Nội dung được dịch bởi AI, chỉ mang tính chất tham khảo
NF-κB: một nhân tố mới trong liệu pháp ức chế sự hình thành mạch máu
Tóm tắt
Sự hình thành mạch máu được coi là một mục tiêu đầy hứa hẹn trong điều trị ung thư. Hầu hết các chất ức chế sự hình thành mạch máu đang trong giai đoạn thử nghiệm lâm sàng muộn hoặc đã được phê duyệt để điều trị ung thư đều tác động gián tiếp lên các tế bào nội mô. Chúng hoặc là vô hiệu hóa các yếu tố tăng trưởng gây hình thành mạch máu từ tuần hoàn hoặc chặn các con đường tín hiệu được kích hoạt bởi các yếu tố tăng trưởng này. Một nhóm khác của các chất ức chế sự hình thành mạch máu là các hợp chất ức chế trực tiếp. Những tác nhân này có tác động trực tiếp lên nội mô, ảnh hưởng đến các con đường điều hòa tế bào, một cách độc lập với các tế bào khối u. Lý do cho việc nhóm tác nhân này chậm trễ trong việc chuyển giao vào lâm sàng có thể là do thiếu kiến thức đầy đủ về cơ chế tác động của những hợp chất này. Yếu tố phiên mã NF-κB gần đây đã được liên kết với nhiều khía cạnh của sự hình thành mạch máu. Thêm vào đó, một số nghiên cứu gần đây báo cáo rằng sự ức chế sự hình thành mạch máu có liên quan đến việc kích hoạt NF-κB. Đây là một điểm thú vị đặc biệt vì trong các tế bào khối u, việc kích hoạt NF-κB đã được liên kết với sự ức chế apoptosis và hiện tại các chiến lược điều trị mới đang được phát triển dựa trên sự ức chế NF-κB. Hệ quả là, có thể cần phải đánh giá lại mô hình rằng việc ức chế hệ thống NF-κB có thể phục vụ như một chiến lược chống ung thư. Dựa trên dữ liệu gần đây, có thể suy đoán rằng việc kích hoạt NF-κB, khi được thực hiện riêng biệt trong các tế bào nội mô, có thể là một chiến lược hiệu quả cho việc điều trị ung thư.
Từ khóa
#Angiogenesis #NF-κB #cancer treatment #endothelial cells #apoptosis #anti-cancer strategyTài liệu tham khảo
citation_journal_title=Oncogene; citation_title=Introduction to NF-kappaB: players, pathways, perspectives; citation_author=TD Gilmore; citation_volume=25; citation_publication_date=2006; citation_pages=6680-6684; citation_doi=10.1038/sj.onc.1209954; citation_id=CR1
citation_journal_title=Oncogene; citation_title=To be, or not to be: NF-kappaB is the answer—role of Rel/NF-kappaB in the regulation of apoptosis; citation_author=J Kucharczak, MJ Simmons, Y Fan; citation_volume=22; citation_publication_date=2003; citation_pages=8961-8982; citation_doi=10.1038/sj.onc.1207230; citation_id=CR2
citation_journal_title=Nature; citation_title=Nuclear factor-kappaB in cancer development and progression; citation_author=M Karin; citation_volume=441; citation_publication_date=2006; citation_pages=431-436; citation_doi=10.1038/nature04870; citation_id=CR3
citation_journal_title=Eur J Cancer; citation_title=NF-kappaB inhibition: a double-edged sword in cancer?; citation_author=E Pikarsky, Y Ben-Neriah; citation_volume=42; citation_publication_date=2006; citation_pages=779-784; citation_doi=10.1016/j.ejca.2006.01.011; citation_id=CR4
citation_journal_title=Biochem Pharmacol; citation_title=Can NF-kappaB be a target for novel and efficient anti-cancer agents?; citation_author=S Olivier, P Robe, V Bours; citation_volume=72; citation_publication_date=2006; citation_pages=1054-1068; citation_doi=10.1016/j.bcp.2006.07.023; citation_id=CR5
citation_journal_title=Oncogene; citation_title=Blockade of NF-kappaB activity in human prostate cancer cells is associated with suppression of angiogenesis, invasion, and metastasis; citation_author=S Huang, CA Pettaway, H Uehara; citation_volume=20; citation_publication_date=2001; citation_pages=4188-4197; citation_doi=10.1038/sj.onc.1204535; citation_id=CR6
