NF-κB as a therapeutic target in chronic inflammation: recent advances
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Baldwin, 1996, The NF-κB and IκB proteins: new discoveries and insights, Annu. Rev. Immunol., 14, 649, 10.1146/annurev.immunol.14.1.649
Ghosh, 1998, NF-κB and Rel proteins: evolutionarily conserved mediators of immune responses, Annu. Rev. Immunol., 16, 225, 10.1146/annurev.immunol.16.1.225
Whiteside, 1997, I kappa B proteins: structure, function and regulation, Semin. Cancer Biol., 8, 75, 10.1006/scbi.1997.0058
Karin, 2000, Phosphorylation meets ubiquitination: the control of NF-κB activity, Annu. Rev. Immunol., 18, 621, 10.1146/annurev.immunol.18.1.621
Israel, 2000, The IKK complex: an integrator of all signals that activate NF-κB?, Trends Cell Biol., 10, 129, 10.1016/S0962-8924(00)01729-3
Maniatis, 1999, A ubiquitin ligase complex essential for the NF-κB, Wnt/Wingless, and Hedgehog signaling pathways, Genes Dev., 13, 505, 10.1101/gad.13.5.505
Shimada, 1999, IKK-i, a novel lipopolysaccharide-inducible kinase that is related to I kappa B kinases, Int. Immunol., 11, 1357, 10.1093/intimm/11.8.1357
Peters, 2000, IKK epsilon is part of a novel PMA-inducible I kappa B kinase complex, Mol. Cell, 5, 513, 10.1016/S1097-2765(00)80445-1
Schulze-Osthoff, 1997, Regulation of NF-κB activation by MAP kinase cascades, Immunobiology, 198, 35, 10.1016/S0171-2985(97)80025-3
Schmitz, 1995, Interaction of the COOH-terminal transactivation domain of p65 NF-κB with TATA-binding protein, transcription factor IIB, and coactivators, J. Biol. Chem., 270, 7219, 10.1074/jbc.270.13.7219
Zhong, 1998, Phosphorylation of NF-κB p65 by PKA stimulates transcriptional activity by promoting a novel bivalent interaction with the coactivator CBP/p300, Mol. Cell, 1, 661, 10.1016/S1097-2765(00)80066-0
Sheppard, 1999, Transcriptional activation by NF-κB requires multiple coactivators, Mol. Cell. Biol., 19, 6367, 10.1128/MCB.19.9.6367
Delhase, 1999, Positive and negative regulation of I kappa B kinase activity through IKK beta subunit phosphorylation, Science, 284, 309, 10.1126/science.284.5412.309
Pahl, 1999, Activators and target genes of Rel/NF-κB transcription factors, Oncogene, 18, 6853, 10.1038/sj.onc.1203239
Rayet, 1999, Aberrant rel/nfkb genes and activity in human cancer, Oncogene, 18, 6938, 10.1038/sj.onc.1203221
Mayo, 2000, The transcription factor NF-κB: control of oncogenesis and cancer therapy resistance, Biochim. Biophys. Acta, 1470, M55
Gerondakis, 1998, The regulation and roles of Rel/NF-κB transcription factors during lymphocyte activation, Curr. Opin. Immunol., 10, 353, 10.1016/S0952-7915(98)80175-1
Grewal, 1998, CD40 and CD154 in cell-mediated immunity, Annu. Rev. Immunol., 16, 111, 10.1146/annurev.immunol.16.1.111
Stout, 1996, The many roles of CD40 in cell-mediated inflammatory responses, Immunol. Today, 17, 487, 10.1016/0167-5699(96)10060-I
Anderson, 1997, A homologue of the TNF receptor and its ligand enhance T-cell growth and dendritic-cell function, Nature, 390, 175, 10.1038/36593
Wong, 1999, TRANCE is a TNF family member that regulates dendritic cell and osteoclast function, J. Leukocyte Biol., 65, 715, 10.1002/jlb.65.6.715
Li, 1999, T suppressor lymphocytes inhibit NF-κB-mediated transcription of CD86 gene in APC, J. Immunol., 163, 6386, 10.4049/jimmunol.163.12.6386
