NLRX1 Sequesters STING to Negatively Regulate the Interferon Response, Thereby Facilitating the Replication of HIV-1 and DNA Viruses

Cell Host & Microbe - Tập 19 - Trang 515-528 - 2016
Haitao Guo1, Renate König2,3, Meng Deng1,4, Maximilian Riess3, Jinyao Mo5, Lu Zhang1, Alex Petrucelli1, Sunnie M. Yoh2, Brice Barefoot6, Melissa Samo6, Gregory D. Sempowski6, Aiping Zhang7, Anamaris M. Colberg-Poley7,8, Hui Feng1, Stanley M. Lemon1,5,9, Yong Liu1,10, Yanping Zhang1,10, Haitao Wen1, Zhigang Zhang1, Blossom Damania1,9
1Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
2Immunity and Pathogenesis Program, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA 92037, USA
3Host-Pathogen Interactions, Paul-Ehrlich-Institut, German Center for Infection Research (DZIF), 63225 Langen, Germany
4Department of Oral Biology, School of Dentistry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
5Division of Infectious Diseases, Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
6Duke Human Vaccine Institute, Duke University Medical Center, Durham, NC 27710, USA
7Research Center for Genetic Medicine, Children’s Research Institute, Children’s National Medical Center, Washington, DC 20010, USA
8Departments of Integrative Systems Biology, Biochemistry and Molecular Biology, School of Medicine and Health Sciences, George Washington University, Washington, DC 20037, USA
9Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 USA
10Department of Radiation Oncology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA

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