citation_journal_title=Cancer Res; citation_title=Squamous cell carcinomas and increased apoptosis in skin with inhibited Rel/nuclear factor-kappaB signaling; citation_author=M Hogerlinden, BL Rozell, L Ahrlund-Richter; citation_volume=59; citation_publication_date=1999; citation_pages=3299-3303; citation_id=CR7
citation_journal_title=Nature; citation_title=NF-kappaB blockade and oncogenic Ras trigger invasive human epidermal neoplasia; citation_author=M Dajee, M Lazarov, JY Zhang; citation_volume=421; citation_publication_date=2003; citation_pages=639-643; citation_doi=10.1038/nature01283; citation_id=CR8
citation_journal_title=Nature; citation_title=Role of NF-kappaB in p53-mediated programmed cell death; citation_author=KM Ryan, MK Ernst, NR Rice; citation_volume=404; citation_publication_date=2000; citation_pages=892-897; citation_doi=10.1038/35009130; citation_id=CR9
citation_journal_title=Cancer Res; citation_title=Loss of nuclear factor-kappaB is tumor promoting but does not substitute for loss of p53; citation_author=KM Ryan, J O’Prey, KH Vousden; citation_volume=64; citation_publication_date=2004; citation_pages=4415-4418; citation_doi=10.1158/0008-5472.CAN-04-1474; citation_id=CR10
citation_journal_title=Biochem Pharmacol; citation_title=Evidence that activation of nuclear factor-kappaB is essential for the cytotoxic effects of doxorubicin and its analogues; citation_author=K Ashikawa, S Shishodia, I Fokt; citation_volume=67; citation_publication_date=2004; citation_pages=353-364; citation_doi=10.1016/j.bcp.2003.08.039; citation_id=CR11
citation_journal_title=J Biol Chem; citation_title=Overexpression of RelA causes G1 arrest and apoptosis in a pro-B cell line; citation_author=AM Sheehy, MS Schlissel; citation_volume=274; citation_publication_date=1999; citation_pages=8708-8716; citation_doi=10.1074/jbc.274.13.8708; citation_id=CR12
citation_journal_title=Eur J Biochem; citation_title=The pro- or anti-apoptotic function of NF-kappaB is determined by the nature of the apoptotic stimulus; citation_author=B Kaltschmidt, C Kaltschmidt, TG Hofmann; citation_volume=267; citation_publication_date=2000; citation_pages=3828-3835; citation_doi=10.1046/j.1432-1327.2000.01421.x; citation_id=CR13
citation_journal_title=Oncogene; citation_title=The c-Rel transcription factor can both induce and inhibit apoptosis in the same cells via the upregulation of MnSOD; citation_author=D Bernard, D Monte, B Vandenbunder; citation_volume=21; citation_publication_date=2002; citation_pages=4392-4402; citation_doi=10.1038/sj.onc.1205536; citation_id=CR14
citation_journal_title=Biochim Biophys Acta; citation_title=Pro-apoptotic role of NF-kappaB: implications for cancer therapy; citation_author=SK Radhakrishnan, S Kamalakaran; citation_volume=1766; citation_publication_date=2006; citation_pages=53-62; citation_id=CR15
citation_journal_title=Cell Death Differ; citation_title=A new role for NF-kappaB in angiogenesis inhibition; citation_author=SP Tabruyn, AW Griffioen; citation_volume=14; citation_publication_date=2007; citation_pages=1393-1397; citation_doi=10.1038/sj.cdd.4402156; citation_id=CR16
citation_journal_title=Nat Genet; citation_title=Birc2 (cIap1) regulates endothelial cell integrity and blood vessel homeostasis; citation_author=MM Santoro, T Samuel, T Mitchell; citation_volume=39; citation_publication_date=2007; citation_pages=1397-1402; citation_doi=10.1038/ng.2007.8; citation_id=CR17
citation_journal_title=J Clin Invest; citation_title=NF-kappaB regulation of endothelial cell function during LPS-induced toxemia and cancer; citation_author=T Kisseleva, L Song, M Vorontchikhina; citation_volume=116; citation_publication_date=2006; citation_pages=2955-2963; citation_doi=10.1172/JCI27392; citation_id=CR18