Verhasselt, 1999, N-acetyl-l-cysteine inhibits primary human T cell responses at the dendritic cell level: association with NF-κB inhibition, J. Immunol., 162, 2569, 10.4049/jimmunol.162.5.2569
Aronica, 1999, Preferential role for NF-κB/Rel signaling in the type 1 but not type 2 T cell-dependent immune response in vivo, J. Immunol., 163, 5116, 10.4049/jimmunol.163.9.5116
Li, 2000, Role of the guanosine triphosphatase Rac2 in T helper 1 cell differentiation, Science, 288, 2219, 10.1126/science.288.5474.2219
Barnes, 1997, Nuclear factor-kappa B: a pivotal transcription factor in chronic inflammatory diseases, New Engl. J. Med., 336, 1066, 10.1056/NEJM199704103361506
Jobin, 2000, The I kappa B/NF-κB system: a key determinant of mucosal inflammation and protection, Am. J. Physiol Cell Physiol., 278, C451, 10.1152/ajpcell.2000.278.3.C451
Miagkov, 1998, NF-κB activation provides the potential link between inflammation and hyperplasia in the arthritic joint, Proc. Natl. Acad. Sci. U. S. A., 95, 13859, 10.1073/pnas.95.23.13859
Tomita, 1999, Suppressed severity of collagen-induced arthritis by in vivo transfection of nuclear factor kappa B decoy oligodeoxynucleotides as a gene therapy, Arthritis Rheum., 42, 2532, 10.1002/1529-0131(199912)42:12<2532::AID-ANR5>3.0.CO;2-2
Bond, 1998, Synergistic upregulation of metalloproteinase-9 by growth factors and inflammatory cytokines: an absolute requirement for transcription factor NF-κB, FEBS Lett., 435, 29, 10.1016/S0014-5793(98)01034-5
Bond, 1999, Nuclear factor κB activity is essential for matrix metalloproteinase-1 and -3 upregulation in rabbit dermal fibroblasts, Biochem. Biophys. Res. Commun., 264, 561, 10.1006/bbrc.1999.1551
Yoshida, 1997, Involvement of interleukin-8, vascular endothelial growth factor, and basic fibroblast growth factor in tumor necrosis factor alpha-dependent angiogenesis, Mol. Cell. Biol., 17, 4015, 10.1128/MCB.17.7.4015
Kong, 1999, Activated T cells regulate bone loss and joint destruction in adjuvant arthritis through osteoprotegerin ligand, Nature, 402, 304, 10.1038/46303
Iotsova, 1997, Osteopetrosis in mice lacking NF-κB1 and NF-κB2, Nat. Med., 3, 1285, 10.1038/nm1197-1285
Barkett, 1999, Control of apoptosis by Rel/NF-κB transcription factors, Oncogene, 18, 6910, 10.1038/sj.onc.1203238
Iimuro, 1998, NF-κB prevents apoptosis and liver dysfunction during liver regeneration, J. Clin. Invest., 101, 802, 10.1172/JCI483
Kaufman, 2000, It's got you covered. NF-κB in the epidermis, J. Cell Biol., 149, 999, 10.1083/jcb.149.5.999
Romashkova, 1999, NF-κB is a target of AKT in anti-apoptotic PDGF signalling, Nature, 401, 86, 10.1038/43474
Guttridge, 1999, NF-κB controls cell growth and differentiation through transcriptional regulation of cyclin D1, Mol. Cell. Biol., 19, 5785, 10.1128/MCB.19.8.5785
Hinz, 1999, NF-κB function in growth control: regulation of cyclin D1 expression and G0/G1-to-S-phase transition, Mol. Cell. Biol., 19, 2690, 10.1128/MCB.19.4.2690
Stein, 2000, PI 3-kinase inhibition: a target for drug development?, Mol. Med. Today, 6, 347, 10.1016/S1357-4310(00)01770-6
Epinat, 1999, Diverse agents act at multiple levels to inhibit the Rel/NF-κB signal transduction pathway, Oncogene, 18, 6896, 10.1038/sj.onc.1203218
Karin, 1998, New twists in gene regulation by glucocorticoid receptor: is DNA binding dispensable?, Cell, 93, 487, 10.1016/S0092-8674(00)81177-0
Yang, 1995, Inhibition of the DNA-binding activity of NF-κB by gold compounds in vitro, FEBS Lett., 361, 89, 10.1016/0014-5793(95)00157-5
