NBQX or Topiramate Treatment after Perinatal Hypoxia‐induced Seizures Prevents Later Increases in Seizure‐induced Neuronal Injury

Epilepsia - Tập 45 Số 6 - Trang 569-575 - 2004
Sookyong Koh1, Felicia D. Tibayan1, Joelle N. Simpson1, Frances E. Jensen1,2
1Department of Neurology
2Program in Neuroscience, Children's Hospital, Harvard Medical School, Boston, Massachusetts, U.S.A.

Tóm tắt

Summary:  Purpose: To evaluate the efficacy of NBQX (2,3‐dihydroxy‐6‐nitro‐7‐sulfamoylbenzo(f) quinoxaline‐2,3‐dione) and topiramate (TPM) given after hypoxia‐induced seizures in preventing the delayed effect of hypoxia on subsequent susceptibility to seizures and neuronal injury. Methods: We used “two‐hit” rodent seizure model to study the long‐term effect of perinatal hypoxia on later kainate (KA) seizure‐induced neuronal damage and investigated the therapeutic efficacy of a postseizure treatment protocol in reversing the conditioning effect of early‐life seizures. Results: Hypoxia at P10 induces seizures without cell death but causes an increase in susceptibility to second seizures induced by KA as early as 96 h after hypoxia, and this lowered seizure threshold persists to adulthood. Furthermore, perinatal hypoxia increases KA‐induced neuronal injury at postnatal day (P)21 and 28/30. Repeated doses of NBQX (20 mg/kg) or TPM (30 mg/kg) given for 48 h after hypoxia‐induced seizures prevent the increase in susceptibility to KA seizure‐induced hippocampal neuronal injury at P28/30. Conclusions: Our results suggest that α‐amino‐3‐hydroxy‐5‐methyl‐4‐isoxazolepropionate (AMPA) receptor blockade after hypoxia prevents the priming effect of perinatal hypoxia‐induced seizures and that this protection occurs independent of its anticonvulsant action.

Từ khóa


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Epilepsia

Tập 45 Số 6

569-575

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