citation_journal_title=Pharmacol Rev; citation_title=Angiogenesis: potentials for pharmacologic intervention in the treatment of cancer, cardiovascular diseases, and chronic inflammation; citation_author=AW Griffioen, G Molema; citation_volume=52; citation_publication_date=2000; citation_pages=237-268; citation_id=CR19
Mountain DJ, Singh M, Menon B et al (2006) Interleukin-1 {beta} increases expression and activity of matrix metalloproteinase-2 in cardiac microvascular endothelial cells: role of PKC {alpha}/{beta}1 and MAPKs. Am J Physiol Cell Physiol
citation_journal_title=J Biol Chem; citation_title=Halofuginone induces matrix metalloproteinases in rat hepatic stellate cells via activation of p38 and NFkappaB; citation_author=Y Popov, E Patsenker, M Bauer; citation_volume=281; citation_publication_date=2006; citation_pages=15090-15098; citation_doi=10.1074/jbc.M600030200; citation_id=CR21
citation_journal_title=FEBS Lett; citation_title=Platelet-activating factor induces matrix metalloproteinase-9 expression through Ca(2+)- or PI3K-dependent signaling pathway in a human vascular endothelial cell line; citation_author=HM Ko, JH Kang, JH Choi; citation_volume=579; citation_publication_date=2005; citation_pages=6451-6458; citation_doi=10.1016/j.febslet.2005.10.027; citation_id=CR22
citation_journal_title=J Biol Chem; citation_title=A novel mechanism of tissue inhibitor of metalloproteinases-1 activation by interleukin-1 in primary human astrocytes; citation_author=KM Wilczynska, SM Gopalan, M Bugno; citation_volume=281; citation_publication_date=2006; citation_pages=34955-34964; citation_doi=10.1074/jbc.M604616200; citation_id=CR23
citation_journal_title=Thromb Haemost; citation_title=Structure and function of the plasminogen/plasmin system; citation_author=FJ Castellino, VA Ploplis; citation_volume=93; citation_publication_date=2005; citation_pages=647-654; citation_id=CR24
citation_journal_title=Febs J; citation_title=Induction of PAI-1 expression by tumor necrosis factor alpha in endothelial cells is mediated by its responsive element located in the 4G/5G site; citation_author=M Swiatkowska, J Szemraj, CS Cierniewski; citation_volume=272; citation_publication_date=2005; citation_pages=5821-5831; citation_doi=10.1111/j.1742-4658.2005.04979.x; citation_id=CR25
citation_journal_title=J Thromb Haemost; citation_title=TNF-alpha mediated suppression of tissue type plasminogen activator expression in vascular endothelial cells is NF-kappaB- and p38 MAPK-dependent; citation_author=E Ulfhammer, P Larsson, L Karlsson; citation_volume=4; citation_publication_date=2006; citation_pages=1781-1789; citation_doi=10.1111/j.1538-7836.2006.02035.x; citation_id=CR26
citation_journal_title=Microsc Res Tech; citation_title=Endothelial cell–matrix interactions; citation_author=E Iivanainen, VM Kahari, J Heino; citation_volume=60; citation_publication_date=2003; citation_pages=13-22; citation_doi=10.1002/jemt.10238; citation_id=CR27
citation_journal_title=J Vasc Res; citation_title=Molecular mediators of alphavbeta3-induced endothelial cell survival; citation_author=J Rice, DL Courter, CM Giachelli; citation_volume=43; citation_publication_date=2006; citation_pages=422-436; citation_doi=10.1159/000094884; citation_id=CR28
citation_journal_title=Biochem Biophys Res Commun; citation_title=Molecular pathways of angiogenesis inhibition; citation_author=SP Tabruyn, AW Griffioen; citation_volume=355; citation_publication_date=2007; citation_pages=1-5; citation_doi=10.1016/j.bbrc.2007.01.123; citation_id=CR29
