that largely eludes early diagnosis, NME1 function remains unstudied, prompting us to investigate its role. The aim of this study is to investigate biological function of NME1 in pancreatic cancer growth and metastasis and explored potential mechanism mediated by MAPK/JNK signaling pathway. Western blots showed lower NME1 expression in pancreatic tumors than in normal tissues, while its overexpression in cultured PC cells induced cell death and inhibited proliferation, growth, migration, and invasion. NME1 was also found involved in multiple signaling pathways that confer metastatic properties. This study identifies the important potential of NME1 in pancreatic cancer cells and role of novel biomarker and/or therapeutic target.

Tài liệu tham khảo

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