Yin, 1998, The anti-inflammatory agents aspirin and salicylate inhibit the activity of IκB kinase-β, Nature, 396, 77, 10.1038/23948
Jobin, 1999, Curcumin blocks cytokine-mediated NF-κB activation and proinflammatory gene expression by inhibiting inhibitory factor IκB kinase activity, J. Immunol., 163, 3474, 10.4049/jimmunol.163.6.3474
Neurath, 1996, Local administration of antisense phosphorothioate oligonucleotides to the p65 subunit of NF-κB abrogates established experimental colitis in mice, Nat. Med., 2, 998, 10.1038/nm0996-998
Morishita, 1997, In vivo transfection of cis element ‘decoy’ against NF-κB binding site prevents myocardial infarction, Nat. Med., 3, 894, 10.1038/nm0897-894
Gerondakis, 1999, Genetic approaches in mice to understand Rel/NF-κB and IκB function: transgenics and knockouts, Oncogene, 18, 6888, 10.1038/sj.onc.1203236
Beg, 1995, Embryonic lethality and liver degeneration in mice lacking the RelA component of NF-κB, Nature, 376, 167, 10.1038/376167a0
Beg, 1996, An essential role for NF-κB in preventing TNF-α-induced cell death, Science, 274, 782, 10.1126/science.274.5288.782
Burkly, 1995, Expression of relB is required for the development of thymic medulla and dendritic cells, Nature, 373, 531, 10.1038/373531a0
Weih, 1995, Multiorgan inflammation and hematopoietic abnormalities in mice with a targeted disruption of RelB, a member of the NF-κB/Rel family, Cell, 80, 331, 10.1016/0092-8674(95)90416-6
Xia, 1999, RelB modulation of I kappa B alpha stability as a mechanism of transcription suppression of IL-1 alpha, IL-1 beta, and tumor necrosis factor alpha in fibroblasts, Mol. Cell. Biol., 19, 7688, 10.1128/MCB.19.11.7688
Mattson, 2000, Roles of nuclear factor kappa B in neuronal survival and plasticity, J. Neurochem., 74, 443, 10.1046/j.1471-4159.2000.740443.x
Schmidt-Supprian, 2000, NEMO/IKK γ-deficient mice model incontinentia pigmenti, Mol. Cell, 5, 981, 10.1016/S1097-2765(00)80263-4
Makris, 2000, Female mice heterozygous for IKK gamma/NEMO deficiencies develop a dermatopathy similar to the human X-linked disorder incontinentia pigmenti, Mol. Cell, 5, 969, 10.1016/S1097-2765(00)80262-2
Smahi, 2000, Genomic rearrangement in NEMO impairs NF-kB activation and is a cause of incontinentia pigmenti. The International Incontinentia Pigmenti (IP) Consortium, Nature, 405, 466, 10.1038/35013114
Soares, 1998, Adenovirus-mediated expression of a dominant negative mutant of p65/RelA inhibits proinflammatory gene expression in endothelial cells without sensitizing to apoptosis, J. Immunol., 161, 4572, 10.4049/jimmunol.161.9.4572
Schmidt, 1996, Anti-psoriatic drug anthralin activates transcription factor NF-κB in murine keratinocytes, J. Immunol., 156, 4514, 10.4049/jimmunol.156.11.4514
Lechman, 1999, Direct adenoviral gene transfer of viral IL-10 to rabbit knees with experimental arthritis ameliorates disease in both injected and contralateral control knees, J. Immunol., 163, 2202, 10.4049/jimmunol.163.4.2202
Ghivizzani, 1998, Direct adenovirus-mediated gene transfer of interleukin 1 and tumor necrosis factor alpha soluble receptors to rabbit knees with experimental arthritis has local and distal anti-arthritic effects, Proc. Natl. Acad. Sci. U. S. A., 95, 4613, 10.1073/pnas.95.8.4613
Bickston, 1998, Treatment of Crohn's disease at the turn of the century, New Engl. J. Med., 339, 401, 10.1056/NEJM199808063390610