citation_journal_title=Respir Res; citation_title=VEGF is upregulated by hypoxia-induced mitogenic factor via the PI-3K/Akt-NF-kappaB signaling pathway; citation_author=Q Tong, L Zheng, L Lin; citation_volume=7; citation_publication_date=2006; citation_pages=37; citation_doi=10.1186/1465-9921-7-37; citation_id=CR30
citation_journal_title=Biochem J; citation_title=Characterization of cis-regulatory elements of the vascular endothelial growth inhibitor gene promoter; citation_author=Q Xiao, CY Hsu, H Chen; citation_volume=388; citation_publication_date=2005; citation_pages=913-920; citation_doi=10.1042/BJ20041739; citation_id=CR31
citation_journal_title=Biochem J; citation_title=Thrombospondin-1 mediates distal tubule hypertrophy induced by glycated albumin; citation_author=YL Yang, LY Chuang, JY Guh; citation_volume=379; citation_publication_date=2004; citation_pages=89-97; citation_doi=10.1042/BJ20031730; citation_id=CR32
citation_journal_title=Cytokine Growth Factor Rev; citation_title=NF-kappaB and cell-cycle regulation: the cyclin connection; citation_author=D Joyce, C Albanese, J Steer; citation_volume=12; citation_publication_date=2001; citation_pages=73-90; citation_doi=10.1016/S1359-6101(00)00018-6; citation_id=CR33
citation_journal_title=Cell Immunol; citation_title=NF-kappaB inducible genes BCL-X and cyclin E promote immature B-cell proliferation and survival; citation_author=B Feng, S Cheng, CY Hsia; citation_volume=232; citation_publication_date=2004; citation_pages=9-20; citation_doi=10.1016/j.cellimm.2005.01.006; citation_id=CR34
citation_journal_title=Mol Cancer Res; citation_title=NF-kappaB-mediated induction of p21(Cip1/Waf1) by tumor necrosis factor alpha induces growth arrest and cytoprotection in normal human keratinocytes; citation_author=JR Basile, A Eichten, V Zacny; citation_volume=1; citation_publication_date=2003; citation_pages=262-270; citation_id=CR35
citation_journal_title=Int J Mol Med; citation_title=Involvement of NF-kappaB and caspases in silibinin-induced apoptosis of endothelial cells; citation_author=HG Yoo, SN Jung, YS Hwang; citation_volume=13; citation_publication_date=2004; citation_pages=81-86; citation_id=CR36
citation_journal_title=Biochem Biophys Res Commun; citation_title=Vascular endothelial growth factor signalling in endothelial cell survival: a role for NFkappaB; citation_author=J Grosjean, S Kiriakidis, K Reilly; citation_volume=340; citation_publication_date=2006; citation_pages=984-994; citation_doi=10.1016/j.bbrc.2005.12.095; citation_id=CR37
citation_journal_title=Circulation; citation_title=High glucose-induced apoptosis in human endothelial cells is mediated by sequential activations of c-Jun NH(2)-terminal kinase and caspase-3; citation_author=FM Ho, SH Liu, CS Liau; citation_volume=101; citation_publication_date=2000; citation_pages=2618-2624; citation_id=CR38
citation_journal_title=Cell Signal; citation_title=High glucose-induced apoptosis in human vascular endothelial cells is mediated through NF-kappaB and c-Jun NH2-terminal kinase pathway and prevented by PI3K/Akt/eNOS pathway; citation_author=FM Ho, WW Lin, BC Chen; citation_volume=18; citation_publication_date=2006; citation_pages=391-399; citation_doi=10.1016/j.cellsig.2005.05.009; citation_id=CR39
citation_journal_title=J Biol Chem; citation_title=Activation of intrinsic and extrinsic proapoptotic signaling pathways in interleukin-18-mediated human cardiac endothelial cell death; citation_author=B Chandrasekar, K Vemula, RM Surabhi; citation_volume=279; citation_publication_date=2004; citation_pages=20221-20233; citation_doi=10.1074/jbc.M313980200; citation_id=CR40
