NADK-mediated de novo NADP(H) synthesis is a metabolic adaptation essential for breast cancer metastasis

Redox Biology - Tập 61 - Trang 102627 - 2023
Didem Ilter1, Stanislav Drapela1, Tanya Schild2, Nathan P. Ward3, Emma Adhikari4, Vivien Low5,6, John Asara7, Thordur Oskarsson1, Eric K. Lau4, Gina M. DeNicola3, Melanie R. McReynolds8,9, Ana P. Gomes1
1Department of Molecular Oncology, H. Lee Moffit Cancer Center & Research Institute, Tampa, FL, USA
2Department of Radiology, Memorial Sloan-Kettering Cancer Center, New York, NY, USA
3Department of Cancer Physiology, H. Lee Moffit Cancer Center & Research Institute, Tampa, FL, USA
4Department of Tumor Biology, H. Lee Moffit Cancer Center & Research Institute, Tampa, FL, USA
5Department of Pharmacology, Weill Cornell Medicine, New York, NY, USA
6Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA
7Mass Spectrometry Core, Beth Israel Deaconess Medical Center, Boston, MA, USA
8Department of Biochemistry and Molecular Biology, Penn State University, University Park, PA, USA
9Huck Institutes of the Life Sciences, Penn State University, University Park, PA, USA

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