citation_journal_title=Blood; citation_title=ABIN-2 protects endothelial cells from death and has a role in the antiapoptotic effect of angiopoietin-1; citation_author=A Tadros, DP Hughes, BJ Dunmore; citation_volume=102; citation_publication_date=2003; citation_pages=4407-4409; citation_doi=10.1182/blood-2003-05-1602; citation_id=CR41
citation_journal_title=Exp Cell Res; citation_title=A new role for the anti-apoptotic gene A20 in angiogenesis; citation_author=HW Chng, RS Camplejohn, MG Stone; citation_volume=312; citation_publication_date=2006; citation_pages=2897-2907; citation_doi=10.1016/j.yexcr.2006.05.015; citation_id=CR42
citation_journal_title=Semin Thromb Hemost; citation_title=Platelet factor 4: an inhibitor of angiogenesis; citation_author=A Bikfalvi; citation_volume=30; citation_publication_date=2004; citation_pages=379-385; citation_doi=10.1055/s-2004-831051; citation_id=CR43
citation_journal_title=Blood; citation_title=Endothelial expression of E-selectin is induced by the platelet-specific chemokine platelet factor 4 through LRP in an NF-kappaB-dependent manner; citation_author=G Yu, AH Rux, P Ma; citation_volume=105; citation_publication_date=2005; citation_pages=3545-3551; citation_doi=10.1182/blood-2004-07-2617; citation_id=CR44
citation_journal_title=Thromb Haemost; citation_title=Anti-angiogenesis mediated by angiostatin K1–3, K1–4 and K1–4.5. Involvement of p53, FasL, AKT and mRNA deregulation; citation_author=YH Chen, HL Wu, C Li; citation_volume=95; citation_publication_date=2006; citation_pages=668-677; citation_id=CR45
citation_journal_title=Mol Endocrinol; citation_title=The antiangiogenic factor, 16-kDa human prolactin, induces endothelial cell cycle arrest by acting at both the G0-G1 and the G2-M phases; citation_author=SP Tabruyn, NQ Nguyen, AM Cornet; citation_volume=19; citation_publication_date=2005; citation_pages=1932-1942; citation_doi=10.1210/me.2004-0515; citation_id=CR46
citation_journal_title=Proc Natl Acad Sci USA; citation_title=Prolactin/growth hormone-derived antiangiogenic peptides highlight a potential role of tilted peptides in angiogenesis; citation_author=NQ Nguyen, SP Tabruyn, L Lins; citation_volume=103; citation_publication_date=2006; citation_pages=14319-14324; citation_doi=10.1073/pnas.0606638103; citation_id=CR47
Nguyen NQ, Cornet A, Blacher S et al (2007) Inhibition of tumor growth and metastasis establishment by adenovirus-mediated gene transfer delivery of the antiangiogenic factor 16 K hPRL. Mol Ther
citation_journal_title=Mol Endocrinol; citation_title=The antiangiogenic factor 16 K human prolactin induces caspase-dependent apoptosis by a mechanism that requires activation of nuclear factor-kappaB; citation_author=SP Tabruyn, CM Sorlet, F Rentier-Delrue; citation_volume=17; citation_publication_date=2003; citation_pages=1815-1823; citation_doi=10.1210/me.2003-0132; citation_id=CR49
citation_journal_title=Biochem Biophys Res Commun; citation_title=Activation of tissue plasminogen activator gene transcription by Neovastat, a multifunctional antiangiogenic agent; citation_author=D Gingras, C Nyalendo, G Di Tomasso; citation_volume=320; citation_publication_date=2004; citation_pages=205-212; citation_doi=10.1016/j.bbrc.2004.05.151; citation_id=CR50
citation_journal_title=Oncologist; citation_title=The role of statins in cancer therapy; citation_author=K Hindler, CS Cleeland, E Rivera; citation_volume=11; citation_publication_date=2006; citation_pages=306-315; citation_doi=10.1634/theoncologist.11-3-306; citation_id=CR51
Nakata S, Tsutsui M, Shimokawa H et al (2006) Statin treatment upregulates vascular neuronal nitric oxide synthase through Akt/NF-{kappa}B pathway. Arterioscler Thromb Vasc Biol
citation_journal_title=Curr Cancer Drug Targets; citation_title=Tumor necrosis factor: how to make a killer molecule tumor-specific?; citation_author=R Lucas, M Kresse, M Latta; citation_volume=5; citation_publication_date=2005; citation_pages=381-392; citation_doi=10.2174/1568009054863627; citation_id=CR53
citation_journal_title=Invest New Drugs; citation_title=Effects of the tumor vasculature targeting agent NGR-TNF on the tumor microenvironment in murine lymphomas; citation_author=HW Laarhoven, G Gambarota, A Heerschap; citation_volume=24; citation_publication_date=2006; citation_pages=27-36; citation_doi=10.1007/s10637-005-4540-2; citation_id=CR54
citation_journal_title=Curr Biol; citation_title=Leukocyte adhesion: what’s the catch?; citation_author=DA Hammer; citation_volume=15; citation_publication_date=2005; citation_pages=R96-R99; citation_doi=10.1016/j.cub.2005.01.028; citation_id=CR55
citation_journal_title=Cancer Res; citation_title=Diminished leukocyte-endothelium interaction in tumor microvessels; citation_author=NZ Wu, B Klitzman, R Dodge; citation_volume=52; citation_publication_date=1992; citation_pages=4265-4268; citation_id=CR56
citation_journal_title=Blood; citation_title=Tumor angiogenesis is accompanied by a decreased inflammatory response of tumor-associated endothelium; citation_author=AW Griffioen, CA Damen, GH Blijham; citation_volume=88; citation_publication_date=1996; citation_pages=667-673; citation_id=CR57
citation_journal_title=Int J Exp Pathol; citation_title=Angiogenesis modulates the tumour immune response; citation_author=AW Griffioen, SC Tromp, HF Hillen; citation_volume=79; citation_publication_date=1998; citation_pages=363-368; citation_doi=10.1046/j.1365-2613.1998.00091.x; citation_id=CR58
citation_journal_title=Int Immunol; citation_title=Tumor angiogenesis factors reduce leukocyte adhesion in vivo; citation_author=SC Tromp, MG oude Egbrink, RP Dings; citation_volume=12; citation_publication_date=2000; citation_pages=671-676; citation_doi=10.1093/intimm/12.5.671; citation_id=CR59
citation_journal_title=Int J Immunopathol Pharmacol; citation_title=Endothelial cell anergy is mediated by bFGF through the sustained activation of p38-MAPK and NF-eb inhibition; citation_author=V Flati, LI Pastore, AW Griffioen; citation_volume=19; citation_publication_date=2006; citation_pages=761-773; citation_id=CR60
citation_journal_title=Faseb J; citation_title=Anti-angiogenesis therapy can overcome endothelial cell anergy and promote leukocyte-endothelium interactions and infiltration in tumors; citation_author=AE Dirkx, MG oude Egbrink, K Castermans; citation_volume=20; citation_publication_date=2006; citation_pages=621-630; citation_doi=10.1096/fj.05-4493com; citation_id=CR61
citation_journal_title=Mol Endocrinol; citation_title=The angiostatic 16 K human prolactin overcomes endothelial cell anergy and promotes leukocyte infiltration via nuclear factor-kappaB activation; citation_author=SP Tabruyn, C Sabatel, NQ Nguyen; citation_volume=21; citation_publication_date=2007; citation_pages=1422-1429; citation_doi=10.1210/me.2007-0021; citation_id=CR62
citation_journal_title=Biochem Biophys Res Commun; citation_title=Angiostatin upregulates E-selectin in proliferating endothelial cells; citation_author=null Luo; citation_volume=245; citation_publication_date=1998; citation_pages=906-911; citation_doi=10.1006/bbrc.1998.8529; citation_id=CR63